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公开(公告)号:US20090012054A1
公开(公告)日:2009-01-08
申请号:US12280419
申请日:2007-03-16
申请人: Toshio Yamanaka , Ayako Toda , Hidenori Ohki , Shinya Okuda , Kohji Kawabata , Kenji Murano , Kazuo Hatano , Shinobu Takeda , Toru Nakai , Masaru Oogaki , Satoshi Inoue , Keiji Misumi , Kenji Itoh
发明人: Toshio Yamanaka , Ayako Toda , Hidenori Ohki , Shinya Okuda , Kohji Kawabata , Kenji Murano , Kazuo Hatano , Shinobu Takeda , Toru Nakai , Masaru Oogaki , Satoshi Inoue , Keiji Misumi , Kenji Itoh
IPC分类号: A61K31/546 , C07D501/16 , A61P31/00
CPC分类号: C07D501/46
摘要: The present invention provides a compound of the formula [I]: wherein R1 is lower alkyl, etc. and R2 is hydrogen, etc., or R1 and R2 are bonded together to form lower alkylene; R3 is a group represented by wherein R6 and R7 are independently optionally protected amino, etc.; m and n are independently an integer of 0 to 6; R8 and R9 are independently optionally protected amino, etc., and q and r are independently an integer of 0 to 6, or R8 and R9, together with the adjacent alkylene(s) and the nitrogen atom, form saturated nitrogen-containing heterocycle optionally having substituent(s); R4 is lower alkyl, etc.; and R5 is amino, etc., or a pharmaceutically acceptable salt thereof.
摘要翻译: 本发明提供式[I]化合物:其中R1是低级烷基等,R2是氢等,或者R1和R2键合在一起形成低级亚烷基; R3是由R6和R7独立地是任意保护的氨基等表示的基团。 m和n分别为0〜6的整数。 R8和R9独立地是任选被保护的氨基等,q和r独立地是0-6的整数,或者R8和R9与相邻的亚烷基和氮原子一起形成饱和的含氮杂环, 具有取代基; R4是低级烷基等; R5为氨基等,或其药学上可接受的盐。