公开(公告)号：US20070191344A1

公开(公告)日：2007-08-16

申请号：US10572043

申请日：2004-09-15

申请人： Axel Choidas ,  Alexander Backes ,  Matt Cotten ,  Ola Engkvist ,  Beatrice Felber ,  Achim Freisleben ,  Klaus Godl ,  Zoltan Greff ,  Peter Habenberger ,  Doris Hafenbradl ,  Christian Hartung ,  Thomas Herget ,  Edmund Hoppe ,  Bert Klebl ,  Andrea Missio ,  Gerhard Muller ,  Wilfried Schwab ,  Birgit Zech ,  Jose Bravo ,  John Harris ,  Joelle Le ,  Jackie Macritchie ,  Vladimir Savic ,  Brad Sherborne ,  Don Simpson

发明人： Axel Choidas ,  Alexander Backes ,  Matt Cotten ,  Ola Engkvist ,  Beatrice Felber ,  Achim Freisleben ,  Klaus Godl ,  Zoltan Greff ,  Peter Habenberger ,  Doris Hafenbradl ,  Christian Hartung ,  Thomas Herget ,  Edmund Hoppe ,  Bert Klebl ,  Andrea Missio ,  Gerhard Muller ,  Wilfried Schwab ,  Birgit Zech ,  Jose Bravo ,  John Harris ,  Joelle Le ,  Jackie Macritchie ,  Vladimir Savic ,  Brad Sherborne ,  Don Simpson

IPC分类号： A61K31/55 ,  A61K31/506 ,  C07D403/02

CPC分类号： C04B35/632 ,  C07D239/42 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, and pharmaceutical compositions containing at least one of said 4,6-di substituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said 4,6-disubstituted aminopyrimidine derivatives as inhibitors for a protein kinase and a medium comprising at least one of said 4,6-disubstituted aminopyrimidine derivatives in an immobilized form and the use of said medium for enriching, purifying and/or depleting nucleotide binding proteins which bind to the immobilized 4,6-disubstituted aminopyrimidine derivatives.

摘要翻译： 本发明涉及4,6-二取代的氨基嘧啶衍生物和/或其药学上可接受的盐，这些衍生物作为药物活性剂的用途，特别是用于预防和/或治疗感染性疾病，包括机会性疾病，朊病毒疾病，免疫学 疾病，自身免疫疾病，双相和临床疾病，心血管疾病，细胞增殖性疾病，糖尿病，炎症，移植排斥，勃起功能障碍，神经变性疾病和中风，以及含有所述4,6-二取代氨基嘧啶衍生物和 /或其药学上可接受的盐。 此外，本发明涉及所述4,6-二取代氨基嘧啶衍生物作为蛋白激酶的抑制剂和包含至少一种固定化形式的所述4,6-二取代氨基嘧啶衍生物的介质和使用所述培养基 用于富集，纯化和/或消除与固定的4,6-二取代氨基嘧啶衍生物结合的核苷酸结合蛋白。

公开(公告)号：US20070015492A1

公开(公告)日：2007-01-18

申请号：US11524340

申请日：2006-09-20

申请人： Jose Bravo ,  Thomas Covalla

发明人： Jose Bravo ,  Thomas Covalla

IPC分类号： H04M1/66

CPC分类号： H04W12/06 ,  G06F12/122 ,  G06F12/127 ,  H04L63/0853 ,  Y02D10/13

摘要： A method and apparatus are disclosed for preventing unauthorized access to a restricted item using a cellular telephone that has been previously associated with a user, for example, during a registration process. The user is initially identified, for example, by entering a password, and a one-time pseudo-random token is provided to the user using a first communication channel. The user is requested to dial a telephone number associated with an access control service using a cellular telephone that has been previously associated with the user and enter the assigned token. The user obtains access to the restricted item if the assigned token is entered from a cellular telephone having a serial number that has been previously associated with the particular user.

摘要翻译： 公开了一种方法和装置，用于防止使用先前已经与用户相关联的蜂窝电话（例如在注册过程中）对受限制的项目的未授权访问。 最初通过输入密码来识别用户，并且使用第一通信信道向用户提供一次性伪随机令牌。 请求用户使用先前与用户相关联的蜂窝电话拨打与访问控制服务相关联的电话号码，并输入分配的令牌。 如果从具有先前与特定用户相关联的序列号的蜂窝电话输入分配的令牌，则用户获得对受限制的项的访问。

公开(公告)号：US08762724B2

公开(公告)日：2014-06-24

申请号：US13613502

申请日：2012-09-13

申请人： Jose Bravo ,  Jeffrey L. Crume

发明人： Jose Bravo ,  Jeffrey L. Crume

IPC分类号： H04L29/06

CPC分类号： G06F21/31 ,  G06F21/83 ,  H04L9/3228 ,  H04L63/0838 ,  H04L63/1483

摘要： Embodiments of website authentication including receiving a request from a user to view a website within a graphical user interface (GUI); generating a one time password (OTP); storing the generated OTP in a database; displaying the generated OTP on the GUI; verifying an identity of the user by receiving an identification datum from a communication device; receiving an entered OTP from the user; comparing the entered OTP with the generated OTP; and communicating whether the website is authenticated.

