公开(公告)号：US08710427B2

公开(公告)日：2014-04-29

申请号：US12949142

申请日：2010-11-18

申请人： Jun Amako ,  Kohei Yamada

发明人： Jun Amako ,  Kohei Yamada

IPC分类号： G01N21/27 ,  G01D5/36 ,  G02B5/18

CPC分类号： G01J1/0407 ,  G01N21/55 ,  G01N21/553 ,  G01N21/658 ,  G01N21/774

摘要： A sensor chip includes: a substrate that has a planar portion; and a diffraction grating, on which a target substance is placed, that includes a plurality of first protrusions periodically arranged in a period equal to or greater than 100 nm and equal to or less than 1000 nm in a first direction that is parallel to the planar portion, a plurality of base portions that is located between two of the first protrusions adjacent to each other and configures a base of the substrate, and a plurality of second protrusions that is formed on upper faces of the plurality of the first protrusions, has a surface formed from a metal, and is formed on the planar portion.

摘要翻译： 传感器芯片包括：具有平面部分的基板; 以及衍射光栅，其上放置目标物质，其包括在与平面平行的第一方向上等于或大于100nm且等于或小于1000nm的周期性周期性排列的多个第一突起 位于彼此相邻的两个第一突起之间的多个基部，并且构成基底的基部，并且形成在多个第一突起的上表面上的多个第二突起具有 表面由金属形成，并且形成在平面部分上。

公开(公告)号：US20120274935A1

公开(公告)日：2012-11-01

申请号：US13455516

申请日：2012-04-25

申请人： Kohei YAMADA ,  Yoshifumi HANO

发明人： Kohei YAMADA ,  Yoshifumi HANO

IPC分类号： G01J3/44 ,  G01N21/55

CPC分类号： G01N21/05 ,  G01N21/658 ,  G01N2021/0346 ,  G01N2021/058 ,  Y10T137/0324

摘要： A detection device includes a sensor chip, a suction section adapted to suck a fluid sample to the sensor chip, a light source adapted to irradiate the sensor chip, a light intensity adjustment section adapted to adjust intensity of the light, a light detection section adapted to detect the light reflecting the sample adsorbed to the sensor chip, and a control section adapted to perform drive control on the suction section. The control section sets the suction flow velocity to V1 in the first mode in which the light detection section performs the detection, and sets the suction flow velocity to V2 (V2>V1) in the second mode. The light intensity adjustment section sets the light intensity to L1 in the first mode, and sets the light intensity to L2 (L2>L1) in the second mode. The first and second modes are switched based on the signal from the light detection section.

摘要翻译： 一种检测装置，包括传感器芯片，适于将流体样本吸入传感器芯片的吸入部，适于照射传感器芯片的光源，适于调节光强度的光强调节部，适于 检测反射吸附在传感器芯片上的样品的光，以及适于对吸引部进行驱动控制的控制部。 控制部在第一模式中将吸引流速设定为V1，在第一模式中，光检测部进行检测，并将吸引流速设定为V2（V2> V1）。 光强度调节部将第一模式的光强度设定为L1，在第二模式中将光强度设定为L2（L2> L1）。 基于来自光检测部的信号来切换第一和第二模式。

公开(公告)号：US20120262718A1

公开(公告)日：2012-10-18

申请号：US13444360

申请日：2012-04-11

申请人： Kohei YAMADA ,  Nobuaki HASHIMOTO

发明人： Kohei YAMADA ,  Nobuaki HASHIMOTO

IPC分类号： G01N21/59

CPC分类号： G01N21/553 ,  G01N5/02 ,  G01N21/474 ,  G01N21/55 ,  G01N21/554 ,  G01N21/658 ,  G01N29/022 ,  G01N2291/0215 ,  G01N2291/02809

摘要： A detection device includes a flow channel for a fluid sample, a suction section adapted to draw the fluid sample into the flow channel, an optical device disposed in the flow channel, a light source adapted to irradiate the optical device with light, a light detection section adapted to detect light emitted from the optical device, a microbalance sensor chip having a piezoelectric substrate provided with an oscillation electrode, and disposed in the flow channel, and a quantitative analysis section adapted to perform quantitative analysis on the fluid sample based on output from the light detection section and the microbalance sensor chip. The optical device has a metal nanostructure including projections ranging in size from 1 through 1000 nm, and emits light representing the fluid sample adsorbed to the metal nanostructure.

