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![Method of producing ethyl (3R, 5S, 6E)-7-[2 cyclopropyl-4-(fluorophenyl) quinoline-3-yl]-3, 5-dihydroxy-6-heptenoate](/abs-image/US/2009/06/23/US07550596B2/abs.jpg.150x150.jpg)
1.发明授权Method of producing ethyl (3R, 5S, 6E)-7-[2 cyclopropyl-4-(fluorophenyl) quinoline-3-yl]-3, 5-dihydroxy-6-heptenoate 失效制备（3R，5S，6E）-7- [2-环丙基-4-（氟苯基）喹啉-3-基] -3,5-二羟基-6-庚烯酸乙酯的方法公开(公告)号：US07550596B2
公开(公告)日：2009-06-23
申请号：US11254864
申请日：2005-10-21
Applicant: Atsushi Onishi , Kozo Tachibana
Inventor： Atsushi Onishi , Kozo Tachibana
IPC: C07D215/38
CPC classification number: C07D215/14 , C07B2200/07
Abstract: A method of producing Ethyl(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-3,5-dihydroxy-6-heptenoate by means of liquid chromatography using a packing material comprising a carrier and, carried thereon, a polysaccharide derivative, wherein a part or all of the hydrogen atoms of hydroxyl and amino groups of the polysaccharide derivative are substituted with one or more substituents, such as a carbamoyl group wherein one hydrogen atom is substituted with an aromatic group having a specific alkyl group. The method allows the production of the above (3R,5S,6E) isomer with enhanced productivity to a conventional method.
Abstract translation: 通过液相色谱法使用（3R，5S，6E）-7- [2-环丙基-4-（4-氟苯基）喹啉-3-基] -3,5-二羟基-6-庚烯酸乙酯 包含载体的载体和载体上的多糖衍生物，其中多糖衍生物的羟基和氨基的一部分或全部氢原子被一个或多个取代基取代，例如氨基甲酰基，其中一个氢原子是 被具有特定烷基的芳基取代。 该方法允许以常规方法以高生产率生产上述（3R，5S，6E）异构体。
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公开(公告)号：US5231196A
公开(公告)日：1993-07-27
申请号：US627637
申请日：1990-12-14
Applicant: Seiji Shinkai , Tsutomu Matsuda , Takashi Arimura , Kirosuke Kawabata , Kozo Tachibana
Inventor： Seiji Shinkai , Tsutomu Matsuda , Takashi Arimura , Kirosuke Kawabata , Kozo Tachibana
CPC classification number: C07D213/30 , C07C43/21 , C07C2103/92
Abstract: The present invention relates to an improvement in the process for preparing a calixarene derivative in which the rotation of its benzene units are hindered and which comprises replacing all or a part of the hydrogen atoms of the hydroxyl groups of a calixarene derivative represented by the general formula: ##STR1## and is characterized by conducting the reaction in the presence of an alkaline earth metal. According to the present invention, an asymmetric calixarene derivative having a "cone" conformation can be selectively prepared by virtue of the template effect of the metal.
Abstract translation: 本发明涉及制备其苯单元旋转受阻的杯芳烃衍生物的制备方法的改进，其包括用通式（I）表示的杯芳烃衍生物的羟基的全部或一部分代替 ：
，其特征在于在碱土金属存在下进行反应。 根据本发明，可以通过金属的模板效应选择性地制备具有“锥形”构型的不对称杯芳烃衍生物。 -
3.发明授权Filler used for separating optical isomers and process for separating optical isomers with the filler 有权用于分离光学异构体的填料和用填料分离光学异构体的方法公开(公告)号：US07749389B2
公开(公告)日：2010-07-06
申请号：US11637157
申请日：2006-12-12
Applicant: Atsushi Onishi , Koichi Murazumi , Kozo Tachibana
Inventor： Atsushi Onishi , Koichi Murazumi , Kozo Tachibana
IPC: B01D15/08
CPC classification number: B01J20/29 , B01D15/1821 , B01D15/185 , B01D15/3833 , B01D2215/023 , B01J20/286 , B01J20/327 , B01J20/3274 , B01J20/328 , C07B57/00
Abstract: The objectives of this invention are to provide a filler for separating optical isomers, capable of efficiently carrying out optical resolution of optical isomer mixtures, and to provide a process for separating optical isomers by a simulated moving bed chromatography utilizing the filler. This invention provides a filler made of a carrier supporting a specific amount of an optically active high molecular weight compound. Separation by the simulated moving bed chromatography using the filler is carried out under the condition that the capacity factors have specific values.