摘要翻译： 网站认证的实施例包括接收用户在图形用户界面（GUI）内查看网站的请求; 生成一次性密码（OTP）; 将生成的OTP存储在数据库中; 在GUI上显示生成的OTP; 通过从通信设备接收标识数据来验证用户的身份; 从用户接收输入的OTP; 将输入的OTP与生成的OTP进行比较; 并通知网站是否被认证。

公开(公告)号：US20100269162A1

公开(公告)日：2010-10-21

申请号：US12423928

申请日：2009-04-15

申请人： Jose Bravo ,  Jeffery L. Crume

发明人： Jose Bravo ,  Jeffery L. Crume

IPC分类号： G06F7/04 ,  G06F17/30 ,  H04L9/00

CPC分类号： G06F21/31 ,  G06F21/83 ,  H04L9/3228 ,  H04L63/0838 ,  H04L63/1483

摘要： Embodiments of website authentication including receiving a request from a user to view a website within a graphical user interface (GUI); generating a one time password (OTP); storing the generated OTP in a database; displaying the generated OTP on the GUI; verifying an identity of the user by receiving an identification datum from a communication device; receiving an entered OTP from the user; comparing the entered OTP with the generated OTP; and communicating whether the website is authenticated.

摘要翻译： 网站认证的实施例包括接收用户在图形用户界面（GUI）内查看网站的请求; 生成一次性密码（OTP）; 将生成的OTP存储在数据库中; 在GUI上显示生成的OTP; 通过从通信设备接收标识数据来验证用户的身份; 从用户接收输入的OTP; 将输入的OTP与生成的OTP进行比较; 并通知网站是否被认证。

公开(公告)号：US08084457B2

公开(公告)日：2011-12-27

申请号：US10572043

申请日：2004-09-15

申请人： Axel Choidas ,  Alexander Backes ,  Matt Cotten ,  Ola Engkvist ,  Beatrice Felber ,  Achim Freisleben ,  Klaus Godl ,  Zoltán Greff ,  Peter Habenberger ,  Doris Hafenbradl ,  Christian Hartung ,  Thomas Herget ,  Edmund Hoppe ,  Bert Klebl ,  Andrea Missio ,  Gerhard Müller ,  Wilfried Schwab ,  Birgit Zech ,  Jose Bravo ,  John Harris ,  Joelle Le ,  Jackie Macritchie ,  Vladimir Savic ,  Brad Sherborne ,  Don Simpson

发明人： Axel Choidas ,  Alexander Backes ,  Matt Cotten ,  Ola Engkvist ,  Beatrice Felber ,  Achim Freisleben ,  Klaus Godl ,  Zoltán Greff ,  Peter Habenberger ,  Doris Hafenbradl ,  Christian Hartung ,  Thomas Herget ,  Edmund Hoppe ,  Bert Klebl ,  Andrea Missio ,  Gerhard Müller ,  Wilfried Schwab ,  Birgit Zech ,  Jose Bravo ,  John Harris ,  Joelle Le ,  Jackie Macritchie ,  Vladimir Savic ,  Brad Sherborne ,  Don Simpson

IPC分类号： A01N43/54 ,  C07D239/42 ,  C07D401/04 ,  C07D239/00 ,  C07D239/02

CPC分类号： C04B35/632 ,  C07D239/42 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, and pharmaceutical compositions containing at least one of said 4,6-di substituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said 4,6-disubstituted aminopyrimidine derivatives as inhibitors for a protein kinase and a medium comprising at least one of said 4,6-disubstituted aminopyrimidine derivatives in an immobilized form and the use of said medium for enriching, purifying and/or depleting nucleotide binding proteins which bind to the immobilized 4,6-disubstituted aminopyrimidine derivatives.