摘要翻译： 检测装置包括用于流体样品的流动通道，适于将流体样品吸入流动通道的抽吸部分，设置在流动通道中的光学装置，适于用光照射光学装置的光源，光检测 适于检测从光学装置发射的光的微型平衡传感器芯片，具有设置有振荡电极的压电基板并设置在流路中的微量平衡传感器芯片，以及定量分析部件，其适于对流体样品进行定量分析， 光检测部和微量平衡传感器芯片。 光学装置具有金属纳米结构，其包括尺寸在1至1000nm之间的突起，并且发射表示吸附到金属纳米结构的流体样品的光。

公开(公告)号：US08193338B2

公开(公告)日：2012-06-05

申请号：US12375152

申请日：2007-07-25

申请人： Satoru Kogo ,  Kohei Yamada ,  Yuko Iwai ,  Kazuomi Osawa ,  Hiroyuki Hayakawa

发明人： Satoru Kogo ,  Kohei Yamada ,  Yuko Iwai ,  Kazuomi Osawa ,  Hiroyuki Hayakawa

IPC分类号： C07H21/00 ,  C07H19/00 ,  C07H19/048 ,  C07H19/06 ,  C07H19/04 ,  C07H21/02 ,  C07H21/04 ,  C07H1/00 ,  C07H3/00 ,  C08B37/00 ,  A01N43/04 ,  A61K31/70

CPC分类号： C07H19/10

摘要： A di(pyrimidine nucleoside 5′-)polyphosphate is synthesized by converting a pyrimidine nucleoside 5′-triphosphate into a pyrimidine nucleoside 5′-cyclic triphosphate by use of a condensing agent, and subsequently reacting the pyrimidine nucleoside 5′-cyclic triphosphate with a pyrimidine nucleotide in the presence of a salt of a metal selected from among magnesium, manganese, and iron.Through the method of the invention, a di(pyrimidine nucleoside 5′-)polyphosphate can be synthesized from an unprotected pyrimidine nucleoside 5′-phosphate serving as a starting material at a synthesis yield of 50% or higher. Therefore, the method of the invention is suitable for large-scale synthesis of a di(pyrimidine nucleoside 5′-)polyphosphate.

摘要翻译： 通过使用缩合剂将嘧啶核苷5'-三磷酸转化成嘧啶核苷5'-环状三磷酸，然后使嘧啶核苷5'-环三磷酸与一 嘧啶核苷酸在选自镁，锰和铁的金属盐存在下进行。 通过本发明的方法，可以以50％以上的合成收率从作为起始原料的未保护的嘧啶核苷5'-磷酸合成二（嘧啶核苷5' - ）多磷酸酯。 因此，本发明的方法适用于二（嘧啶核苷5' - ）多磷酸酯的大规模合成。

公开(公告)号：US20110203717A1

公开(公告)日：2011-08-25

申请号：US13082007

申请日：2011-04-07

申请人： Kohei Yamada

发明人： Kohei Yamada

IPC分类号： D05C15/00

CPC分类号： B29C33/02 ,  B29C33/0033 ,  B29C33/76 ,  B29C43/021 ,  B29C2035/1658 ,  B29C2043/023 ,  B29C2043/3266 ,  B29C2791/008 ,  B29C2793/0045 ,  B29K2995/0091 ,  B29L2031/3017 ,  B29L2031/721 ,  B29L2031/7322 ,  B29L2031/737 ,  B29L2031/7652 ,  Y10T428/23979

摘要： A process for making a noise absorber carpet including a fabric layer and a resinous backing layer, the process including providing an uncured resinous backing layer within a mold having perforation pins, heating the backing layer to activate the resin, providing a fabric layer, pressing the fabric layer into the backing layer while maintaining the heating process to the backing layer, and providing a cooling medium to cool the mold to fix and cure the perforations within the backing layer thereby forming noise absorber perforations in the resinous backing layer.

摘要翻译： 一种用于制造包括织物层和树脂背衬层的噪声吸收器地毯的方法，所述方法包括在具有穿孔针的模具内提供未固化的树脂背衬层，加热背衬层以活化树脂，提供织物层， 织物层进入背衬层，同时保持对背衬层的加热过程，并提供冷却介质以冷却模具以固定和固化背衬层内的穿孔，从而在树脂背衬层中形成噪声吸收器穿孔。

