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16 条记录 (耗时 0.019 秒)

    BENZODIAZEPINE DERIVATIVES FOR TREATING HEPATITIS C INFECTION
    1.
    发明申请
    BENZODIAZEPINE DERIVATIVES FOR TREATING HEPATITIS C INFECTION 失效

    公开(公告)号：US20090318427A1

    公开(公告)日：2009-12-24

    申请号：US12067318

    申请日：2005-09-19

    申请人： Helena Dennison ,  Justin Warne ,  Keith Spencer ,  George Cockerill ,  James Lumley

    发明人： Helena Dennison ,  Justin Warne ,  Keith Spencer ,  George Cockerill ,  James Lumley

    IPC分类号： A61K31/5513 ,  A61P31/12 ,  C07D243/24

    CPC分类号： C07D243/24 ,  A61K31/5513

    摘要： Use of a benzodiazepine of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in treating or preventing a hepatitis C infection, wherein: —R1 represents C1-6 alkyl, aryl or heteroaryl; —R2 represents hydrogen or C1-6 alkyl; —each R3 is the same or different and represents halogen, hydroxy, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 haloalkyl, C1-6 haloalkoxy, amino, mono(C1-6 alkyl)amino, di(C1-6 alkyl)amino, nitro, cyano, —CO2R′, —CONR′R″, —NH—C0-R′, —S(O)R′, —S(O)2R′, —NH—S(O)2R′, —S(O)NR′R″ or —S(O)2NR′R″, wherein each R′ and R″ is the same or different and represents hydrogen or C1-6 alkyl; —n is from 0 to 3; —R4 represents hydrogen or C1-6 alkyl; —R5 represents C1-6alkyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl-(C1-6 alkyl)-, heteroaryl-(C1-6 alkyl)-, carbocyclyl-(C1-6 alkyl)-, heterocyclyl-(C1-6 alkyl)-, aryl-(C1-6 hydroxyalkyl)-, heteroaryl-(C1-6hydroxyalkyl)-, carbocyclyl-(C1-6 hydroxyalkyl)-, heterocyclyl-(C1-6hydroxyalkyl)-, aryl-C(O)—C(O)—, heteroaryl-C(O)—C(O)—, carbocyclyl-C(O)—C(O)—, heterocyclyl-C(O)—C(O)— or —XR6; —X represents —CO—, —S(O)— or —S(O)2—; and —R6 represents C1-6 alkyl, hydroxy, C1-6 alkoxy, C1-6 alkylthio, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl-(C1-6 alkyl)-, heteroaryl-(C1-6 alkyl)-, carbocyclyl-(C1-6 alkyl)-, heterocyclyl-(C1-6 alkyl)-, aryl-(C1-6 alkyl)-O—, heteroaryl-(C1-6 alkyl)-O—, carbocyclyl-(C1-6 alkyl)-O—, heterocyclyl-(C1-6 alkyl)-O— or —NR′R″ wherein each R′ and R″ is the same or different and represents hydrogen, C1-6 alkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, aryl-(C1-6 alkyl)-, heteroaryl-(C1-6 alkyl)-, carbocyclyl-(C1-6 alkyl)- or heterocyclyl-(C1-6 alkyl)-.

    Systems for Efficient Insulation of Electrical Structures
    2.
    发明申请
    Systems for Efficient Insulation of Electrical Structures 有权
    电气结构高效绝缘系统

    公开(公告)号：US20090294170A1

    公开(公告)日：2009-12-03

    申请号：US12471153

    申请日：2009-05-22

    申请人： Ronald Keith Spencer

    发明人： Ronald Keith Spencer

    IPC分类号： H02G7/00

    CPC分类号： A01M29/30 ,  A01M29/32

    摘要： An animal deterrent system to be placed on structures such as electrical apparatus to deter and protect birds, wildlife and other animals. Specifically, a perching deterrent having a saddle made to fit over any desired member of a structure and deterrent extensions may be used separately or in combination. The deterrent extensions may protrude in various configurations from the above-mentioned saddle to inhibit, deter, or insulate animals contracting structures. Also possible is an insulator cap with spiral conductor covers.

