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1.发明授权公开(公告)号：US06362169B1
公开(公告)日：2002-03-26
申请号：US09622712
申请日：2000-08-22
IPC分类号： A61K3170
CPC分类号： A61K45/00 , A61K31/395 , A61K31/415 , A61K31/44 , A61K31/60 , A61K33/245 , A61K2300/00
摘要： Antibacterial compositions comprising (1) a rifamycin derivative represented by the formula (I) or its physiologically acceptable salt, and (2) a proton pump inhibitor (a) or a bismuth preparation (b) wherein the components (1) and (2) are used in such amounts as producing a synergistic effect against Helicobacter pylori, drugs and remedies for digestive organ diseases which contain the antibacterial compositions, process for producing them, and pharmaceutical preparations related to the antibacterial compositions. The compositions can be administered to patients with digestive diseases caused by infection of Helicobacter pylori in a smaller dose and at a lower administration frequency as compared with conventional remedies.
摘要翻译： 抗菌组合物，其包含（1）由式（I）表示的利福霉素衍生物或其生理学上可接受的盐，和（2）质子泵抑制剂（a）或铋制剂（b），其中组分（1）和（2） 用于产生对幽门螺杆菌的协同效应，含有抗菌组合物的消化器官疾病的药物和补救剂，其制备方法和与抗菌组合物相关的药物制剂。 与常规治疗相比，组合物可以以较小的剂量和较低的施用频率施用于由幽门螺杆菌感染引起的消化系统疾病的患者。
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公开(公告)号：US4451433A
公开(公告)日：1984-05-29
申请号：US319078
申请日：1981-11-06
申请人： Katsuji Yamashita , Hiroshi Umetsu , Hirotaka Sato , Yoshio Matsuoka , Kei Kida
发明人： Katsuji Yamashita , Hiroshi Umetsu , Hirotaka Sato , Yoshio Matsuoka , Kei Kida
CPC分类号： G01N35/02 , G01N35/00663 , G01N35/1011 , G01N2035/00673 , G01N2035/1025 , G01N2035/1086 , G01N35/1004 , G01N35/1083 , Y10T436/119163 , Y10T436/2575
摘要： An automatic chemical analyzer suitable for chemically analyzing a number of analysis items is disclosed. Samples in sample containers are sequentially dispensed to an array of reaction vessels using a first pipetting tube. Reagent solutions selected in accordance with the analysis items are fed to the reaction vessels using a second conductive pipetting tube. The reaction solutions in the reaction vessels are measured by a photometer. When the reagent solutions are sucked into the second pipetting tube, the liquid levels of the reagent solutions in the reagent containers are detected by a liquid level sensor formed by the second pipetting tube and a conductive electrode. The amounts of the reagent solutions remaining in the reagent containers are determined based on the position of the liquid level sensor and the numbers of times of dispense allowed to the reagent solutions with respect to the analysis items are displayed on a cathode ray tube.
摘要翻译： 公开了一种适用于化学分析多个分析项目的自动化学分析仪。 使用第一移液管将样品容器中的样品顺次分配到反应容器阵列中。 根据分析项目选择的试剂溶液使用第二导电移液管进料至反应容器。 通过光度计测量反应容器中的反应溶液。 当试剂溶液被吸入第二移液管时，试剂容器中的试剂溶液的液面由由第二移液管形成的液位传感器和导电电极检测。 基于液位传感器的位置确定残留在试剂容器中的试剂溶液的量，并且在阴极射线管上显示相对于分析项目向试剂溶液允许的分配次数。
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公开(公告)号：US4313735A
公开(公告)日：1982-02-02
申请号：US180476
申请日：1980-08-22
申请人： Katsuji Yamashita , Yasushi Nomura
发明人： Katsuji Yamashita , Yasushi Nomura
CPC分类号： G01N21/253 , G01N35/025 , G01N2035/00396 , G01N2035/0437 , G01N2201/0415 , Y10T436/113332
摘要： A train of cuvettes are held on a turntable and serum specimen is sequentially sampled each time the turntable makes a revolution through more than 360.degree.. While the turntable is at rest, blank solution is poured into one cuvette, reagent is put into another cuvette and reactant solution is drawn out of still another cuvette in specified positions respectively in the path along which the train of cuvettes are conveyed. During a single rotational operation of the turntable, these cuvettes sequentially transverses the light path in the photometer so that the light absorbances for the respective cuvettes are measured. Both the absorbances for cuvettes containing reactant solutions for different samples and the absorbance for a cuvette containing only the blank solution are measured by a single photometer. The difference between the value of measurement obtained from a specified cuvette filled with reactant solution and the value of measurement obtained from the same cuvette filled with blank solution alone, is calculated and an analyzed value corrected is obtained for any desired analysis item in accordance with the calculated difference.