摘要翻译： 本发明涉及4,6-二取代的氨基嘧啶衍生物和/或其药学上可接受的盐，这些衍生物作为药物活性剂的用途，特别是用于预防和/或治疗感染性疾病，包括机会性疾病，朊病毒疾病，免疫学 疾病，自身免疫疾病，双相和临床疾病，心血管疾病，细胞增殖性疾病，糖尿病，炎症，移植排斥，勃起功能障碍，神经变性疾病和中风，以及含有所述4,6-二取代氨基嘧啶衍生物和 /或其药学上可接受的盐。 此外，本发明涉及所述4,6-二取代氨基嘧啶衍生物作为蛋白激酶的抑制剂和包含至少一种固定化形式的所述4,6-二取代氨基嘧啶衍生物的介质和使用所述培养基 用于富集，纯化和/或消除与固定的4,6-二取代氨基嘧啶衍生物结合的核苷酸结合蛋白。

公开(公告)号：US20080318548A1

公开(公告)日：2008-12-25

申请号：US11765193

申请日：2007-06-19

申请人： JOSE BRAVO ,  Jeffery L. Crume

发明人： JOSE BRAVO ,  Jeffery L. Crume

IPC分类号： H04M1/66

CPC分类号： H04L63/18 ,  H04L63/0853 ,  H04L63/107

摘要： A man-in-the-middle attack resistant method of and system for controlling access of a user to a restricted item receives a request from a user of a first device for access to a restricted item. The system determines the physical location of the first device. The system provides a token to the user and prompts the user to send the token to a recipient using a second device. The system denies the user access to the restricted item if the token is sent from a physical location not matching the physical location of the first device.

摘要翻译： 用于控制用户对受限制项目的访问的中间人攻击方法和系统接收来自用于访问受限制项目的第一设备的用户的请求。 系统确定第一个设备的物理位置。 系统向用户提供令牌，并提示用户使用第二个设备将令牌发送到收件人。 如果从不匹配第一设备的物理位置的物理位置发送令牌，系统将拒绝用户对受限制项目的访问。

公开(公告)号：US20060288887A1

公开(公告)日：2006-12-28

申请号：US11170710

申请日：2005-06-23

申请人： Jose Bravo ,  Jesus Pacheco

发明人： Jose Bravo ,  Jesus Pacheco

IPC分类号： B41F17/00

CPC分类号： B41F33/02 ,  B41F15/0804 ,  B41F15/16 ,  B41F15/26 ,  B41F33/12 ,  B41P2215/55

摘要： An apparatus, system and method for detecting ink errors in optical disk printing are provided. The apparatus, system and method include a sensor mount structure and a plurality of optical sensors mounted on the mount structure and in registration with a print table. A controller selectively activates the optical sensors in accordance with a relative motion between the optical sensors and the printing station such that the optical sensors each scan an assigned region of the print table to detect ink outside of an area where an object to be printed is placed.

摘要翻译： 提供了用于检测光盘打印中的墨错误的装置，系统和方法。 装置，系统和方法包括传感器安装结构和安装在安装结构上并与打印台对准的多个光学传感器。 控制器根据光学传感器和打印站之间的相对运动选择性地激活光学传感器，使得光学传感器每个扫描印刷台的分配区域以检测待放置物体的区域外的墨水 。

公开(公告)号：USD350127S

公开(公告)日：1994-08-30

申请号：US2832

申请日：1992-12-21

申请人： Phillip C. Gummeson ,  Jose Bravo

设计人： Phillip C. Gummeson ,  Jose Bravo

公开(公告)号：US20130007859A1

公开(公告)日：2013-01-03

申请号：US13613502

申请日：2012-09-13

申请人： Jose Bravo ,  Jeffrey L. Crume

发明人： Jose Bravo ,  Jeffrey L. Crume

IPC分类号： G06F21/00

CPC分类号： G06F21/31 ,  G06F21/83 ,  H04L9/3228 ,  H04L63/0838 ,  H04L63/1483

摘要： Embodiments of website authentication including receiving a request from a user to view a website within a graphical user interface (GUI); generating a one time password (OTP); storing the generated OTP in a database; displaying the generated OTP on the GUI; verifying an identity of the user by receiving an identification datum from a communication device; receiving an entered OTP from the user; comparing the entered OTP with the generated OTP; and communicating whether the website is authenticated.

摘要翻译： 网站认证的实施例包括接收用户在图形用户界面（GUI）内查看网站的请求; 生成一次性密码（OTP）; 将生成的OTP存储在数据库中; 在GUI上显示生成的OTP; 通过从通信设备接收标识数据来验证用户的身份; 从用户接收输入的OTP; 将输入的OTP与生成的OTP进行比较; 并通知网站是否被认证。