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    2,6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin D2 receptor antagonists
    2.
    发明授权
    2,6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin D2 receptor antagonists 失效
    2,6-取代-4-单取代氨基嘧啶作为前列腺素D2受体拮抗剂

    公开(公告)号：US07517889B2

    公开(公告)日：2009-04-14

    申请号：US11735760

    申请日：2007-04-16

    申请人： Keith John Harris ,  Bin Cao

    发明人： Keith John Harris ,  Bin Cao

    IPC分类号： C07D239/46 ,  A61K31/505

    CPC分类号： C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

    摘要： The present invention is directed to a compound of Formula (I) wherein Cy1, Cy2, L1, L2, and R1 are as defined herein, a pharmaceutical composition comprising a pharmaceutically effective amount of one or more compounds according to Formula (I) in admixture with a pharmaceutically acceptable carrier, and a method of treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like by administering to said patient a pharmaceutically effective amount of a compound according to Formula (I).

    摘要翻译： 本发明涉及式（I）的化合物，其中Cy1，Cy2，L1，L2和R1如本文所定义，药物组合物包含药学上有效量的一种或多种式（I）化合物的混合物 与药学上可接受的载体和治疗患有PGD2介导的病症的患者的方法，包括但不限于过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症 ，伴有系统性肥大细胞活化，过敏性休克，支气管收缩，支气管炎，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍） 由于伴随瘙痒的行为（如刮伤和跳动），炎症，慢性阻塞性肺疾病 脑缺血再灌注损伤，脑血管意外，慢性类风湿性关节炎，胸膜炎，溃疡性结肠炎等，通过向所述患者施用药学有效量的根据式（I）的化合物。

    2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS
    5.
    发明申请
    2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS 审中-公开
    2-PHENYL-INDOLES作为PROSTAGLANDIN D2受体拮抗剂

    公开(公告)号：US20090176804A1

    公开(公告)日：2009-07-09

    申请号：US12357725

    申请日：2009-01-22

    申请人： Zhaoxia YANG ,  Stephan REILING ,  Thaddeus NIEDUZAK ,  Rose M. MATHEW ,  Sharon JACKSON ,  Keith John HARRIS

    发明人： Zhaoxia YANG ,  Stephan REILING ,  Thaddeus NIEDUZAK ,  Rose M. MATHEW ,  Sharon JACKSON ,  Keith John HARRIS

    IPC分类号： A61K31/404 ,  C07D209/18 ,  C07D209/20 ,  C07D257/06 ,  A61K31/41 ,  A61P17/00 ,  A61P37/08 ,  A61K31/496 ,  A61K31/435

    CPC分类号： C07D209/18

    摘要： The present invention is directed to 2-phenyl-indole compounds, their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, eczema, urticaria diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which are generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like.

    摘要翻译： 本发明涉及2-苯基 - 吲哚化合物，其制备方法，含有这些化合物的药物组合物及其在治疗患有PGD2介导的病症的患者中的药物用途，包括但不限于过敏性疾病（如过敏性疾病 鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），全身肥大细胞增多症，伴有系统性肥大细胞活化的疾病，过敏性休克，支气管收缩，支气管炎，湿疹，伴有瘙痒的荨麻疹（如特应性皮炎和荨麻疹） （如白内障，视网膜脱离，炎症，感染和睡眠障碍），其由于伴随瘙痒的行为（例如划伤和打浆），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性 类风湿性关节炎，胸膜炎，溃疡性结肠炎等。