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公开(公告)号:US20120190666A1
公开(公告)日:2012-07-26
申请号:US13319683
申请日:2010-05-12
申请人: Christiane Bode , Alessandro Boezio , Alan C. Cheng , Deborah Choquette , James Robert Coats , Katrina Woodin Copeland , Hongbing Huang , Daniel La , Richard Thomas Lewis , Hongyu Liao , Michele Potashman , John Stellwagen , Shuyan Yi , Mark H. Norman , Markian M. Stec , Emily Anne Peterson , Russell Graceffa
发明人: Christiane Bode , Alessandro Boezio , Alan C. Cheng , Deborah Choquette , James Robert Coats , Katrina Woodin Copeland , Hongbing Huang , Daniel La , Richard Thomas Lewis , Hongyu Liao , Michele Potashman , John Stellwagen , Shuyan Yi , Mark H. Norman , Markian M. Stec , Emily Anne Peterson , Russell Graceffa
IPC分类号: A61K31/52 , C07D401/14 , A61K31/506 , A61P35/02 , A61K31/53 , C07D487/04 , A61K31/5377 , A61P35/00 , C07D473/40 , C07D471/04
CPC分类号: C07D401/14 , C07D403/04 , C07D403/14 , C07D471/04 , C07D487/04 , C07D519/00
摘要: The present invention provides compounds that are PIKK inhibitors, more specifically, mTOR and/or PI3Kα kinase inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of kinases, specifically PI3 kinases, more specifically, mTOR and/or PI3Kα, such as cancer. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
摘要翻译: 本发明提供了PIKK抑制剂,更具体地,mTOR和/或PI3Kα激酶抑制剂的化合物,因此可用于治疗通过抑制激酶可治疗的疾病,特别是PI3激酶,更具体地,mTOR和/或PI3Kα,例如 癌症。 还提供含有这些化合物的药物组合物和制备这些化合物的方法。
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公开(公告)号:US08415345B2
公开(公告)日:2013-04-09
申请号:US12991004
申请日:2009-05-04
申请人: George Adjabeng , Jerry Leroy Adams , Scott Howard Dickerson , Keith Hornberger , Neil W. Johnson , Kevin Kuntz , Kimberly Petrov , Jeffrey M. Ralph , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , Xinrong Tian , David E. Uehling , Alex G. Waterson , Brian Wilson
发明人: George Adjabeng , Jerry Leroy Adams , Scott Howard Dickerson , Keith Hornberger , Neil W. Johnson , Kevin Kuntz , Kimberly Petrov , Jeffrey M. Ralph , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , Xinrong Tian , David E. Uehling , Alex G. Waterson , Brian Wilson
IPC分类号: C07D403/14 , A61K31/505
CPC分类号: C07D417/14 , A61K31/427 , C07D413/04 , C07D413/14 , C07D417/04
摘要: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译: 本发明提供噻唑磺酰胺和恶唑磺酰胺化合物,含有它们的组合物,以及其制备方法和用作药剂的方法。
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公开(公告)号:US20110190280A1
公开(公告)日:2011-08-04
申请号:US12674016
申请日:2008-08-27
申请人: George Adjabeng , Neil Bifulco , Ronda G. Davis-Ward , Scott Howard Dickerson , Kelly Horne Donaldson , Philip Anthony Harris , Keith Hornberger , Kimberly Petrov , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , David Edward Uehling , Alex Gregory Waterson
发明人: George Adjabeng , Neil Bifulco , Ronda G. Davis-Ward , Scott Howard Dickerson , Kelly Horne Donaldson , Philip Anthony Harris , Keith Hornberger , Kimberly Petrov , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , David Edward Uehling , Alex Gregory Waterson
IPC分类号: A61K31/541 , C07D403/14 , A61K31/506 , C07D413/14 , A61K31/5377 , C07D417/14 , C07D498/04 , A61K31/5365 , A61P35/00
CPC分类号: C07D417/04 , C07D413/04 , C07D413/14 , C07D417/14
摘要: The present invention provides thiazole and oxazole compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译: 本发明提供噻唑和恶唑化合物,含有它们的组合物,以及制备方法及其用作药剂的方法。
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公开(公告)号:US20090298815A1
公开(公告)日:2009-12-03
申请号:US12434963
申请日:2009-05-04
申请人: Jerry Leroy Adams , Scott Howard Dickerson , Neil W. Johnson , Kevin Kuntz , Kimberly Petrov , Jeffrey M. Ralph , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , Xinrong Tian , David Edward Uehling , Alex Gregory Waterson , Brian Wilson
发明人: Jerry Leroy Adams , Scott Howard Dickerson , Neil W. Johnson , Kevin Kuntz , Kimberly Petrov , Jeffrey M. Ralph , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , Xinrong Tian , David Edward Uehling , Alex Gregory Waterson , Brian Wilson
IPC分类号: A61K31/506 , C07D417/04 , C07D417/14 , A61K31/5377 , A61K31/541 , A61P35/00
CPC分类号: C07D417/14 , A61K31/427 , C07D413/04 , C07D413/14 , C07D417/04
摘要: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译: 本发明提供噻唑磺酰胺和恶唑磺酰胺化合物,含有它们的组合物,以及其制备方法和用作药剂的方法。
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公开(公告)号:US20130144055A1
公开(公告)日:2013-06-06
申请号:US13755466
申请日:2013-01-31
申请人: George Adjabeng , Jerry Leroy Adams , Scott Howard Dickerson , Keith Hornberger , Neil W. Johnson , Kevin Kuntz , Kimberly Petrov , Jeffrey M. Ralph , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , Xinrong Tian , David E. Uehling , Alex G. Waterson , Brian Wilson
发明人: George Adjabeng , Jerry Leroy Adams , Scott Howard Dickerson , Keith Hornberger , Neil W. Johnson , Kevin Kuntz , Kimberly Petrov , Jeffrey M. Ralph , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , Xinrong Tian , David E. Uehling , Alex G. Waterson , Brian Wilson
IPC分类号: C07D417/14 , C07D417/04 , C07D413/04 , C07D413/14 , C07D403/14
CPC分类号: C07D417/14 , A61K31/427 , C07D413/04 , C07D413/14 , C07D417/04
摘要: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译: 本发明提供噻唑磺酰胺和恶唑磺酰胺化合物,含有它们的组合物,以及其制备方法和用作药剂的方法。
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公开(公告)号:US20110172215A1
公开(公告)日:2011-07-14
申请号:US12991004
申请日:2009-05-04
申请人: George Adjabeng , Jeffrey Leroy Adams , Scott Howard Dickerson , Keith Hornberger , Neil W. Johnson , Kevin Kuntz , Kimberly Petrov , Jeffrey M. Ralph , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , Xinrong Tian , David E. Uehling , Alex G. Waterson , Brian Wilson
发明人: George Adjabeng , Jeffrey Leroy Adams , Scott Howard Dickerson , Keith Hornberger , Neil W. Johnson , Kevin Kuntz , Kimberly Petrov , Jeffrey M. Ralph , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , Xinrong Tian , David E. Uehling , Alex G. Waterson , Brian Wilson
IPC分类号: A61K31/541 , C07D417/14 , A61K31/5377 , A61K31/506 , C07D413/14 , C07D417/04 , A61P35/00
CPC分类号: C07D417/14 , A61K31/427 , C07D413/04 , C07D413/14 , C07D417/04
摘要: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译: 本发明提供噻唑磺酰胺和恶唑磺酰胺化合物,含有它们的组合物,以及其制备方法和用作药剂的方法。
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