公开(公告)号：US20240238445A1

公开(公告)日：2024-07-18

申请号：US18552290

申请日：2022-07-08

Applicant: NEURACLE SCIENCE CO., LTD. ,  KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION ,  KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUS

Inventor： Jae Young SEONG ,  Youngjoo BYUN ,  Hoyun KWAK ,  Sitaek OH ,  Min-Hyeok LEE ,  Yongwoo JEONG ,  Nui HA ,  Eun-Ho CHO ,  Suhyun LEE ,  Sang-Myeong LEE ,  Yerim LEE ,  Eun Bee CHO ,  Jae Keun LEE ,  Han-Byul KIM ,  Soon-gu KWON

IPC: A61K48/00 ,  A61K31/055 ,  A61K31/085 ,  A61K31/136 ,  A61K31/137 ,  A61K38/08 ,  A61K38/10 ,  A61K38/17 ,  A61K45/06 ,  A61K47/64 ,  A61P25/02 ,  A61P25/28 ,  C12N5/0793

CPC classification number: A61K48/005 ,  A61K31/055 ,  A61K31/085 ,  A61K31/136 ,  A61K31/137 ,  A61K38/08 ,  A61K38/10 ,  A61K38/1709 ,  A61K45/06 ,  A61K47/64 ,  A61P25/02 ,  A61P25/28 ,  C12N5/0619

Abstract: The present disclosure provides mimic molecules that are capable of specifically targeting a FAM19A5 protein, and thereby, inhibiting, reducing, and/or dissociating the interaction between members of the LRRC4 protein family and the FAM19A5 protein. The present disclosure also provides methods for promoting neurite outgrowth, by administering a mimic molecule described herein.

公开(公告)号：US20240212800A1

公开(公告)日：2024-06-27

申请号：US18544488

申请日：2023-12-19

Applicant: LumanLab Inc. ,  Korea University Research and Business Foundation ,  Korea University Research and Business Foundation, Sejong Campus

Inventor： Jae Hyun LIM ,  Chul Hyun CHO ,  Seung Pil PACK

IPC: G16H10/20 ,  A61B5/16 ,  G16H50/20 ,  G16H50/30

CPC classification number: G16H10/20 ,  A61B5/16 ,  G16H50/20 ,  G16H50/30 ,  A61B2503/06

Abstract: An electronic device and a method to assess a mental health state of an adolescent by using a survey formed based on an artificial intelligence (AI). The method comprises: collecting physical information of a user through a pre-installed application, verifying survey questions regarding a mental health depending on the physical information, and verifying answers to the verified survey questions through the application; forming additional survey questions after having verified the answers and calculating a prediction rate of an appearance of symptoms of a mental illness regarding the additional survey questions by using AI models; verifying a set of survey questions including a plurality of sub-questions depending on the calculated prediction rate; outputting the verified set of survey questions through the application; outputting result data by adjusting the prediction rate; and transmitting the outputted result data.

公开(公告)号：US20220289657A1

公开(公告)日：2022-09-15

申请号：US17637565

申请日：2020-08-21

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUS ,  KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Youngjoo BYUN ,  Hee Deung PARK ,  Sangjin NAM ,  Sang-Hyun SON ,  So Young HAM ,  Han Shin KIM

IPC: C07C49/255 ,  C07C49/248 ,  C07C49/235 ,  A61K31/12 ,  A61P31/04

Abstract: The present invention relates to a 4-gingerol derivative compound, or a racemate, isomer, or pharmaceutically acceptable salt thereof, the compound being capable of inhibiting biofilm formation and production of virulence factors. The 4-gingerol derivative compound according to the present invention has binding affinity to RhlR and corresponding RhlR antagonism activity that are significantly improved, and therefore can effectively inhibit biofilm formation and production of virulence factors. Furthermore, various bacterial infectious diseases caused by biofilms can be fundamentally prevented or treated by using a pharmaceutical composition comprising the 4-gingerol derivative compound, or a racemate, isomer, or pharmaceutically acceptable salt thereof as an active ingredient.

公开(公告)号：US20200283364A1

公开(公告)日：2020-09-10

申请号：US16632592

申请日：2018-07-19

Applicant: Korea University Research and Business Foundation, Sejong Campus ,  Korea University Research and Business Foundation

Inventor： Youngjoo BYUN ,  Hee-Deung PARK ,  Sang-Hyun SON ,  Eunji CHA ,  So-Young HAM ,  Hyunsuk CHOI

IPC: C07C49/255 ,  C07C49/245 ,  A61P31/04

Abstract: The present invention relates to a gingerol derivative having inhibitory activity against biofilm formation and a pharmaceutical composition for preventing or treating infections caused by biofilms including the gingerol derivative as an active ingredient. The gingerol derivative of the present invention exhibits significantly improved binding affinity for LasR and inhibitory activity against biofilm formation. Therefore, the gingerol derivative of the present invention can act on various membrane surfaces where biofilms tend to form and can effectively inhibit the formation of the corresponding biofilms. In addition, the use of the pharmaceutical composition according to the present invention can fundamentally prevent or treat a variety of infections caused by biofilms due to the presence of the gingerol derivative in the pharmaceutical composition.