摘要翻译： 一列比色皿被放在转盘上，每次转盘通过360度以上的转速，依次采样血清样本。 当转盘静止时，将空白溶液倒入一个试管中，将试剂放入另一个比色皿中，并将反应物溶液从指定位置的另一个比色皿中分别引导到传送比色杯列的路径中。 在转台的单次旋转操作期间，这些比色皿依次横切光度计中的光路，从而测量各个比色皿的光吸收。 通过单个光度计测量含有不同样品的反应物溶液的比色皿的吸光度和仅含有空白溶液的比色杯的吸光度。 计算从填充有反应物溶液的规定比色皿获得的测量值与仅从填充有空白溶液的相同比色皿获得的测量值之间的差异，并根据所得到的任何所需分析项目获得分析值 计算差额。
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公开(公告)号：US4158545A
公开(公告)日：1979-06-19
申请号：US834902
申请日：1977-09-20
CPC分类号： G01N35/021 , Y10T436/113332 , Y10T436/115831
摘要： In an automatic chemical analyzing method and apparatus in which a plurality of samples each added with a reagent are discretely transported through a reaction line and subjected to a reaction during the transportation for optical measurement to generate measured signals and to process them, the samples to be analyzed are grouped into a plurality of sample groups each including a plurality of samples which are to be measured with respect to the same test items, which are previously stored for each sample group in a memory of a central control unit. The samples are divided by a number corresponding to the number of test items and successively fed to the reaction line one by one in sample groups, and, at the time of change of the sample group receiving the analysis, test items corresponding to a new sample group are read from the memory to carry out a chemical analysis for the samples in each sample group according to the read test items.
摘要翻译： 在自动化学分析方法和装置中，每个加入试剂的多个样品离散地通过反应管线输送并在光学测量运输期间进行反应以产生测量信号并进行处理，样品为 分析被分组成多个采样组，每个样本组包括相对于中央控制单元的存储器中的每个样本组预先存储的相同测试项目要测量的多个样本。 将样品除以与测试项目数相对应的数字，并在样品组中逐个进料到反应线，并且在接收分析的样品组的变化时，对应于新样品的测试项目 从存储器读取组，根据读取的测试项目对每个样品组中的样品进行化学分析。
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5.发明授权公开(公告)号：US06486161B1
公开(公告)日：2002-11-26
申请号：US09463580
申请日：2000-05-23
IPC分类号： A61K3150
CPC分类号： A61K31/5383
摘要： A method for treating mastitis in a domestic animal in need of such a treatment, which comprises administering to the animal a pharmaceutical composition comprising a rifamycin derivative of the formula (1): wherein R is an alkyl group having 1 to 7 carbon atoms or a physiologically acceptable salt thereof as an active ingredient, and a physiologically acceptable carrier. The present invention provides a novel therapeutic method effective for treatment of mastitis caused by bacterial infection in a domestic animal.
摘要翻译： 一种在需要这种治疗的家畜中治疗乳腺炎的方法，其包括向动物施用包含式（1）的利福霉素衍生物的药物组合物：其中R是具有1至7个碳原子的烷基或 其生理学上可接受的盐作为活性成分，以及生理上可接受的载体。 本发明提供了一种有效治疗家畜细菌感染引起的乳腺炎的新型治疗方法。
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公开(公告)号：US5981522A
公开(公告)日：1999-11-09
申请号：US41821
申请日：1998-03-12
申请人： Katsuji Yamashita , Takehiko Yamane , Shinichi Sakashita , Kazunori Hosoe , Kenji Fujii , Yasuhiro Saka
发明人： Katsuji Yamashita , Takehiko Yamane , Shinichi Sakashita , Kazunori Hosoe , Kenji Fujii , Yasuhiro Saka
IPC分类号： A61K31/438 , A61K31/5383 , A61K31/542 , A61K31/54
CPC分类号： A61K31/541 , A61K31/438 , A61K31/5383 , A61K31/542
摘要： A method for treating a digestive organ disease caused by the infection of Helicobacter, comprising administering a rifamycin derivative expressed by the formula (I), or a physiologically acceptable salt thereof ##STR1##
摘要翻译： 一种治疗由幽门螺杆菌感染引起的消化器官疾病的方法，其包括施用式（I）表示的利福霉素衍生物或其生理学上可接受的盐
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7.发明授权Alkyl-substituted benzoxazinorifamycin derivative, process for preparing the same and antibacterial agent containing the same 失效烷基取代的苯并恶嗪利霉素衍生物，其制备方法和含有它们的抗菌剂
公开(公告)号：US4859661A
公开(公告)日：1989-08-22
申请号：US75021
申请日：1987-07-13
IPC分类号： C07D498/18 , A61K31/365 , A61K31/535 , A61P31/04 , C07D498/14
CPC分类号： C07D498/18 , C07D519/00
摘要： A novel rifamycin derivative having the formula (I): ##STR1## wherein X.sup.1 is an alkyl group with 1 to 6 carbon atoms or a cycloalkyl group with 3 to 8 carbon atoms; X.sup.2 is a hydrogen atom or an alkyl group with 1 to 4 carbon atoms; R.sup.1 is hydrogen atom or acetyl group; A is a group represented by the formula: ##STR2## wherein R.sup.2 is an alkyl group with 1 to 4 carbon atoms or an alkoxyalkyl group with 2 to 6 carbon atoms and R.sup.3 is an alkyl group with 1 to 6 carbon atoms or an alkoxyalkyl group with 2 to 6 carbon atoms, or a group represented by the formula ##STR3## wherein ##STR4## is a 3 to 9 membered cyclic amino group with 2 to 8 carbon atoms, R.sup.4 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, or salts thereof, a process for preparing the same and antibacterial agents containing the same as an effective ingredient.The rifamycin derivative of the present invention having the formula (I) shows a strong antibacterial activity against the Gram-positive bacteria and the acid-fast bacteria.
