-
公开(公告)号：US20170253921A1
公开(公告)日：2017-09-07
申请号：US15518016
申请日：2015-10-13
发明人： Chunmei LIU , Shoulian DONG , Junko STEVENS
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6851 , C12Q1/6853 , C12Q1/686 , C12Q1/6883 , C12Q2537/16 , C12Q2537/161 , C12Q2545/107 , C12Q2545/113 , C12Q2600/16
摘要： The present specification relates to methods, compositions, and kits for determining the presence of the number of copies of a gene. The present disclosure provides methods and compositions to determine zygosity in transgenic plants, number of transgenes in a plant or animal, karyotyping, determine CNV in human and animal samples, diagnose and detect diseases and conditions that are characterized by having variations in the number of copies of one or more genes.
-
公开(公告)号：US20240361348A1
公开(公告)日：2024-10-31
申请号：US18640345
申请日：2024-04-19
发明人： Alexandre VLASSOV , Timothy BARTA , Justin INSLEE , Ethan GENTERT , Robert SMITH , Sara THIELE , Carolyn ADAMS , Kraig KRUGER , Robert Schneider , Wade LUKIANOW , Jay GRECO , Jason JONES , David CERRONE , Sumonto GHOSH , Brian VAJDA , Andrew BASTA , Allan EVANS , Christopher CROWLEY , Robert SETTERQUIST , Anne COX , Mark MAYERNICK
CPC分类号： G01N35/1016 , B01D61/58 , B01D69/02 , G01N1/405 , G01N1/4077 , G01N21/59 , G01N35/00584 , G01N35/1081 , B01D2311/2642 , B01D2313/44 , B01D2313/50 , B01D2313/58 , B01D2319/025 , B01D2325/42 , G01N2001/4088 , G01N2035/1025 , G01N2035/1053
摘要： Purifying target biomolecules, such as nucleic acids or proteins, from a biological source is a time intensive process and is typically performed by a skilled technician or scientist owing to the highly technical nature of the work. Systems, devices, and methods disclosed herein enable the automated bioprocessing and purification of target biomolecules from a biological source. For example, an instrument and disposable cartridge are provided for automatedly isolating and purifying nucleic acids (such as plasmid DNA from a bacterial culture) or for isolating protein from any biological sample. Such an exemplary instrument and cartridge can work in concert to timely release, mix, and move the target biomolecule and various reagents and buffers through a target biomolecule purification process, resulting in a purified target biomolecule with less manual oversight than traditional approaches.
-
公开(公告)号：US12131399B2
公开(公告)日：2024-10-29
申请号：US16543475
申请日：2019-08-16
发明人： Shanti Shankar , Sean Zimmerman , Mark Beauchemin , John Thompson
CPC分类号： G06T1/0014 , G01N2035/00801
摘要： A method for user guided initiating of an instrument includes receiving a run plan via a user interface of the instrument; indicating on the user interface, based on the run plan, a consumable to be provided to the instrument; detecting the presence of the consumable using a vision system; and indicating the presence of the consumable via the user interface.
-
4.发明授权公开(公告)号：US12098424B2
公开(公告)日：2024-09-24
申请号：US16999001
申请日：2020-08-20
发明人： Marcin Sikora
IPC分类号： C12Q1/6874 , G16B30/00 , G16B30/10
CPC分类号： C12Q1/6874 , G16B30/00 , G16B30/10 , C12Q1/6874 , C12Q2537/157 , C12Q2545/101
摘要： A method for designing test or control sequences may include identifying, using a variant caller, loci with systematic errors present in a plurality of sequencing runs included in a training set of sequencing runs obtained using sequencing-by-synthesis; and selecting a representative set of loci, including selecting from the identified loci an approximately equal number of loci involving errors in A, T, C, and G homopolymers and selecting from the identified loci an approximately equal number of loci involving homopolymers having a length of two, three, and four.
-
公开(公告)号：US20240309441A1
公开(公告)日：2024-09-19
申请号：US18583747
申请日：2024-02-21
发明人： Mingsong Chen , Soo Yong Lau , Kuan Moon Boo , Mauro Aguanno , Huei Yeo , Tiong Han Toh , Wei Fuh Teo
CPC分类号： C12Q1/686 , B01L7/52 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/6458 , G02B21/244 , B01L2200/10 , B01L2300/0654 , B01L2300/0829 , B01L2300/168 , B01L2300/18 , G01N2021/6463
摘要： An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The instrument may further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.
-
公开(公告)号：US12092605B2
公开(公告)日：2024-09-17
申请号：US18166745
申请日：2023-02-09
发明人： Marc Haberstroh , Geoffrey Dahlhoff
IPC分类号： G01N27/447 , G01F23/263 , G01R19/25
CPC分类号： G01N27/44713 , G01F23/263 , G01N27/44782 , G01R19/25
摘要： The present disclosure relates, in some embodiments, to a system for measuring capillary electrophoresis current. The system includes a plurality of capillaries, where each capillary has a cathode end and an anode end. The system further includes a plurality of cathode buffers. Each of the cathode buffers is configured to be electrically isolated from the other cathode buffers. Further, each cathode buffer is associated with one capillary of the plurality of capillaries. The cathode end of each capillary is immersed in its associated cathode buffer. The system includes a plurality of current sensors, each current sensor associated with one capillary of the plurality of capillaries for measuring current. In some embodiments, the plurality of capillaries is four capillaries.
