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公开(公告)号：US4968693A
公开(公告)日：1990-11-06
申请号：US363792
申请日：1989-06-09
IPC分类号： A61K31/22 , A61K31/365 , A61P3/06 , A61P9/10 , C07C69/28 , C07C69/738 , C07C219/10 , C07D309/30
CPC分类号： C07D309/30 , Y10S514/824
摘要： Compounds of formula (I) and (II): ##STR1## are HMG-CoA reductase inhibitors.
摘要翻译： 式（I）和（II）的化合物：HMG-CoA还原酶抑制剂。
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公开(公告)号：US4476139A
公开(公告)日：1984-10-09
申请号：US426585
申请日：1982-09-29
申请人： August J. Kempf , Kenneth E. Wilson , Otto D. Hensens , Richard L. Monaghan , Sheldon B. Zimmerman , Eugene L. Dulaney
发明人： August J. Kempf , Kenneth E. Wilson , Otto D. Hensens , Richard L. Monaghan , Sheldon B. Zimmerman , Eugene L. Dulaney
IPC分类号： A23K20/195 , C07H7/02 , C12P19/44 , A61K31/35 , C07D309/04
CPC分类号： C12R1/465 , A23K20/195 , C07H7/02 , C12P19/44
摘要： The antibiotic, L-681,217, having antibacterial and growth-permittant activity, is produced by fermentation of Streptomyces cattleya in a suitable nutrient media.
摘要翻译： 具有抗菌和生长 - 吸收活性的抗生素L-681,217通过在合适的营养培养基中发酵链霉菌（Streptomyces cattleya）产生。
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公开(公告)号：US5164375A
公开(公告)日：1992-11-17
申请号：US766311
申请日：1991-09-27
摘要： A phospholipid having the formula ##STR1## is described. The compound has antifungal properties.
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公开(公告)号：US4609742A
公开(公告)日：1986-09-02
申请号：US697806
申请日：1985-02-04
IPC分类号： C07F9/09 , A61K31/665 , A61P31/04 , C07D313/00 , C07F9/655 , C12P17/08 , C12R1/125
CPC分类号： C12R1/125 , C07D313/00 , C07F9/65525 , C12P17/08
摘要： The subject disclosure discloses a chemical intermediate in antibiotic synthesis of the structure: ##STR1## wherein R.sub.1 is H or OH and the asterisks indicate asymmetric carbon atoms. Compounds of this type may be obtained by fermentation with a strain of B. subtilis under aerobic conditions. Compounds of the above structure are biologically inactive but are converted by phosphorylation of the hydroxyl group to produce compounds of the structure: ##STR2## wherein R.sub.1 is H or OH, which are useful antibacterial substances having a broad spectrum of antibacterial activity.
摘要翻译： 本发明公开了一种结构抗生素合成中的化学中间体：其中R 1是H或OH并且星号表示不对称碳原子。 这种类型的化合物可以通过在需氧条件下用枯草芽孢杆菌菌株发酵来获得。 上述结构的化合物是生物学上无活性的，但是通过羟基的磷酸化转化而产生下列结构的化合物：其中R1是H或OH，它们是具有广谱抗菌活性的有用的抗菌物质。
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公开(公告)号：US4545991A
公开(公告)日：1985-10-08
申请号：US503951
申请日：1983-06-13
申请人： Sheldon B. Zimmerman , Kenneth E. Wilson , Richard L. Monaghan , Sagrario M. Del Val , Maria I. M. Fernandez , Otto D. Hensens , James E. Flor , Cheryl Deriso
发明人： Sheldon B. Zimmerman , Kenneth E. Wilson , Richard L. Monaghan , Sagrario M. Del Val , Maria I. M. Fernandez , Otto D. Hensens , James E. Flor , Cheryl Deriso
IPC分类号： C07F9/117 , A61K31/335 , A61P31/04 , C07F9/655 , C12P17/08 , C12R1/125 , A61K31/665 , C07F9/16
CPC分类号： C12R1/125 , C07F9/65525 , C12P17/08
摘要： Difficidin and derivative antibacterial compounds of the formula: ##STR1## where R.sub.a and R.sub.b are members independently selected from the group consisting of hydrogen; alkali metal and alkaline earth metal cations; ammonium; and substituted ammonium; and R.sup.1 is hydrogen or hydroxy.