Abstract translation: 本发明的目的是提供一种用于分离光学异构体的填料，其能够有效地进行光学异构体混合物的光学拆分，并提供通过使用填料的模拟移动床色谱分离光学异构体的方法。 本发明提供了由支持特定量的光学活性高分子量化合物的载体制成的填料。 在容量因子具有特定值的条件下，通过使用填料的模拟移动床层析法进行分离。
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公开(公告)号：US07459579B2
公开(公告)日：2008-12-02
申请号：US11254856
申请日：2005-10-21
Applicant: Keiko Kudo , Kozo Tachibana , Koichi Murazumi
Inventor： Keiko Kudo , Kozo Tachibana , Koichi Murazumi
CPC classification number: C07D209/24 , B01D15/1821 , B01D15/3833 , B01J20/285 , B01J20/286 , B01J20/3272 , B01J20/328 , C07B2200/07 , C07D209/12
Abstract: An optically active dihydroxyheptenoic acid ester having an aromatic group is separated from a solution containing a mixture of optical isomers of digydroxyheptenoic acid ester by liquid chromatography with a packing material constituted of a carrier and a polysaccharide derivative carried on the carrier. The polysaccharide derivative is a polysaccharide in which the hydrogen atoms constituting the hydroxyl and amino groups are partially or all replaced by one or more kinds of groups selected from among carbamoyl groups monosubstituted with aromatic groups having specific alkyl groups and benzoyl groups having specific alkyl groups. According to the invention, optically active dihydroxyheptenoic acid esters can be separated more distinctly.
Abstract translation: 具有芳族基团的光学活性二羟基庚烯酸酯通过液相色谱与含有载体的载体和载体上的多糖衍生物的包装材料从含有二羟基庚酸的旋光异构体的混合物的溶液中分离出来。 多糖衍生物是其中构成羟基和氨基的氢原子部分或全部被选自由具有特定烷基的芳族基团和具有特定烷基的苯甲酰基单取代的氨基甲酰基中的一种或多种基团取代的多糖。 根据本发明，可以更明确地分离光学活性的二羟基庚烯酸酯。
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5.发明申请Filler used for separating optical isomers and process for separating optical isomers with the filler 有权用于分离光学异构体的填料和用填料分离光学异构体的方法公开(公告)号：US20070084796A1
公开(公告)日：2007-04-19
申请号：US11637157
申请日：2006-12-12
Applicant: Atsushi Onishi , Koichi Murazumi , Kozo Tachibana
Inventor： Atsushi Onishi , Koichi Murazumi , Kozo Tachibana
IPC: B01D15/08
CPC classification number: B01J20/29 , B01D15/1821 , B01D15/185 , B01D15/3833 , B01D2215/023 , B01J20/286 , B01J20/327 , B01J20/3274 , B01J20/328 , C07B57/00
Abstract: The objectives of this invention are to provide a filler for separating optical isomers, capable of efficiently carrying out optical resolution of optical isomer mixtures, and to provide a process for separating optical isomers by a simulated moving bed chromatography utilizing the filler. This invention provides a filler made of a carrier supporting a specific amount of an optically active high molecular weight compound. Separation by the simulated moving bed chromatography using the filler is carried out under the condition that the capacity factors have specific values.
Abstract translation: 本发明的目的是提供一种用于分离光学异构体的填料，其能够有效地进行光学异构体混合物的光学拆分，并提供通过使用填料的模拟移动床色谱分离光学异构体的方法。 本发明提供了由支持特定量的光学活性高分子量化合物的载体制成的填料。 在容量因子具有特定值的条件下，通过使用填料的模拟移动床层析法进行分离。
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Patent Agency Ranking
![Process for producing optically active ethly (3r, 5s, 6e)-7- [2-cycloproply-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate](/abs-image/US/2005/04/07/US20050075502A1/abs.jpg.150x150.jpg)
6.发明申请Process for producing optically active ethly (3r, 5s, 6e)-7- [2-cycloproply-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate 失效制备光学活性的乙基（3r，5s，6e）-7- [2-环丙基-4-（4-氟苯基）喹啉-3-基] -3,5-二羟基-6-庚烯酸乙酯的方法公开(公告)号：US20050075502A1
公开(公告)日：2005-04-07
申请号：US10398915
申请日：2001-10-12
Applicant: Atsushi Onishi , Koichi Murazumi , Kozo Tachibana
Inventor： Atsushi Onishi , Koichi Murazumi , Kozo Tachibana
IPC: A61K31/47 , B01D15/08 , B01D15/18 , B01D15/38 , B01J20/26 , B01J20/281 , B01J20/29 , B01J20/32 , C07B57/00 , C07D215/04 , C07D215/14
CPC classification number: B01J20/328 , B01D15/185 , B01D15/3833 , B01J20/262 , B01J20/265 , B01J20/286 , B01J20/29 , B01J20/3204 , B01J20/3272 , B01J2220/54 , C07B2200/07 , C07D215/14
Abstract: The objective of this invention is to provide a process for producing an optically active isomer of ethyl 7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate by optically resolving an optical isomer mixture of the compound at a high productivity. The process is characterized by employing a filler comprising a carrier and a specific amount of cellulose tris (4-chlorophenyl carbamate) supported the carrier and carrying out chromatographic separation under the condition that the capacity factors have specific values.
