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    Urea derivatives and uses thereof
    2.
    发明授权
    Urea derivatives and uses thereof 有权

    公开(公告)号：US11352343B2

    公开(公告)日：2022-06-07

    申请号：US16900657

    申请日：2020-06-12

    Applicant: Kala Pharmaceuticals, Inc.

    Inventor： Winston Zapanta Ong ,  Pawel Wojciech Nowak ,  John Thomas Feutrill ,  Jinsoo Kim

    IPC: C07D413/14 ,  A61P35/00 ,  C07D403/10 ,  A61K9/00 ,  A61K9/14 ,  C07D471/04 ,  C07D231/56 ,  C07D401/04 ,  C07D403/04 ,  A61K31/416

    Abstract: The present invention provides novel compounds of any one of Formulae (I)-(III), and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I)-(III) and pharmaceutical compositions thereof that are mucus penetrating. The invention also provides methods and kits for using the inventive compounds, and pharmaceutical compositions thereof, for treating and/or preventing diseases associated with abnormal or pathological angiogenesis and/or aberrant signaling of a growth factor (e.g., vascular endothelial growth factor (VEGF)), such as proliferative diseases (e.g., cancers, benign neoplasms, inflammatory diseases, autoimmune diseases) and ocular diseases (e.g., macular degeneration, glaucoma, diabetic retinopathy, retinoblastoma, edema, uveitis, dry eye, blepharitis, and post-surgical inflammation) in a subject in need thereof.

    COMPOSITIONS AND METHODS UTILIZING POLY(VINYL ALCOHOL) AND/OR OTHER POLYMERS THAT AID PARTICLE TRANSPORT IN MUCUS
    6.
    发明申请
    COMPOSITIONS AND METHODS UTILIZING POLY(VINYL ALCOHOL) AND/OR OTHER POLYMERS THAT AID PARTICLE TRANSPORT IN MUCUS 审中-公开

    公开(公告)号：US20200289405A1

    公开(公告)日：2020-09-17

    申请号：US16883778

    申请日：2020-05-26

    Applicant: Kala Pharmaceuticals, Inc.

    Inventor： Alexey Popov

    IPC: A61K9/00 ,  A61K47/32 ,  A61K9/10 ,  A61K9/51 ,  A61K31/56 ,  A61K9/50

    Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles including pharmaceutical agents that have a low water/aqueous solubility. In some embodiments, a surface coating includes a synthetic polymer having pendant hydroxyl groups on the backbone of the polymer, such as poly(vinyl alcohol) (PVA). Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

    Crystalline forms of a therapeutic compound and uses thereof
    8.
    发明授权
    Crystalline forms of a therapeutic compound and uses thereof 有权

    公开(公告)号：US10253045B2

    公开(公告)日：2019-04-09

    申请号：US15529969

    申请日：2015-11-24

    Applicant: Kala Pharmaceuticals, Inc.

    Inventor： Tadeas Liska ,  Elizabeth Enlow ,  Jinsoo Kim ,  Winston Ong

    IPC: C07D519/00 ,  A61K31/5025 ,  A61P27/02

    Abstract: Disclosed herein are certain crystalline forms of Compound 5, N-(5-((2-(4-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butanamido)imidazo[1,2-0]pyridazin-6-yl)oxy)-2-methylphenyl)-1,3-dimethyl-1/-/-pyrazole-5-carboxamide, as well as pharmaceutical compositions comprising the crystalline forms. The present disclosure further relates to methods for treating or preventing diseases or disorders using the crystalline forms or pharmaceutical compositions thereof in a subject in need thereof, including diseases or disorders associated with abnormal or pathological angiogenesis and/or aberrant signaling of a growth factor signaling pathway (e.g., vascular endothelial growth factor (VEGF)), such as proliferative diseases and ocular diseases.

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