公开(公告)号：US08470829B2

公开(公告)日：2013-06-25

申请号：US11662289

申请日：2005-09-09

申请人： Kazutaka Tachibana ,  Haruhiko Sato ,  Masateru Ohta ,  Mitsuaki Nakamura ,  Takuya Shiraishi ,  Hitoshi Yoshino ,  Takashi Emura ,  Akie Honma ,  Etsuro Onuma ,  Hiromitsu Kawata ,  Kenji Taniguchi

发明人： Kazutaka Tachibana ,  Haruhiko Sato ,  Masateru Ohta ,  Mitsuaki Nakamura ,  Takuya Shiraishi ,  Hitoshi Yoshino ,  Takashi Emura ,  Akie Honma ,  Etsuro Onuma ,  Hiromitsu Kawata ,  Kenji Taniguchi

IPC分类号： A61K31/426 ,  A61K31/454 ,  A61K31/428 ,  A61K31/4166 ,  C07D401/12 ,  C07D403/12 ,  C07D277/82 ,  C07D233/72 ,  C07D233/70

CPC分类号： C07D417/04 ,  C07D211/58 ,  C07D233/74 ,  C07D233/86 ,  C07D277/82 ,  C07D401/04

摘要： An imidazole derivative represented by formula (I): wherein Q is: A is hydrogen, halogen, or a substituted or unsubstituted C1-4 alkyl group; E is independently selected from a C1-6 alkyl group; R2 and R3 are independently selected from C1-6 alkyls; X1 and X2 are independently selected from O and S; Y is selected from a substituted or unsubstituted arylene group and a substituted or unsubstituted divalent 5- or 6-membered monocyclic or 8- to 10-membered condensed heterocyclic group; Z is —CON(—Ra)—, —CO—, —OOO—, —NRa—C(═NH)NRb—, —NRa—C(═N—CN)NRb—, —N(—Ra)COO—, —C(═NH)—, —SO2—, —SO2N(—Ra)—, —SO2NR1—, —N(—Ra)CO—, —N(—Ra)CON(—Rb)—, —N(COR1)CO—, —N(—Ra)SO2—, —N(SO2R1)SO2—, —N(—Ra)— or —N(—Ra)SO2N(—Rb)—; R1 is independently a hydrogen atom, a hydroxyl group, or substituted or unsubstituted group selected from C1-6 alkyl group, heterocyclic group, aryl group, C3-8 cycloalkyl group and C3-8 cycloalkenyl group; or salt or prodrug thereof.

摘要翻译： 由式（I）表示的咪唑衍生物：其中Q是：A是氢，卤素或取代或未取代的C1-4烷基; E独立地选自C 1-6烷基; R2和R3独立地选自C1-6烷基; X1和X2独立地选自O和S; Y选自取代或未取代的亚芳基和取代或未取代的二价5元或6元单环或8至10元稠合杂环基; Z是-CON（-R a） - ， - CO - ， - OO-，-NR a -C（= NH）NR b - ， - NR a -C（= N-CN）NR b - ， - N（-R a） ，-C（= NH） - ， - SO 2 - ， - SO 2 N（-R a） - ， - SO 2 NR 1 - ， - N（-R a）CO - ， - N（-R a）CON（-R b） COR 1）CO - ， - N（-R a）SO 2 - ， - N（SO 2 R 1）SO 2 - ， - N（-R a） - 或-N（-R a）SO 2 N（-R b） R 1独立地为氢原子，羟基或取代或未取代的选自C 1-6烷基，杂环基，芳基，C 3-8环烷基和C 3-8环烯基的基团; 或其盐或前药。

公开(公告)号：US08175116B2

公开(公告)日：2012-05-08

申请号：US11685994

申请日：2007-03-14

申请人： Kazutaka Tachibana ,  Taku Tanaka ,  Kazuyoshi Horie

发明人： Kazutaka Tachibana ,  Taku Tanaka ,  Kazuyoshi Horie

IPC分类号： H04J3/16

CPC分类号： H04L47/10 ,  H04L47/36

摘要： A network processing apparatus is provided. A send buffer receives from a protocol stack a long packet with a data length exceeding a maximum transmission unit defined for a network and stores the long packet. A payload dividing unit divides the payload of the long packet into a plurality of divided payloads. A header duplicating unit duplicates the header of the long packet so as to generate a duplicated header for the respective divided payload. A short packet generating unit attaches the duplicated header to the respective divided payload so as to generate a short packet with a data length equal to or less than the maximum transmission unit to be sent to the network. A sending unit sends the short packet to the network via a physical interface.

