公开(公告)号：US07767456B2

公开(公告)日：2010-08-03

申请号：US11809816

申请日：2007-06-01

申请人： Per Artursson ,  Bjorn Erik Christensen ,  Magnus Koping-Hoggard ,  Kjell Morten Varnum

发明人： Per Artursson ,  Bjorn Erik Christensen ,  Magnus Koping-Hoggard ,  Kjell Morten Varnum

IPC分类号： C12N15/00 ,  A01N43/04 ,  C08B37/08 ,  C07H21/00

CPC分类号： C12N15/87 ,  A61K9/0073 ,  A61K47/61 ,  A61K48/0041

摘要： The present invention concerns a composition comprising complexes of cationic chitosan oligomers derived from the cationic polysaccharide chitosan, wherein said cationic oligomers contain a weight fraction of less than 20% of oligomers with a Degree of Polymerization (DP) 50, and a nucleic acid. These compositions comprising well-defined cationic chitosan oligomers having a certain distribution of chain lengths, and nucleic acid are advantageous to achieve delivery of the nucleic acid into cells of a selected tissue, and to obtain in vivo expression of the desired molecules encoded for by the nucleic acid.

摘要翻译： 本发明涉及一种组合物，其包含衍生自阳离子多糖壳聚糖的阳离子壳聚糖低聚物的复合物，其中所述阳离子低聚物除了重量分数外还含有小于20％聚合度（DP）<10的低聚物的重量分数 小于20％，DP> 50，和核酸。 包含具有一定分子量链长度的定义明确的阳离子壳聚糖低聚物的这些组合物和核酸有利于实现将核酸递送至选定组织的细胞中，并获得所编码的所需分子的体内表达 核酸。