公开(公告)号：US20110116088A1

公开(公告)日：2011-05-19

申请号：US12947888

申请日：2010-11-17

申请人： Jun AMAKO ,  Kohei YAMADA

发明人： Jun AMAKO ,  Kohei YAMADA

IPC分类号： G01J3/00 ,  H01L31/0232

CPC分类号： G01J1/0407 ,  G01N21/55 ,  G01N21/553 ,  G01N21/658 ,  G01N21/774

摘要： A sensor chip includes: a substrate that has a planar portion; and a diffraction grating on the planar portion and having a metal surface, the diffraction grating having a target substance thereon and including: a plurality of first protrusions periodically arranged in a period equal to or greater than 100 nm and equal to or less than 1000 nm in a first direction parallel to the planar portion, a plurality of base portions located between two adjacent first protrusions and configures a base of the substrate, a plurality of second protrusions formed on upper faces of the plurality of first protrusions, and a plurality of third protrusions formed on the plurality of base portions.

摘要翻译： 传感器芯片包括：具有平面部分的基板; 以及在平面部分上具有金属表面的衍射光栅，所述衍射光栅在其上具有目标物质，并且包括：周期性地等于或大于100nm且等于或小于1000nm的周期性排列的多个第一突起 在与平面部平行的第一方向上，位于两个相邻的第一突起之间的多个基部，构成基板的基部，形成在多个第一突起的上表面上的多个第二突起，以及多个第三突起 形成在多个基部上的突起。

公开(公告)号：US20090274863A1

公开(公告)日：2009-11-05

申请号：US12113550

申请日：2008-05-01

申请人： Kohei Yamada

发明人： Kohei Yamada

IPC分类号： D03D27/00 ,  B29D31/00

CPC分类号： B29C33/02 ,  B29C33/0033 ,  B29C33/76 ,  B29C43/021 ,  B29C2035/1658 ,  B29C2043/023 ,  B29C2043/3266 ,  B29C2791/008 ,  B29C2793/0045 ,  B29K2995/0091 ,  B29L2031/3017 ,  B29L2031/721 ,  B29L2031/7322 ,  B29L2031/737 ,  B29L2031/7652 ,  Y10T428/23979

摘要： A noise absorber carpet comprised of a fabric layer portion and a resinous backing layer portion, wherein the fabric layer portion and the resinous backing layer portion are heat bonded with a press into the noise absorber carpet. The press includes perforation pins and a cooling medium. The resinous backing layer portion is provided with noise absorbing perforations formed by contact with the perforation pins of the press and cooled by the cooling medium. The perforations are cooled by the cooling medium with the press simultaneously with the bonding of the resinous backing layer portion with the fabric layer portion and the cooling of the press by the cooling medium, thereby providing for instant curing and fixation of the shape of the perforations.

摘要翻译： 一种由织物层部分和树脂背衬层部分组成的噪声吸收器地毯，其中织物层部分和树脂背衬层部分用压力加热粘合到噪声吸收器地毯中。 印刷机包括穿孔销和冷却介质。 树脂背衬层部分设置有通过与压力机的穿孔销接触形成的噪声吸收穿孔，并由冷却介质冷却。 通过具有压力机的冷却介质同时通过树脂背衬层部分与织物层部分的接合以及通过冷却介质冷却压力机来将穿孔冷却，从而提供穿孔形状的即时固化和固定 。

公开(公告)号：US20080283183A1

公开(公告)日：2008-11-20

申请号：US12109570

申请日：2008-04-25

申请人： Kohei Yamada

发明人： Kohei Yamada

IPC分类号： B32B37/20 ,  D06N7/00 ,  B32B38/04 ,  B32B7/04

CPC分类号： B60N3/048 ,  B29C47/0021 ,  B29C47/0038 ,  B29C47/32 ,  B29C47/8805 ,  B29C47/8845 ,  B29C2793/0045 ,  B29K2007/00 ,  B29K2009/06 ,  B29K2011/00 ,  B29K2021/00 ,  B29K2027/06 ,  B29K2101/10 ,  B29K2105/045 ,  B29K2313/00 ,  B29K2995/0002 ,  B29L2009/00 ,  B29L2031/3017 ,  B29L2031/732 ,  B32B37/08 ,  B32B38/04 ,  B32B2038/047 ,  B32B2305/18 ,  B32B2307/102 ,  B32B2471/04 ,  D06N7/0071 ,  D06N2209/025 ,  D06N2213/04 ,  D06N2213/065 ,  Y10T156/1054 ,  Y10T156/1056 ,  Y10T156/1304 ,  Y10T156/1317 ,  Y10T156/1741 ,  Y10T428/23979

摘要： A noise absorber carpet comprised of a fabric layer portion and a resinous backing layer portion is provided. The fabric layer portion and the resinous backing layer portion are heat bonded with a press into the noise absorber carpet, and the press includes perforation pins and a cooling medium. The resinous backing layer portion is provided with noise absorbing perforations formed by contact with the perforation pins of the press and cooled by the cooling medium. The perforations having been cooled by the cooling medium with the press simultaneously with the bonding of the resinous backing layer portion with the fabric layer portion and the cooling of the press by the cooling medium, thereby providing for instant curing and fixation of the shape of the perforations.