摘要翻译： 其中R a和R b为独立地选自氢的成员，其具有下式的化合物和衍生抗菌化合物： 碱金属和碱土金属阳离子; 铵; 和取代的铵; 并且R 1是氢或羟基。
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公开(公告)号：US5021453A
公开(公告)日：1991-06-04
申请号：US533745
申请日：1990-06-06
IPC分类号： C07C59/90 , C07C69/738 , C07D309/30 , C07F7/18 , C12P7/62 , C12P17/06
CPC分类号： C07F7/1856 , C07C59/90 , C07C69/738 , C07D309/30 , C12P17/06 , C12P7/62 , Y10S514/824
摘要： Compounds of formula (I) and (II): ##STR1## are HMG-CoA reductase inhibitors.
摘要翻译： 式（I）和（II）的化合物：HMG-CoA还原酶抑制剂。
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7.发明授权Thermal isomer of difficidin and thermal isomer of oxydifficidin antibacterials 失效苦霉菌素的热异构体和oxydifficidin抗菌剂的热异构体
公开(公告)号：US4816448A
公开(公告)日：1989-03-28
申请号：US11189
申请日：1987-02-05
IPC分类号： C07D313/00 , C07F9/655 , C12P17/08 , A61K31/665 , C07F9/09
CPC分类号： C12R1/125 , C07D313/00 , C07F9/65525 , C12P17/08
摘要： The present invention relates to novel antibacterial compounds referred to herein generally as a thermal isomer of difficidin and thermal isomer of oxydifficidin. Also disclosed is process for preparing, isolating and purifying said compounds.
摘要翻译： 本发明涉及新颖的抗菌化合物，本文通常称作艰难小分子的热异构体和氧联吡啶的热异构体。 还公开了制备，分离和纯化所述化合物的方法。
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8.发明授权
公开(公告)号：US4681846A
公开(公告)日：1987-07-21
申请号：US667664
申请日：1985-05-06
申请人： Kenneth E. Wilson , Richard L. Monaghan , Cheryl DeRiso , Sheldon B. Zimmerman , Otto D. Hensens , James E. Flor , Sagrario M. Del Val , Maria I. M. Fernandez
发明人： Kenneth E. Wilson , Richard L. Monaghan , Cheryl DeRiso , Sheldon B. Zimmerman , Otto D. Hensens , James E. Flor , Sagrario M. Del Val , Maria I. M. Fernandez
CPC分类号： C12R1/125 , C07F9/65525 , C12P17/08 , Y10S435/839
摘要： Process for the preparation of difficidin and derivative antibacterial compounds of the formula: ##STR1## where R.sub.a and R.sub.b are members independently selected from the group consisting of hydrogen; alkali metal and alkaline earth metal cations; ammonium; and substituted ammonium; and R.sup.1 is hydrogen or hydroxy.
摘要翻译： 制备具有下式的艰难idin啶和衍生抗菌化合物的方法：其中Ra和Rb是独立地选自氢的成员; 碱金属和碱土金属阳离子; 铵; 和取代的铵; 并且R 1是氢或羟基。
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公开(公告)号：US4160084A
公开(公告)日：1979-07-03
申请号：US840921
申请日：1977-10-11
CPC分类号： C07H19/01 , Y10S435/886
摘要： This case relates to a novel process which aids in the isolation and purification of novel compounds which are produced by the microorganism, Streptomyces avermitilis. The process described utilizes a column containing a hydroxyalkylated dextran gel as a step in the separation of the desired compounds. The compounds which are isolated and purified are described generically as C-076 and have significant parasiticidal activity.
摘要翻译： 这种情况涉及一种有助于分离和纯化由微生物链霉菌（Streptomyces avermitilis）产生的新化合物的新方法。 所述方法使用含有羟烷基化葡聚糖凝胶的柱作为分离所需化合物的步骤。 分离和纯化的化合物一般被描述为C-076并且具有显着的杀寄生虫活性。
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公开(公告)号：US5091413A
公开(公告)日：1992-02-25
申请号：US479482
申请日：1990-02-13
申请人： George M. Garrity , Sagrario M. Del Val , Mary Nallin , Dennis M. Schmatz , Jack L. Smith , Frank L. VanMiddlesworth , Kenneth E. Wilson , Marcia M. Zweerink
发明人： George M. Garrity , Sagrario M. Del Val , Mary Nallin , Dennis M. Schmatz , Jack L. Smith , Frank L. VanMiddlesworth , Kenneth E. Wilson , Marcia M. Zweerink
IPC分类号： C07H17/04 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , A61P31/10 , C07D493/10 , C07H19/01 , C12N1/14 , C12P17/18 , C12P19/44 , C12R1/645
CPC分类号： C07D493/10 , C07H19/01 , C12P17/181
摘要： An antibiotic agent produced by the cultivation of Dictyochaeta simplex is described. The compound has broad antifungal activity and antipneumocystis activity.
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