-
公开(公告)号：US12077742B2
公开(公告)日：2024-09-03
申请号：US16853865
申请日：2020-04-21
IPC分类号： C12M1/06 , B01F27/1111 , B01F27/191 , B01F27/2111 , B01F35/41 , B01F35/513 , B01F101/44 , C12M1/00 , C12M1/02 , C12N1/00
CPC分类号： C12M27/02 , B01F27/1111 , B01F27/191 , B01F27/2111 , B01F35/4121 , B01F35/513 , C12M1/007 , C12M1/02 , C12M23/14 , C12N1/00 , B01F2101/44
摘要： A method for mixing a biological suspension includes disposing a biological suspension within a compartment of a container, the biological suspension comprising cells or microorganisms suspended within a nutrient growth medium; and rotating a first drive line and laterally spaced apart second drive line within the compartment of the container so as to cause the drive lines to twist into a helical configuration and mix the biological suspension.
-
公开(公告)号：US20240287428A1
公开(公告)日：2024-08-29
申请号：US18654917
申请日：2024-05-03
发明人： Michael E. Goodwin , Nephi D. JONES
IPC分类号： C12M1/00 , B01F27/07 , B01F27/113 , B01F27/2121 , B01F27/213 , B01F27/231 , B01F27/61 , B01F33/00 , B01F35/22 , B01F35/513 , B01F35/71 , C12M1/06 , C12M1/34 , C12M3/00
CPC分类号： C12M23/14 , B01F27/071 , B01F27/113 , B01F27/2121 , B01F27/213 , B01F27/2312 , B01F27/61 , B01F33/86 , B01F35/2209 , B01F35/513 , C12M23/26 , C12M23/48 , C12M23/52 , C12M27/02 , C12M27/06 , C12M41/00 , B01F35/715
摘要： A fluid mixing system includes a support housing having an interior surface bounding a chamber. A flexible bag is disposed within the chamber of the support housing, the flexible bag having an interior surface bounding a compartment. An impeller is disposed within the chamber of the flexible bag. A drive shaft is coupled with the impeller such that rotation of the drive shaft facilitates rotation of the impeller. A drive motor assembly is coupled with the draft shaft and is adapted to rotate the drive shaft. An adjustable arm assembly is coupled with the drive motor assembly and is adapted to move the drive motor assembly which in turn moves the position of the drive shaft and impeller. An electrical controller can control movement of the adjustable arm.
-
公开(公告)号：US20240286066A1
公开(公告)日：2024-08-29
申请号：US18692700
申请日：2022-09-16
发明人： Scott T. Hanks , Steven R. KJAR
IPC分类号： B01D19/00
CPC分类号： B01D19/0068 , B01D19/0063
摘要： A bubble trap includes a body having an interior surface bounding a cavity that extends between an upper end and an opposing lower end, an axis extends centrally through the cavity of the body between the upper end and the lower end, a first plane extends through the body orthogonal to the axis so as to divide the body into an upper body portion and a lower body, the interior surface of the lower body portion having a constant first radius from a fixed first center point, the interior surface of the upper body portion not having a constant radius from a fixed center point. A tubular spout projects into the cavity at the lower end encircles a channel that communicates with the cavity. A liquid inlet port, a liquid outlet port, and a gas outlet port communicate with the cavity.
-
公开(公告)号：US12070731B2
公开(公告)日：2024-08-27
申请号：US17505075
申请日：2021-10-19
发明人： Colin Brenan , Jamie Cho , Javier Garcia , Robert Hess , Tanya Kanigan , Arrin Katz , Namyong Kim , John Linton , Shailesh Srivastava , Karl Yoder
CPC分类号： B01J19/0046 , B01L3/50857 , B01J2219/0059 , B01J2219/00596 , B01J2219/00659 , B01L3/0244 , B01L3/5025 , B01L2200/12 , B01L2200/16 , B01L2300/16
摘要： A method of registering a location of a dispenser array in relation to a microfluidic array is provided. One of the dispenser array and the microfluidic array can be movable in relation to the frame, and the other can be fixed relative to the frame. Their relative positions can be identified by a set of coordinates. Identification of a fiducial marker can occur in a manner permitting the fiducial reference to appear in a first position of a field of view of a first camera when the dispenser array or the microfluidic array is in an alignment position. Quantities related to a vector displacement from the alignment position to a fixed position on the microfluidic array or the dispenser array can be identified. Quantities determined can be used to guide positioning of the dispenser array relative to the microfluidic array.
-
-
-
-
-
-
-
-
-
搜索结果
2729 条记录 (耗时 0.043 秒)
