公开(公告)号：US20110172601A1

公开(公告)日：2011-07-14

申请号：US12684566

申请日：2010-01-08

申请人： David J. Beebe ,  Benjamin J. Moga ,  Kent B. Chase ,  Garrick D.S. Smith ,  Jake W. Myre

发明人： David J. Beebe ,  Benjamin J. Moga ,  Kent B. Chase ,  Garrick D.S. Smith ,  Jake W. Myre

IPC分类号： A61M5/142 ,  A61M5/14 ,  A61M5/168

CPC分类号： A61M37/0015 ,  A61M2037/0023

摘要： A bladder arrangement is provided for a microneedle-based drug delivery device. The bladder arrangement includes a flexible membrane having an inner surface, an outer surface and an outer periphery. A bladder member, having a rigidity greater than the flexible membrane, includes an inner surface, an outer surface and an outer periphery. The inner surface of the flexible membrane and the inner surface of the bladder member define a chamber for receiving a drug therein. At least one microneedle is operatively connected to the bladder member. The at least one microneedle has an input and an output receivable within the individual. A valve operatively connects the input of the at least one microneedle and the chamber.

摘要翻译： 为基于微针的药物输送装置提供膀胱装置。 囊状结构包括具有内表面，外表面和外周边的柔性膜。 具有大于柔性膜的刚性的囊状构件包括内表面，外表面和外周。 柔性膜的内表面和气囊构件的内表面限定了用于在其中接收药物的腔室。 至少一个微针可操作地连接到膀胱构件。 至少一个微针具有在个体内的输入和输出可接收。 阀可操作地连接至少一个微针的输入和腔室。

公开(公告)号：US20120109066A1

公开(公告)日：2012-05-03

申请号：US13288266

申请日：2011-11-03

申请人： Kent B. Chase ,  Garrick D.S. Smith

发明人： Kent B. Chase ,  Garrick D.S. Smith

IPC分类号： A61M5/32 ,  A61M5/31

CPC分类号： A61M5/14248 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0061

摘要： A drug delivery device is provided. The drug delivery device includes a drug reservoir in fluid communication with a microneedle array. The drug delivery device has a sliding actuation mechanism that may be activated by a button or lever. Actuation of the drug delivery device inserts the microneedle array into the skin of a subject and causes a piston to compress the drug reservoir, thereby delivering the drug through the microneedle array to the subject.

摘要翻译： 提供药物输送装置。 药物递送装置包括与微针阵列流体连通的药物储存器。 药物输送装置具有滑动致动机构，其可以由按钮或杠杆来启动。 药物递送装置的致动将微针阵列插入受试者的皮肤中，并使活塞压缩药物储存器，从而将药物通过微针阵列输送到受试者。

公开(公告)号：US20110172645A1

公开(公告)日：2011-07-14

申请号：US12684832

申请日：2010-01-08

申请人： Benjamin J. Moga ,  Kent B. Chase ,  Garrick D.S. Smith

发明人： Benjamin J. Moga ,  Kent B. Chase ,  Garrick D.S. Smith

IPC分类号： A61K9/22

CPC分类号： A61K9/0021 ,  A61K9/703 ,  A61M5/14224 ,  A61M5/14248 ,  A61M5/14586 ,  A61M5/14593 ,  A61M37/0015 ,  A61M2037/0023

摘要： A drug delivery device for delivering a drug to a subject is provided. The drug delivery device includes a housing, a drug reservoir supported by the housing containing the drug and a hollow microneedle supported by the housing. The hollow microneedle is moveable from an inactive position to an activated position, wherein, when the hollow microneedle is moved to the activated position, the tip portion of the hollow microneedle is configured to penetrate the skin of the subject. The drug delivery device includes a channel having an input in communication with the drug reservoir and an output in communication with the hollow microneedle. The channel provides fluid communication between the drug reservoir and the hollow microneedle, such that the drug is permitted to flow from the drug reservoir through the channel and through the hollow microneedle. The channel moves from a first position to a second position as the hollow microneedle moves from the inactive position to the activated position, and the position of the drug reservoir relative to the housing remains fixed as the hollow microneedle moves from the inactive position to the activated position.