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8.发明授权Substituted benzoxazinorifamycin derivative and antibacterial agent containing the same 失效取代的苯并恶嗪利霉素衍生物和含有它们的抗菌剂
公开(公告)号：US4965261A
公开(公告)日：1990-10-23
申请号：US324499
申请日：1989-03-16
申请人： Fumihiko Kanoo , Takehiko Yamane , Hideo Kondo , Takuji Hashizume , Katsuji Yamashita , Kazunori Hosoe , Fumiyuki Kuze , Kiyoshi Watanabe
发明人： Fumihiko Kanoo , Takehiko Yamane , Hideo Kondo , Takuji Hashizume , Katsuji Yamashita , Kazunori Hosoe , Fumiyuki Kuze , Kiyoshi Watanabe
IPC分类号： C07D498/18
CPC分类号： C07D498/18
摘要： A rifamycin derivative having the formula (I): ##STR1## wherein R.sup.1 is hydrogen atom, methyl group or ethyl group, R.sup.2 is an alkyl group having 1 to 4 carbon atoms, and A is a group having the formula: ##STR2## in which n is an integer of 3 to 5, or group having the formula: ##STR3## in which R.sup.3 is a alkyl group having 1 to 5 carbon atoms; or a salt thereof. The rifamycin derivative (I) exhibits a strong antibacterial activity against Gram-positive bacteria and acid-fast bacteria, and also exhibits a strong antibacterial activity against tubercle bacilli.
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9.发明授权Benzoxazinorifamycin derivative, process for preparing the same and antibacterial agent containing the same 失效苯并恶嗪利霉素衍生物，其制备方法和含有它们的抗菌剂
公开(公告)号：US4690919A
公开(公告)日：1987-09-01
申请号：US826398
申请日：1986-02-05
IPC分类号： C07D498/18 , C07D519/00 , A61K31/535
CPC分类号： C07D498/18 , C07D519/00
摘要： A novel rifamycin derivative having the general formula (I): ##STR1## or salts thereof, a process for preparing the same and antibacterial agents containing the same as an effective component.The rifamycin derivative of the present invention having the general formula (I) shows a strong antibacterial activity against the Gram-positive bacteria and the acid-fast bacteria.
摘要翻译： 具有通式（I）的新型利福霉素衍生物或其盐，其制备方法和含有该有效成分的抗菌剂。 具有通式（I）的本发明的利福霉素衍生物显示出对革兰氏阳性菌和耐酸细菌的强抗菌活性。
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公开(公告)号：US4483823A
公开(公告)日：1984-11-20
申请号：US414387
申请日：1982-09-02
CPC分类号： G01N35/025 , G01N2035/00396 , G01N2035/00435 , G01N2035/00455
摘要： A chemical analyzer is disclosed in which a sample is supplied from a sample cup on a sample table to an array of reaction cups on a reaction table so that the reaction cups contain the same amount of sample, a reagent pipetting nozzle sucks an appropriate reagent solution from an array of reagent tanks and discharges the reagent solution into a corresponding reaction cup, the sample having reacted with the reagent solution is optically measured by a multi-wavelength photometer, a plurality of reagent tanks containing different reagent solutions are placed in a refrigerator with the openings of the reagent tanks being directed upward, the refrigerator is provided with a cover which has holes provided at positions corresponding to the openings of the reagent tanks, these holes are closed by a shutter except when the reagent pipetting nozzle is inserted into these holes, the array of reaction cups is immersed in constant-temperature-water contained in a reaction bath, the reaction bath is supplied with water which is kept at 37.degree. C. in a liquid bath by means of an evaporator and a heater, and a refrigerant from a refrigerating machine passes through an evaporator provided in the refrigerator and the evaporator provided in the liquid bath to be returned to the refrigerating machine.
摘要翻译： 公开了一种化学分析仪，其中将样品从样品台上的样品杯供应到反应台上的反应杯阵列，使得反应杯含有相同量的样品，试剂吸移喷嘴吸取适当的试剂溶液 从一系列试剂罐中取出试剂溶液到相应的反应杯中，通过多波长光度计光学测量与试剂溶液反应的样品，将含有不同试剂溶液的多个试剂罐放置在具有 试剂箱的开口被向上引导，冰箱设置有盖，该盖具有设置在与试剂罐的开口相对应的位置处的孔，除了当试剂移液喷嘴插入这些孔之外，这些孔被挡板关闭 将反应杯阵列浸入反应槽中所含的恒温水中，反应槽i s通过蒸发器和加热器在液浴中供应保持在37℃的水，并且来自制冷机的制冷剂通过设在冰箱中的蒸发器和设置在液槽中的蒸发器 返回制冷机。
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