Microfluidic device and its use for positioning of cells or organisms
    4.
    发明授权
    Microfluidic device and its use for positioning of cells or organisms 有权
    微流体装置及其用于定位细胞或生物体的用途

    公开(公告)号:US09511366B2

    公开(公告)日:2016-12-06

    申请号:US13991848

    申请日:2012-01-13

    摘要: A micro fluidic device comprises one microstructure layer (5) and one cover layer (1), wherein the cover layer (1) is connected to the microstructure layer (5). The microstructure layer (5) comprises one bottom layer and a plurality of microstructures on it to position samples. The cover layer (1) comprises one top layer, one positioning well (6) and at least one inlet pool (4). The positioning well (6) is right above the microstructures and connected with each other. The inlet pools (4) and the positioning well (6) are connected by microchannels (3) which are formed between the microstructure layer (5) and the cover layer (1). The micro fluidic device can be applied in vitro fertilization, in determining how glial cells affect neurons, in constructing neural network and in detecting cell growth conditions.

    摘要翻译: 微流体装置包括一个微结构层(5)和一个覆盖层(1),其中覆盖层(1)连接到微结构层(5)。 微结构层(5)包括一个底层和多个微结构,用于定位样品。 覆盖层(1)包括一个顶层,一个定位孔(6)和至少一个入口池(4)。 定位井(6)位于微结构的正上方并相互连接。 入口池(4)和定位井(6)通过形成在微结构层(5)和覆盖层(1)之间的微通道(3)连接。 微流体装置可以应用于体外受精,确定神经胶质细胞如何影响神经元,构建神经网络和检测细胞生长条件。

    Integrated microfluidic device for single oocyte trapping
    5.
    发明授权
    Integrated microfluidic device for single oocyte trapping 有权
    用于单卵母细胞捕获的集成微流体装置

    公开(公告)号:US09445840B2

    公开(公告)日:2016-09-20

    申请号:US13805322

    申请日:2011-06-17

    摘要: An integrated microfluidic device and its usage are provided. The microfluidic device comprises an upper layer (1) and a lower layer (2), wherein the lower layer (2) is bound to the upper layer (1). The upper layer (1) comprises a micro-channel (3) and the lower layer (2) comprises a micro-well (7) array. The micro-channel (3) is in fluidic connection with the micro-well (7) array, and the height of the micro-channel (3) is greater than the diameter of the oocyte (4) flowing through the micro-channel (3). The integrated microfluidic device has many advantages including low cost, high integration, and convenient operation, and has application prospects in reproductive medicine and the research of fertilization and embryo early development.

    摘要翻译: 提供集成的微流体装置及其用途。 微流体装置包括上层(1)和下层(2),其中下层(2)与上层(1)结合。 上层(1)包括微通道(3),下层(2)包括微孔(7)阵列。 微通道(3)与微孔(7)阵列流体连接,并且微通道(3)的高度大于流过微通道的卵母细胞(4)的直径( 3)。 集成微流体装置具有成本低,整合性高,操作方便等优点,在生殖医学和受精胚胎早期发育研究中具有应用前景。

    Methods for forming silicon-based hermetic thermal solutions
    7.
    发明授权
    Methods for forming silicon-based hermetic thermal solutions 有权
    形成硅基密封热解决方案的方法

    公开(公告)号:US09391000B2

    公开(公告)日:2016-07-12

    申请号:US13445734

    申请日:2012-04-12

    IPC分类号: H01L23/473 H01L21/48

    摘要: A method includes forming a first oxide layer on a surface of an integrated heat spreader, and forming a second oxide layer on top surfaces of fins, wherein the fins are parts of a heat sink. The integrated heat spreader is bonded to the heat sink through the bonding of the first oxide layer to the second oxide layer.

    摘要翻译: 一种方法包括在集成散热器的表面上形成第一氧化物层,并且在翅片的顶表面上形成第二氧化物层,其中散热片是散热片的一部分。 集成散热器通过第一氧化物层与第二氧化物层的结合而结合到散热器。