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1.发明授权Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists 失效用作趋化因子受体拮抗剂的取代的哌嗪基 - 吡咯烷化合物公开(公告)号：US08648197B2
公开(公告)日：2014-02-11
申请号：US13429575
申请日：2012-03-26
申请人： Kenneth G. Carson , Shomir Ghosh , Prakash Raman , Francois Soucy , Qing Ye
发明人： Kenneth G. Carson , Shomir Ghosh , Prakash Raman , Francois Soucy , Qing Ye
IPC分类号： C07D401/00 , A61K31/535
CPC分类号： C07D207/12 , A61K31/454 , A61K31/496 , A61K31/498 , A61K31/506 , A61K31/517 , A61K31/52 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D207/14 , C07D211/46 , C07D239/30 , C07D239/86 , C07D239/90 , C07D295/073 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/14 , C07D473/32
摘要： The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions for the inhibition of Chemokine Receptors and also for the treatment of various diseases, conditions, or disorders, including acute or chronic inflammatory disease, cancer or osteolytic bone disorders.
摘要翻译： 本发明涉及可用作趋化因子受体拮抗剂的化合物。 提供通式I的化合物：或其药学上可接受的盐。 本发明还提供包含所述化合物的药学上可接受的组合物和使用化合物和组合物抑制趋化因子受体的方法，还用于治疗各种疾病，病症或病症，包括急性或慢性炎性疾病，癌症或溶骨性骨骼疾病 。
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公开(公告)号：US08394817B2
公开(公告)日：2013-03-12
申请号：US13151701
申请日：2011-06-02
IPC分类号： A61K31/4353 , C07D491/044 , A61P29/00 , A61P9/10 , A61P3/10 , A61P17/06 , A61P37/00 , A61P37/08 , A61P37/06
CPC分类号： C07D491/044 , C07D491/04
摘要： The invention provides compounds having the formula: wherein R1 is halogen. The invention also provides compositions comprising the compounds, and methods of treating diseases or disorders that comprise administering one or more of the compounds to a subject in need thereof. The disclosed compounds have CCR1 antagonist activity.
摘要翻译： 本发明提供具有下式的化合物：其中R1是卤素。 本发明还提供包含该化合物的组合物，以及治疗疾病或病症的方法，其包括向有需要的受试者施用一种或多种化合物。 所公开的化合物具有CCR1拮抗剂活性。
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公开(公告)号：US08093267B2
公开(公告)日：2012-01-10
申请号：US12628309
申请日：2009-12-01
申请人： David J. Augeri , Jeffrey Bagdanoff , Lakmal W. Boteju , Kenneth G. Carson , Theodore C. Jessop , Spencer David Kimball
发明人： David J. Augeri , Jeffrey Bagdanoff , Lakmal W. Boteju , Kenneth G. Carson , Theodore C. Jessop , Spencer David Kimball
IPC分类号： A61K31/4164 , C07D233/64
CPC分类号： C07D233/64 , A61K31/4164 , C07D401/12
摘要： Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:
摘要翻译： 公开了基于咪唑的化合物，包含它们的组合物及其用于治疗，预防和控制炎症和自身免疫性疾病和病症的方法。 特定的化合物具有式I：
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4.发明授权Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists 有权用作趋化因子受体拮抗剂的取代的哌嗪基 - 吡咯烷化合物公开(公告)号：US07880002B2
公开(公告)日：2011-02-01
申请号：US11320414
申请日：2005-12-28
申请人： Kenneth G. Carson , Prakash Raman , Francois Soucy , Qing Ye , Shomir Ghosh
发明人： Kenneth G. Carson , Prakash Raman , Francois Soucy , Qing Ye , Shomir Ghosh
IPC分类号： C07D403/00 , A61K31/497
CPC分类号： C07D207/12 , A61K31/454 , A61K31/496 , A61K31/498 , A61K31/506 , A61K31/517 , A61K31/52 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D207/14 , C07D211/46 , C07D239/30 , C07D239/86 , C07D239/90 , C07D295/073 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/14 , C07D473/32
摘要： The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions for the inhibition of Chemokine Receptors and also for the treatment of various diseases, conditions, or disorders, including acute or chronic inflammatory disease, cancer or osteolytic bone disorders.
