-
公开(公告)号:US06254873B1
公开(公告)日:2001-07-03
申请号:US08423338
申请日:1995-04-17
IPC分类号: C07K1418
CPC分类号: C12N7/00 , A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , C12N2770/24134 , C12N2770/24161 , Y02A50/386
摘要: An inactivated dengue virus vaccine to immunize and protect humans against dengue fever is described. The vaccine is based on dengue viruses which have been propagated to high titers in suitable cells, purified and inactivated under conditions which destroy infectivity but preserve immunogenicity, a high level of which is demonstrated in animal models.
摘要翻译: 描述了免疫和保护人类登革热的灭活登革病毒疫苗。 该疫苗是基于在合适的细胞中传播到高滴度的登革病毒,在破坏感染性但保持免疫原性的条件下纯化和灭活,在动物模型中证明了这一点。
-
公开(公告)号:US20070087015A1
公开(公告)日:2007-04-19
申请号:US10626315
申请日:2003-07-24
申请人: Kenneth Eckels , Joseph Putnak , Doria Dubois , Bruce Innis , Charles Hoke , Wellington Sun , Niranjan Kanesa-Thasan
发明人: Kenneth Eckels , Joseph Putnak , Doria Dubois , Bruce Innis , Charles Hoke , Wellington Sun , Niranjan Kanesa-Thasan
IPC分类号: A61K39/395 , A61K39/12
CPC分类号: C12N7/00 , A61K39/12 , A61K2039/5254 , A61K2039/70 , C12N2770/24134 , C12N2770/24164 , Y02A50/386
摘要: The present invention provides vaccine compositions of attenuated dengue virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against all four dengue virus serotypes by administration of attenuated dengue-1, dengue-2, dengue-3, and dengue-4 virus.
摘要翻译: 本发明提供了减毒登革热病毒的疫苗组合物。 更具体地说,减毒病毒是通过PDK细胞中连续传代产生的。 本发明还提供了通过施用减毒登革热-1,登革热2,登革热-3和登革热-4病毒刺激个体的免疫系统以诱导针对所有四种登革热病毒血清型的保护的方法。
-
公开(公告)号:US06190859B1
公开(公告)日:2001-02-20
申请号:US08422458
申请日:1995-04-17
IPC分类号: A61K3912
CPC分类号: C12N7/00 , A61K2039/5252 , C12N2770/24163 , Y02A50/386
摘要: An inactivated dengue virus vaccine to immunize and protect humans against dengue fever is described. The vaccine is based on dengue viruses which have been propagated to high titers in suitable cells, purified and inactivated under conditions which destroy infectivity but preserve immunogenicity, a high level of which is demonstrated in animal models. Uses of the inactivated dengue virus for detecting antibodies to dengue and kits therefor are also described.
摘要翻译: 描述了免疫和保护人类登革热的灭活登革病毒疫苗。 该疫苗是基于在合适的细胞中传播到高滴度的登革病毒,在破坏感染性但保持免疫原性的条件下纯化和灭活,在动物模型中证明了这一点。 还描述了灭活登革病毒用于检测登革热抗体及其试剂盒的用途。
-
-