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1.发明授权Process for preparing a particle comprising a biological molecule and a carrier polymer 有权制备包含生物分子和载体聚合物的颗粒的方法公开(公告)号：US08932640B2
公开(公告)日：2015-01-13
申请号：US12278855
申请日：2007-02-08
CPC分类号： A61K48/00 , A61K9/146 , A61K9/1647 , A61K9/1682
摘要： A process for preparing a particle comprising a biological molecule typically a DNA plasmid, and a carrier polymer, typically poly-lactic acid (PLA), in which an organic solvent solution of the biological molecule and the carrier polymer in an organic solvent medium, nearly saturated with the biological molecule, is prepared, then this solution is contacted with an antisolvent substance, typically supercritical carbon dioxide to separate a particle comprising the biological molecule and the carrier polymer. High loadings of the biological molecule in the particle can be achieved.
摘要翻译： 制备包含通常为DNA质粒的生物分子的颗粒和通常为聚乳酸（PLA）的载体聚合物的方法，其中生物分子和载体聚合物的有机溶剂溶液在有机溶剂介质中几乎 与生物分子饱和，然后将该溶液与抗溶剂物质（通常为超临界二氧化碳）接触以分离包含生物分子和载体聚合物的颗粒。 可以实现颗粒中生物分子的高负荷。
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公开(公告)号：US20130284778A1
公开(公告)日：2013-10-31
申请号：US13702989
申请日：2011-06-07
IPC分类号： B60R9/048
摘要： The invention relates to a roof box 1 for mounting to a vehicle. The roof box 1 includes a securing mechanism 10 that enables the top section 2 of the box 1 to be secured to the base section 3 of the box 1 via a single locking point and which urges the top section 2 from the base section 3 when the roof box 1 securing mechanism 10 is opened allowing the user access to lift the top section 2 open.
摘要翻译： 本发明涉及一种用于安装到车辆的车顶箱1。 车顶箱1包括固定机构10，其能够使盒1的顶部2经由单个锁定点固定到箱体1的基部3，并且当顶盖部分2从基部3推压时， 车顶箱1固定机构10打开，允许用户进入以抬起顶部2打开。
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公开(公告)号：US20130043288A1
公开(公告)日：2013-02-21
申请号：US13512266
申请日：2010-11-29
IPC分类号： B60R9/058
摘要： A leg assembly is described that links a roof rack bar to a vehicle roof. The leg assembly utilises a T-bar member linked to a rocker member and via a biasing arrangement, the T-bar flanges impinge with the bar flanges to lock the leg assembly in place or optionally move the leg assembly along the bar length by forcing the T-bar member flanges up from the bar flanges until the desired position is reached before release and re-locking.
摘要翻译： 描述了将车顶支架杆连接到车顶的腿组件。 腿组件利用连接到摇杆构件的T形杆构件并且经由偏压装置，T形杆凸缘与杆凸缘碰撞，以将腿组件锁定在适当位置，或者可选地通过迫使腿组件沿杆长度移动 T型杆构件法兰从杆法兰上升到达到所需位置，然后释放和重新锁定。
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公开(公告)号：US20120055740A1
公开(公告)日：2012-03-08
申请号：US13255625
申请日：2010-01-29
CPC分类号： A62B1/08 , A62B1/10 , A63B69/0048 , H02K7/116 , H02K7/12 , H02K16/005 , H02K49/046 , H02K2213/09
摘要： An eddy-current braking mechanism including a rotor, rotatable about a rotor axis; at least one electrically conductive member coupled to the rotor for rotation therewith; at least one magnet configured to apply a magnetic field extending at least partially orthogonal to the plane of rotation of the conductive member, and characterised in that upon rotation of the rotor, the conductive member is configured to move at least partially radially from the rotor axis into the applied magnetic field.