公开(公告)号：US11964935B2

公开(公告)日：2024-04-23

申请号：US16632592

申请日：2018-07-19

Applicant: Korea University Research and Business Foundation, Sejong Campus ,  Korea University Research and Business Foundation

Inventor： Youngjoo Byun ,  Hee-Deung Park ,  Sang-Hyun Son ,  Eunji Cha ,  So-Young Ham ,  Hyunsuk Choi

IPC: C07C49/255 ,  A61P31/04 ,  C07C49/245

CPC classification number: C07C49/255 ,  A61P31/04 ,  C07C49/245

Abstract: The present invention relates to a gingerol derivative having inhibitory activity against biofilm formation and a pharmaceutical composition for preventing or treating infections caused by biofilms including the gingerol derivative as an active ingredient. The gingerol derivative of the present invention exhibits significantly improved binding affinity for LasR and inhibitory activity against biofilm formation. Therefore, the gingerol derivative of the present invention can act on various membrane surfaces where biofilms tend to form and can effectively inhibit the formation of the corresponding biofilms. In addition, the use of the pharmaceutical composition according to the present invention can fundamentally prevent or treat a variety of infections caused by biofilms due to the presence of the gingerol derivative in the pharmaceutical composition.

公开(公告)号：US11298534B2

公开(公告)日：2022-04-12

申请号：US16235498

申请日：2018-12-28

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION ,  Korea University Research and Business Foundation, Sejong Campus

Inventor： Hoon Jai Chun ,  Jung Hwa Hong ,  Dong Geun Sul ,  Bora Keum ,  Eun Sun Kim ,  Hyuk Soon Choi ,  Seung Han Kim

IPC: A61N1/00 ,  A61N1/36 ,  A61N1/372 ,  A61N1/05 ,  A61B17/00

Abstract: A stimulator for a digestive organ includes a case, a substrate member disposed in the case, and an electrode member connected to the substrate member and extending to protrude outwardly from the case. The electrode member may have a shape of a wire and may be configured to provide an electrical stimulation in a state of being inserted and fixed at a predetermined location within a digestive organ.

公开(公告)号：US20190321631A1

公开(公告)日：2019-10-24

申请号：US16235498

申请日：2018-12-28

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION ,  KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Hoon Jai Chun ,  Jung Hwa Hong ,  Dong Geun Sul ,  Bora Keum ,  Eun Sun Kim ,  Hyuk Soon Choi ,  Seung Han Kim

IPC: A61N1/36 ,  A61N1/372 ,  A61N1/05

Abstract: A stimulator for a digestive organ includes a case, a substrate member disposed in the case, and an electrode member connected to the substrate member and extending to protrude outwardly from the case. The electrode member may have a shape of a wire and may be configured to provide an electrical stimulation in a state of being inserted and fixed at a predetermined location within a digestive organ.

公开(公告)号：US20250064719A1

公开(公告)日：2025-02-27

申请号：US18939509

申请日：2024-11-06

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Sung Hoi HONG ,  In Sik HWANG

IPC: A61K8/98 ,  A61K8/02 ,  A61K8/04 ,  A61K8/64 ,  A61K8/66 ,  A61Q1/12 ,  A61Q19/00 ,  A61Q19/08 ,  A61Q19/10

Abstract: The present invention relates to a method of preparing a culture broth of neural stem cells, having excellent abilities of reducing skin wrinkles or increasing skin elasticity, the culture broth comprising high concentrations of TIMP-1 and TIMP-2 capable of inhibiting the expression and activity of matrix metalloproteinases (MMPs) involved in collagen decomposition in the dermis. The culture broth of neural stem cells according to the present invention, which comprises, as active ingredients, high concentrations of TIMP-1 and TIMP-2 and low concentrations of various MMPs, restores the synthesis of collagen and elastin by suppressing the expression and activity of MMPs inhibiting collagen formation, and thus is useful as a composition for reducing skin wrinkles or increasing skin elasticity.

公开(公告)号：US12225327B2

公开(公告)日：2025-02-11

申请号：US18139683

申请日：2023-04-26

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION ,  AJOU UNIVERSITY INDUSTRY—ACADEMIC COOPERATION FOUNDATION

Inventor： Joongheon Kim ,  Soyi Jung ,  Jae-Hyun Kim ,  Won Joon Yun ,  SooHyun Park

IPC: H04N7/18 ,  B64U10/00 ,  B64U101/20 ,  B64U101/31 ,  H04N23/661

Abstract: Provided is a surveillance system employing a plurality of unmanned aerial vehicles (UAVs), the surveillance system showing improved surveillance performance while optimizing common energy consumption for computing of all the UAVs and also providing a stable visual monitoring service using autonomous mobility of the plurality of UAVs regardless of movement of an object to be monitored and action uncertainty of an adjacent UAV.

公开(公告)号：US12223447B2

公开(公告)日：2025-02-11

申请号：US17690231

申请日：2022-03-09

Applicant: Korea University Research and Business Foundation ,  AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Joongheon Kim ,  Won Joon Yun ,  Jae-Hyun Kim ,  Soyi Jung

IPC: G06Q10/0631 ,  B64U101/61 ,  G01C21/20 ,  G05D1/00

Abstract: Provided are a drone taxi system based on multi-agent reinforcement learning and a drone taxi operation method using the same. The drone taxi system includes a plurality of drone taxies configured to receive call information including departure point information and destination information from passenger terminals present within a certain range and a control server configured to receive call information of passengers from each drone taxi, select a candidate passenger depending on whether a passenger is present, generate travel route information of each drone taxi from drone state information of the plurality of drone taxies through multi-agent reinforcement learning, and transmit the travel route information to the drone taxi.