公开(公告)号：US20080039439A1

公开(公告)日：2008-02-14

申请号：US11705673

申请日：2007-02-13

Applicant: Kevin McCormick ,  Christopher Boyce ,  Neng-Yang Shih ,  Chia-Yu Huang ,  Robert Aslanian ,  Salem Fevrier ,  Bo Liang ,  Rong-qiang Liu ,  Ruiyan Liu ,  Pietro Mangiaracina ,  Manuel de Lera Ruiz ,  Younong Yu ,  Lisa Guise-Zawacki ,  Junying Zheng

Inventor： Kevin McCormick ,  Christopher Boyce ,  Neng-Yang Shih ,  Chia-Yu Huang ,  Robert Aslanian ,  Salem Fevrier ,  Bo Liang ,  Rong-qiang Liu ,  Ruiyan Liu ,  Pietro Mangiaracina ,  Manuel de Lera Ruiz ,  Younong Yu ,  Lisa Guise-Zawacki ,  Junying Zheng

IPC: A61K31/535 ,  A61K31/502 ,  A61K31/54 ,  A61K31/553 ,  A61P1/00 ,  A61P25/00 ,  A61P37/00 ,  A61P9/00 ,  C07D241/36 ,  C07D279/06 ,  C07D498/04 ,  C12N5/06

CPC classification number: C07D413/14 ,  C07D241/36 ,  C07D279/06 ,  C07D403/06 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14 ,  C07D471/04 ,  C07D498/04

Abstract: In its many embodiments, the present invention relates to a novel class of phenylmorpholine and phenylthiomorpholine compounds useful as α2C adrenergic receptor agonists, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the α2C adrenergic receptor agonists using such compounds or pharmaceutical compositions.

Abstract translation: 在其许多实施方案中，本发明涉及可用作α2C肾上腺素能受体激动剂的新型苯基吗啉和苯硫基吗啉化合物，含有该化合物的药物组合物，以及治疗，预防，抑制或改善一种或多种与 α2C肾上腺素能受体激动剂，使用这些化合物或药物组合物。

公开(公告)号：US20070189026A1

公开(公告)日：2007-08-16

申请号：US11737805

申请日：2007-04-20

Applicant: Brian Chemel ,  John Warwick ,  Frederick Morgan ,  Michael Blackwell ,  Kevin McCormick ,  Ihor Lys

Inventor： Brian Chemel ,  John Warwick ,  Frederick Morgan ,  Michael Blackwell ,  Kevin McCormick ,  Ihor Lys

IPC: B60Q1/124

CPC classification number: H05B37/029

Abstract: Methods and systems are provided for lighting control, including a lighting system manager, a light show composer, a light system engine, and related facilities for the convenient authoring and execution of lighting shows using semiconductor-based illumination units.

Abstract translation: 为照明控制提供了方法和系统，包括照明系统管理员，灯光作曲家，光系统引擎，以及使用半导体照明单元方便创作和执行照明设备的相关设施。

公开(公告)号：US20070066644A1

公开(公告)日：2007-03-22

申请号：US11523489

申请日：2006-09-19

Applicant: Manuel de Lera Ruiz ,  Robert Aslanian ,  Michael Berlin ,  Kevin McCormick ,  Chander Celly

Inventor： Manuel de Lera Ruiz ,  Robert Aslanian ,  Michael Berlin ,  Kevin McCormick ,  Chander Celly

IPC: A61K31/4745 ,  C07D471/02

CPC classification number: C07D471/04

Abstract: The present invention discloses the compound of Formula I and pharmaceutically acceptable salts and solvates thereof. The invention also relates to pharmaceutical compositions comprising the Compound of Formula I and its use in treating obesity, metabolic syndrome, diabetes, hepatic lipidosis or nonalcoholic fatty liver disease. The invention also relates to the use of a combination of the Compound of Formula I with additional therapeutic agents for treating obesity, metabolic syndrome, diabetes, hepatic lipidosis or nonalcoholic fatty liver disease.

Abstract translation: 本发明公开了式I化合物及其药学上可接受的盐和溶剂化物。 本发明还涉及包含式I化合物及其在治疗肥胖，代谢综合征，糖尿病，肝脏脂质沉积或非酒精性脂肪性肝病中的用途的药物组合物。 本发明还涉及式I化合物与用于治疗肥胖，代谢综合征，糖尿病，肝脏脂质沉积或非酒精性脂肪性肝病的其它治疗剂的组合的用途。

公开(公告)号：US20050113383A1

公开(公告)日：2005-05-26

申请号：US10974329

申请日：2004-10-27

Applicant: Stuart Rosenblum ,  Qingbei Zeng ,  Mwangi Mutahi ,  Robert Aslanian ,  Pauline Ting ,  Neng-Yang Shih ,  Daniel Solomon ,  Jianhua Cao ,  Henry Vaccaro ,  Kevin McCormick ,  John Baldwin ,  Ge Li

