利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

10 条记录 (耗时 0.018 秒)

    Use of thyrotropin for regeneration of bone
    1.
    发明申请
    Use of thyrotropin for regeneration of bone 审中-公开
    使用促甲状腺激素再生骨

    公开(公告)号：US20060052303A1

    公开(公告)日：2006-03-09

    申请号：US11190465

    申请日：2005-07-27

    申请人： Kuber Sampath ,  John McPherson

    发明人： Kuber Sampath ,  John McPherson

    IPC分类号： A61K38/22

    CPC分类号： A61K38/24 ,  A61K38/29 ,  A61K2300/00

    摘要： The invention provides methods for treating or preventing bone degenerative disorders. The disorders treated or prevented include, for example, osteopenia, osteomalacia, osteoporosis, osteomyeloma, osteodystrophy, Paget's disease, osteogenesis imprerfecta, and bone degenerative disorders associated with chronic renal disease, hyperparathyroidism, high levels of endogenous thyrotropin, and long-term use of corticosteroids. The disclosed therapeutic methods include administering to a mammal a TSHR agonist in an amount effective to: (1) treat or prevent a bone degenerative disorder; (2) slow bone deterioration; (3) restore lost bone; (4) stimulate new bone formation; and/or (5) maintain bone mass and/or bone quality. TSHR agonists such as thyrotropin and its modified forms are provided along with other compounds, such as anti-resorptive agent and bone metabolic agents.

    摘要翻译： 本发明提供治疗或预防骨退行性疾病的方法。 所治疗或预防的疾病包括例如骨质减少症，骨软化症，骨质疏松症，骨软骨病，骨营养不良，佩吉特氏病，成骨发生不全症以及与慢性肾脏病，甲状旁腺功能亢进，高水平的内源性促甲状腺激素相关的骨退行性疾病，以及长期使用 皮质类固醇。 所公开的治疗方法包括向哺乳动物施用有效量的TSHR激动剂：（1）治疗或预防骨退行性疾病; （2）慢骨退化; （3）恢复失骨; （4）刺激新骨形成; 和/或（5）维持骨量和/或骨质量。 TSHR激动剂如促甲状腺激素及其修饰形式与其他化合物一起提供，如抗吸收剂和骨代谢剂。

    Methods and compositions for identifying morphogen analogs
    5.
    发明申请
    Methods and compositions for identifying morphogen analogs 审中-公开
    用于鉴定形态发生物类似物的方法和组合物

    公开(公告)号：US20080003675A1

    公开(公告)日：2008-01-03

    申请号：US11801900

    申请日：2007-05-11

    申请人： Shun-ichi Harada ,  Gideon Rodan ,  Kuber Sampath

    发明人： Shun-ichi Harada ,  Gideon Rodan ,  Kuber Sampath

    IPC分类号： C12N5/10 ,  C07H21/04

    CPC分类号： C07K14/4705 ,  A61K38/00 ,  C07K14/51

    摘要： Disclosed herein are methods and compositions for identifying morphogen analogs. The preferred methods and compositions relate to the discovery that morphogen upregulation of the mouse type X collagen promoter activity is mediated by a MEF-2 like sequence and requires an adjacent AP-1 sequence. Certain methods rest on the use of test cells comprising DNA defining a morphogen-responsive transcription activating element operatively associated with a reporter gene. Other methods rest on the use of DNAs for measuring morphogen-inducible DNA-binding. In certain preferred embodiments, the methods and DNAs involve an osteogenic protein 1 (OP-1) responsive transcription activating element. Substances that mediate interaction with and/or activate the OP-1 responsive transcription activating element are considered herein likely to be useful for reproducing in vivo effects of morphogens such as OP-1.

    摘要翻译： 本文公开了用于鉴定形态发生类似物的方法和组合物。 优选的方法和组合物涉及小鼠X型胶原启动子活性的形态发生上调由MEF-2样序列介导并需要相邻的AP-1序列的发现。 某些方法依赖于使用测试细胞，其包括定义与报告基因可操作地相关的形态发生反应性转录激活元件的DNA。 其他方法依赖于使用DNA来测量形态发生诱导型DNA结合。 在某些优选的实施方案中，所述方法和DNA涉及成骨蛋白1（OP-1）响应转录激活元件。 介导与OP-1反应性转录激活元件的相互作用和/或激活的物质在本文中被认为可能用于再现诸如OP-1的形态发生体的作用。

    Morphogen-induced dendritic growth
    8.
    发明申请
    Morphogen-induced dendritic growth 审中-公开
    形态诱导树突生长

    公开(公告)号：US20060025571A1

    公开(公告)日：2006-02-02

    申请号：US11226555

    申请日：2005-09-13

    申请人： David Rueger ,  Kuber Sampath ,  John Smart ,  Hermann Oppermann ,  Engin Ozkaynak ,  Charles Cohen ,  Dennis Higgins

    发明人： David Rueger ,  Kuber Sampath ,  John Smart ,  Hermann Oppermann ,  Engin Ozkaynak ,  Charles Cohen ,  Dennis Higgins

    IPC分类号： A61K38/18 ,  C07K14/475

    CPC分类号： C07K14/51 ,  A01N1/021 ,  A61K38/00 ,  A61K38/1841 ,  A61K38/185

    摘要： Disclosed are methods and compositions for maintaining neural pathways in a mammal including: enhancing survival of neurons at risk of dying; inducing cellular repair of damaged neurons and neural pathways; stimulating neurons to maintain their differentiated phenotype; and promoting dendritic outgrowth, including maintaining dendritic arbors and regenerating dendritic architecture. In one embodiment, the invention provides means for stimulating CAM expression in neurons. The invention also provides means for evaluating the status of nerve tissue, including means for detecting and monitoring neuropathies in a mammal. The methods, devices and compositions include a morphogen or morphogen-stimulating agent provided to the mammal in a therapeutically effective concentration. In another embodiment, the invention provides methods and compositions which include a morphogen or morphogen-stimulating agent, and a nerve trophic factor or nerve trophic factor-stimulating agent at concentrations effective for stimulating dendrite outgrowth. The morphogen and the nerve trophic factor can be admixed in combination.

    摘要翻译： 公开了用于在哺乳动物中维持神经通路的方法和组合物，包括：增加有死亡风险的神经元的存活; 诱导损伤的神经元和神经通路的细胞修复; 刺激神经元维持其分化表型; 并促进树突生长，包括保持树枝状树枝和再生树枝状结构。 在一个实施方案中，本发明提供用于刺激神经元中的CAM表达的装置。 本发明还提供用于评估神经组织状态的手段，包括用于检测和监测哺乳动物神经病变的手段。 方法，装置和组合物包括以治疗有效浓度提供给哺乳动物的形态发生剂或形态发生剂。 在另一个实施方案中，本发明提供了包括形态发生剂或形态发生剂刺激剂以及神经营养因子或神经营养因子刺激剂的方法和组合物，其浓度有效刺激枝晶生长。 形态发生剂和神经营养因子可以组合使用。