    摘要翻译： 将动物威慑系统放置在诸如电气设备的结构上，以阻止和保护鸟类，野生动物和其他动物。 具体来说，可以单独地或组合地使用具有安装在任何所需的结构构件和阻尼延伸部件上的鞍座的歪斜威慑。 阻力延伸部可以以上述马鞍的各种构造突出，以抑制，阻止或绝缘动物收缩结构。 具有螺旋形导体盖的绝缘体盖也是可能的。

    FULL FUNCTION PRECISION WELDING SYSTEM
    3.
    发明申请
    FULL FUNCTION PRECISION WELDING SYSTEM 审中-公开
    全功能精密焊接系统

    公开(公告)号：US20070297556A1

    公开(公告)日：2007-12-27

    申请号：US11752733

    申请日：2007-05-23

    申请人： Keith Spencer ,  Bradley Powell

    发明人： Keith Spencer ,  Bradley Powell

    IPC分类号： G21C17/00

    CPC分类号： G21C17/017 ,  B23K9/0286 ,  B23K2101/06

    摘要： A welding system for performing a welding process on a pipe in a confined space includes a motor housing, a weld head assembly and an insertion tube that extends between the motor housing and the weld head assembly with the weld head assembly remote from the motor housing. The motor housing is supported on a platform for rotational and translational movement of the weld head assembly and houses a motor for positioning the weld head assembly relative to the pipe. The weld head assembly includes a clamp assembly for attaching the weld head assembly to the pipe and a weld tool assembly mounted adjacent the clamp assembly for welding the pipe. An arc length gear and a travel gear adjust the distance between a torch assembly and the pipe and adjust the location of the torch assembly around the pipe when the weld head assembly is attached to the pipe.

    摘要翻译： 用于在密闭空间中的管子上执行焊接过程的焊接系统包括马达壳体，焊接头组件和插入管，其在马达壳体和焊接头组件之间延伸，焊头组件远离马达壳体。 电动机壳体支撑在用于焊头组件的旋转和平移运动的平台上，并且容纳用于相对于管定位焊头组件的电动机。 焊头组件包括用于将焊接头组件附接到管道的夹具组件和邻近夹具组件安装以焊接管道的焊接工具组件。 电弧长度齿轮和行走齿轮调节焊枪组件和管道之间的距离，并且当焊头组件附接到管道时调整焊枪组件在管道周围的位置。

    Pipette tip with an internal sleeve and method for forming same
    4.
    发明授权
    Pipette tip with an internal sleeve and method for forming same 有权
    移液器顶端带有内套管及其形成方法

    公开(公告)号：US06955077B2

    公开(公告)日：2005-10-18

    申请号：US10140990

    申请日：2002-05-09

    申请人： Peter Paul Blaszcak ,  Howard Keith Spencer ,  Thomas Taggart

    发明人： Peter Paul Blaszcak ,  Howard Keith Spencer ,  Thomas Taggart

    IPC分类号： B01L3/02 ,  G01N1/00

    CPC分类号： B01L3/0279 ,  B01L2200/0689 ,  B01L2200/087

    摘要： A pipette tip member having an elongated tubular receptacle having a sidewall with a bifurcated section that comprises first, second, and third sidewall portions. The first sidewall portion comprises a base wall and the second and third sidewall portions branch therefrom. The second sidewall portion comprises an outside branch wall, and the third sidewall portion comprises an inside branch wall spaced substantially parallel with and radially inward from the second sidewall portion. The inside branch wall is flexible in the radial direction and engages a pipette tip when it is inserted into the receptacle and to form a fluid-tight seal therewith. A method of forming a pipette tip member is also disclosed.