摘要翻译： 提供网络处理装置。 发送缓冲器从协议栈接收数据长度超过为网络定义的最大传输单元的长分组，并存储长分组。 有效载荷分割单元将长分组的有效载荷分成多个分割的有效载荷。 报头复制单元复制长分组的报头，以便为相应的分割的有效载荷生成重复的报头。 短分组产生单元将复制的报头附加到相应的分割的有效载荷，以便生成数据长度等于或小于要发送到网络的最大传输单元的短分组。 发送单元通过物理接口向网络发送短消息包。

公开(公告)号：US07271188B2

公开(公告)日：2007-09-18

申请号：US10560281

申请日：2004-06-11

申请人： Kazutaka Tachibana ,  Haruhiko Sato ,  Masateru Ohta ,  Mitsuaki Nakamura ,  Takuya Shiraishi ,  Ikuhiro Imaoka ,  Hitoshi Yoshino ,  Masahiro Nagamuta ,  Hiromitsu Kawata

发明人： Kazutaka Tachibana ,  Haruhiko Sato ,  Masateru Ohta ,  Mitsuaki Nakamura ,  Takuya Shiraishi ,  Ikuhiro Imaoka ,  Hitoshi Yoshino ,  Masahiro Nagamuta ,  Hiromitsu Kawata

IPC分类号： A61K31/4166 ,  C07D233/86 ,  C07C311/03

CPC分类号： C07D233/86

摘要： The present invention provides a compound represented by formula (I):[Formula 1] wherein n is an integer selected from 1 to 20, and R1 and R2, which may be the same or different, each represent a hydrogen atom, or a linear or branched C1-C6 alkyl group, or a salt, a prodrug or a solvate thereof, as well as a drug, a pharmaceutical composition containing the compound, and the like.

摘要翻译： 本发明提供由式（I）表示的化合物：[式1]其中n是选自1至20，R 1和R 2的整数，其中 可以相同或不同，各自表示氢原子或直链或支链C 1 -C 6烷基，或其盐，前药或溶剂合物 ，以及药物，含有该化合物的药物组合物等。

公开(公告)号：US20060135583A1

公开(公告)日：2006-06-22

申请号：US10560281

申请日：2004-06-11

申请人： Kazutaka Tachibana ,  Haruhiko Sato ,  Masateru Ohta ,  Mitsuaki Nakamura ,  Takuya Shiraishi ,  Ikuhiro Imaoka ,  Hitoshi Yoshino ,  Masahiro Nagamuta ,  Hiromitsu Kawata

发明人： Kazutaka Tachibana ,  Haruhiko Sato ,  Masateru Ohta ,  Mitsuaki Nakamura ,  Takuya Shiraishi ,  Ikuhiro Imaoka ,  Hitoshi Yoshino ,  Masahiro Nagamuta ,  Hiromitsu Kawata

IPC分类号： A61K31/4166 ,  C07D233/76

CPC分类号： C07D233/86

摘要： The present invention provides a compound represented by formula (I): wherein n is an integer selected from 1 to 20, and R1 and R2, which may be the same or different, each represent a hydrogen atom, or a linear or branched C1-C6 alkyl group, or a salt, a prodrug or a solvate thereof, as well as a drug, a pharmaceutical composition containing the compound, and the like.