摘要翻译： 一种涡流制动机构，包括可围绕转子轴线旋转的转子; 耦合到所述转子的至少一个导电构件与其一起旋转; 至少一个磁体被配置为施加至少部分地垂直于所述导电构件的旋转平面延伸的磁场，并且其特征在于，在所述转子旋转时，所述导电构件构造成至少部分地从所述转子轴线 进入施加的磁场。
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公开(公告)号：US20120050554A1
公开(公告)日：2012-03-01
申请号：US13215799
申请日：2011-08-23
申请人： Peter Alan Levine , Rui Zhu , John Robertson Tower
发明人： Peter Alan Levine , Rui Zhu , John Robertson Tower
IPC分类号： H04N5/225
CPC分类号： H04N5/33 , H01L27/14609 , H01L27/14627 , H01L27/14629 , H01L27/1464 , H04N5/374
摘要： A pixel design is disclosed. The pixel includes a photo-sensitive element. A first reflective layer substantially overlies the photo-sensitive element. A second reflective layer substantially underlies the photo-sensitive element and forms a cavity with the first reflective layer that is non-resonant with respect to photon absorption. An aperture is formed in either the first reflective layer or the second reflective layer. When electromagnetic radiation enters the aperture, the first reflective layer and the second reflective layer are configured to reflect the electromagnetic radiation substantially toward each other until substantially absorbed in the cavity.
摘要翻译： 公开了像素设计。 像素包括光敏元件。 基本上覆盖光敏元件的第一反射层。 第二反射层基本上位于感光元件下面，并且形成与第一反射层相对于光子吸收不共振的空腔。 在第一反射层或第二反射层中形成孔。 当电磁辐射进入孔径时，第一反射层和第二反射层构造成基本上彼此相对地反射电磁辐射，直到基本上被吸收在空腔中。
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公开(公告)号：US20110290983A1
公开(公告)日：2011-12-01
申请号：US13114694
申请日：2011-05-24
IPC分类号： H01L27/146
CPC分类号： H04N5/378 , H04N5/35509
摘要： A non-linear conversion capability within an on-chip, per-column analog-to-digital converter (ADC) is provided to expand a compressed analog signal such that the resulting digital output that has a predetermined (linear or non-linear) mapping with respect to input brightness level of an incoming light signal to a row of pixels. The predetermined mapping may also be provided by a non-linear amplifier coupled to a linear or non-linear ADC and a resulting compressed non-linear digital representation at the output of the ADC is substantially linearized by an on-chip or an off-chip look-up table (LUT).
摘要翻译： 提供片内，每列模数转换器（ADC）中的非线性转换能力以扩展压缩模拟信号，使得所得到的数字输出具有预定的（线性或非线性）映射 相对于输入光信号到一行像素的输入亮度水平。 预定的映射也可以由耦合到线性或非线性ADC的非线性放大器提供，并且在ADC的输出端产生的压缩非线性数字表示基本上由片上或片外 查找表（LUT）。
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公开(公告)号：US07948536B2
公开(公告)日：2011-05-24
申请号：US12128890
申请日：2008-05-29
CPC分类号： H04N5/365 , H01L27/14609 , H01L27/14643 , H04N5/369
摘要： A method and apparatus for equalizing gain in an array of electron multiplication (EM) pixels is disclosed, each pixel having one or more impact ionization gain stages with implants to achieve charge transfer directionality and comprising a phase 1 clocked gate, an EM clocked gate, and two DC gates formed between the phase 1 clocked gate and the EM clocked gate, comprising the steps of (a) applying initial voltages to each of the DC gates and the EM clocked gates of at least two pixels of a plurality of pixels; (b) clocking phase 1 clock gates and an EM clock gates associated with the at least two pixels of the plurality of pixels a predetermined number of times to achieve an average pixel intensity value after impact ionization gain; and (c) selectively adjusting the difference in voltage between the DC gate and corresponding EM clocked gate of the at least two pixels of the plurality of pixels until the difference between the resulting pixel intensity values and the average pixel intensity value needed to produce a desired uniform gain image is below a predetermined threshold.
摘要翻译： 公开了一种用于均衡电子倍增（EM）像素阵列中的增益的方法和装置，每个像素具有一个或多个具有植入物的冲击电离增益级，以实现电荷转移方向性，并且包括相位1时钟门，EM时钟门， 和形成在相位1时钟门和EM时钟门之间的两个DC门，包括以下步骤：（a）向多个像素中的至少两个像素的DC门和EM时钟门中的每一个施加初始电压; （b）将预定次数与所述多个像素中的所述至少两个像素相关联的时钟相位1个时钟门和EM时钟门，以实现冲击电离增益之后的平均像素强度值; 以及（c）选择性地调整所述多个像素中的所述至少两个像素的所述DC栅极与所述对应的EM时钟栅极之间的电压差，直到得到的像素强度值与产生所需的像素强度值所需的平均像素强度值之间的差值 均匀增益图像低于预定阈值。
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公开(公告)号：US20080280320A1
公开(公告)日：2008-11-13
申请号：US12070676
申请日：2008-02-19
IPC分类号： C12Q1/02
CPC分类号： G01N33/505 , A61K39/00
摘要： The present invention regards methods and formulations for diagnosis, prevention and treatment of disease. More particularly, the present invention teaches methods and formulations for diagnosis, prevention and treatment with antigen in autoimmune disease, allergy, rejection of transplants and cancer. Examples illustrate how the methods of formulations of the invention may be used for diagnosis and amelioration of autoimmune diabetes in which the 65kd isotype of glutamic acid decarboxylase (GAD) is a major antigen.
