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公开(公告)号:US20050124676A1
公开(公告)日:2005-06-09
申请号:US10964831
申请日:2004-10-15
申请人: David Clark , Neil Harris , Garry Fenton , George Hynd , Keith Stuttle , Jonathan Sutton , Alexander Oxford , Richard Davis , Robert Coleman , Kenneth Clark
发明人: David Clark , Neil Harris , Garry Fenton , George Hynd , Keith Stuttle , Jonathan Sutton , Alexander Oxford , Richard Davis , Robert Coleman , Kenneth Clark
IPC分类号: A61K31/34 , A61K31/41 , C07D307/68 , C07D45/02
CPC分类号: C07D307/68
摘要: A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein one of R2 and R5 is: (i) H or an optionally substituted C1-4 alkyl group; or (ii)an optionally substituted C5-7 aryl; and the other of R2 and R5 is the other group; m and n can be 0 or 1, and m+n=1 or 2 RN is H or optionally substituted C1-4 alkyl R3 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl, or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; or (iv) tetrazol-5-yl.
摘要翻译: 式(I)化合物或其盐,溶剂合物和化学保护形式,其中R 2和R 5中的一个为:(i)H或任选地 取代的C 1-4烷基; 或(ii)任选取代的C 5-7芳基; R 2和R 5中的另一个是另一个基团; m和n可以是0或1,m + n = 1或2 R N是H或任选取代的C 1-4烷基R 3, SUP>是:(i)羧基; (ii)式(II)的基团:(iii)式(III)的基团:其中R是任选取代的C 1-7烷基,C 5〜20 其中R 3,N 3和R 4各自独立地选自任选取代的C 1 -C 6芳基或NR N 3 N, 1-4个C 1-4烷基; 或(iv)四唑-5-基。
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公开(公告)号:US20080039502A1
公开(公告)日:2008-02-14
申请号:US11889570
申请日:2007-08-14
申请人: Alexander Oxford , Richard Davis , Robert Coleman , Kenneth Clark , David Clark , Neil Harris , Garry Fenton , George Hynd , Keith Stuttle , Jonathan Sutton , Christopher Newton
发明人: Alexander Oxford , Richard Davis , Robert Coleman , Kenneth Clark , David Clark , Neil Harris , Garry Fenton , George Hynd , Keith Stuttle , Jonathan Sutton , Christopher Newton
IPC分类号: A61K31/34 , A61K31/341 , A61K31/4155 , A61K31/443 , A61P25/06 , C07D231/12 , C07D231/18 , C07D307/68 , C07D307/77 , C07D405/12 , C07D413/12
CPC分类号: C07D307/54 , A61K31/34 , A61K31/341 , A61K31/4155 , A61K31/443 , C07D307/64 , C07D307/68 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要: Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl, or Y is —C(═O)NRN2—, where RN2 is selected from H, and optionally substituted C1-7 alkyl or C5-20 aryl; R3 is an optionally substituted C6 aryl group linked to a further optionally substituted C6 aryl group, wherein if both C6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C1-3 alkylene group; and R5 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; (iv) tetrazol-5-yl.
摘要翻译: 式(I)的化合物:其中:R 2是H或任选取代的C 1-4烷基; Y是 - (CH 2)n -X-,其中n是1或2,X是O,S,S(-O),S(-O )N 2,或NR 11,其中R 0,1选自H或任选取代的C 1-4烷基 ,或Y是-C(-O)NR N2 - ,其中R N2选自H和任选取代的C 1-7 - 烷基或C 5-20-20芳基; R 3是与另外任选取代的C 6 -C 6芳基连接的任选取代的C 6-14芳基,其中如果两个C 6 芳基是苯环,两个环之间可能有一个氧桥,与两个环上的连接相邻; A是单键或C 1-3-3亚烷基; 和R 5是:(i)羧基; (ii)式(II)的基团:(iii)式(III)的基团:其中R是任选取代的C 1-7烷基,C 5〜20 其中R“N 3”和“R”N 4“独立地选自任选取代的C 1 -C 6烷基, 烷基; (ⅳ)四唑-5-基。
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公开(公告)号:US20070135503A1
公开(公告)日:2007-06-14
申请号:US10576095
申请日:2004-10-15
申请人: David Clark , Neil Harris , Garry Fenton , George Hynd , Keith Stuttle , Jonathan Sutton , Alexander Oxford , Richard Davis , Robert Coleman , Kenneth Clark
发明人: David Clark , Neil Harris , Garry Fenton , George Hynd , Keith Stuttle , Jonathan Sutton , Alexander Oxford , Richard Davis , Robert Coleman , Kenneth Clark
IPC分类号: A61K31/41 , A61K31/34 , A61K31/405 , C07D307/02
CPC分类号: C07D307/68
摘要: A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein one of R2 and R5 is: (i) H or an optionally substituted C1-4 alkyl group; or (ii) an optionally substituted C5-7 aryl; and the other of R2 and R5 is the other group; m and n can be 0 or 1, and m+n=1 or 2 RN is H or optionally substituted C1-4 alkyl R3 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl, or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; or (iv) tetrazol-5-yl.