摘要翻译： 提供了用于将药物递送到受试者的药物递送装置。 药物输送装置包括壳体，由容纳药物的壳体支撑的药物储存器和由壳体支撑的中空微针。 空心微针可以从非活动位置移动到激活位置，其中当中空微针移动到激活位置时，中空微针的顶端部分被构造成穿透被检体的皮肤。 药物输送装置包括具有与药物储存器连通的输入的通道和与中空微针连通的输出。 通道提供药物储存器和中空微针之间的流体连通，使得药物被允许从药物储存器流过通道并通过中空微针。 当空心微针从非活动位置移动到激活位置时，通道从第一位置移动到第二位置，并且当空心微针从非活动位置移动到激活状态时，药物储存器相对于外壳的位置保持固定 位置。

公开(公告)号：US07766630B2

公开(公告)日：2010-08-03

申请号：US11835798

申请日：2007-08-08

申请人： Marwan A. Fathallah ,  John Stephen Ziegler ,  David C. Franchino ,  Todd J. Bakken ,  Kent B. Chase ,  Daniel J. Lee

发明人： Marwan A. Fathallah ,  John Stephen Ziegler ,  David C. Franchino ,  Todd J. Bakken ,  Kent B. Chase ,  Daniel J. Lee

IPC分类号： F04B43/12

CPC分类号： A61M5/14224 ,  A61M5/1413 ,  A61M2205/12 ,  A61M2205/14 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/6045 ,  A61M2205/6081

摘要： A medical pump includes a chassis having a fixed seat, and a main carriage having a carriage footing for receiving a fluid delivery device and restricting its movement. An actuator automatically moves the main carriage between open and closed positions to engage the fluid delivery device to the seat. The seat establishes the position of both the main carriage and fluid delivery device in the closed position. The actuator is connected to the main carriage by a rear carriage assembly having a manual release element for disengaging the actuator from rear carriage assembly and thereby from the main carriage. A processing unit detects jam conditions by processing carriage position data and electrical load data from the actuator.

摘要翻译： 医疗泵包括具有固定座椅的底架和具有用于接收流体输送装置并限制其移动的滑架基座的主滑架。 致动器在打开和关闭位置之间自动移动主支架，以使流体输送装置接合到座椅上。 座椅确定主滑架和液体输送装置在关闭位置的位置。 致动器通过具有手动释放元件的后托架组件连接到主托架，用于使致动器与后托架组件从而从主托架脱离。 处理单元通过处理来自致动器的滑架位置数据和电气负载数据来检测堵塞状况。

公开(公告)号：US07258534B2

公开(公告)日：2007-08-21

申请号：US10667611

申请日：2003-09-22

申请人： Marwan A. Fathallah ,  John S. Ziegler ,  David C. Franchino ,  Kent B. Chase ,  Todd J. Bakken ,  Daniel J. Lee

发明人： Marwan A. Fathallah ,  John S. Ziegler ,  David C. Franchino ,  Kent B. Chase ,  Todd J. Bakken ,  Daniel J. Lee

IPC分类号： F04B43/08

CPC分类号： A61M5/14224 ,  A61M5/1413 ,  A61M2205/12 ,  A61M2205/14 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/6045 ,  A61M2205/6081

摘要： A medical pump includes a chassis having a fixed seat, and a main carriage having a carriage footing for receiving a fluid delivery device and restricting its movement. An actuator automatically moves the main carriage between open and closed positions to engage the fluid delivery device to the seat. The seat establishes the position of both the main carriage and fluid delivery device in the closed position. The actuator is connected to the main carriage by a rear carriage assembly having a manual release element for disengaging the actuator from rear carriage assembly and thereby from the main carriage. A processing unit detects jam conditions by processing carriage position data and electrical load data from the actuator.