Inventor： Stuart Rosenblum ,  Qingbei Zeng ,  Mwangi Mutahi ,  Robert Aslanian ,  Pauline Ting ,  Neng-Yang Shih ,  Daniel Solomon ,  Jianhua Cao ,  Henry Vaccaro ,  Kevin McCormick ,  John Baldwin ,  Ge Li

IPC: C07D211/34 ,  A61K31/496 ,  A61P1/00 ,  A61P1/04 ,  A61P3/04 ,  A61P9/00 ,  A61P9/04 ,  A61P11/00 ,  A61P25/00 ,  A61P25/06 ,  A61P25/18 ,  A61P25/20 ,  A61P25/28 ,  A61P37/08 ,  A61P43/00 ,  C07D211/26 ,  C07D211/38 ,  C07D211/62 ,  C07D211/96 ,  C07D243/08 ,  C07D401/06 ,  C07D401/14 ,  C07D405/14 ,  C07D407/12 ,  C07D407/14 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14 ,  C07D451/02 ,  C07D487/06 ,  A61K31/4545 ,  C07D43/14 ,  C07D45/14

CPC classification number: C07D401/14 ,  C07D211/26 ,  C07D211/38 ,  C07D211/62 ,  C07D211/96 ,  C07D243/08 ,  C07D401/06 ,  C07D407/12 ,  C07D407/14 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14 ,  C07D451/02 ,  C07D487/06

Abstract: Disclosed are novel compounds of the formula Also disclosed are pharmaceutical compositions comprising the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I in combination with a H1 receptor antagonist.

Abstract translation: 公开的是式的新化合物还公开了包含式I化合物的药物组合物。还公开了治疗各种疾病或病症的方法，例如过敏，过敏诱发的气道反应和充血（例如，鼻 拥塞）。还公开了使用组合式I化合物来治疗各种疾病或病症的方法，例如过敏，过敏诱发的气道反应和充血（例如，鼻塞） 具有H 1受体拮抗剂。

公开(公告)号：US07495671B2

公开(公告)日：2009-02-24

申请号：US11737805

申请日：2007-04-20

Applicant: Brian Chemel ,  John Warwick ,  Frederick M. Morgan ,  Michael K. Blackwell ,  Kevin McCormick ,  Ihor A. Lys

Inventor： Brian Chemel ,  John Warwick ,  Frederick M. Morgan ,  Michael K. Blackwell ,  Kevin McCormick ,  Ihor A. Lys

IPC: G09G5/02 ,  G05B11/01 ,  G06F3/048

CPC classification number: H05B37/029

Abstract: Methods and systems are provided for lighting control, including a lighting system manager, a light show composer, a light system engine, and related facilities for the convenient authoring and execution of lighting shows using semiconductor-based illumination units.

Abstract translation: 为照明控制提供了方法和系统，包括照明系统管理员，灯光作曲家，光系统引擎，以及使用半导体照明单元方便创作和执行照明设备的相关设施。

公开(公告)号：US20070167435A1

公开(公告)日：2007-07-19

申请号：US11641175

申请日：2006-12-19

Applicant: Mwangi Mutahi ,  Robert Aslanian ,  Michael Berlin ,  Christopher Boyce ,  Manuel de Lera Ruiz ,  Kevin McCormick ,  Daniel Solomon ,  Henry Vaccaro ,  Junying Zheng ,  Purakkattle Biju ,  Younong Yu ,  Wei Zhou ,  Xiaohong Zhu

Inventor： Mwangi Mutahi ,  Robert Aslanian ,  Michael Berlin ,  Christopher Boyce ,  Manuel de Lera Ruiz ,  Kevin McCormick ,  Daniel Solomon ,  Henry Vaccaro ,  Junying Zheng ,  Purakkattle Biju ,  Younong Yu ,  Wei Zhou ,  Xiaohong Zhu

IPC: A61K31/551 ,  A61K31/501 ,  A61K31/506 ,  A61K31/4745 ,  C07D471/02

CPC classification number: C07D471/04 ,  C07D213/38 ,  C07D213/73 ,  C07D277/40 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D409/12 ,  C07D417/06 ,  C07D417/14 ,  C07D473/00

Abstract: Disclosed are compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein: M is CH or N; U and W are each CH, or one of U and W is CH and the other is N; X is a bond, alkylene, —C(O)—, —C(N—OR5)—, —C(N—OR5)—CH(R6)—, —CH(R6)—C(N—OR5)—, —O—, —OCH2—, —CH2O— or —S(O)0-2—; Y is —O—, —(CH2)2—, —C(═O)—, —C(═NOR7)— or —SO0-2—; Z is a bond, optionally substituted alkylene or alkylene interrupted by a heteroatom or heterocyclic group; R1 is optionally substituted alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocycloalkyl, or benzimidazolyl or a derivative thereof; R2 is optionally substituted alkyl, alkenyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl or heterocycloalkyl; and the remaining variables are as defined in the specification; compositions and methods for treating an allergy-induced airway response, congestion, diabetes, obesity, an obesity-related disorder, metabolic syndrome and a cognition deficit disorder using said compounds, alone or in combination with other agents.