摘要翻译： 本发明涉及可用作趋化因子受体拮抗剂的化合物。 提供通式I的化合物：或其药学上可接受的盐。 本发明还提供包含所述化合物的药学上可接受的组合物和使用化合物和组合物抑制趋化因子受体的方法，还用于治疗各种疾病，病症或病症，包括急性或慢性炎性疾病，癌症或溶骨性骨骼疾病 。
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公开(公告)号：US07541365B2
公开(公告)日：2009-06-02
申请号：US11595653
申请日：2006-11-10
申请人： Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
发明人： Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
IPC分类号： A01N43/42 , A61K31/44 , C07D455/04 , C07D491/00 , C07D221/00 , C07D221/06
CPC分类号： C07D519/00 , C07D211/44 , C07D211/46 , C07D211/52 , C07D401/06 , C07D401/14 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04 , C07D497/04 , C07D513/04
摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
摘要翻译： 公开了新型化合物和治疗与异常白细胞募集和/或激活相关的疾病的方法。 该方法包括向有需要的受试者施用有效量的由其表示的化合物或其生理上可接受的盐。
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公开(公告)号：US07186729B2
公开(公告)日：2007-03-06
申请号：US10487168
申请日：2002-11-13
申请人： Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
发明人： Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
IPC分类号： A01N43/42 , A61K31/44 , C07D401/00 , C07D451/00 , C07D453/00
摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof
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公开(公告)号：US20120046311A1
公开(公告)日：2012-02-23
申请号：US13245436
申请日：2011-09-26
申请人： Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
发明人： Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
IPC分类号： A61K31/4353 , A61P19/02 , A61P9/10 , A61P3/10 , A61P29/00 , A61P25/00 , A61P1/00 , A61P37/08 , A61P11/06 , C07D491/044 , A61P17/06
CPC分类号： C07D519/00 , C07D211/44 , C07D211/46 , C07D211/52 , C07D401/06 , C07D401/14 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04 , C07D497/04 , C07D513/04
摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
摘要翻译： 公开了新型化合物和治疗与异常白细胞募集和/或激活相关的疾病的方法。 该方法包括向有需要的受试者施用有效量的由其表示的化合物或其生理上可接受的盐。
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8.发明授权4-amino-1H-pyrimidin-2-one based compounds, compositions comprising them and methods of their use 有权4-氨基-1H-嘧啶-2-酮基化合物，包含它们的组合物及其使用方法公开(公告)号：US08093245B2
公开(公告)日：2012-01-10
申请号：US11954421
申请日：2007-12-12
申请人： David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Alexander Heim-Riether , Theodore C. Jessop , James E. Tarver , Jerry A. Taylor
发明人： David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Alexander Heim-Riether , Theodore C. Jessop , James E. Tarver , Jerry A. Taylor
IPC分类号： C07D239/47 , C07D403/04 , A61K31/506
CPC分类号： C07D239/47 , C07D239/54 , C07D403/04 , C07D403/08 , C07D403/12 , C07D405/12 , C07D409/14 , C07D417/12 , C07D471/04
摘要： 4-Amino-1H-pyrimidin-2-one-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of various diseases and disorders are disclosed. Particular compounds are of formula I:
摘要翻译： 公开了4-氨基-1H-嘧啶-2-酮基化合物，包含它们的组合物及其用于治疗，预防和治疗各种疾病和病症的方法。 特定的化合物具有式I：
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公开(公告)号：US20100249174A1
公开(公告)日：2010-09-30
申请号：US12765070
申请日：2010-04-22
IPC分类号： A61K31/4353 , C07D491/044 , A61P29/00 , A61P9/10 , A61P3/10 , A61P17/06 , A61P37/00 , A61P37/08 , A61P37/06 , A61P11/06
CPC分类号： C07D491/044 , C07D491/04
摘要： The invention provides compounds having the formula: wherein R1 is halogen. The invention also provides compositions comprising the compounds, and methods of treating diseases or disorders that comprise administering one or more of the compounds to a subject in need thereof. The disclosed compounds have CCR1 antagonist activity.
摘要翻译： 本发明提供具有下式的化合物：其中R1是卤素。 本发明还提供包含该化合物的组合物，以及治疗疾病或病症的方法，所述疾病或病症包括向有需要的受试者施用一种或多种化合物。 所公开的化合物具有CCR1拮抗剂活性。
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公开(公告)号：US20090281081A1
公开(公告)日：2009-11-12
申请号：US12436271
申请日：2009-05-06
申请人： Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
发明人： Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
IPC分类号： A61K31/4523 , C07D211/22 , C07D405/06 , C07D409/06 , C07D401/06 , C07D413/14 , C07D491/044 , A61K31/451 , A61K31/4535 , A61K31/4353 , A61K31/55 , A61K31/5377 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/537 , A61K31/438 , A61P9/00 , A61P29/00 , A61P37/00
CPC分类号： C07D519/00 , C07D211/44 , C07D211/46 , C07D211/52 , C07D401/06 , C07D401/14 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04 , C07D497/04 , C07D513/04
摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
摘要翻译： 公开了新型化合物和治疗与异常白细胞募集和/或激活相关的疾病的方法。 该方法包括向有需要的受试者施用有效量的由其表示的化合物或其生理上可接受的盐。
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