摘要翻译： 医疗泵包括具有固定座椅的底架和具有用于接收流体输送装置并限制其移动的滑架基座的主滑架。 致动器在打开和关闭位置之间自动移动主支架，以使流体输送装置接合到座椅上。 座椅确定主滑架和液体输送装置在关闭位置的位置。 致动器通过具有手动释放元件的后托架组件连接到主托架，用于使致动器与后托架组件从而从主托架脱离。 处理单元通过处理来自致动器的滑架位置数据和电气负载数据来检测堵塞状况。

公开(公告)号：US08328757B2

公开(公告)日：2012-12-11

申请号：US12684566

申请日：2010-01-08

申请人： David J. Beebe ,  Benjamin J. Moga ,  Kent B. Chase ,  Garrick D. S. Smith ,  Jake W. Myre

发明人： David J. Beebe ,  Benjamin J. Moga ,  Kent B. Chase ,  Garrick D. S. Smith ,  Jake W. Myre

IPC分类号： A61M37/01

CPC分类号： A61M37/0015 ,  A61M2037/0023

摘要： A bladder arrangement is provided for a microneedle-based drug delivery device. The bladder arrangement includes a flexible membrane having an inner surface, an outer surface and an outer periphery. A bladder member, having a rigidity greater than the flexible membrane, includes an inner surface, an outer surface and an outer periphery. The inner surface of the flexible membrane and the inner surface of the bladder member define a chamber for receiving a drug therein. At least one microneedle is operatively connected to the bladder member. The at least one microneedle has an input and an output receivable within the individual. A valve operatively connects the input of the at least one microneedle and the chamber.

摘要翻译： 为基于微针的药物输送装置提供膀胱装置。 囊状结构包括具有内表面，外表面和外周边的柔性膜。 具有大于柔性膜的刚性的囊状构件包括内表面，外表面和外周。 柔性膜的内表面和气囊构件的内表面限定了用于在其中接收药物的腔室。 至少一个微针可操作地连接到膀胱构件。 至少一个微针具有在个体内的输入和输出可接收。 阀可操作地连接至少一个微针的输入和腔室。

公开(公告)号：US20110172639A1

公开(公告)日：2011-07-14

申请号：US12684844

申请日：2010-01-08

申请人： Benjamin J. Moga ,  Kent B. Chase ,  Garrick D.S. Smith

发明人： Benjamin J. Moga ,  Kent B. Chase ,  Garrick D.S. Smith

IPC分类号： A61M5/32

CPC分类号： A61M37/0015 ,  A61M5/14224 ,  A61M5/14248 ,  A61M5/14586 ,  A61M5/14593 ,  A61M5/42 ,  A61M5/46 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0061

摘要： A device for delivering a drug into the skin of a subject is provided. The device includes a drug reservoir and a microneedle having a tip, a length, and a tip sharpness. The microneedle is coupled to the reservoir. The device includes a microneedle actuator coupled to the microneedle configured to drive the microneedle into the skin of the subject upon activation. The tip sharpness and the actuator allow the microneedle to pass through an outer layer of the skin upon activation, and the length is limited such that the tip does not extend past a desired depth below the surface of the skin of the subject, wherein the desired depth is located in the papillary dermis or the reticular dermis.

摘要翻译： 提供了用于将药物递送到受试者皮肤的装置。 该装置包括药物储存器和具有尖端，长度和尖端锋利度的微针。 微针联接到储存器。 该装置包括耦合到该微针的微针致动器，该微针被配置为在激活时将微针驱动到被摄体的皮肤中。 尖端锐度和致动器允许微针在激活时通过皮肤的外层，并且长度受到限制，使得尖端不延伸超过受试者皮肤表面下方的期望深度，其中期望的 深度位于乳头真皮或网状真皮。

公开(公告)号：US20100094224A1

公开(公告)日：2010-04-15

申请号：US12635897

申请日：2009-12-11

申请人： Marwan A. Fathallah ,  John S. Ziegler ,  David C. Franchino ,  Kent B. Chase ,  Todd J. Bakken ,  Daniel J. Lee

发明人： Marwan A. Fathallah ,  John S. Ziegler ,  David C. Franchino ,  Kent B. Chase ,  Todd J. Bakken ,  Daniel J. Lee