Abstract translation: 本发明的目的是提供通过光学制备7- [2-环丙基-4-（4-氟苯基）喹啉-3-基] -3,5-二羟基-6-庚烯酸乙酯的旋光异构体的方法 以高生产率分解化合物的旋光异构体混合物。 该方法的特征在于使用包含载体和特定量的纤维素三（4-氯苯基氨基甲酸酯）的填料负载载体并在容量因子具有特定值的条件下进行色谱分离。
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7.发明授权公开(公告)号：US08854068B2
公开(公告)日：2014-10-07
申请号：US12996215
申请日：2008-08-18
Applicant: Eiichi Nagao , Kentaro Taninouchi , Noboru Hosokawa , Tsuyoshi Amimoto , Kozo Tachibana , Hirotaka Muto , Junji Tanimura , Satoru Toyama
Inventor： Eiichi Nagao , Kentaro Taninouchi , Noboru Hosokawa , Tsuyoshi Amimoto , Kozo Tachibana , Hirotaka Muto , Junji Tanimura , Satoru Toyama
CPC classification number: H01F27/14 , G01N27/92 , G01R27/14 , H01F27/402 , H01F2027/404
Abstract: An object of the invention is to provide a diagnostic method for an oil-filled electrical device that considers a temperature distribution in the oil-filled electrical device and enables accurate diagnosis to be conducted even when the method is applied to diagnosis of an actually operating device, and further provide a method with which such diagnosis of an oil-filled electrical device can be conducted from a component analysis value of an insulating oil in the oil-filled electrical device. The invention is a diagnostic method for an oil-filled electrical device including in an insulating oil a metal part wrapped with insulating paper, and determines that a time when a surface resistivity of a maximum precipitation site where metal sulfide is most precipitated on the insulating paper reaches a preset surface resistivity management value is a time of occurrence of an abnormality.
Abstract translation: 本发明的目的是提供一种充油电气装置的诊断方法，其考虑充油电气装置中的温度分布，并且即使当该方法应用于实际操作装置的诊断时也能够进行准确的诊断 并且还提供了一种通过充油电气装置中的绝缘油的成分分析值来进行充油电气装置的这种诊断的方法。 本发明是一种充油电气装置的诊断方法，其包括绝缘油中的绝缘纸包裹的金属部件，并且确定在绝缘纸上金属硫化物最沉淀的最大析出位置的表面电阻率 达到预设的表面电阻率管理值是发生异常的时间。
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公开(公告)号：US08305179B2
公开(公告)日：2012-11-06
申请号：US12999919
申请日：2008-09-26
Applicant: Eiichi Nagao , Kentaro Taninouchi , Noboru Hosokawa , Tsuyoshi Amimoto , Kozo Tachibana , Takanori Sone , Junji Tanimura , Satoru Toyama
Inventor： Eiichi Nagao , Kentaro Taninouchi , Noboru Hosokawa , Tsuyoshi Amimoto , Kozo Tachibana , Takanori Sone , Junji Tanimura , Satoru Toyama
CPC classification number: H01F27/14 , G01N33/287 , H01F27/402
Abstract: An oil immersed electrical apparatus such as an oil immersed transformer that can detect copper sulfide precipitated on coil insulating paper is provided. In the oil immersed transformer in which a coil with its surface covered by insulating paper is arranged in a container filled with insulating oil, a detection member is prepared by providing two electrodes on a surface of a plate-like pressboard formed of cellulose, which is a same material as that of the insulating paper, this detection member is arranged in contact with the insulating oil, and generation of copper sulfide is detected from reduction in a surface resistance between the electrodes. The temperature of the detection member is set higher than the temperature of the coil so that copper sulfide is generated thereon prior to generation of copper sulfide on a coil unit.
