公开(公告)号：US07799557B2

公开(公告)日：2010-09-21

申请号：US11080705

申请日：2005-03-15

申请人： Kwang-wook Oh ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park ,  Yoon-kyoung Cho

发明人： Kwang-wook Oh ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park ,  Yoon-kyoung Cho

IPC分类号： C12M1/34 ,  C12M3/00

CPC分类号： G01N21/6486 ,  B01L3/50851 ,  B01L7/52 ,  B01L2300/0627 ,  B01L2300/18 ,  G01N21/0332

摘要： Provided are a DNA PCR module and a multiple PCR system using the same. More particularly, provided are a DNA PCR module with a combined PCR thermal cycler and PCR product detector, and a multiple PCR system using the same.

摘要翻译： 提供了DNA PCR模块和使用其的多重PCR系统。 更具体地，提供了具有组合的PCR热循环仪和PCR产物检测器的DNA PCR模块，以及使用其的多重PCR系统。

公开(公告)号：US07736050B2

公开(公告)日：2010-06-15

申请号：US11433594

申请日：2006-05-12

申请人： Chin-sung Park ,  Joon-ho Kim ,  Kak Namkoong ,  Kwang-wook Oh

发明人： Chin-sung Park ,  Joon-ho Kim ,  Kak Namkoong ,  Kwang-wook Oh

IPC分类号： B01F5/00

CPC分类号： B01F13/1013 ,  B01F5/0475 ,  B01F5/0478 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01F13/1019 ,  B01F15/0203 ,  B01F15/0404 ,  B01F2015/0221 ,  G01N1/38

摘要： Provided is a fluid mixing device which produces a series of solutions with a concentration gradient. The fluid mixing device includes: a plurality of first channels disposed parallel to each other on a layer, and into which an equal amount of diluent flows from its upstream; a plurality of second channels formed perpendicular to the first channels on an adjacent layer to the layer on which the first channels are formed, and into which an equal amount of sample solution flows from its upstream; and via holes formed at at least one intersection between each of the first channel and a plurality of second channels so that a predetermined amount of sample solution flows from the second channels into corresponding first channels, wherein a series of solutions with different concentrations is produced in the first channels depending on the amount of sample solution that flows into the first channels through the via holes. Thus, a series of solutions with different concentrations is output from the first channels.

摘要翻译： 提供了一种流体混合装置，其产生具有浓度梯度的一系列溶液。 流体混合装置包括：在层上彼此平行设置的多个第一通道，等量的稀释剂从其上游流入其中; 多个第二通道，其垂直于与形成有第一通道的层相邻的第一通道形成，并且等量的样品溶液从其上游流入其中; 以及形成在每个第一通道和多个第二通道之间的至少一个相交处的通孔，使得预定量的样品溶液从第二通道流入相应的第一通道，其中一系列具有不同浓度的溶液在 第一通道取决于通过通孔流入第一通道的样品溶液的量。 因此，从第一通道输出一系列具有不同浓度的溶液。

公开(公告)号：US07413707B2

公开(公告)日：2008-08-19

申请号：US11430741

申请日：2006-05-09

申请人： Kwang-wook Oh ,  Yu-jin Seo

发明人： Kwang-wook Oh ,  Yu-jin Seo

IPC分类号： B01D59/44

CPC分类号： B01L3/502715 ,  B01L3/502707 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/043 ,  B01L2300/0816 ,  B01L2400/0406 ,  G01N2035/00158

摘要： Provided is a microchip assembly including a base holder, a microchip installed on the base holder and having at least one input hole into which a reaction sample is input and at least one microchamber accommodating the input reaction sample, a flipper rotatably installed at the outside of the microchip on the base holder and opening and closing the input hole of the microchip while flipping up in a vertically erected state or flipping down in a horizontal state, and slider installed at the outside of the flipper on the base holder to be capable of sliding and supporting the flipper in the erected state and flipping down the flipper while moving inside.