摘要翻译： 提供了由织物层部分和树脂背衬层部分组成的消音器地毯。 织物层部分和树脂背衬层部分通过压力热粘合到噪声吸收器地毯中，并且压力机包括穿孔销和冷却介质。 树脂背衬层部分设置有通过与压力机的穿孔销接触形成的噪声吸收穿孔，并由冷却介质冷却。 通过挤压机将冷却介质冷却的穿孔与树脂背衬层部分与织物层部分的接合以及通过冷却介质的压力机的冷却同时提供立即固化和固定的形状 穿孔

公开(公告)号：US07381820B2

公开(公告)日：2008-06-03

申请号：US10577064

申请日：2004-10-22

申请人： Kohei Yamada ,  Noritake Matsumoto ,  Hiroyuki Hayakawa

发明人： Kohei Yamada ,  Noritake Matsumoto ,  Hiroyuki Hayakawa

IPC分类号： C07H21/00 ,  A01N43/04 ,  A61K31/70

CPC分类号： C12P19/40 ,  C07H1/02 ,  C07H11/04

摘要： A method for producing 2′-deoxy-2′-fluoro-β-D-arabinonucleoside represented by formula (II): (wherein B represents a base), in particular, 2′-deoxy-2′-fluoro-β-D-arabinopurinenucleoside, which method comprises causing a nucleoside phosphorylase to act on α-1-phosphorylated-2-deoxy-2-fluoroarabinoside represented by formula (I): or a mixture of α- and β-isomers of 1-phosphorylated-2-deoxy-2-fluoroarabinoside represented by formula (V′): and on a base. The compound can be produced at high yield and in a convenient and highly stereoselective manner.

摘要翻译： 由式（II）表示的2'-脱氧-2'-氟-β-D-阿拉伯糖核苷的制备方法：其中B表示碱，特别是2'-脱氧-2'-氟-β-D 所述方法包括使核苷磷酸化酶作用于由式（I）表示的α-1-磷酸化-2-脱氧-2-氟阿拉伯糖苷：或1-磷酸化-2-磷酸化2-氟阿拉伯糖苷的α-和β-异构体的混合物， 由式（V'）表示的脱氧-2-氟阿拉伯糖苷：和在碱上。 该化合物可以以高产率和方便且高度立体选择的方式制备。

公开(公告)号：US20070135627A1

公开(公告)日：2007-06-14

申请号：US10577064

申请日：2004-10-22

申请人： Kohei Yamada ,  Noritake Matsumoto ,  Hiroyuki Hayakawa

发明人： Kohei Yamada ,  Noritake Matsumoto ,  Hiroyuki Hayakawa

IPC分类号： C07H19/167 ,  C07H19/173

CPC分类号： C12P19/40 ,  C07H1/02 ,  C07H11/04

摘要： A method for producing 2′-deoxy-2′-fluoro-β-D-arabinonucleoside represented by formula (II): [F3] (wherein B represents a base), in particular, 2′-deoxy-2′-fluoro-β-D-arabinopurinenucleoside, which method comprises causing a nucleoside phosphorylase to act on α-1-phosphorylated-2-deoxy-2-fluoroarabinoside represented by formula (I): [F1] or a mixture of α- and β-isomers of 1-phosphorylated-2-deoxy-2-fluoroarabinoside represented by formula (V′): [F2] and on a base. The compound can be produced at high yield and in a convenient and highly stereoselective manner.

摘要翻译： 由式（II）表示的2'-脱氧-2'-氟-β-D-阿拉伯糖核苷的制备方法：[F3]（其中B表示碱），特别是2'-脱氧-2'-氟 - 所述方法包括使核苷磷酸化酶作用于由式（I）表示的α-1-磷酸化-2-脱氧-2-氟阿拉伯糖苷：[F1]或α-和β-异构体的α-异构体和β-异构体的混合物 由式（Ⅴ'）表示的1-磷酸化2-氟阿拉糖苷：[F2]和碱。 该化合物可以以高产率和方便且高度立体选择的方式制备。