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公开(公告)号:US08987442B2
公开(公告)日:2015-03-24
申请号:US13448930
申请日:2012-04-17
申请人: Roger D. Tung , Julie F. Liu , Scott L. Harbeson
发明人: Roger D. Tung , Julie F. Liu , Scott L. Harbeson
IPC分类号: A61K31/522 , A61P13/12 , A61P43/00 , C07D473/06
CPC分类号: A61K31/522 , C07D473/06
摘要: This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.
摘要翻译: 本发明涉及作为取代黄嘌呤衍生物的新化合物及其药学上可接受的盐。 例如,本发明涉及作为己酮可可碱衍生物的新型取代黄嘌呤衍生物。 本发明还提供了包含一种或多种本发明化合物和载体的组合物,以及所述化合物和组合物在治疗己酮可可碱和相关化合物有益的疾病和病症的方法中的用途。
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公开(公告)号:US20130281456A1
公开(公告)日:2013-10-24
申请号:US13678093
申请日:2012-11-15
申请人: Julie F. Liu , Xuejun Tang , Scott L. Harbeson , Craig E. Masse
发明人: Julie F. Liu , Xuejun Tang , Scott L. Harbeson , Craig E. Masse
IPC分类号: C07D263/06
CPC分类号: C07D413/10 , A61K31/5377 , A61K45/06 , C07B2200/05 , C07C215/12 , C07D263/06 , C07D295/02 , C07D295/033 , C07D295/06 , C07D295/12 , C07D295/135 , C07D413/14
摘要: The present invention is directed to a process for preparing a 2,26,6-d4-morpholine derivative represented by Structural Formula (I): or a salt thereof.
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公开(公告)号:US08349817B2
公开(公告)日:2013-01-08
申请号:US12644758
申请日:2009-12-22
IPC分类号: A61K31/4709 , A61K31/4365 , A61K31/616 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/06 , A61P29/00 , C07D401/12
CPC分类号: C07D215/20 , A61K31/10 , A61K31/4365 , A61K31/4709 , A61K31/60 , C07D401/12
摘要: This invention relates to novel compounds which are derivatives of the phosphodiesterase inhibitor, cilostazol and pharmaceutically acceptable salts thereof. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administration of a phosphodiesterase inhibitor, such as cilostazol. The invention also relates to the use of the disclosed compounds and compositions as reagents in analytical studies involving cilostazol.
摘要翻译: 本发明涉及作为磷酸二酯酶抑制剂西洛他唑及其药学上可接受的盐的衍生物的新化合物。 本发明还提供了包含一种或多种本发明化合物的无热原组合物,以及所公开的化合物和组合物在治疗通过施用磷酸二酯酶抑制剂如西洛他唑治疗的疾病和病症的方法中的用途。 本发明还涉及所公开的化合物和组合物在涉及西洛他唑的分析研究中作为试剂的用途。
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公开(公告)号:US20130005742A1
公开(公告)日:2013-01-03
申请号:US13388806
申请日:2010-08-06
申请人: Scott L. Harbeson , Craig E. Masse , Julie F. Liu
发明人: Scott L. Harbeson , Craig E. Masse , Julie F. Liu
IPC分类号: A61K31/4965 , A61P7/02 , A61P9/00 , A61P9/10 , C07D241/20 , A61P9/12
CPC分类号: A61K31/50 , A61K45/06 , C07D241/20 , A61K2300/00
摘要: This invention relates to novel substituted diphenylpyrazines and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a PGI2 receptor agonist.
摘要翻译: 本发明涉及新型取代的二苯基吡嗪及其药学上可接受的盐。 本发明还提供包含本发明化合物的组合物以及这些组合物在治疗通过施用PGI 2受体激动剂有益治疗的疾病和病症的方法中的用途。
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公开(公告)号:US20120202830A1
公开(公告)日:2012-08-09
申请号:US13448930
申请日:2012-04-17
申请人: Roger D. Tung , Julie F. Liu , Scott L. Harbeson
发明人: Roger D. Tung , Julie F. Liu , Scott L. Harbeson
IPC分类号: A61K31/522 , A61P13/12 , A61P43/00
CPC分类号: A61K31/522 , C07D473/06
摘要: This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.
摘要翻译: 本发明涉及作为取代黄嘌呤衍生物的新化合物及其药学上可接受的盐。 例如,本发明涉及作为己酮可可碱衍生物的新型取代黄嘌呤衍生物。 本发明还提供了包含一种或多种本发明化合物和载体的组合物,以及所述化合物和组合物在治疗己酮可可碱和相关化合物有益的疾病和病症的方法中的用途。
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公开(公告)号:US20110082147A1
公开(公告)日:2011-04-07
申请号:US12842589
申请日:2010-07-23
申请人: Scott L. Harbeson , Roger D. Tung , Julie F. Liu
发明人: Scott L. Harbeson , Roger D. Tung , Julie F. Liu
CPC分类号: C07D487/04
摘要: This invention relates to novel substituted imidazotriazines and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a compound showing partial-agonist activity at the GABA α2, α3 and α5 subtype receptors, and antagonist activity at the al subtype receptor.