摘要翻译： 本发明提供由式（I）表示的化合物：其中n是选自1至20的整数，R 1和R 2可以相同 或不同的，各自表示氢原子或直链或支链C 1 -C 6烷基，或其盐，前药或溶剂合物，以及 药物，含有该化合物的药物组合物等。

公开(公告)号：US20110306615A1

公开(公告)日：2011-12-15

申请号：US11662289

申请日：2005-09-09

申请人： Kazutaka Tachibana ,  Haruhiko Sato ,  Masateru Ohta ,  Mitsuaki Nakamura ,  Takuya Shiraishi ,  Hitoshi Yoshino ,  Takashi Emura ,  Akie Honma ,  Etsuro Onuma ,  Hiromitsu Kawata ,  Kenji Taniguchi

发明人： Kazutaka Tachibana ,  Haruhiko Sato ,  Masateru Ohta ,  Mitsuaki Nakamura ,  Takuya Shiraishi ,  Hitoshi Yoshino ,  Takashi Emura ,  Akie Honma ,  Etsuro Onuma ,  Hiromitsu Kawata ,  Kenji Taniguchi

IPC分类号： A61K31/454 ,  C07D233/74 ,  C07D417/10 ,  C07D403/12 ,  C07D233/86 ,  C07D413/12 ,  A61K31/4166 ,  A61K31/428 ,  A61K31/496 ,  A61K31/4439 ,  A61K31/5377 ,  A61P35/00 ,  A61P13/08 ,  A61Q7/00 ,  A61P15/00 ,  A61P17/10 ,  C07D401/04

CPC分类号： C07D417/04 ,  C07D211/58 ,  C07D233/74 ,  C07D233/86 ,  C07D277/82 ,  C07D401/04

摘要： According to the present invention, a compound represented by formula (I): wherein Q is: A is a hydrogen atom, a halogen atom, —ORa or a C1-4 alkyl group which may be substituted by one or more halogen atoms; E is independently selected from a C1-6 alkyl group; m is selected from integers from 0 to 3; R2 and R3 are independently selected from a C1-6 alkyl group; X1 and X2 are independently selected from O and S; Y is selected from an arylene group and a divalent 5- or 6-membered monocyclic or 8- to 10-membered condensed heterocyclic group, wherein the arylene group and the heterocyclic group may be substituted by 1 to 3 substituents independently selected from E1; E1 is independently selected from a hydroxyl group, a halogen atom, a C1-4 alkyl group, a cyano group, a C1-4 alkoky group, a carbamoyl group, a C1-4 alkylcarbamoyl group, a di(C1-4 alkyl)carbamoyl group, an amino group, a C1-4 alkylamino group, a di(C1-4 alkylamino group, a sulfamoyl group, a C1-4 alkylsulfamoyl group and a di(C1-4 alkyl)sulfamoyl group; Z is —CON(—Ra)—, —CO—, —COO—, —NRa—C(═NH)NRb—, —NRa—C(═N—CN)NRb—, —N(—Ra)COO—, —C(═NH)—, —SO2—, —SO2N(—Ra)—, —SO2NR1—, —N(—Ra)CO—, —N(—Ra)CON(—Rb)—, —N(COR1)CO—, —N(—Ra)SO2—, —N(SO2R1)SO2—, —N(—Ra)— or —N(—Ra)SO2N(—Rb)—; R1 is independently a hydrogen atom, a hydroxyl group, a C1-6 alkyl group which may be substituted by one or more substituents, a heterocyclic group which may be substituted by one or more substituents, an aryl group which may be substituted by one or more substituents, a C3-8 cycloalkyl group which may be substituted by one or more substituents or a C3-8 cycloalkenyl group which may be substituted by one or more substituents, or a salt, prodrug or solvate thereof is provided. Furthermore, a pharmaceutical composition containing the compound, and the like are also provided.