摘要翻译: 式(I)化合物或其盐,溶剂合物和化学保护形式,其中R 2和R 5中的一个为:(i)H或任选地 取代的C 1-4烷基; 或(ii)任选取代的C 5-7芳基; R 2和R 5中的另一个是另一个基团; m和n可以是0或1,m + n = 1或2 R N是H或任选取代的C 1-4烷基R 3, SUP>是:(i)羧基; (ii)式(II)的基团:(iii)式(III)的基团:其中R是任选取代的C 1-7烷基,C 5〜20 其中R 3,N 3和R 4各自独立地选自任选取代的C 1 -C 6芳基或NR N 3 N, 1-4个C 1-4烷基; 或(iv)四唑-5-基。
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公开(公告)号:US20070123575A1
公开(公告)日:2007-05-31
申请号:US11615024
申请日:2006-12-22
申请人: Alexander Oxford , Richard Davis , Robert Coleman , Kenneth Clark , David Clark , Neil Harris , Garry Fenton , George Hynd , Keith Stuttle , Jonathan Sutton , Christopher Newton
发明人: Alexander Oxford , Richard Davis , Robert Coleman , Kenneth Clark , David Clark , Neil Harris , Garry Fenton , George Hynd , Keith Stuttle , Jonathan Sutton , Christopher Newton
IPC分类号: A61K31/41 , A61K31/34 , C07D405/02
CPC分类号: C07D307/54 , A61K31/34 , A61K31/341 , A61K31/4155 , A61K31/443 , C07D307/64 , C07D307/68 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要: Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl, or Y is —C(═O)NRN2—, where RN2 is selected from H, and optionally substituted C1-7 alkyl or C5-20 aryl; R3 is an optionally substituted C6 aryl group linked to a further optionally substituted C6 aryl group, wherein if both C6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C1-3 alkylene group; and R5 is either: (i) carboxy; (ii) a group of formula (II): ; or (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; (iv) tetrazol-5-yl.
摘要翻译: 式(I)的化合物:其中:R 2是H或任选取代的C 1-4烷基; Y是 - (CH 2)n -X-,其中n是1或2,X是O,S,S(-O),S(-O )N 2,或NR 11,其中R 0,1选自H或任选取代的C 1-4烷基 ,或Y是-C(-O)NR N2 - ,其中R N2选自H和任选取代的C 1-7 - 烷基或C 5-20-20芳基; R 3是与另外任选取代的C 6 -C 6芳基连接的任选取代的C 6-14芳基,其中如果两个C 6 芳基是苯环,两个环之间可能有一个氧桥,与两个环上的连接相邻; A是单键或C 1-3-3亚烷基; 和R 5是:(i)羧基; (ii)式(II)的组: 或(iii)式(III)的基团:其中R是任选取代的C 1-7烷基,C 5-20-20芳基或NR N 3, 其中R“N 3”和“R”N 4“独立地选自任选取代的C 1-4烷基 ; (ⅳ)四唑-5-基。
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公开(公告)号:US20050256170A1
公开(公告)日:2005-11-17
申请号:US11055724
申请日:2005-02-11
申请人: Alexander Oxford , Richard Davis , Robert Coleman , Kenneth Clark , David Clark , Neil Harris , Garry Fenton , George Hynd , Keith Stuttle , Jonathan Sutton , Mark Ashton , Edward Boyd , Shirley Brunton
发明人: Alexander Oxford , Richard Davis , Robert Coleman , Kenneth Clark , David Clark , Neil Harris , Garry Fenton , George Hynd , Keith Stuttle , Jonathan Sutton , Mark Ashton , Edward Boyd , Shirley Brunton
IPC分类号: A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/4439 , C07C233/75 , C07C233/81 , C07C235/84 , C07D213/81 , C07D233/90 , C07D257/04 , C07D277/24 , C07D277/26 , C07D277/56 , C07D307/46 , C07D307/68 , C07D307/91 , C07D333/38 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号: C07D213/81 , C07C233/75 , C07C233/81 , C07C235/84 , C07D233/90 , C07D257/04 , C07D277/24 , C07D277/26 , C07D277/56 , C07D307/46 , C07D307/68 , C07D307/91 , C07D333/38 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/12
摘要: A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein: R5is an optionally substituted C5-20 aryl or C4-20 alkyl group; A is selected from the group consisting of: wherein X and Y are selected from the group consisiting of: O and CR3; S and CR3; NH and CR3; NH and N; O and N; S and N; N and S; and N and O., and where the dotted lines indicate a double bond in the appropriate location, and where Q is either N or CH; R3 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl and C5-7 aryl-C1-4 alkyl groups; R4 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl and C5-7 aryl-C1-4 alkyl groups; R6 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl and C5-7 aryl-C1-4 alkyl groups; D is selected from: B is selected from the group consisting of: where RN′ is selected from H and C1-4 alkyl; where one of RP3 and RP4 is —Cm alkylene-R2 and the other of RP3 and RP4 is H, m and n can be 0 or 1, and m+n=1 or 2; and additionally when RP3 is —Cm alkylene-R2, m can also be 2 or 3, and m+n=1, 2, 3 or 4, and when R2 is tetrazol-5-yl, m+n may be 0; or where one of RP3 and RP4 is —O—CH2—R2, and the other of RP3 and RP4 is H, n is 0; RN is H or optionally substituted C1-4 alkyl; R2 is either: —CO2H (carboxy); —CONH2; —CH2-OH; or tetrazol-5-yl.
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