摘要翻译: 本发明涉及新的取代的咪唑并嗪及其药学上可接受的盐。 本发明还提供包含本发明化合物的组合物和这些组合物在治疗通过给予在GABAα2,α3和α5亚型受体上显示部分激动剂活性的化合物和拮抗剂有益处理的疾病和病症的方法中的用途 在亚型受体的活性。
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公开(公告)号:US20110053961A1
公开(公告)日:2011-03-03
申请号:US12873991
申请日:2010-09-01
申请人: Roger D. Tung , Julie F. Liu , Scott L. Harbeson
发明人: Roger D. Tung , Julie F. Liu , Scott L. Harbeson
IPC分类号: A61K31/522 , C07D473/10 , A61P9/12 , A61P13/12 , A61P1/16 , A61P27/02 , A61P3/10 , A61P3/04
CPC分类号: C07D473/04
摘要: This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.
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公开(公告)号:US20100324108A1
公开(公告)日:2010-12-23
申请号:US12816295
申请日:2010-06-15
申请人: Julie F. LIU
发明人: Julie F. LIU
IPC分类号: A61K31/4035 , C07D209/50 , A61P31/00 , A61P17/06 , A61P19/02 , A61P9/00 , A61P1/04 , A61P11/06 , A61P35/00
CPC分类号: C07D209/48 , C07B59/002 , C07B2200/05 , C07D207/404 , C07D209/46 , C07D405/12
摘要: This invention relates to novel substituted isoindoline-1,3-dione derivatives and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel substituted isoindoline-1,3-dione derivatives that are analogues of apremilast. This invention also provides compositions comprising a compound of this invention and a carrier and the use of disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering apremilast.
摘要翻译: 本发明涉及新的取代的异二氢吲哚-1,3-二酮衍生物及其药学上可接受的盐。 更具体地,本发明涉及作为去甲生物的类似物的新的取代的异二氢吲哚-1,3-二酮衍生物。 本发明还提供了包含本发明化合物和载体的组合物,以及所述化合物和组合物在治疗通过施用去甲苯磺酸酯有益治疗的疾病和病症的方法中的用途。
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公开(公告)号:US20100004340A1
公开(公告)日:2010-01-07
申请号:US12563708
申请日:2009-09-21
申请人: Julie F. Liu , Roger Tung
发明人: Julie F. Liu , Roger Tung
IPC分类号: A61K31/165 , C07C233/11 , A61P25/00 , A61P25/24 , A61P25/22
CPC分类号: C07C233/18 , C07B2200/05 , C07C233/22
摘要: This disclosure relates to novel melatonin analogues or naphthyl(ethyl)acetamides, their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a dual melatoninergic agonist and serotoninergic antagonist.
摘要翻译: 本公开涉及新颖的褪黑素类似物或萘基(乙基)乙酰胺,其衍生物,药学上可接受的盐,溶剂化物和其水合物。 本公开还提供了包含本公开的化合物和这种组合物在治疗通过施用双褪黑素激动剂和5-羟色胺能拮抗剂有益治疗的疾病和病症的方法中的用途的组合物。
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公开(公告)号:US20090042842A1
公开(公告)日:2009-02-12
申请号:US12150107
申请日:2008-04-24
申请人: Julie F. Liu , Rose A. Persichetti
发明人: Julie F. Liu , Rose A. Persichetti
IPC分类号: A61K31/60 , C07D215/20 , A61K31/4365 , A61P3/10 , A61P29/00 , A61P9/00 , A61K31/47
CPC分类号: C07D401/12
摘要: This invention relates to novel compounds which are derivatives of the phosphodiesterase inhibitor, cilostazol and pharmaceutically acceptable salts thereof. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administration of an phosphodiesterase inhibitor, such as cilostazol. The invention also relates to the use of the disclosed compounds and compositions as reagents in analytical studies involving cilostazol.
摘要翻译: 本发明涉及作为磷酸二酯酶抑制剂西洛他唑及其药学上可接受的盐的衍生物的新化合物。 本发明还提供了包含一种或多种本发明化合物的无热原组合物,以及所公开的化合物和组合物在治疗通过施用磷酸二酯酶抑制剂如西洛他唑治疗的疾病和病症的方法中的用途。 本发明还涉及所公开的化合物和组合物在涉及西洛他唑的分析研究中作为试剂的用途。
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