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14 条记录 (耗时 0.023 秒)

    Fused purine derivatives
    3.
    发明授权
    Fused purine derivatives 失效
    融合嘌呤衍生物

    公开(公告)号：US07005430B2

    公开(公告)日：2006-02-28

    申请号：US10149423

    申请日：2000-12-22

    申请人： Kimihisa Ueno ,  Akira Ogawa ,  Yoshihisa Ohta ,  Yuji Nomoto ,  Kotaro Takasaki ,  Hideaki Kusaka ,  Hiroshi Yano ,  Chiharu Nakagawa ,  Satoshi Nakanishi

    发明人： Kimihisa Ueno ,  Akira Ogawa ,  Yoshihisa Ohta ,  Yuji Nomoto ,  Kotaro Takasaki ,  Hideaki Kusaka ,  Hiroshi Yano ,  Chiharu Nakagawa ,  Satoshi Nakanishi

    IPC分类号： C07D487/14 ,  C07D473/24 ,  C07D473/22 ,  A61K31/519 ,  A61P3/10

    CPC分类号： C07D487/14

    摘要： A condensed purine derivative represented by Formula (I): wherein X—Y-Z represents R1N—C═O or N═C—W, R2 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aromatic heterocyclic group, a substituted or unsubstituted alicyclic heterocyclic group or the like, n represents an integer of from 0 to 3, V1 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aromatic heterocyclic group, V2 represents a substituted lower alkyl group or a substituted or unsubstituted aromatic heterocyclic group, and when V1 represents a hydrogen atom, a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group, and for example, X—Y-Z represents R1aN—C═O and R2 represents a substituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted alicyclic heterocyclic group, a halogen atom, a lower alkylthio group, —NR7R8, —CO2H, a lower alkoxycarbonyl group, —COHal, —CONR9R10 or —CHO, V2 may represent a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group; or a pharmacologically acceptable salt thereof.

    摘要翻译： 由式（I）表示的稠合嘌呤衍生物：化学式id =“CHEM-US-00001”num =“000”

    5-aminoflavone derivatives
    5.
    发明授权
    5-aminoflavone derivatives 失效
    5-氨基黄酮衍生物

    公开(公告)号：US5539112A

    公开(公告)日：1996-07-23

    申请号：US464093

    申请日：1995-06-05

    申请人： Tsutomu Akama ,  Shun-ichi Ikeda ,  Yasushi Shida ,  Masaji Kasai ,  Hiroyuki Ishida ,  Uichiro Kimura ,  Katsushige Gomi ,  Hiromitsu Saito ,  Kimihisa Ueno

    发明人： Tsutomu Akama ,  Shun-ichi Ikeda ,  Yasushi Shida ,  Masaji Kasai ,  Hiroyuki Ishida ,  Uichiro Kimura ,  Katsushige Gomi ,  Hiromitsu Saito ,  Kimihisa Ueno

    IPC分类号： C07D311/30 ,  C07D413/12

    CPC分类号： C07D311/30

    摘要： 5-Aminoflavone derivatives represented by the formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different and represent hydrogen, substituted or unsubstituted lower alkyl, lower alkenyl, halogen-substituted or unsubstituted lower alkanoyl or lower alkoxycarbonyl, X.sup.1, X.sup.2, Y.sup.1 and Y.sup.2 are the same or different and represent hydrogen, halogen or lower alkyl, at least one of X.sup.1 and X.sup.2 represents halogen or lower alkyl, X.sup.3 represents hydrogen, substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, halogen, hydroxy, substituted or unsubstituted lower alkoxy, NR.sup.5 R.sup.6 (wherein R.sup.5 and R.sup.6 are the same or different and represent hydrogen, or substituted or unsubstituted lower alkyl, or R.sup.5 and R.sup.6 are taken together to form a heterocyclic group containing the nitrogen atom in the ring), lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, carboxy, lower alkoxycarbonyl, lower alkanoyl, adizo, cyano, substituted or unsubstituted carbamoyl or lower alkylthiothiocarbonyl: or pharmaceutically acceptable salts thereof.

    摘要翻译： 由式（I）表示的5-氨基黄酮衍生物：其中R 1，R 2，R 3和R 4相同或不同，表示氢，取代或未取代的低级烷基，低级烯基，卤素取代或未取代的低级 烷酰基或低级烷氧基羰基，X 1，X 2，Y 1和Y 2相同或不同，表示氢，卤素或低级烷基，X 1和X 2中的至少一个表示卤素或低级烷基，X 3表示氢，取代或未取代的低级烷基，低级 烯基，低级炔基，卤素，羟基，取代或未取代的低级烷氧基，NR5R6（其中R5和R6相同或不同，代表氢，或取代或未取代的低级烷基，或R5和R6一起形成含有 环中的氮原子），低级烷硫基，低级烷基亚磺酰基，低级烷基磺酰基，羧基，低级烷氧基羰基，低级烷酰基，二唑基，氰基，取代或未取代的氨基甲酰基或低级烷硫基硫代 辛基或其药学上可接受的盐。