公开(公告)号：US20140335146A1

公开(公告)日：2014-11-13

申请号：US14117599

申请日：2012-03-26

申请人： Kentaro Uchida ,  Koji Naruse ,  Masashi Takaso ,  Takehiko Mima ,  Osamu Matsushita ,  Takashi Haraguchi ,  Nozomu Nishi

发明人： Kentaro Uchida ,  Koji Naruse ,  Masashi Takaso ,  Takehiko Mima ,  Osamu Matsushita ,  Takashi Haraguchi ,  Nozomu Nishi

IPC分类号： A61K38/18 ,  A61K38/48

CPC分类号： A61K38/1825 ,  A61K38/1808 ,  A61K38/4886 ,  A61L27/3608 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2430/02 ,  C07K14/33 ,  C07K14/485 ,  C07K2319/00 ,  C07K2319/03 ,  C07K2319/70 ,  C12N9/52

摘要： Provided is a growth factor anchoring type bone graft material, wherein a bone graft substrate exposing at least a collagen fiber is bound to a collagen-binding-site-containing growth factor which contains a growth factor receptor agonist peptide and a collagen-binding peptide. The same can be produced by mixing a bone graft substrate and a collagen-binding-site-containing growth factor which contains a growth factor receptor agonist peptide and a collagen-binding peptide, and is also superior in osteogenic ability.

摘要翻译： 提供了一种生长因子锚定型骨移植材料，其中暴露至少胶原纤维的骨移植基质与含有生长因子受体激动剂肽和胶原结合肽的含胶原结合位点的生长因子结合。 通过混合骨移植基质和含有生长因子受体激动剂肽和胶原结合肽的含有胶原结合位点的生长因子，也可以产生同样的效果，并且成骨能力也优异。

公开(公告)号：US09248164B2

公开(公告)日：2016-02-02

申请号：US14117599

申请日：2012-03-26

申请人： Kentaro Uchida ,  Koji Naruse ,  Masashi Takaso ,  Takehiko Mima ,  Osamu Matsushita ,  Takashi Haraguchi ,  Nozomu Nishi

发明人： Kentaro Uchida ,  Koji Naruse ,  Masashi Takaso ,  Takehiko Mima ,  Osamu Matsushita ,  Takashi Haraguchi ,  Nozomu Nishi

IPC分类号： A61K38/18 ,  A61K9/70 ,  A61K47/42 ,  A61L27/54 ,  A61K38/48 ,  A61L27/36 ,  C07K14/33 ,  C07K14/485 ,  C12N9/52

CPC分类号： A61K38/1825 ,  A61K38/1808 ,  A61K38/4886 ,  A61L27/3608 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2430/02 ,  C07K14/33 ,  C07K14/485 ,  C07K2319/00 ,  C07K2319/03 ,  C07K2319/70 ,  C12N9/52

摘要： Provided is a growth factor anchoring type bone graft material, wherein a bone graft substrate exposing at least a collagen fiber is bound to a collagen-binding-site-containing growth factor which contains a growth factor receptor agonist peptide and a collagen-binding peptide. The same can be produced by mixing a bone graft substrate and a collagen-binding-site-containing growth factor which contains a growth factor receptor agonist peptide and a collagen-binding peptide, and is also superior in osteogenic ability.

摘要翻译： 提供了一种生长因子锚定型骨移植材料，其中暴露至少胶原纤维的骨移植基质与含有生长因子受体激动剂肽和胶原结合肽的含胶原结合位点的生长因子结合。 通过混合骨移植基质和含有生长因子受体激动剂肽和胶原结合肽的含有胶原结合位点的生长因子，也可以产生同样的效果，并且成骨能力也优异。

公开(公告)号：US08446205B2

公开(公告)日：2013-05-21

申请号：US13045234

申请日：2011-03-10

申请人： Shingo Sakamoto ,  Jialin Ren ,  Kentaro Uchida

发明人： Shingo Sakamoto ,  Jialin Ren ,  Kentaro Uchida

IPC分类号： G06F7/44

CPC分类号： H03D7/1441 ,  H03D7/1458 ,  H03D7/1466 ,  H03D7/165 ,  H03D2200/0084 ,  H03D2200/0088

摘要： A mixer circuit includes: a mixer circuit including a first transistor pair to output a first differential input signal and a second transistor pair to output a second differential input signal by inversing the first differential signal; a local signal supply circuit to supply a pair of local signals to gates of the first transistor pair and the second transistor pair; an operational amplifier including an input pair coupled to an output pair of the mixer circuit and an output pair coupled to the input pair via feedback resistors, the operational amplifier to amplify the first differential input signal and output a differential output signal; a common mode feedback circuit to control a center voltage of the differential output signal so that the center voltage maintains a common voltage; and a common voltage generator circuit to generate the common voltage according to an amplitude of the local signal.

摘要翻译： 一种混频器电路包括：混频器电路，包括第一晶体管对以输出第一差分输入信号和第二晶体管对，以通过反转第一差分信号输出第二差分输入信号; 本地信号供给电路，用于向第一晶体管对和第二晶体管对的栅极提供一对本地信号; 运算放大器，包括耦合到所述混频器电路的输出对的输入对和经由反馈电阻耦合到所述输入对的输出对，所述运算放大器放大所述第一差分输入信号并输出​​差分输出信号; 共模反馈电路，用于控制差分输出信号的中心电压，使得中心电压维持公共电压; 以及公共电压发生器电路，以根据本地信号的幅度产生公共电压。

公开(公告)号：US20110241753A1

公开(公告)日：2011-10-06

申请号：US13045234

申请日：2011-03-10

申请人： Shingo SAKAMOTO ,  Jialin REN ,  Kentaro UCHIDA

发明人： Shingo SAKAMOTO ,  Jialin REN ,  Kentaro UCHIDA

IPC分类号： H03L5/00

CPC分类号： H03D7/1441 ,  H03D7/1458 ,  H03D7/1466 ,  H03D7/165 ,  H03D2200/0084 ,  H03D2200/0088

摘要： A mixer circuit includes: a mixer circuit including a first transistor pair to output a first differential input signal and a second transistor pair to output a second differential input signal by inversing the first differential signal; a local signal supply circuit to supply a pair of local signals to gates of the first transistor pair and the second transistor pair; an operational amplifier including an input pair coupled to an output pair of the mixer circuit and an output pair coupled to the input pair via feedback resistors, the operational amplifier to amplify the first differential input signal and output a differential output signal; a common mode feedback circuit to control a center voltage of the differential output signal so that the center voltage maintains a common voltage; and a common voltage generator circuit to generate the common voltage according to an amplitude of the local signal.

摘要翻译： 一种混频器电路包括：混频器电路，包括第一晶体管对以输出第一差分输入信号和第二晶体管对，以通过反转第一差分信号输出第二差分输入信号; 本地信号供给电路，用于向第一晶体管对和第二晶体管对的栅极提供一对本地信号; 运算放大器，包括耦合到所述混频器电路的输出对的输入对和经由反馈电阻耦合到所述输入对的输出对，所述运算放大器放大所述第一差分输入信号并输出​​差分输出信号; 共模反馈电路，用于控制差分输出信号的中心电压，使得中心电压维持公共电压; 以及公共电压发生器电路，以根据本地信号的幅度产生公共电压。