公开(公告)号：US20080013448A1

公开(公告)日：2008-01-17

申请号：US11774998

申请日：2007-07-09

申请人： Kazuyoshi Horie ,  Kazutaka Tachibana ,  Taku Tanaka

发明人： Kazuyoshi Horie ,  Kazutaka Tachibana ,  Taku Tanaka

IPC分类号： G06F11/00

CPC分类号： G06F13/105 ,  H04L49/90 ,  H04L49/901 ,  H04L49/9063 ,  H04L49/9073 ,  H04L67/1097 ,  H04L69/32

摘要： A multiprocessor system is provided for emulating remote direct memory access (RDMA) functions. The first sub-processing unit (SPU) generates a message to be transmitted. The second SPU is a processor for emulating the RDMA functions. Upon receiving a notification from the first SPU, the second SPU synthesizes the message into a packet according to a RDMA protocol. The third SPU is a processor for performing a TCP/IP protocol processing. Upon receiving a notification from the second SPU, the third SPU synthesizes the packet generated according to the RDMA protocol into a TCP/IP packet and then sends it out from a network interface card.

摘要翻译： 提供了一种用于仿真远程直接存储器访问（RDMA）功能的多处理器系统。 第一子处理单元（SPU）生成要发送的消息。 第二个SPU是用于模拟RDMA功能的处理器。 在从第一SPU接收到通知时，第二SPU根据RDMA协议将消息合成为分组。 第三SPU是用于执行TCP / IP协议处理的处理器。 在从第二SPU接收到通知时，第三SPU将根据RDMA协议生成的分组合成为TCP / IP分组，然后从网络接口卡发送。

公开(公告)号：US07803826B2

公开(公告)日：2010-09-28

申请号：US11659369

申请日：2005-08-03

申请人： Kazutaka Tachibana ,  Haruhiko Sato ,  Masateru Ohta ,  Mitsuaki Nakamura ,  Takuya Shiraishi ,  Ikuhiro Imaoka ,  Hitoshi Yoshino ,  Masahiro Nagamuta ,  Hiromitsu Kawata

发明人： Kazutaka Tachibana ,  Haruhiko Sato ,  Masateru Ohta ,  Mitsuaki Nakamura ,  Takuya Shiraishi ,  Ikuhiro Imaoka ,  Hitoshi Yoshino ,  Masahiro Nagamuta ,  Hiromitsu Kawata

IPC分类号： A61K31/4166 ,  C07D233/40

CPC分类号： C07D233/86 ,  C07D233/76

摘要： The present invention provides a compound represented by formula (I): wherein n is an integer selected from 1 to 20, Q is A is cyano or the like; B is hydrogen, halogen, or the like; X1 and X2 are each independently selected from O and S; E is a C1-4 alkyl group; and R1, R2, R3 and R4 are each independently selected from a hydrogen atom and a C1-C6 alkyl group, and a drug, a pharmaceutical composition containing the compound, and the like.

摘要翻译： 本发明提供由式（I）表示的化合物：其中n是选自1至20的整数，Q是A是氰基等; B是氢，卤素等; X1和X2各自独立地选自O和S; E是C 1-4烷基; R 1，R 2，R 3和R 4各自独立地选自氢原子和C 1 -C 6烷基，以及药物，含有该化合物的药物组合物等。

公开(公告)号：US07783810B2

公开(公告)日：2010-08-24

申请号：US11669766

申请日：2007-01-31

申请人： Hiroshi Kyusojin ,  Masato Kajimoto ,  Chiaki Yamana ,  Kazuyoshi Horie ,  Taku Tanaka ,  Kazutaka Tachibana

发明人： Hiroshi Kyusojin ,  Masato Kajimoto ,  Chiaki Yamana ,  Kazuyoshi Horie ,  Taku Tanaka ,  Kazutaka Tachibana

IPC分类号： G06F13/24 ,  G06F15/16

CPC分类号： G06F13/24

摘要： An information processing apparatus is provided. Plural processors respectively execute separate operating systems to process data that has been received from a network. The apparatus includes receiving device that receives the data in predetermined units from the network and analyzing device that analyzes identification data added to the data received by the receiving device. The apparatus also includes maintaining device which maintains a table that relates the identification data to information on identification of an interrupt register in each of the processors that execute the operating systems. The apparatus further includes interrupting device that allows interrupt processing to any of the processors to occur by writing the data received with the receiving device into the interrupt register that is related to the identification data, which is identified on the based of the table maintained by the maintaining device, analyzed by the analyzing device.

