公开(公告)号：US20070129391A1

公开(公告)日：2007-06-07

申请号：US11604269

申请日：2006-11-27

申请人： Ki-Baik Hahm ,  Dong-Kyu Kim ,  Mi-Sun Kwak ,  Sang-Aun Joo ,  Byoung-Seok Moon ,  Geun-Seog Song

发明人： Ki-Baik Hahm ,  Dong-Kyu Kim ,  Mi-Sun Kwak ,  Sang-Aun Joo ,  Byoung-Seok Moon ,  Geun-Seog Song

IPC分类号： A61K31/506

CPC分类号： A61K31/505 ,  A61K31/495 ,  A61K31/506

摘要： Provided is a composition for preventing or treating damages of the mucosa in the gastrointestinal tracts, comprising revaprazan or a salt thereof and a pharmaceutically acceptable carrier. Revaprazan or its salt has an excellent preventive or treatment effect for gastrointestinal mucosal damage by potentiating a defensive factor in the gastrointestinal mucosa, simultaneously with acting as an acid pump antagonist.

摘要翻译： 提供了用于预防或治疗胃肠道中粘膜损伤的组合物，其包含雷帕拉坦或其盐和药学上可接受的载体。 Revaprazan或其盐通过增强胃肠粘膜中的防御因子，同时作为酸泵拮抗剂，对胃肠粘膜损伤具有极好的预防或治疗作用。

公开(公告)号：US08455470B2

公开(公告)日：2013-06-04

申请号：US12296747

申请日：2007-04-13

申请人： Byoung-Joo Gwag ,  Sung-Ig Cho ,  Jae-Young Cho ,  Young-Ae Lee ,  Han-Yeol Byun ,  Doo-Soon Lim ,  Ki-Baik Hahm ,  Young-Bae Kwon ,  Jin-Hwan Lee ,  Bok-Seon Yoon ,  Chun-San An ,  Keun-Sil Ryu

发明人： Byoung-Joo Gwag ,  Sung-Ig Cho ,  Jae-Young Cho ,  Young-Ae Lee ,  Han-Yeol Byun ,  Doo-Soon Lim ,  Ki-Baik Hahm ,  Young-Bae Kwon ,  Jin-Hwan Lee ,  Bok-Seon Yoon ,  Chun-San An ,  Keun-Sil Ryu

IPC分类号： A61K31/33

CPC分类号： A61K31/606 ,  A61K31/136 ,  A61K31/196

摘要： The present invention relates to a pharmaceutical composition useful for treating or preventing inflammatory disease and cell damage, and a method for treating or preventing inflammatory disease and cell damage. The present invention uses the 2-hydroxybenzoic acid derivative represented by the specific chemical formula or its pharmaceutically acceptable salt. The compound of the present invention is useful for treating or preventing cell damage and inflammatory disease including gastritis, gastric ulcer, pancreatitis, colitis, arthritis, diabetes, arteriosclerosis, nephritis, hepatitis, Alzheimer's disease, Parkinson's disease and Lou Gehrig's disease.

公开(公告)号：US20090281181A1

公开(公告)日：2009-11-12

申请号：US12296747

申请日：2007-04-13

申请人： Byoung-Joo Gwag ,  Sung-Ig Cho ,  Jae-Young Cho ,  Young-Ae Lee ,  Han-Yeol Byun ,  Doo-Soon Lim ,  Ki-Baik Hahm ,  Young-Bae Kwon ,  Jin-Hwan Lee ,  Bok-Seon Yoon ,  Chun-San An ,  Keun-Sil Ryu

发明人： Byoung-Joo Gwag ,  Sung-Ig Cho ,  Jae-Young Cho ,  Young-Ae Lee ,  Han-Yeol Byun ,  Doo-Soon Lim ,  Ki-Baik Hahm ,  Young-Bae Kwon ,  Jin-Hwan Lee ,  Bok-Seon Yoon ,  Chun-San An ,  Keun-Sil Ryu

IPC分类号： A61K31/24

CPC分类号： A61K31/606 ,  A61K31/136 ,  A61K31/196

摘要： The present invention relates to a pharmaceutical composition useful for treating or preventing inflammatory disease and cell damage, and a method for treating or preventing inflammatory disease and cell damage. The present invention uses the 2-hydroxybenzoic acid derivative represented by the specific chemical formula or its pharmaceutically acceptable salt. The compound of the present invention is useful for treating or preventing cell damage and inflammatory disease including gastritis, gastric ulcer, pancreatitis, colitis, arthritis, diabetes, arteriosclerosis, nephritis, hepatitis, Alzheimer's disease, Parkinson's disease and Lou Gehrig's disease.