Abstract translation: 提供了一种油浸式电气设备，例如可以检测在线圈绝缘纸上析出的硫化铜的油浸变压器。 在将其表面被绝缘纸覆盖的线圈布置在填充有绝缘油的容器中的油浸变压器中，通过在由纤维素形成的板状压板的表面上设置两个电极来制备检测构件，该电极为 与绝缘纸相同的材料，该检测部件被布置成与绝缘油接触，并且通过降低电极之间的表面电阻来检测硫化铜的产生。 检测部件的温度被设定为高于线圈的温度，使得在线圈单元上产生硫化铜之前产生硫化铜。
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公开(公告)号：US20110090034A1
公开(公告)日：2011-04-21
申请号：US12999919
申请日：2008-09-26
Applicant: Eiichi Nagao , Kentaro Taninouchi , Noboru Hosokawa , Tsuyoshi Amimoto , Kozo Tachibana , Takanori Sone , Junji Tanimura , Satoru Toyama
Inventor： Eiichi Nagao , Kentaro Taninouchi , Noboru Hosokawa , Tsuyoshi Amimoto , Kozo Tachibana , Takanori Sone , Junji Tanimura , Satoru Toyama
IPC: H01F27/10
CPC classification number: H01F27/14 , G01N33/287 , H01F27/402
Abstract: An oil immersed electrical apparatus such as an oil immersed transformer that can detect copper sulfide precipitated on coil insulating paper is provided. In the oil immersed transformer in which a coil with its surface covered by insulating paper is arranged in a container filled with insulating oil, a detection member is prepared by providing two electrodes on a surface of a plate-like pressboard formed of cellulose, which is a same material as that of the insulating paper, this detection member is arranged in contact with the insulating oil, and generation of copper sulfide is detected from reduction in a surface resistance between the electrodes. The temperature of the detection member is set higher than the temperature of the coil so that copper sulfide is generated thereon prior to generation of copper sulfide on a coil unit.
Abstract translation: 提供了一种油浸式电气设备，例如可以检测在线圈绝缘纸上析出的硫化铜的油浸变压器。 在将其表面被绝缘纸覆盖的线圈布置在填充有绝缘油的容器中的油浸变压器中，通过在由纤维素形成的板状压板的表面上设置两个电极来制备检测构件，该电极为 与绝缘纸相同的材料，该检测部件被布置成与绝缘油接触，并且通过降低电极之间的表面电阻来检测硫化铜的产生。 检测部件的温度被设定为高于线圈的温度，使得在线圈单元上产生硫化铜之前产生硫化铜。
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10.发明授权Packing material for separation of optical isomer and method of separating optical isomer with the same 有权用于分离光学异构体的包装材料和与其分离光学异构体的方法公开(公告)号：US07399409B2
公开(公告)日：2008-07-15
申请号：US10398937
申请日：2001-10-12
Applicant: Atsushi Onishi , Koichi Murazumi , Kozo Tachibana
Inventor： Atsushi Onishi , Koichi Murazumi , Kozo Tachibana
IPC: B01D15/08
CPC classification number: B01J20/29 , B01D15/1821 , B01D15/185 , B01D15/3833 , B01D2215/023 , B01J20/286 , B01J20/327 , B01J20/3274 , B01J20/328 , C07B57/00
Abstract: The objectives of this invention are to provide a filler for separating optical isomers, capable of efficiently carrying out optical resolution of optical isomer mixtures, and to provide a process for separating optical isomers by a simulated moving bed chromatography utilizing the filler. This invention provides a filler made of a carrier supporting a specific amount of an optically active high molecular weight compound. Separation by the simulated moving bed chromatography using the filler is carried out under the condition that the capacity factors have specific values.
Abstract translation: 本发明的目的是提供一种用于分离光学异构体的填料，其能够有效地进行光学异构体混合物的光学拆分，并提供通过使用填料的模拟移动床色谱分离光学异构体的方法。 本发明提供了由支持特定量的光学活性高分子量化合物的载体制成的填料。 在容量因子具有特定值的条件下，通过使用填料的模拟移动床层析法进行分离。
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