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公开(公告)号:US20090281072A1
公开(公告)日:2009-11-12
申请号:US12235189
申请日:2008-09-22
申请人: Shinya Nagashima , Hiroshi Nagata , Masashiro Iwata , Masaki Yokota , Hiroyuki Moritomo , Eiichi Nakai , Sadao Kuromitsu , Keiko Ohga , Makoto Takeuchi
发明人: Shinya Nagashima , Hiroshi Nagata , Masashiro Iwata , Masaki Yokota , Hiroyuki Moritomo , Eiichi Nakai , Sadao Kuromitsu , Keiko Ohga , Makoto Takeuchi
IPC分类号: A61K31/5377 , A61K31/551 , A61K31/397 , A61P11/06
CPC分类号: C07D403/12 , C07D239/48 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D451/04 , C07D453/02 , C07D471/10 , C07D487/08
摘要: A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided.A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.
摘要翻译: 提供了可用于预防或治疗其中涉及STAT6的呼吸系统疾病的化合物,特别是哮喘,慢性阻塞性肺病等。 具有可以被特定取代基取代的芳基氨基或芳基乙氨基的嘧啶衍生物或其盐在2-位被苄基取代的氨基或4-位上的氨基甲酰基和氨基甲酰基, 可以在5位被提供。
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公开(公告)号:US20110294749A1
公开(公告)日:2011-12-01
申请号:US13171411
申请日:2011-06-28
申请人: Shinya Nagashima , Hiroshi Nagata , Masahiro Iwata , Masaki Yokota , Hiroyuki Moritomo , Eiichi Nakai , Sadao Kuromitsu , Keiko Ohga , Makoto Takeuchi
发明人: Shinya Nagashima , Hiroshi Nagata , Masahiro Iwata , Masaki Yokota , Hiroyuki Moritomo , Eiichi Nakai , Sadao Kuromitsu , Keiko Ohga , Makoto Takeuchi
IPC分类号: A61K31/505 , C07D413/12 , A61K31/5377 , C07D413/14 , C07D417/12 , A61K31/541 , C07H15/26 , A61K31/7064 , C07D403/12 , A61K31/551 , A61K31/553 , A61P11/06 , A61P11/00 , A61K31/506 , C07D239/48
CPC分类号: C07D403/12 , C07D239/48 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D451/04 , C07D453/02 , C07D471/10 , C07D487/08
摘要: A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided.A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.
摘要翻译: 提供了可用于预防或治疗其中涉及STAT6的呼吸系统疾病的化合物,特别是哮喘,慢性阻塞性肺病等。 具有可以被特定取代基取代的芳基氨基或芳基乙氨基的嘧啶衍生物或其盐在2-位被苄基取代的4-氨基甲酰基和氨基甲酰基上, 可以在5位被提供。
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公开(公告)号:US08012959B2
公开(公告)日:2011-09-06
申请号:US12235189
申请日:2008-09-22
申请人: Shinya Nagashima , Hiroshi Nagata , Masashiro Iwata , Masaki Yokota , Hiroyuki Moritomo , Eiichi Nakai , Sadao Kuromitsu , Keiko Ohga , Makoto Takeuchi
发明人: Shinya Nagashima , Hiroshi Nagata , Masashiro Iwata , Masaki Yokota , Hiroyuki Moritomo , Eiichi Nakai , Sadao Kuromitsu , Keiko Ohga , Makoto Takeuchi
IPC分类号: C07D239/48 , A61K31/506
CPC分类号: C07D403/12 , C07D239/48 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D451/04 , C07D453/02 , C07D471/10 , C07D487/08
摘要: A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided.A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.
摘要翻译: 提供了可用于预防或治疗其中涉及STAT6的呼吸系统疾病的化合物,特别是哮喘,慢性阻塞性肺病等。 具有可以被特定取代基取代的芳基氨基或芳基乙氨基的嘧啶衍生物或其盐在2-位被苄基取代的氨基或4-位上的氨基甲酰基和氨基甲酰基, 可以在5位被提供。
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公开(公告)号:US07449456B2
公开(公告)日:2008-11-11
申请号:US10518043
申请日:2003-06-26
申请人: Shinya Nagashima , Hiroshi Nagata , Masahiro Iwata , Masaki Yokota , Hiroyuki Moritomo , Eiichi Nakai , Sadao Kuromitsu , Keiko Ohga , Makoto Takeuchi
发明人: Shinya Nagashima , Hiroshi Nagata , Masahiro Iwata , Masaki Yokota , Hiroyuki Moritomo , Eiichi Nakai , Sadao Kuromitsu , Keiko Ohga , Makoto Takeuchi
IPC分类号: C07D239/48 , A61K31/506
CPC分类号: C07D403/12 , C07D239/48 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D451/04 , C07D453/02 , C07D471/10 , C07D487/08
摘要: A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided.A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.
摘要翻译: 提供了可用于预防或治疗其中涉及STAT6的呼吸系统疾病的化合物,特别是哮喘,慢性阻塞性肺病等。 具有可以被特定取代基取代的芳基氨基或芳基乙氨基的嘧啶衍生物或其盐在2-位被苄基取代的氨基或4-位上的氨基甲酰基和氨基甲酰基, 可以在5位被提供。
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公开(公告)号:US20050272753A1
公开(公告)日:2005-12-08
申请号:US10518043
申请日:2003-06-26
申请人: Shinya Nagashima , Hiroshi Nagata , Masahiro Iwata , Masaki Yokota , Hiroyuki Moritomo , Eiichi Nakai , Sadao Kuromitsu , Keiko Ohga , Makoto Takeuchi
发明人: Shinya Nagashima , Hiroshi Nagata , Masahiro Iwata , Masaki Yokota , Hiroyuki Moritomo , Eiichi Nakai , Sadao Kuromitsu , Keiko Ohga , Makoto Takeuchi
IPC分类号: A61P11/00 , A61P11/06 , A61P43/00 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D451/04 , C07D453/02 , C07D471/08 , C07D471/10 , C07D487/08 , A61K31/506 , A61K31/505 , C07D43/02
CPC分类号: C07D403/12 , C07D239/48 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D451/04 , C07D453/02 , C07D471/10 , C07D487/08
摘要: A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided. A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.
摘要翻译: 提供了可用于预防或治疗其中涉及STAT6的呼吸系统疾病的化合物,特别是哮喘,慢性阻塞性肺病等。 具有可以被特定取代基取代的芳基氨基或芳基乙氨基的嘧啶衍生物或其盐在2-位被苄基取代的氨基或4-位上的氨基甲酰基和氨基甲酰基, 可以在5位被提供。
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