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公开(公告)号:US20070281949A1
公开(公告)日:2007-12-06
申请号:US11803320
申请日:2007-05-14
申请人: Edward Bacon , Thomas Bailey , Nadine Becknell , Diane Gingrich , Greg Hostetler , Robert Hudkins , Keith Learn , Jason Wagner
发明人: Edward Bacon , Thomas Bailey , Nadine Becknell , Diane Gingrich , Greg Hostetler , Robert Hudkins , Keith Learn , Jason Wagner
IPC分类号: A61K31/519 , A61K31/517 , C07D487/02 , C07D403/02
CPC分类号: C07D401/14 , C07D403/04 , C07D487/04
摘要: The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted heterobicyclic pyrimidines of Formula (I): wherein R1, R2, R3, R4, R5, X, W, and ring A are as defined herein; pharmaceutical compositions of substituted heterobicyclic pyrimidines of Formula (I); and their use in the treatment of chronic neurodegenerative diseases, neurotraumatic diseases, depression and/or diabetes. More particularly, the present invention relates to substituted pyrazolopyrimidines of Formula (I).
摘要翻译: 本发明涉及化学组成,其制备方法和组合物的用途。 特别地,本发明涉及包含式(I)的取代的杂双环嘧啶的组合物:其中R 1,R 2,R 3, R 4,R 5,X,W和环A如本文所定义; 式(I)的取代杂双环嘧啶的药物组合物; 以及它们在治疗慢性神经变性疾病,神经创伤性疾病,抑郁症和/或糖尿病中的用途。 更具体地,本发明涉及式(I)的取代的吡唑并嘧啶。