摘要:
Compound having formula (I), wherein —W is NH—, —N(CH3)— or piperazine, —X is a bond, —C(═O)— or S(═O)2—, —Y is C3-7alkylene, and —Z is NH—C(═O)— or —O—, and pharmaceutically acceptable salts thereof, their pharmaceutical formulations and use as HIV inhibitors.
摘要:
HIV inhibitors of formula (I) wherein R1 is halo, C1-4 alkoxy, trifluoromethoxy; R2 is a group of formula (A); R3 is a group of formula (B); R4 is a group of formula (C); n is 0 or 1; A is CH or N; R5 and R6 are hydrogen, C1-4 allyl, halo; R7 and R8 are C1-4 allyl or C1-4 alkoxy-C1-4 alkyl; R9 is C1-4 allyl, cyclopropyl, trifluoromethyl, C1-4 alkoxy, or dimethylamino; R10 is hydrogen, C1-4 alkyl, cyclopropyl, trifluoromethyl, C1-4 alkoxy, or dimethylamino; pharmaceutically acceptable addition salts and solvates thereof; pharmaceutical compositions containing these compounds as active ingredient and processes for preparing said compounds.
摘要翻译:式(I)的HIV抑制剂,其中R 1是卤素,C 1-4烷氧基,三氟甲氧基; R2是式(A)的基团; R3是式(B)的基团; R4是式(C)的基团; n为0或1; A是CH或N; R5和R6是氢,C1-4烷基,卤素; R 7和R 8是C 1-4烯丙基或C 1-4烷氧基-C 1-4烷基; R 9为C 1-4烯丙基,环丙基,三氟甲基,C 1-4烷氧基或二甲基氨基; R 10是氢,C 1-4烷基,环丙基,三氟甲基,C 1-4烷氧基或二甲基氨基; 其药学上可接受的加成盐和溶剂合物; 含有这些化合物作为活性成分的药物组合物和制备所述化合物的方法。
摘要:
This invention concerns to naphthyridin derivatives of formula (I) for use in the treatment or prevention of feline immunodeficiency virus (FIV). Furthermore the present invention relates to a method of treating or preventing infection of feline immunodeficiency virus in a feline animal wherein said method comprises the administration to said feline animal of a therapeutically effective amount of a naphthyridin derivative.
摘要:
HIV inhibitors of formula wherein R1 is halo, C1-4alkoxy, trifluoromethoxy; n is 0 or 1; A is CH or N; R5 and R6 are hydrogen, C1-4alkyl, halo; R7 and R8 are C1-4alkyl or C1-4alkoxyC1-4alkyl; R9 is C1-4alkyl, cyclopropyl, trifluoromethyl, C1-4alkoxy, or dimethylamino; R10 is hydrogen, C1-4alkyl, cyclopropyl, trifluoromethyl, C1-4alkoxy, or dimethylamino; pharmaceutically acceptable addition salts and solvates thereof; pharmaceutical compositions containing these compounds as active ingredient and processes for preparing said compounds.
摘要翻译:下式的HIV抑制剂其中R1是卤素,C1-4烷氧基,三氟甲氧基; n为0或1; A是CH或N; R5和R6是氢,C1-4烷基,卤素; R 7和R 8是C 1-4烷基或C 1-4烷氧基C 1-4烷基; R 9为C 1-4烷基,环丙基,三氟甲基,C 1-4烷氧基或二甲基氨基; R 10是氢,C 1-4烷基,环丙基,三氟甲基,C 1-4烷氧基或二甲基氨基; 其药学上可接受的加成盐和溶剂合物; 含有这些化合物作为活性成分的药物组合物和制备所述化合物的方法。
摘要:
Compound having formula (I), wherein —W is NH—, —N(CH3)— or piperazine, —X is a bond, —C(═O)— or S(═O)2—, —Y is C3-7alkylene, and —Z is NH—C(═O)— or —O—, and pharmaceutically acceptable salts thereof, their pharmaceutical formulations and use as HIV inhibitors.