IPC分类号： A61M5/142 ,  F04B49/00 ,  F04B53/22

CPC分类号： A61M5/14224 ,  A61M5/1413 ,  A61M2205/12 ,  A61M2205/14 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/6045 ,  A61M2205/6081

摘要： A medical pump includes a chassis having a fixed seat, and a main carriage having a carriage footing for receiving a fluid delivery device and restricting its movement. An actuator automatically moves the main carriage between open and closed positions to engage the fluid delivery device to the seat. The seat establishes the position of both the main carriage and fluid delivery device in the closed position. The actuator is connected to the main carriage by a rear carriage assembly having a manual release element for disengaging the actuator from rear carriage assembly and thereby from the main carriage. A processing unit detects jam conditions by processing carriage position data and electrical load data from the actuator.

摘要翻译： 医疗泵包括具有固定座椅的底架和具有用于接收流体输送装置并限制其移动的滑架基座的主滑架。 致动器在打开和关闭位置之间自动移动主支架，以使流体输送装置接合到座椅上。 座椅确定主滑架和液体输送装置在关闭位置的位置。 致动器通过具有手动释放元件的后托架组件连接到主托架，用于使致动器与后托架组件从而从主托架脱离。 处理单元通过处理来自致动器的滑架位置数据和电气负载数据来检测堵塞状况。

公开(公告)号：US4978063A

公开(公告)日：1990-12-18

申请号：US472791

申请日：1990-01-31

申请人： Kent B. Chase

发明人： Kent B. Chase

IPC分类号： F24D19/10 ,  G05D23/19

CPC分类号： F24D19/1051 ,  G05D23/1934

摘要： An automatic control device for a hot water heating system, comprises a first relay being connectable to a water temperature switch such that the first relay is energized when the switch is closed and a second relay connected to the first relay such that the second relay is energized when the first relay is energized. The first relay is connectable to an electrically operated valve controlling the flow of high temperature water from a boiler to a heat exchanger operably associated with a water heater such that the electrically operated valve is opened when the first relay is energized and closed when the first relay is de-energized. The first relay is connectable to the boiler such that the boiler is turned on when the first relay is energized. The second relay is connectable to a plurality of zone valves controlling the flow of high temperature water from the boiler to a plurality of space heaters such that the plurality of zone valves are turned off when the second relay is energized, thereby diverting a substantial portion of the output of the boiler to the water heater when the water temperature switch is closed.

摘要翻译： 一种用于热水加热系统的自动控制装置，包括可连接到水温开关的第一继电器，使得当开关闭合时第一继电器通电，以及连接到第一继电器的第二继电器，使得第二继电器通电 当第一个继电器通电时。 第一继电器可连接到电控阀，其控制从锅炉到热水器的高温水流动，其与热水器可操作地相关联，使得当第一继电器通电并且当第一继电器闭合时，电动阀打开 被断电。 第一个继电器可连接到锅炉，使得锅炉在第一个继电器通电时打开。 第二继电器可连接到控制从锅炉到多个空间加热器的高温水流的多个区域阀，使得当第二继电器通电时多个区域阀被关闭，从而将大部分 当水温开关关闭时，锅炉输出到热水器。

公开(公告)号：US08668675B2

公开(公告)日：2014-03-11

申请号：US13288266

申请日：2011-11-03

申请人： Kent B. Chase ,  Garrick D. S. Smith

发明人： Kent B. Chase ,  Garrick D. S. Smith

IPC分类号： A61M5/00

CPC分类号： A61M5/14248 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0061

摘要： A drug delivery device is provided. The drug delivery device includes a drug reservoir in fluid communication with a microneedle array. The drug delivery device has a sliding actuation mechanism that may be activated by a button or lever. Actuation of the drug delivery device inserts the microneedle array into the skin of a subject and causes a piston to compress the drug reservoir, thereby delivering the drug through the microneedle array to the subject.

摘要翻译： 提供药物输送装置。 药物递送装置包括与微针阵列流体连通的药物储存器。 药物输送装置具有滑动致动机构，其可以由按钮或杠杆来启动。 药物递送装置的致动将微针阵列插入受试者的皮肤中，并使活塞压缩药物储存器，从而将药物通过微针阵列输送到受试者。