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公开(公告)号：US20130193598A1
公开(公告)日：2013-08-01
申请号：US13825770
申请日：2011-09-22
IPC分类号： B29B9/00
摘要： The process comprises delivering a spray solution comprising at least one solute in a solvent to a spray-drying apparatus, using a flash nozzle to atomize the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution is directed to a heat exchanger, thereby increasing the temperature of the spray solution to a temperature T2, wherein T2 is greater than T1. The flash nozzle comprises a central tube through which the spray solution is delivered and an outer tube through which a sweep gas is delivered. The central tube may have a first outer diameter at an inlet and a second outer diameter at an outlet, wherein the first outer diameter is greater than the second outer diameter.
摘要翻译： 该方法包括将包含至少一种溶剂的溶液在溶剂中输送到喷雾干燥装置，使用闪蒸喷嘴将喷雾溶液雾化成喷雾干燥装置内的液滴，以从溶剂中除去至少一部分溶剂 液滴形成多个颗粒，并收集颗粒。 喷雾溶液被引导到热交换器，从而将喷雾溶液的温度升高到T2，其中T2大于T1。 闪光喷嘴包括中心管，喷射溶液通过该中心管和外部管，吹扫气体通过该外部管输送。 中心管可以在入口处具有第一外径，在出口处可以具有第二外径，其中第一外径大于第二外径。
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公开(公告)号：US09724664B2
公开(公告)日：2017-08-08
申请号：US13259082
申请日：2010-03-19
IPC分类号： B01J2/04
CPC分类号： B01J2/04
摘要： The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T1, and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T2, wherein T2 is greater than T1, and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T2, such that the active agent and matrix material are soluble in the organic solvent at T2.
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公开(公告)号：US09248584B2
公开(公告)日：2016-02-02
申请号：US13825770
申请日：2011-09-22
摘要： The process comprises delivering a spray solution comprising at least one solute in a solvent to a spray-drying apparatus, using a flash nozzle to atomize the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution is directed to a heat exchanger, thereby increasing the temperature of the spray solution to a temperature T2, wherein T2 is greater than T1. The flash nozzle comprises a central tube through which the spray solution is delivered and an outer tube through which a sweep gas is delivered. The central tube may have a first outer diameter at an inlet and a second outer diameter at an outlet, wherein the first outer diameter is greater than the second outer diameter.
摘要翻译： 该方法包括将包含至少一种溶剂的溶液在溶剂中输送到喷雾干燥装置，使用闪蒸喷嘴将喷雾溶液雾化成喷雾干燥装置内的液滴，以从溶剂中除去至少一部分溶剂 液滴形成多个颗粒，并收集颗粒。 喷雾溶液被引导到热交换器，从而将喷雾溶液的温度升高到T2，其中T2大于T1。 闪光喷嘴包括中心管，喷射溶液通过该中心管和外部管，吹扫气体通过该外部管输送。 中心管可以在入口处具有第一外径，在出口处可以具有第二外径，其中第一外径大于第二外径。
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公开(公告)号：US20120015924A1
公开(公告)日：2012-01-19
申请号：US13259082
申请日：2010-03-19
CPC分类号： B01J2/04
摘要： The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T1, and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T2, wherein T2 is greater than T1, and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T2, such that the active agent and matrix material are soluble in the organic solvent at T2.
摘要翻译： 该方法包括将包含活性剂和基质材料的喷雾溶液在有机溶剂中输送到喷雾干燥装置，将喷雾溶液雾化成喷雾干燥装置内的液滴，以将至少一部分有机溶剂从 液滴形成多个颗粒，并收集颗粒。 喷雾溶液可以通过形成包含活性剂，基质材料和有机溶剂的进料悬浮液形成，其中进料悬浮液处于温度T1，并将进料悬浮液引导至热交换器，从而提高 进料悬浮液温度T2，其中T2大于T1，并且喷雾溶液的压力大于T2处的有机溶剂的蒸气压，使得活性剂和基质材料可溶于有机溶剂中 T2。
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公开(公告)号：US20130165371A1
公开(公告)日：2013-06-27
申请号：US13820494
申请日：2011-09-01
申请人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard , Dwayne T. Friesen , David D. Newbold , John M. Baumann , Devon B. Dubose
发明人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard , Dwayne T. Friesen , David D. Newbold , John M. Baumann , Devon B. Dubose
IPC分类号： B01D1/20
摘要： A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.
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公开(公告)号：US09084976B2
公开(公告)日：2015-07-21
申请号：US13820494
申请日：2011-09-01
申请人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard , Dwayne T. Friesen , David D. Newbold , John M. Baumann , Devon B. Dubose
发明人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard , Dwayne T. Friesen , David D. Newbold , John M. Baumann , Devon B. Dubose
摘要： A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.
摘要翻译： 喷雾干燥设备包括干燥室，其具有第一端，第二端和在第一和第二端之间延伸的至少一个侧壁，以限定具有中心轴线的干燥室的内部。 喷嘴可以位于干燥室的第一端处，并且被配置成雾化液体并且以相对于中心轴线的最大喷射图形角度将雾化的液体喷射到干燥室的内部。 可以提供加热装置以在引入干燥室之前加热液体。
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公开(公告)号：US20160287568A1
公开(公告)日：2016-10-06
申请号：US15038373
申请日：2014-11-19
申请人： John M. BAUMANN , Michael LOWINGER , Aditya S. TATAVARTI , Patrick Jules MARSAC , Kristin J. M. PLOEGER , Corey J. BLOOM , Katherine Anne BROOKHART , MERCK SHARP & DOHME CORP.
发明人： Michael Lowinger , Aditya S. Tatavarti , Patrick Jules Marsac , Kristin J.M. Ploeger , John M. Baumann , Corey J. Bloom , Katherine Anne Brookhart
IPC分类号： A61K31/4439 , A61K9/16
CPC分类号： A61K31/4439 , A61K9/1652 , A61K9/1682 , A61K9/4808
摘要： The invention encompasses a composition comprising the reverse transcriptase (“RT”) inhibitor 3-chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl}oxy)benzonitrile sufficiently mixed in a concentration enhancing polymer, and processes for making the same. The composition and processes of the present invention significantly improve the bioavailability of the aforementioned RT inhibitor, while maintaining physical stability.
摘要翻译： 本发明包括含有逆转录酶（“RT”）抑制剂3-氯-5 - （{1 - [（4-甲基-5-氧代-4,5-二氢-1H-1,2,4-三唑） -3-基）甲基] -2-氧代-4-（三氟甲基）-1,2-二氢吡啶-3-基}氧基）苄腈及其制备方法。 本发明的组合物和方法在保持物理稳定性的同时显着提高了上述RT抑制剂的生物利用度。
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