-
公开(公告)号：US08697133B2
公开(公告)日：2014-04-15
申请号：US12808314
申请日：2008-12-15
Applicant: Barry Douglas Moore , Johann Partridge , Louise Bradley , Jan Vos
Inventor： Barry Douglas Moore , Johann Partridge , Louise Bradley , Jan Vos
IPC: A61K9/14 , A61K33/06 , A61K33/08 , A61K33/10 , A61K31/7088 , A61K31/715 , A61K38/00
CPC classification number: A61K9/14 , A61K9/501 , A61K9/5089 , A61K31/7088 , A61K33/06 , A61K33/08 , A61K38/00 , A61K39/00 , A61K47/02 , A61K47/183 , A61K2039/60
Abstract: The present invention relates to the provision of micron or sub-micron sized particles formed from one or more water-soluble crystals comprising a surface coating comprising one or more bioactive molecules wherein the particles are prepared such that in use the release of the bioactive molecule(s) is/are delayed and/or continually released over a period of time. Processes for the preparation of said particles, as well as the particles themselves are described, as well as uses of the particles.
Abstract translation: 本发明涉及提供由一种或多种水溶性晶体形成的微米或亚微米级的颗粒，其包含包含一种或多种生物活性分子的表面涂层，其中制备颗粒使得在使用中释放生物活性分子（ s）被延迟和/或持续释放一段时间。 描述了用于制备所述颗粒的方法以及颗粒本身以及颗粒的用途。
-
公开(公告)号：US20060120992A1
公开(公告)日：2006-06-08
申请号：US11287653
申请日：2005-11-28
Applicant: Barry Moore , Marie Parker , Peter Halling , Johann Partridge , Howard Stevens
Inventor： Barry Moore , Marie Parker , Peter Halling , Johann Partridge , Howard Stevens
Abstract: The present invention relates to protein-coated micro-crystals and their method of preparation. The protein-coated micro-crystals may find particular application in preparing enzymes for use as biocatalysts; preparation of therapeutic proteins for use in pharmaceutical formulations; production of cleansing agents comprising enzymes; production of paints, varnishes, coatings, films and the like comprising proteins which impart protective and/or antifouling properties; production of films, polymers, inks, coatings, electrodes and/or optical materials comprising proteins for diagnostic kits and/or biosensor applications; use of proteins for studies of molecular recognition, molecular binding and inhibitor binding in non-aqueous media; and preparation of protein based food additives.
-
公开(公告)号：US07014869B2
公开(公告)日：2006-03-21
申请号：US10007257
申请日：2001-11-13
Applicant: Barry Douglas Moore , Marie Claire Parker , Peter James Halling , Johann Partridge , Howard Norman Ernest Stevens
Inventor： Barry Douglas Moore , Marie Claire Parker , Peter James Halling , Johann Partridge , Howard Norman Ernest Stevens
Abstract: The present invention relates to protein-coated micro-crystals and their method of preparation. The protein-coated micro-crystals may find particular application in preparing enzymes for use as biocatalysts; preparation of therapeutic proteins for use in pharmaceutical formulations; production of cleansing agents comprising enzymes; production of paints, varnishes, coatings, films and the like comprising proteins which impart protective and/or antifouling properties; production of films, polymers, inks, coatings, electrodes and/or optical materials comprising proteins for diagnostic kits and/or biosensor applications; use of proteins for studies of molecular recognition, molecular binding and inhibitor binding in non-aqueous media; and preparation of protein based food additives.
-
公开(公告)号：US20060292224A1
公开(公告)日：2006-12-28
申请号：US10541786
申请日：2004-01-09
Applicant: Barry Moore , Marie Parker , Johann Partridge , Jan Vos , Michaela Kreiner , Howard Steven , Maria Flores , Alistair Ross
Inventor： Barry Moore , Marie Parker , Johann Partridge , Jan Vos , Michaela Kreiner , Howard Steven , Maria Flores , Alistair Ross
IPC: A61K48/00 , A61K38/28 , B29B9/00 , A61K39/12 , A61K39/02 , A61K38/21 , A61K9/14 , A61K38/38 , A61K38/54
CPC classification number: A61K9/1682 , A61K9/145 , A61K9/1617 , A61K9/1623 , A61K38/28 , A61K39/05 , A61K2039/55555 , Y02A50/466
Abstract: This invention relates to pharmaceutical formulations comprising particles with a substantially non-hygroscopic inner crystalline core and an outer coating comprising at least one bioactive molecule. The invention also relates to methods of forming particles comprising a substantially non-hygroscopic inner crystalline core and an outer coating comprising at least one bioactive molecule.