    摘要翻译： 具有细长管状容器的移液管尖端构件，其具有侧壁，所述侧壁具有包括第一，第二和第三侧壁部分的分叉部分。 第一侧壁部分包括底壁，并且第二和第三侧壁部分从其分支。 第二侧壁部分包括外侧分支壁，并且第三侧壁部分包括与第二侧壁部分基本上平行且径向向内间隔开的内部分支壁。 内分支壁在径向方向上是柔性的，并且当移液管插头插入到容器中并且与移液管尖端形成不透液体的密封。 还公开了一种形成移液管末端部件的方法。

    Pipette tip with an internal sleeve and stabilizing projections
    6.
    发明授权
    Pipette tip with an internal sleeve and stabilizing projections 有权
    移液器顶端带有内部套筒和稳定突起

    公开(公告)号：US07047828B2

    公开(公告)日：2006-05-23

    申请号：US10364667

    申请日：2003-02-12

    申请人： Peter Paul Blaszcak ,  Howard Keith Spencer ,  Thomas Taggart

    发明人： Peter Paul Blaszcak ,  Howard Keith Spencer ,  Thomas Taggart

    IPC分类号： G01N1/00

    CPC分类号： B01L3/0279 ,  B01L2200/0689 ,  B01L2200/087

    摘要： A pipette tip member has an elongated tubular receptacle including a sidewall with a plurality of stabilizing projections extending from the sidewall for aligning the pipette shaft, and a sidewall with a bifurcated section that includes first, second, and third sidewall portions. The first sidewall portion defines a base wall and the second and third sidewall portions branch therefrom. The second sidewall portion is an outside branch wall, and the third sidewall portion is an inside branch wall spaced substantially parallel with and radially inward from the second sidewall portion. The inside branch wall is flexible in the radial direction and engages a pipette shaft when it is inserted into the receptacle and to form a fluid-tight seal therewith. A method of forming a pipette tip member is also enclosed.

    摘要翻译： 移液管末端构件具有细长的管状容器，其包括侧壁，所述侧壁具有从侧壁延伸用于对准移液管轴的多个稳定突起，以及具有包括第一，第二和第三侧壁部分的分叉部分的侧壁。 第一侧壁部分限定底壁，并且第二和第三侧壁部分从其分支。 第二侧壁部分是外侧分支壁，并且第三侧壁部分是与第二侧壁部分大致平行且径向向内间隔的内部分支壁。 内分支壁在径向方向上是柔性的，并且当移入管轴被插入到容器中并且与其形成流体密封时。 也封闭形成移液管末端部件的方法。

    Surface wave radar
    9.
    发明授权
    Surface wave radar 有权
    表波雷达

    公开(公告)号：US07145503B2

    公开(公告)日：2006-12-05

    申请号：US10291697

    申请日：2002-11-12

    申请人： Yuri Abramovich ,  Pavel Turcaj ,  Nicholas Keith Spencer ,  Robert M Ellard ,  Yuriy Lyudviga

    发明人： Yuri Abramovich ,  Pavel Turcaj ,  Nicholas Keith Spencer ,  Robert M Ellard ,  Yuriy Lyudviga

    IPC分类号： G01S7/292 ,  G01S13/02 ,  G01S13/04 ,  G01S13/18

    CPC分类号： G01S13/0218 ,  G01S7/352 ,  G01S7/4021 ,  G01S7/414 ,  G01S13/536 ,  G01S2013/0227 ,  H01Q1/04 ,  H01Q11/10 ,  H01Q21/062 ,  H01Q21/24

    摘要： A surface wave radar system including a receive antenna array (20, 22) for generating receive signals, and a data processing system (24) for processing received data representing the receive signals to mitigate ionospheric clutter. The received data is range and Doppler processed, and a spatial adaptive filter (52) is trained using training data selected from the processed data. The training data includes ionospheric clutter data and excludes cells which contain target data and substantial sea clutter. The processed data is filtered using the filter (52), which may be based on loaded sample matrix inversion. The antenna array (20,22) may be two-dimensional having an L or T shape.

    摘要翻译： 包括用于产生接收信号的接收天线阵列（20,22）的表面波雷达系统以及用于处理表示接收信号的接收数据以缓解电离层杂波的数据处理系统（24）。 接收的数据是范围和多普勒处理，并且使用从处理的数据中选择的训练数据训练空间自适应滤波器（52）。 训练数据包括电离层杂波数据，并排除包含目标数据和大量海杂波的细胞。 使用过滤器（52）对经处理的数据进行过滤，其可以基于加载的样本矩阵反演。 天线阵列（20,22）可以是具有L或T形状的二维。