摘要翻译： 提供了一种信息处理装置。 多个处理器分别执行单独的操作系统来处理从网络接收到的数据。 该装置包括从网络以预定单位接收数据的接收装置和分析由接收装置接收到的数据添加的识别数据的分析装置。 该装置还包括维护装置，其将与标识数据相关联的表保持在执行操作系统的每个处理器中的关于中断寄存器的标识的信息。 该装置还包括中断装置，其允许通过将与接收装置接收的数据写入与识别数据相关的中断寄存器来允许对任何处理器的中断处理，所述中断寄存器基于由 维护装置，由分析装置分析。

公开(公告)号：US20070249697A1

公开(公告)日：2007-10-25

申请号：US11659369

申请日：2005-08-03

申请人： Kazutaka Tachibana ,  Haruhiko Sato ,  Masateru Ohta ,  Mitsuaki Nakamura ,  Takuya Shiraishi ,  Ikuhiro Imaoka ,  Hitoshi Yoshino ,  Masahiro Nagamuta ,  Hiromitsu Kawata

发明人： Kazutaka Tachibana ,  Haruhiko Sato ,  Masateru Ohta ,  Mitsuaki Nakamura ,  Takuya Shiraishi ,  Ikuhiro Imaoka ,  Hitoshi Yoshino ,  Masahiro Nagamuta ,  Hiromitsu Kawata

IPC分类号： A61K31/4164 ,  A61P5/26 ,  C07D233/00

CPC分类号： C07D233/86 ,  C07D233/76

摘要： The present invention provides a compound represented by formula (I): wherein n is an integer selected from 1 to 20, Q is A is cyano or the like; B is hydrogen, halogen, or the like; X1 and X2 are each independently selected from O and S; E is a C1-4 alkyl group; and R1, R2, R3 and R4 are each independently selected from a hydrogen atom and a C1-C6 alkyl group, and a drug, a pharmaceutical composition containing the compound, and the like.

摘要翻译： 本发明提供由式（I）表示的化合物：其中n是选自1至20的整数，Q是A是氰基等; B是氢，卤素等; X 1和X 2各自独立地选自O和S; E是C 1-4烷基; 且R 1，R 2，R 3和R 4各自独立地选自氢原子和 C 1 -C 6烷基，以及药物，含有该化合物的药物组合物等。

公开(公告)号：US20070223472A1

公开(公告)日：2007-09-27

申请号：US11685994

申请日：2007-03-14

申请人： Kazutaka TACHIBANA ,  Taku TANAKA ,  Kazuyoshi HORIE

发明人： Kazutaka TACHIBANA ,  Taku TANAKA ,  Kazuyoshi HORIE

IPC分类号： H04L12/56 ,  H04J3/24

CPC分类号： H04L47/10 ,  H04L47/36

摘要： A network processing apparatus is provided. A send buffer receives from a protocol stack a long packet with a data length exceeding a maximum transmission unit defined for a network and stores the long packet. A payload dividing unit divides the payload of the long packet into a plurality of divided payloads. A header duplicating unit duplicates the header of the long packet so as to generate a duplicated header for the respective divided payload. A short packet generating unit attaches the duplicated header to the respective divided payload so as to generate a short packet with a data length equal to or less than the maximum transmission unit to be sent to the network. A sending unit sends the short packet to the network via a physical interface.

摘要翻译： 提供网络处理装置。 发送缓冲器从协议栈接收数据长度超过为网络定义的最大传输单元的长分组，并存储长分组。 有效载荷分割单元将长分组的有效载荷分成多个分割的有效载荷。 报头复制单元复制长分组的报头，以便为相应的分割的有效载荷生成重复的报头。 短分组产生单元将复制的报头附加到相应的分割的有效载荷，以便生成数据长度等于或小于要发送到网络的最大传输单元的短分组。 发送单元通过物理接口向网络发送短消息包。