摘要翻译： 本发明涉及用于诊断，预防和治疗疾病的方法和制剂。 更具体地说，本发明教导了用于在自身免疫性疾病，变态反应，移植物排斥和癌症中用抗原进行诊断，预防和治疗的方法和制剂。 实施例说明了本发明制剂的方法如何用于谷氨酸脱羧酶（GAD）的65kd同种型是主要抗原的自身免疫性糖尿病的诊断和改善。
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9.发明申请Immunomodulation by a therapeutic medication intended for treatment of diabetes and prevention of autoimmune diabetes 审中-公开用于治疗糖尿病和预防自身免疫性糖尿病的治疗药物的免疫调节公开(公告)号：US20080226668A1
公开(公告)日：2008-09-18
申请号：US11906608
申请日：2007-10-03
IPC分类号： A61K39/00 , A61K38/16 , A61K31/7088 , A61K39/02 , A61K39/385
摘要： The present invention regards methods and formulations for the treatment of diabetes and the prevention of autoimmune diabetes. The invention includes the administration of human recombinant GAD65 protein in a pharmaceutically acceptable adjuvant.
摘要翻译： 本发明涉及用于治疗糖尿病和预防自身免疫性糖尿病的方法和制剂。 本发明包括在药学上可接受的佐剂中施用人重组GAD65蛋白。
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10.发明申请Nanoparticle colloid, method for its production and its use in the growth of carbon nanotubes 审中-公开纳米粒子胶体，其生产方法及其在碳纳米管生长中的应用公开(公告)号：US20070202304A1
公开(公告)日：2007-08-30
申请号：US11362261
申请日：2006-02-27
申请人： Vladimir Golovko , Brian Johnson , John Robertson , Mirco Cantoro , Angel Berenguer , Wilhelm Huck , Hongwei Li , Zongqiang Yang
发明人： Vladimir Golovko , Brian Johnson , John Robertson , Mirco Cantoro , Angel Berenguer , Wilhelm Huck , Hongwei Li , Zongqiang Yang
IPC分类号： B44C1/17
CPC分类号： B22F1/0022 , B01J13/0043 , B82Y30/00 , Y10T428/24802
摘要： A method for producing a colloid of metallic nanoparticles including the steps of: providing metal ions in solution; providing a stabilizing agent; and reducing said metal ions in the presence of said stabilizing agent, so that metallic nanoparticles are formed with a surrounding layer of said stabilizing agent, wherein the reduction step is carried out at a temperature of not less than 20° C. and not more than 150° C. The metallic nanoparticles are formed of a mixture of transition metal and noble metal, such as Ni—Pd. The resultant nanoparticles have a high stability in terms of size and chemical degradation and so can be stored for long periods. They are therefore particularly suited for forming patterned nanoparticle arrays on a substrate by nanocontact printing for the subsequent formation of a corresponding array of carbon nanotubes or nanofibers via plasma enhanced CVD.
摘要翻译： 一种制造金属纳米粒子胶体的方法，包括以下步骤：在溶液中提供金属离子; 提供稳定剂; 并在所述稳定剂存在下还原所述金属离子，使金属纳米颗粒与所述稳定剂的周围层形成，其中所述还原步骤在不低于20℃且不大于 150℃。金属纳米颗粒由过渡金属和贵金属的混合物如Ni-Pd形成。 所得纳米颗粒在尺寸和化学降解方面具有高稳定性，因此可以长期储存。 因此，它们特别适用于通过纳米接触印刷在衬底上形成图案化纳米颗粒阵列，以便随后通过等离子体增强CVD形成相应阵列的碳纳米管或纳米纤维。
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