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    Process for producing protein with reduction of acidic sugar chain and glycoprotein produced thereby
    1.
    发明申请
    Process for producing protein with reduction of acidic sugar chain and glycoprotein produced thereby 有权
    生产蛋白质的方法是由此产生的酸性糖链和糖蛋白的还原

    公开(公告)号：US20070202569A1

    公开(公告)日：2007-08-30

    申请号：US11707737

    申请日：2007-02-16

    申请人： Masami Miura ,  Masaaki Hirose ,  Taeko Miwa ,  Hiroyuki Irie ,  Shinobu Kuwae ,  Kenmi Miyano ,  Wataru Otani ,  Hideyuki Ohi

    发明人： Masami Miura ,  Masaaki Hirose ,  Taeko Miwa ,  Hiroyuki Irie ,  Shinobu Kuwae ,  Kenmi Miyano ,  Wataru Otani ,  Hideyuki Ohi

    IPC分类号： C12P21/06 ,  C12P19/04 ,  C12N15/74 ,  C12N1/21 ,  C12N1/18

    CPC分类号： C12N9/1205 ,  C12P21/005

    摘要： The present invention intends to find out a gene participating in addition of mannose phosphate to a sugar chain of a glycoprotein originating in a yeast belonging to the genus Pichia and provide a means of controlling the same. The present invention also intends to provide a process for producing a protein with reduction of an acidic sugar chain by using the thus controlled yeast strain belonging to the genus Pichia. Namely, the present invention includes a protein participating in the addition of mannose phosphate to a sugar chain of a glycoprotein; a gene coding this protein; a mutant of this gene; a vector carrying the mutant gene; a yeast strain belonging to the genus Pichia having been transformed by this vector; a process for producing a protein with reduction of an acidic sugar chain by using the transformed yeast strain; and a glycoprotein thus produced.

    摘要翻译： 本发明意图将参与加入甘露糖磷酸酯的基因找到源自属于毕赤酵母属的酵母的糖蛋白的糖链，并提供对其进行控制的方法。 本发明还提供通过使用由此控制的属于毕赤酵母属的酵母菌株来制备具有酸性糖链还原性蛋白质的方法。 即，本发明包括参与向糖蛋白的糖链添加甘露糖磷酸的蛋白质; 编码该蛋白的基因; 该基因的突变体; 携带突变基因的载体; 已经通过该载体转化了属于毕赤酵母属的酵母菌株; 通过使用转化的酵母菌株来生产具有降低酸性糖链的蛋白质的方法; 和由此产生的糖蛋白。

    Process for heat treating fibrinogen
    5.
    发明授权
    Process for heat treating fibrinogen 失效
    热处理纤维蛋白原的方法

    公开(公告)号：US5116950A

    公开(公告)日：1992-05-26

    申请号：US184303

    申请日：1988-04-21

    申请人： Kenmi Miyano ,  Kenji Tanaka ,  Hideo Nishimaki ,  Yoshiro Iga

    发明人： Kenmi Miyano ,  Kenji Tanaka ,  Hideo Nishimaki ,  Yoshiro Iga

    IPC分类号： A61K38/36 ,  A61L2/00

    CPC分类号： A61L2/0023 ,  A61K38/363

    摘要： An aqueous solution containing fibrinogen is heated in the presence of at least a sugar, an amino acid and a magnesium salt to thereby inactivate virus(es) possibly contaminating said fibrinogen. According to this process, the inactivation of the contaminating viruses can be achieved while maintaining the activity of the fibrinogen. Thus a highly safe fibrinogen preparation of excellent qualities can be prepared on an industrial scale.

    摘要翻译： 含有纤维蛋白原的水溶液在至少糖，氨基酸和镁盐的存在下加热，从而灭活可能污染所述纤维蛋白原的病毒。 根据该方法，可以在维持纤维蛋白原的活性的同时实现污染性病毒的灭活。 因此，可以以工业规模制备具有优异品质的高度安全的纤维蛋白原制剂。

    Process For Producing Protein With Reduction of Acidic Sugar Chain and Glycoprotein Produced Thereby
    6.
    发明申请
    Process For Producing Protein With Reduction of Acidic Sugar Chain and Glycoprotein Produced Thereby 有权
    通过减少酸性糖链和糖蛋白产生蛋白质的方法

    公开(公告)号：US20090004725A1

    公开(公告)日：2009-01-01

    申请号：US12184334

    申请日：2008-08-01

    申请人： Masami Miura ,  Masaaki Hirose ,  Taeko Miwa ,  Hiroyuki Irie ,  Shinobu Kuwae ,  Kenmi Miyano ,  Wataru Otani ,  Hideyuki Ohi