Abstract translation: 公开了下式的化合物或其药学上可接受的盐或溶剂化物，其中：M是CH或N; U和W各自为CH，或U和W中的一个为CH，另一个为N; X是键，亚烷基，-C（O） - ， - C（N-OR 5） - ， - （N -OR 5）-CH（R - （CH 3） - ， - CH（R 6） - ， - （N-OR 5） - ， - O - ， - 2 - ， - CH 2 O-或-S（O）0-2 - 。 Y是-O-， - （CH 2）2 - ， - C（-O） - ， - C（-NOR 7） - 或-SO <0-2 - ; - Z是一个键，任选取代的被杂原子或杂环基中断的亚烷基或亚烷基; R 1是任选取代的烷基，环烷基，芳基，芳基烷基，杂芳基，杂环烷基或苯并咪唑基或其衍生物; R 2是任选取代的烷基，烯基，芳基，芳基烷基，杂芳基，杂芳基烷基，环烷基或杂环烷基; 剩余的变量如规范中所定义; 使用所述化合物单独或与其它试剂组合治疗过敏引起的气道反应，充血，糖尿病，肥胖，肥胖相关病症，代谢综合征和认知缺陷障碍的组合物和方法。

公开(公告)号：US20070142369A1

公开(公告)日：2007-06-21

申请号：US11640729

申请日：2006-12-18

Applicant: Margaret van Heek ,  Joyce Hwa ,  Michael Graziano ,  Jean Lachowicz ,  Timothy Kowalski ,  Enrico Veltri ,  Kevin McCormick ,  Michael Berlin ,  Robert Aslanian

Inventor： Margaret van Heek ,  Joyce Hwa ,  Michael Graziano ,  Jean Lachowicz ,  Timothy Kowalski ,  Enrico Veltri ,  Kevin McCormick ,  Michael Berlin ,  Robert Aslanian

IPC: A61K31/541 ,  A61K31/517 ,  A61K31/4745 ,  A61K31/4192 ,  A61K31/428 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/423 ,  A61K31/4184 ,  A61K31/4178

CPC classification number: A61K45/06 ,  A61K31/00 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/423 ,  A61K31/428 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  A61K2300/00

Abstract: The present invention relates to pharmaceutical compositions comprising therapeutic combinations comprising: one or more H3 antagonists/inverse agonists; one or more appetite suppressants selected from the group consisting of CB1 antagonists/inverse agonists, sibutramine, phentermine and topiramate; and optionally one or more HMG-CoA reductase inhibitors. The invention also relates to medicaments and kits comprising the pharmaceutical compositions of the present invention, and methods of treating obesity, obesity related disorders and diabetes using the pharmaceutical compositions of the present invention.

Abstract translation: 本发明涉及包含治疗组合的药物组合物，其包含：一种或多种H 3拮抗剂/反向激动剂; 一种或多种选自CB 1拮抗剂/反向激动剂，西布曲明，苯丁胺和托吡酯的食欲抑制剂; 和任选的一种或多种HMG-CoA还原酶抑制剂。 本发明还涉及包含本发明的药物组合物的药物和试剂盒，以及使用本发明的药物组合物治疗肥胖，肥胖相关疾病和糖尿病的方法。

公开(公告)号：US20070015807A1

公开(公告)日：2007-01-18

申请号：US11455625

申请日：2006-06-19

Applicant: Robert Aslanian ,  Michael Berlin ,  Christopher Boyce ,  Jianhua Chao ,  Manuel de Lera Ruiz ,  Pietro Mangiaracina ,  Kevin McCormick ,  Mwangi Mutahi ,  Stuart Rosenblum ,  Neng-Yang Shih ,  Daniel Solomon ,  Wing Tom ,  Henry Vaccaro ,  Junying Zheng ,  Xiaohong Zhu

Inventor： Robert Aslanian ,  Michael Berlin ,  Christopher Boyce ,  Jianhua Chao ,  Manuel de Lera Ruiz ,  Pietro Mangiaracina ,  Kevin McCormick ,  Mwangi Mutahi ,  Stuart Rosenblum ,  Neng-Yang Shih ,  Daniel Solomon ,  Wing Tom ,  Henry Vaccaro ,  Junying Zheng ,  Xiaohong Zhu

