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公开(公告)号:US07638517B2
公开(公告)日:2009-12-29
申请号:US11605729
申请日:2006-11-29
申请人: Robert Greenhouse , Saul Jaime-Figueroa , Stephen M. Lynch , Lubica Raptova , Karin Ann Stein , Robert James Weikert
发明人: Robert Greenhouse , Saul Jaime-Figueroa , Stephen M. Lynch , Lubica Raptova , Karin Ann Stein , Robert James Weikert
IPC分类号: A61K31/519 , A61K31/506 , A61K31/4745 , C07D487/02 , C07D471/02
CPC分类号: C07D471/04 , C07D487/04 , C07D487/14
摘要: The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
摘要翻译: 本发明提供下式的化合物或其药学上可接受的盐,溶剂合物或前药,其中p,Ar,R 1,R 2,R 3,R a,R b,R c,R d和R Re如本文所定义。 还提供药物组合物,使用方法和制备化合物的方法。
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公开(公告)号:US20100056499A1
公开(公告)日:2010-03-04
申请号:US12619275
申请日:2009-11-16
申请人: Robert Greenhouse , Saul Jaime-Figueroa , Stephen M. Lynch , Lubica Raptova , Karin Ann Stein , Robert James Weikert
发明人: Robert Greenhouse , Saul Jaime-Figueroa , Stephen M. Lynch , Lubica Raptova , Karin Ann Stein , Robert James Weikert
IPC分类号: A61K31/519 , C07D487/04 , C07D471/04 , C07D471/16 , A61K31/551 , A61K31/437 , A61P25/24 , A61P25/22
CPC分类号: C07D471/04 , C07D487/04 , C07D487/14
摘要: The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
摘要翻译: 本发明提供下式的化合物或其药学上可接受的盐,溶剂合物或前药,其中p,Ar,R 1,R 2,R 3,R a,R b,R c,R d和R Re如本文所定义。 还提供药物组合物,使用方法和制备化合物的方法。
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3.
公开(公告)号:US07863305B2
公开(公告)日:2011-01-04
申请号:US11142076
申请日:2005-06-01
申请人: Robert Greenhouse , Saul Jaime-Figueroa , Lubica Raptova , Deborah Carol Reuter , Karin Ann Stein , Robert Weikert
发明人: Robert Greenhouse , Saul Jaime-Figueroa , Lubica Raptova , Deborah Carol Reuter , Karin Ann Stein , Robert Weikert
IPC分类号: A61K31/404 , A61K31/416 , A61K31/4184 , A61K31/423 , A61K31/428 , C07D209/04 , C07D231/56 , C07D235/04 , C07D263/54 , C07D277/64
CPC分类号: C07D401/06 , C07D209/08 , C07D209/14 , C07D231/56 , C07D307/14
摘要: Compounds of formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
摘要翻译: 式I化合物或其药学上可接受的盐,溶剂合物或前药,其中p,Ar,R 1,R 2,R 3,R a,R b,R c,R d和R e定义如下。 还提供药物组合物,使用方法和制备化合物的方法。
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