Abstract translation: 本发明涉及包含具有基本上非吸湿性内晶核的颗粒和包含至少一种生物活性分子的外涂层的药物制剂。 本发明还涉及形成包含基本上非吸湿性内晶核和包含至少一种生物活性分子的外涂层的颗粒的方法。
-
公开(公告)号：US20100151247A1
公开(公告)日：2010-06-17
申请号：US12597300
申请日：2008-04-25
Applicant: Barry Douglas Moore , Jan Vos , Johann Partridge
Inventor： Barry Douglas Moore , Jan Vos , Johann Partridge
IPC: C07K16/00
CPC classification number: A61K9/145 , A61K39/39591 , C07K16/00 , C07K16/2818 , C07K2317/21 , Y10T428/2982 , Y10T428/2991
Abstract: The present invention relates to maintaining bioactive molecules in their native or substantially near-native form and preventing or reduce aggregation. In particular, the present invention relates to precipitation-protective or stabilising additives and a method of using said precipitation-protective/stabilising additives to protect and maintain the bioactive molecules in a native or substantially near-native form and to prevent or reduce aggregation during or following precipitation to form particles.
Abstract translation: 本发明涉及将生物活性分子维持在天然或基本上近乎天然的形式，并防止或减少聚集。 特别地，本发明涉及沉淀保护或稳定添加剂以及使用所述沉淀保护/稳定添加剂来保护和维持天然或基本上近乎天然形式的生物活性分子并防止或减少在 随后沉淀形成颗粒。
-
6.发明授权Precipitation stabilising compositions comprising bioactive molecule and at least one cationic and one anionic precipitation stabilizing additives 有权沉淀稳定组合物包含生物活性分子和至少一种阳离子和一种阴离子沉淀稳定添加剂
公开(公告)号：US08932715B2
公开(公告)日：2015-01-13
申请号：US12597300
申请日：2008-04-25
Applicant: Barry Douglas Moore , Jan Vos , Johann Partridge
Inventor： Barry Douglas Moore , Jan Vos , Johann Partridge
IPC: A61K9/14 , A61K9/16 , A61K39/395 , C07K16/28 , C07K16/00
CPC classification number: A61K9/145 , A61K39/39591 , C07K16/00 , C07K16/2818 , C07K2317/21 , Y10T428/2982 , Y10T428/2991
Abstract: The present invention relates to maintaining bioactive molecules in their native or substantially near-native form and preventing or reduce aggregation. In particular, the present invention relates to precipitation-protective or stabilizing additives and a method of using said precipitation-protective/stabilizing additives to protect and maintain the bioactive molecules in a native or substantially near-native form and to prevent or reduce aggregation during or following precipitation to form particles.
Abstract translation: 本发明涉及将生物活性分子维持在天然或基本上近乎天然的形式，并防止或减少聚集。 特别地，本发明涉及沉淀保护或稳定添加剂以及使用所述沉淀保护/稳定添加剂来保护和维持天然或基本上近乎天然形式的生物活性分子并防止或减少在 随后沉淀形成颗粒。
-
公开(公告)号：US20110008450A1
公开(公告)日：2011-01-13
申请号：US12808314
申请日：2008-12-15
Applicant: Barry Douglas Moore , Johann Partridge , Louise Bradley , Jan Vos
Inventor： Barry Douglas Moore , Johann Partridge , Louise Bradley , Jan Vos
CPC classification number: A61K9/14 , A61K9/501 , A61K9/5089 , A61K31/7088 , A61K33/06 , A61K33/08 , A61K38/00 , A61K39/00 , A61K47/02 , A61K47/183 , A61K2039/60
Abstract: The present invention relates to the provision of micron or sub-micron sized particles formed from one or more water-soluble crystals comprising a surface coating comprising one or more bioactive molecules wherein the particles are prepared such that in use the release of the bioactive molecule(s) is/are delayed and/or continually released over a period of time. Processes for the preparation of said particles, as well as the particles themselves are described, as well as uses of the particles.
Abstract translation: 本发明涉及提供由一种或多种水溶性晶体形成的微米或亚微米级的颗粒，其包含包含一种或多种生物活性分子的表面涂层，其中制备颗粒使得在使用中释放生物活性分子（ s）被延迟和/或持续释放一段时间。 描述了用于制备所述颗粒的方法以及颗粒本身以及颗粒的用途。