    发明人： Masami Miura ,  Masaaki Hirose ,  Taeko Miwa ,  Hiroyuki Irie ,  Shinobu Kuwae ,  Kenmi Miyano ,  Wataru Otani ,  Hideyuki Ohi

    IPC分类号： C12N1/19 ,  C07H21/04 ,  C12N15/64

    CPC分类号： C12N9/1205 ,  C12P21/005

    摘要： The present invention intends to find out a gene participating in addition of mannose phosphate to a sugar chain of a glycoprotein originating in a yeast belonging to the genus Pichia and provide a means of controlling the same. The present invention also intends to provide a process for producing a protein with reduction of an acidic sugar chain by using the thus controlled yeast strain belonging to the genus Pichia. Namely, the present invention includes a protein participating in the addition of mannose phosphate to a sugar chain of a glycoprotein; a gene coding this protein; a mutant of this gene; a vector carrying the mutant gene; a yeast strain belonging to the genus Pichia having been transformed by this vector; a process for producing a protein with reduction of an acidic sugar chain by using the transformed yeast strain; and a glycoprotein thus produced.

    摘要翻译： 本发明意图将参与加入甘露糖磷酸酯的基因找到源自属于毕赤酵母属的酵母的糖蛋白的糖链，并提供对其进行控制的方法。 本发明还提供通过使用由此控制的属于毕赤酵母属的酵母菌株来制备具有酸性糖链还原性蛋白质的方法。 即，本发明包括参与向糖蛋白的糖链添加甘露糖磷酸的蛋白质; 编码该蛋白的基因; 该基因的突变体; 携带突变基因的载体; 已经通过该载体转化了属于毕赤酵母属的酵母菌株; 通过使用转化的酵母菌株来生产具有降低酸性糖链的蛋白质的方法; 和由此产生的糖蛋白。

    Process for producing protein with reduction of acidic sugar chain and glycoprotein produced thereby
    7.
    发明授权
    Process for producing protein with reduction of acidic sugar chain and glycoprotein produced thereby 有权
    生产蛋白质的方法是由此产生的酸性糖链和糖蛋白的还原

    公开(公告)号：US07198921B2

    公开(公告)日：2007-04-03

    申请号：US10276075

    申请日：2001-05-16

    申请人： Masami Miura ,  Masaaki Hirose ,  Taeko Miwa ,  Hiroyuki Irie ,  Shinobu Kuwae ,  Kenmi Miyano ,  Wataru Otani ,  Hideyuki Ohi

    发明人： Masami Miura ,  Masaaki Hirose ,  Taeko Miwa ,  Hiroyuki Irie ,  Shinobu Kuwae ,  Kenmi Miyano ,  Wataru Otani ,  Hideyuki Ohi

    IPC分类号： C12P19/04 ,  C12P21/02 ,  C12N1/18 ,  C07H21/04 ,  C12N14/39

    CPC分类号： C12N9/1205 ,  C12P21/005

    摘要： The present invention intends to find out a gene participating in addition of mannose phosphate to a sugar chain of a glycoprotein originating in a yeast belonging to the genus Pichia and provide a means of controlling the same. The present invention also intends to provide a process for producing a protein with reduction of an acidic sugar chain by using the thus controlled yeast strain belonging to the genus Pichia. Namely, the present invention includes a protein participating in the addition of mannose phosphate to a sugar chain of a glycoprotein; a gene encoding this protein; a mutant of this gene; a vector carrying the mutant gene; a yeast strain belonging to the genus Pichia having been transformed by this vector; a process for producing a protein with reduction of an acidic sugar chain by using the transformed yeast strain; and a glycoprotein thus produced.

    摘要翻译： 本发明意图将参与加入甘露糖磷酸酯的基因找到源自属于毕赤酵母属的酵母的糖蛋白的糖链，并提供对其进行控制的方法。 本发明还提供通过使用由此控制的属于毕赤酵母属的酵母菌株来制备具有酸性糖链还原性蛋白质的方法。 即，本发明包括参与向糖蛋白的糖链添加甘露糖磷酸的蛋白质; 编码该蛋白的基因; 该基因的突变体; 携带突变基因的载体; 已经通过该载体转化了属于毕赤酵母属的酵母菌株; 通过使用转化的酵母菌株来生产具有降低酸性糖链的蛋白质的方法; 和由此产生的糖蛋白。