IPC: C07D403/02 ,  A61K31/4178 ,  A61K31/4025

CPC classification number: C07D295/185 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  Y02P20/582

Abstract: Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt thereof, wherein: M1 and M3 are CH or N; M2 is CH, CF or N; Y is —C(═O)—, —C(═S)—, —(CH2)q—, —C(═NOR7)— or —SO1-2—; Z is a bond or optionally substituted alkylene or alkenylene; R1 is H, or alkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, all optionally substituted, or a group of the formula: where ring A is a heteroaryl ring; R2 is optionally substituted alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; R3 is H, —C(O)NH2, or alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl, all optionally substituted; and the remaining variables are as defined in the specification; compositions and methods of treating allergy-induced airway responses, congestion, obesity, metabolic syndrome, alcoholic fatty liver disease, hepatic steatosis, nonalcoholic steatohepatitis, cirrhosis, hepatacellular carcinoma and cognition deficit disorders using said compounds, alone or in combination with other agents.

Abstract translation: 公开了下式的新化合物或其药学上可接受的盐，其中：M 1和M 3是CH或N; M 2是CH，CF或N; Y是-C（-O） - ， - C（-S） - ， - （CH 2 CH 2）q - ， - C（-NOR 7） / SO 2 - ） - 或-SO 2 1-2。 Z是键或任选取代的亚烷基或亚烯基; R 1是H或烷基，环烷基，芳基，杂芳基，杂环烷基，全部是任选取代的，或下式的基团：其中环A是杂芳基环; R 2是任选取代的烷基，烯基，芳基，杂芳基，环烷基或杂环烷基; R 3是H，-C（O）NH 2或烷基，芳基，环烷基，杂环烷基或杂芳基，全部任选被取代; 剩余的变量如规范中所定义; 使用所述化合物单独或与其它试剂组合治疗过敏引起的气道反应，充血，肥胖，代谢综合征，酒精性脂肪肝疾病，肝脂肪变性，非酒精性脂肪性肝炎，肝硬化，肝细胞癌和认知缺陷障碍的组合物和方法。

公开(公告)号：US20060002110A1

公开(公告)日：2006-01-05

申请号：US11081020

申请日：2005-03-15

Applicant: Kevin Dowling ,  Kevin McCormick

Inventor： Kevin Dowling ,  Kevin McCormick

IPC: F21S4/00

CPC classification number: H05B33/0863 ,  F21K9/00 ,  F21K9/23 ,  F21V21/08 ,  F21V23/005 ,  F21V23/006 ,  F21Y2103/10 ,  F21Y2105/10 ,  F21Y2115/10 ,  H05B33/0842 ,  H05B37/0245 ,  H05B37/029 ,  H05K1/142

Abstract: Methods and systems are provided for lighting systems, including high output linear lighting systems for various environments. The linear lighting systems may include power systems for driving light sources in high-voltage environments.

Abstract translation: 为照明系统提供了方法和系统，包括用于各种环境的高输出线性照明系统。 线性照明系统可以包括用于在高压环境中驱动光源的电力系统。

公开(公告)号：US20050128751A1

公开(公告)日：2005-06-16

申请号：US10839765

申请日：2004-05-05

Applicant: Brian Roberge ,  Colin Piepgras ,  Jeffrey Hyer ,  Kevin McCormick ,  Peter Swai ,  Frederick Morgan

Inventor： Brian Roberge ,  Colin Piepgras ,  Jeffrey Hyer ,  Kevin McCormick ,  Peter Swai ,  Frederick Morgan

IPC: B60Q1/00 ,  B60Q1/06 ,  F21K99/00 ,  F21S2/00 ,  F21S4/00 ,  F21V1/00 ,  F21V7/04 ,  F21V13/00 ,  F21V21/00 ,  F21V29/00 ,  H05K20060101

CPC classification number: H05B37/0245 ,  F21K9/00 ,  F21V15/013 ,  F21V21/30 ,  F21V29/507 ,  F21V29/745 ,  F21V29/75 ,  F21W2111/027 ,  F21W2111/047 ,  F21W2111/08 ,  F21W2121/004 ,  F21W2121/04 ,  F21W2131/401 ,  F21Y2103/10 ,  F21Y2105/10 ,  F21Y2115/10 ,  G06F3/1446 ,  Y10S362/80

Abstract: Methods and systems are provided for lighting systems, including high output linear lighting systems for various environments. The linear lighting systems may include power systems for driving light sources in high-voltage environments.

Abstract translation: 为照明系统提供了方法和系统，包括用于各种环境的高输出线性照明系统。 线性照明系统可以包括用于在高压环境中驱动光源的电力系统。