摘要翻译： 提供了一种微芯片组件，其包括基座，安装在基座上的微芯片，并具有输入反应样品的至少一个输入孔和容纳该输入反应样品的至少一个微室， 该微型芯片位于基座上，并且在垂直竖立状态下翻转或以水平状态翻转时打开和关闭微芯片的输入孔，以及滑块安装在底架上的导板外侧以能够滑动 并且在竖立状态下支撑导板，并在向内移动的情况下翻转导板。

公开(公告)号：US20060246487A1

公开(公告)日：2006-11-02

申请号：US11391850

申请日：2006-03-29

申请人： Kwang-wook Oh ,  Yu-jin Seo

发明人： Kwang-wook Oh ,  Yu-jin Seo

IPC分类号： C12Q1/68

CPC分类号： B01L3/502715 ,  B01L3/565 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/0816 ,  B01L2400/065

摘要： Provided is an apparatus for performing a chemical reaction using a microchip having at least one micro-channel. The device, which is a semiautomatic operating device for a microchip on which at least one micro-channel with a reagent inlet is formed, includes: a base which accommodates the microchip; a slider with injection inlets corresponding to the reagent inlets that reciprocally move parallel to the base; and a slider moving unit which selectively moves the slider to a first location at which the microchip is opened, after the injection inlet of the slider and the reagent inlet are aligned, and to a second location where the microchip is sealed by a bottom surface of the slider covering the reagent inlet.

摘要翻译： 提供一种使用具有至少一个微通道的微芯片进行化学反应的装置。 该装置是其上形成有至少一个具有试剂入口的微通道的微芯片的半自动操作装置，包括：容纳微芯片的基座; 具有与所述试剂入口相对应的注射入口的滑块，所述试剂入口与所述底座平行地往复移动; 以及滑块移动单元，其在滑块和试剂入口的注入口对齐之后，将滑块选择性地移动到微芯片打开的第一位置，并且在第二位置，微芯片被底部表面密封 滑块覆盖试剂入口。

公开(公告)号：US07112452B2

公开(公告)日：2006-09-26

申请号：US10278691

申请日：2002-10-23

申请人： Yoon-kyoung Cho ,  Sun-hee Kim ,  Kwang-wook Oh ,  Geun-bae Lim ,  Dae-sung Yoon

发明人： Yoon-kyoung Cho ,  Sun-hee Kim ,  Kwang-wook Oh ,  Geun-bae Lim ,  Dae-sung Yoon

IPC分类号： G01N33/543

CPC分类号： C12Q1/6825 ,  Y10S436/806 ,  C12Q2565/107 ,  C12Q2565/607

摘要： A method and sensor are provided for detecting the binding of a probe and a target biomolecule by measuring a difference in the shear stress on the surface of the sensor before and after hybridization of the target molecule to the probe, such as nucleic acids or proteins. The shear stress may be measured sensitively and conveniently as an electrical signal without additional fluorescent labeling and without use of expensive additional devices.

摘要翻译： 提供了一种方法和传感器，用于通过测量靶分子与探针如核酸或蛋白质杂交前后的传感器表面上的剪切应力差异来检测探针和靶生物分子的结合。 剪切应力可以作为电信号被灵敏地和方便地测量，而不需要额外的荧光标记，而不使用昂贵的附加装置。

公开(公告)号：US20060151732A1

公开(公告)日：2006-07-13

申请号：US11327236

申请日：2006-01-05

申请人： Kwang-wook Oh ,  Kak Namkoong

发明人： Kwang-wook Oh ,  Kak Namkoong

IPC分类号： F16K31/02

CPC分类号： F16K31/0679 ,  Y10T137/87788

摘要： A valve is provided. The valve includes a plunger, a chamber having a first region and a second region where the plunger moves back and forth, a first electromagnet and a second electromagnet which are located around the first region and the second region to apply a magnetic field to the plunger, a fluid inlet through which a fluid enters into the chamber, located between the first region and the second region of the chamber, and a second fluid outlet located on a vertical end part of the second region away from the first region.

