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    SYNERGISTIC COMBINATIONS OF NORKETAMINE AND OPIOID ANALGESICS
    1.
    发明申请
    SYNERGISTIC COMBINATIONS OF NORKETAMINE AND OPIOID ANALGESICS 审中-公开
    诺卡胺和阿片类药物的协同联合

    公开(公告)号：US20080132531A1

    公开(公告)日：2008-06-05

    申请号：US11558782

    申请日：2006-11-10

    申请人： Joseph R. Holtman ,  Peter A. Crooks

    发明人： Joseph R. Holtman ,  Peter A. Crooks

    IPC分类号： A61K31/439 ,  A61P29/00 ,  A61P25/00 ,  A61K31/135 ,  A61K31/445 ,  A61K31/4355

    CPC分类号： A61K31/473 ,  A61K31/485 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to methods of alleviating pain with the administration of norketamine with a narcotic. More particularly, the invention provides a method of alleviating pain through the administration of a dose of norketamine, which, if administered alone would provide sub-optimal analgesic relief, yet provides analgesic relief when combined with a narcotic. In some embodiments, the combination of norketamine with a narcotic, further allows for the administration of a dose narcotic, which would be sub-optimal if used alone, but provides adequate pain relief in combination with norketamine. The invention relates to self-management of pain on an outpatient basis comprising administering via conventional routes, including transdermal, nasal, rectal, oral, transmucosal, intravenous, intramuscular, and other routes, one or more doses of norketamine/opioid compositions effective to alleviate pain to a subject suffering from pain. Uses of norketamine/opioid compositions would also apply, to treating headaches, drug abuse, mood and anxiety disorders, as well as other, neuropsychiatric disorders, both motoric and cognitive, such as Alzheimer's disease, Parkinson's syndrome, which are thought to be caused by neurodegeneration.

    摘要翻译： 本发明涉及通过麻醉剂施用诺可泰胺来缓解疼痛的方法。 更具体地，本发明提供了一种通过施用一剂剂量的诺卡胺来减轻疼痛的方法，如果单独给予，它将提供次优的止痛缓解，但当与麻醉剂组合时提供镇痛缓解。 在一些实施方案中，诺替卡胺与麻醉剂的组合进一步允许施用剂量麻醉剂，其如果单独使用则为次优，但与诺替胺组合提供足够的疼痛缓解。 本发明涉及门诊患者疼痛的自我管理，包括通过常规途径给药，包括透皮，鼻，直肠，口服，经粘膜，静脉内，肌内和其他途径，一种或多种剂量的有效减轻的诺尔et胺/阿片样物质组合物 疼痛痛苦的受试者。 诺卡胺/阿片样物质组合物的使用也适用于治疗头痛，药物滥用，情绪和焦虑症，以及其他神经精神障碍，包括运动和认知，如阿尔茨海默氏病，帕金森综合征，被认为是由 神经退行性疾病