公开(公告)号：US08598383B2

公开(公告)日：2013-12-03

申请号：US13453978

申请日：2012-04-23

申请人： Byoung-Joo Gwag ,  Sung-Ig Cho ,  Jae-Young Cho ,  Young-Ae Lee ,  Han-Yeol Byun ,  Doo-Soon Lim ,  Ki-Baik Hahm ,  Young-Bae Kwon ,  Jin-Hwan Lee ,  Bok-Seon Yoon ,  Chun-San An ,  Keun-Sil Ryu

发明人： Byoung-Joo Gwag ,  Sung-Ig Cho ,  Jae-Young Cho ,  Young-Ae Lee ,  Han-Yeol Byun ,  Doo-Soon Lim ,  Ki-Baik Hahm ,  Young-Bae Kwon ,  Jin-Hwan Lee ,  Bok-Seon Yoon ,  Chun-San An ,  Keun-Sil Ryu

IPC分类号： C07C51/00

CPC分类号： A61K31/606 ,  A61K31/136 ,  A61K31/196

摘要： The present invention relates to a pharmaceutical composition useful for treating or preventing inflammatory disease and cell damage, and a method for treating or preventing inflammatory disease and cell damage. The present invention uses the 2-hydroxybenzoic acid derivative represented by the specific chemical formula or its pharmaceutically acceptable salt. The compound of the present invention is useful for treating or preventing cell damage and inflammatory disease including gastritis, gastric ulcer, pancreatitis, colitis, arthritis, diabetes, arteriosclerosis, nephritis, hepatitis, Alzheimer's disease, Parkinson's disease and Lou Gehrig's disease.

摘要翻译： 本发明涉及可用于治疗或预防炎症性疾病和细胞损伤的药物组合物，以及治疗或预防炎性疾病和细胞损伤的方法。 本发明使用由特定化学式表示的2-羟基苯甲酸衍生物或其药学上可接受的盐。 本发明的化合物可用于治疗或预防细胞损伤和炎性疾病，包括胃炎，胃溃疡，胰腺炎，结肠炎，关节炎，糖尿病，动脉硬化，肾炎，肝炎，阿尔茨海默病，帕金森病和Lou Gehrig病。

公开(公告)号：US07776873B2

公开(公告)日：2010-08-17

申请号：US11604269

申请日：2006-11-27

申请人： Ki-Baik Hahm ,  Dong-Kyu Kim ,  Mi-Sun Kwak ,  Sang-Aun Joo ,  Byoung-Seok Moon ,  Geun-Seog Song

发明人： Ki-Baik Hahm ,  Dong-Kyu Kim ,  Mi-Sun Kwak ,  Sang-Aun Joo ,  Byoung-Seok Moon ,  Geun-Seog Song

IPC分类号： A61K31/506

CPC分类号： A61K31/505 ,  A61K31/495 ,  A61K31/506

摘要： Provided is a method for treating damage to the gastric mucosa with a cytoprotective agent, comprising administering to a human in need thereof a pharmaceutical composition comprising an effective amount for treating damage to gastric mucosa of a pharmaceutically acceptable salt of revaprazan as the cytoprotective agent, and a pharmaceutically acceptable carrier. Revaprazan or its salt has an excellent treatment effect for gastrointestinal mucosal damage by potentiating a defensive factor in the gastrointestinal mucosa, simultaneously with acting as an acid pump antagonist.

摘要翻译： 本发明提供了一种用细胞保护剂治疗对胃粘膜的损害的方法，其包括向有需要的人施用药物组合物，该药物组合物包含治疗对作为细胞保护剂的雷帕沙坦的药学上可接受的盐的胃粘膜的损伤的有效量，以及 药学上可接受的载体。 Revaprazan或其盐通过增强胃肠粘膜中的防御因子，同时作为酸泵拮抗剂，对胃肠粘膜损伤具有极好的治疗作用。

公开(公告)号：US20120209025A1

公开(公告)日：2012-08-16

申请号：US13453978

申请日：2012-04-23

申请人： Byoung-Joo GWAG ,  Sung-Ig CHO ,  Jae-Young Cho ,  Young-Ae LEE ,  Han-Yeol Byun ,  Doo-Soon Lim ,  Ki-Baik Hahm ,  Young-Bae Kwon ,  Jin-Hwan Lee ,  Bok-Seon Yoon ,  Chun-San An ,  Keun-Sil Ryu

发明人： Byoung-Joo GWAG ,  Sung-Ig CHO ,  Jae-Young Cho ,  Young-Ae LEE ,  Han-Yeol Byun ,  Doo-Soon Lim ,  Ki-Baik Hahm ,  Young-Bae Kwon ,  Jin-Hwan Lee ,  Bok-Seon Yoon ,  Chun-San An ,  Keun-Sil Ryu

IPC分类号： C07C227/16

CPC分类号： A61K31/606 ,  A61K31/136 ,  A61K31/196

摘要： The present invention relates to a pharmaceutical composition useful for treating or preventing inflammatory disease and cell damage, and a method for treating or preventing inflammatory disease and cell damage. The present invention uses the 2-hydroxybenzoic acid derivative represented by the specific chemical formula or its pharmaceutically acceptable salt. The compound of the present invention is useful for treating or preventing cell damage and inflammatory disease including gastritis, gastric ulcer, pancreatitis, colitis, arthritis, diabetes, arteriosclerosis, nephritis, hepatitis, Alzheimer's disease, Parkinson's disease and Lou Gehrig's disease.

摘要翻译： 本发明涉及可用于治疗或预防炎症性疾病和细胞损伤的药物组合物，以及治疗或预防炎性疾病和细胞损伤的方法。 本发明使用由特定化学式表示的2-羟基苯甲酸衍生物或其药学上可接受的盐。 本发明的化合物可用于治疗或预防细胞损伤和炎性疾病，包括胃炎，胃溃疡，胰腺炎，结肠炎，关节炎，糖尿病，动脉硬化，肾炎，肝炎，阿尔茨海默病，帕金森病和Lou Gehrig病。