摘要翻译： 提供阀门。 阀包括柱塞，具有第一区域和柱塞前后移动的第二区域的腔室，位于第一区域和第二区域周围的第一电磁体和第二电磁体，以向柱塞施加磁场 ，流体入口，流体通过所述流体入口位于所述室的所述第一区域和所述第二区域之间，以及位于所述第二区域的远离所述第一区域的垂直端部的第二流体出口。

公开(公告)号：US20060078931A1

公开(公告)日：2006-04-13

申请号：US11245348

申请日：2005-10-06

申请人： Kwang-wook Oh ,  Yu-jin Seo ,  Gyeong-sik Ok ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park

发明人： Kwang-wook Oh ,  Yu-jin Seo ,  Gyeong-sik Ok ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park

IPC分类号： C12Q1/68 ,  C12M1/34

CPC分类号： B01L3/502715 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/0816 ,  B01L2400/065

摘要： Provided is a microchip unit, including a microchip on which a plurality of micro-channels are formed, a housing disposed below the microchip to fix the microchip; and at least two injecting and sealing elements having through-holes corresponding to inlets of the microchip. The injecting and sealing elements are vertically fixed on the top of the housing and slide in a horizontal direction from a first location to a second location and vice versa. The through-holes are aligned with inlets of the microchip so that a reaction solution can be injected through the through-holes when the injecting and sealing elements are placed at the first location. The inlets of the microchip are sealed by elastic members formed on bottom surfaces of the injecting and sealing elements when the injecting and sealing elements are placed at the second location.

摘要翻译： 提供一种微芯片单元，其包括形成有多个微通道的微芯片，设置在微芯片下面以固定微芯片的壳体; 以及至少两个具有对应于微芯片的入口的通孔的注入和密封元件。 注射和密封元件垂直地固定在壳体的顶部上，并且在从第一位置到第二位置的水平方向上滑动，反之亦然。 通孔与微芯片的入口对准，使得当注射和密封元件放置在第一位置时，反应溶液可以通过通孔注入。 当注射和密封元件放置在第二位置时，微芯片的入口由形成在注射和密封元件的底表面上的弹性构件密封。

公开(公告)号：US08403292B2

公开(公告)日：2013-03-26

申请号：US13402271

申请日：2012-02-22

申请人： Kwang-wook Oh ,  Kak Namkoong ,  Chin-sung Park

发明人： Kwang-wook Oh ,  Kak Namkoong ,  Chin-sung Park

IPC分类号： F16K31/00 ,  F16K31/18

CPC分类号： F15C5/00 ,  F16K99/0001 ,  F16K99/0032 ,  F16K99/0044 ,  F16K99/0046 ,  F16K2099/0084 ,  F16K2099/0086 ,  F16K2099/0092 ,  Y10T137/0391 ,  Y10T137/2191 ,  Y10T137/2196 ,  Y10T137/2224 ,  Y10T137/4643

摘要： Provided is a microvalve having a magnetic wax plug which includes a micro fluidic structure having an inlet portion and an outlet portion, a magnetic wax plug provided at a predetermined 5 section where the inlet portion and the outlet portion meet, existing in a solid state, melted at a temperature higher than a predetermined temperature, and reversibly moving along a magnetic field, so as to control flux of a fluid through the micro fluidic structure, a heating portion provided corresponding to the section and heating the magnetic wax plug to be melted, and a magnetic field 10 application portion selectively applying a magnetic field to a position where the melted magnetic wax plug arrives.

