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1.发明授权公开(公告)号：US09173890B2
公开(公告)日：2015-11-03
申请号：US11946028
申请日：2007-11-27
Applicant: Katsuyuki Murase , Jinping Wan , John Stankus , Dariush Davalian , Florian Ludwig
Inventor： Katsuyuki Murase , Jinping Wan , John Stankus , Dariush Davalian , Florian Ludwig
IPC: A61K38/00 , A61K31/661 , A61K9/14 , A61K38/10 , A61K38/17 , A61P3/00 , A61K9/00 , A61K9/127 , A61K9/16 , A61K9/51
CPC classification number: A61K31/661 , A61K9/0019 , A61K9/0024 , A61K9/127 , A61K9/1647 , A61K9/5153 , A61K38/17
Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.
Abstract translation: 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质 胆固醇运输。 包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。
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2.发明授权Poly(amide) and poly(ester-amide) polymers and drug delivery particles and coatings containing same 有权聚（酰胺）和聚（酯 - 酰胺）聚合物和药物递送颗粒和含有它们的涂层公开(公告)号：US08916187B2
公开(公告)日：2014-12-23
申请号：US13221767
申请日：2011-08-30
Applicant: Michael Huy Ngo , Mikael O. Trollsas , Thierry Glauser , Jinping Wan , Bozena Zofia Maslanka
Inventor： Michael Huy Ngo , Mikael O. Trollsas , Thierry Glauser , Jinping Wan , Bozena Zofia Maslanka
CPC classification number: C08L77/12 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/62 , C08G69/44 , C08G69/48
Abstract: The current invention relates to poly(amide) and poly(ester-amide) polymers, coatings including the polymers, and narrow polydispersity drug delivery particles including the polymers.
Abstract translation: 本发明涉及聚（酰胺）和聚（酯 - 酰胺）聚合物，包括聚合物的涂层和包括聚合物的窄多分散药物递送颗粒。
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公开(公告)号：US20090081299A1
公开(公告)日：2009-03-26
申请号：US11946029
申请日：2007-11-27
Applicant: Syed F. A. Hossainy , Jinping Wan , Dariush Davalian , Florian Ludwig , Katsuyuki Murase
Inventor： Syed F. A. Hossainy , Jinping Wan , Dariush Davalian , Florian Ludwig , Katsuyuki Murase
CPC classification number: A61K31/661 , A61K9/1647 , A61K9/5084 , A61K38/00
Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.
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公开(公告)号：US08388948B2
公开(公告)日：2013-03-05
申请号：US13525158
申请日：2012-06-15
Applicant: Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
Inventor： Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
CPC classification number: A61L27/52 , A61L27/20 , A61L27/3604 , A61L27/3641 , A61L27/365 , A61L27/3804 , A61L27/3839 , C08L5/04
Abstract: The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.
Abstract translation: 本发明涉及一种制备细胞相容性藻酸盐凝胶的方法及其在治疗心肌病中的应用。
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公开(公告)号：US08293226B1
公开(公告)日：2012-10-23
申请号：US13525165
申请日：2012-06-15
Applicant: Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
Inventor： Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
IPC: A01N63/00
CPC classification number: A61L27/52 , A61L27/20 , A61L27/3604 , A61L27/3641 , A61L27/365 , A61L27/3804 , A61L27/3839 , C08L5/04
Abstract: The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.
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Patent Agency Ranking
公开(公告)号：US20120251508A1
公开(公告)日：2012-10-04
申请号：US13525158
申请日：2012-06-15
Applicant: Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
Inventor： Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
CPC classification number: A61L27/52 , A61L27/20 , A61L27/3604 , A61L27/3641 , A61L27/365 , A61L27/3804 , A61L27/3839 , C08L5/04
Abstract: The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.
Abstract translation: 本发明涉及一种制备细胞相容性藻酸盐凝胶的方法及其在治疗心肌病中的应用。
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7.发明申请公开(公告)号：US20110196474A1
公开(公告)日：2011-08-11
申请号：US12704136
申请日：2010-02-11
Applicant: Dariush Davalian , Syed Faiyaz Ahmed Hossainy , Rachel Bright , Jinping Wan , Florian Niklas Ludwig
Inventor： Dariush Davalian , Syed Faiyaz Ahmed Hossainy , Rachel Bright , Jinping Wan , Florian Niklas Ludwig
CPC classification number: A61K31/436 , A61K9/0009 , A61K9/0019 , A61K9/19 , A61K9/5094
Abstract: Compositions of matter comprising a magnetically sensitive drug carrier and a related drug as well as methods for administering these compositions and causing them to localize within the patient using an internal or external magnetic field are described.
Abstract translation: 描述了包含磁敏感药物载体和相关药物的物质组合物以及用于施用这些组合物并使其使用内部或外部磁场定位在患者体内的方法。
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8.发明授权公开(公告)号：US07985728B1
公开(公告)日：2011-07-26
申请号：US11858862
申请日：2007-09-20
Applicant: Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
Inventor： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
CPC classification number: C07K14/775 , A61K38/00
Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (Apo A-I) synthetic peptide, or combination of an Apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various Apo A-I mimetic peptides, or endogenous Apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous Apo A-I.
Abstract translation: 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白A-I（Apo A-I）合成模拟肽的组合物引入所述特定区域的血管壁中，其中所述肽具有使所述肽在反向胆固醇转运中有效的性质。 一种包含载体载脂蛋白AI（Apo AI）合成肽或Apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列的顺序与各种Apo AI模拟肽或内源性Apo AI类似物的顺序相反，或内源Apo AI的螺旋1和螺旋9的嵌合体。
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9.发明申请公开(公告)号：US20110009949A1
公开(公告)日：2011-01-13
申请号：US12888305
申请日：2010-09-22
Applicant: John Stankus , Syed F.A. Hossainy , Jinping Wan
Inventor： John Stankus , Syed F.A. Hossainy , Jinping Wan
IPC: A61F2/82
CPC classification number: A61F2/86 , A61L31/14 , B32B1/08 , D01D5/0069 , D01F1/10 , D04H1/728 , D04H1/76
Abstract: Medical devices, such as stents, including a fibrous layer including particles are disclosed. Methods of forming such medical devices using electrospinning are disclosed.
Abstract translation: 公开了包括包括颗粒的纤维层在内的医疗装置，例如支架。 公开了使用静电纺丝形成这种医疗装置的方法。
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10.发明申请公开(公告)号：US20090081293A1
公开(公告)日：2009-03-26
申请号：US11946028
申请日：2007-11-27
Applicant: Katsuyuki Murase , Jinping Wan , John Stankus , Dariush Davalian , Florian Ludwig
Inventor： Katsuyuki Murase , Jinping Wan , John Stankus , Dariush Davalian , Florian Ludwig
CPC classification number: A61K31/661 , A61K9/0019 , A61K9/0024 , A61K9/127 , A61K9/1647 , A61K9/5153 , A61K38/17
Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.
Abstract translation: 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质 胆固醇运输。 包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。
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