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23 条记录 (耗时 0.03 秒)

    N-substituted oxindoline derivatives as calcium channel blockers
    6.
    发明授权
    N-substituted oxindoline derivatives as calcium channel blockers 失效
    N-取代的羟基吲哚衍生物作为钙通道阻断剂

    公开(公告)号：US08273749B2

    公开(公告)日：2012-09-25

    申请号：US12678357

    申请日：2008-09-30

    申请人： Joseph L. Duffy ,  Scott B. Hoyt ,  Clare London

    发明人： Joseph L. Duffy ,  Scott B. Hoyt ,  Clare London

    IPC分类号： A61K31/4015 ,  C07D209/34 ,  C07D241/14 ,  C07D401/04

    CPC分类号： C07D403/14 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04

    摘要： A series of N-substituted oxindole derivatives represented by Formula I, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, calcium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, urinary incontinence, itchiness, allergic dermatitis, epilepsy, diabetic neuropathy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, sleep disorder, bipolar disorder and stroke, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds.

    摘要翻译： 一系列由式I表示的N-取代的羟基吲哚衍生物或其药学上可接受的盐。 药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。 治疗与钙通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，尿失禁，瘙痒，过敏性皮炎，癫痫，糖尿病性神经病，肠易激综合征 综合征，抑郁症，焦虑症，多发性硬化症，睡眠障碍，双相性精神障碍和中风，包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。

    Substituted Dihydroisoquinolinone and Isoquinolinedione Derivatives as Calcium Channel Blockers
    8.
    发明申请
    Substituted Dihydroisoquinolinone and Isoquinolinedione Derivatives as Calcium Channel Blockers 审中-公开
    取代的二氢异喹啉酮和异喹啉二酮衍生物作为钙通道阻断剂

    公开(公告)号：US20110136842A1

    公开(公告)日：2011-06-09

    申请号：US13057326

    申请日：2009-07-27

    申请人： Joseph L. Duffy ,  Scott B. Hoyt ,  Clare London ,  Christian P. Stevenson ,  Andres M. Ullman

    发明人： Joseph L. Duffy ,  Scott B. Hoyt ,  Clare London ,  Christian P. Stevenson ,  Andres M. Ullman

    IPC分类号： A61K31/47 ,  C07D217/24 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  A61K31/506 ,  A61P29/00 ,  A61P25/00 ,  A61P25/08

    CPC分类号： C07D217/24

    摘要： A series of disubstituted dihydroisoquinolinone and isoquinolinedione derivatives represented by Formula I, or pharmaceutically acceptable salts thereof are presented. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, calcium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, urinary incontinence, itchiness, allergic dermatitis, epilepsy, diabetic neuropathy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, sleep disorder, bipolar disorder and stroke, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds.

    摘要翻译： 提供了一系列由式I表示的二取代二氢异喹啉酮和异喹啉二酮衍生物或其药学上可接受的盐。 药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。 治疗与钙通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，尿失禁，瘙痒，过敏性皮炎，癫痫，糖尿病性神经病，肠易激综合征 综合征，抑郁症，焦虑症，多发性硬化症，睡眠障碍，双相性精神障碍和中风，包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。