摘要翻译： 本发明提供一种具有磁性蜡塞的微型阀，其包括具有入口部和出口部的微流体结构，以固态存在的入口部和出口部相遇的规定5部设置的磁性蜡塞， 在高于预定温度的温度下熔化，并且沿着磁场可逆地移动，以便控制通过微流体结构的流体的流量，对应于该部分设置的加热部分并加热要熔化的磁性蜡塞， 以及选择性地将磁场施加到熔融的磁性蜡塞到达的位置的磁场10施加部。

公开(公告)号：US20120168016A1

公开(公告)日：2012-07-05

申请号：US13402271

申请日：2012-02-22

申请人： Kwang-wook OH ,  Kak NAMKOONG ,  Chin-sung PARK

发明人： Kwang-wook OH ,  Kak NAMKOONG ,  Chin-sung PARK

IPC分类号： F15C1/04 ,  F15C1/06 ,  F15C7/00 ,  F16K31/66

CPC分类号： F15C5/00 ,  F16K99/0001 ,  F16K99/0032 ,  F16K99/0044 ,  F16K99/0046 ,  F16K2099/0084 ,  F16K2099/0086 ,  F16K2099/0092 ,  Y10T137/0391 ,  Y10T137/2191 ,  Y10T137/2196 ,  Y10T137/2224 ,  Y10T137/4643

摘要： Provided is a microvalve having a magnetic wax plug which includes a micro fluidic structure having an inlet portion and an outlet portion, a magnetic wax plug provided at a predetermined 5 section where the inlet portion and the outlet portion meet, existing in a solid state, melted at a temperature higher than a predetermined temperature, and reversibly moving along a magnetic field, so as to control flux of a fluid through the micro fluidic structure, a heating portion provided corresponding to the section and heating the magnetic wax plug to be melted, and a magnetic field 10 application portion selectively applying a magnetic field to a position where the melted magnetic wax plug arrives.

摘要翻译： 本发明提供一种具有磁性蜡塞的微型阀，其包括具有入口部和出口部的微流体结构，以固态存在的入口部和出口部相遇的规定5部设置的磁性蜡塞， 在高于预定温度的温度下熔化，并且沿着磁场可逆地移动，以便控制通过微流体结构的流体的流量，对应于该部分设置的加热部分并加热待熔化的磁性蜡塞， 以及选择性地将磁场施加到熔融的磁性蜡塞到达的位置的磁场10施加部。

公开(公告)号：US20110079289A1

公开(公告)日：2011-04-07

申请号：US12968752

申请日：2010-12-15

申请人： Kwang-wook OH ,  Kak NAMKOONG ,  Chin-sung PARK

发明人： Kwang-wook OH ,  Kak NAMKOONG ,  Chin-sung PARK

IPC分类号： F15D1/00

CPC分类号： F15C5/00 ,  F16K99/0001 ,  F16K99/0032 ,  F16K99/0044 ,  F16K99/0046 ,  F16K2099/0084 ,  F16K2099/0086 ,  F16K2099/0092 ,  Y10T137/0391 ,  Y10T137/2191 ,  Y10T137/2196 ,  Y10T137/2224 ,  Y10T137/4643

摘要： Provided is a microvalve having a magnetic wax plug which includes a micro fluidic structure having an inlet portion and an outlet portion, a magnetic wax plug provided at a predetermined section where the inlet portion and the outlet portion meet, existing in a solid state, melted at a temperature higher than a predetermined temperature, and reversibly moving along a magnetic field, so as to control flux of a fluid through the micro fluidic structure, a heating portion provided corresponding to the section and heating the magnetic wax plug to be melted, and a magnetic field application portion selectively applying a magnetic field to a position where the melted magnetic wax plug arrives.

摘要翻译： 提供一种具有磁性蜡塞的微型阀，其包括具有入口部分和出口部分的微流体结构，设置在入口部分和出口部分相遇的预定部分处的固体状态的熔融蜡 在高于预定温度的温度下，并且沿着磁场可逆地移动，以便控制通过微流体结构的流体的通量;对应于该部分设置的加热部分，并加热待熔化的磁性蜡塞;以及 选择性地将磁场施加到熔融的磁性蜡塞到达的位置的磁场施加部。