公开(公告)号：US08853212B2

公开(公告)日：2014-10-07

申请号：US13520653

申请日：2011-02-17

申请人： Robert R. Wilkening ,  James M. Apgar ,  Tesfaye Biftu ,  Danqing Feng ,  Xiaoxia Qian ,  Lan Wei

发明人： Robert R. Wilkening ,  James M. Apgar ,  Tesfaye Biftu ,  Danqing Feng ,  Xiaoxia Qian ,  Lan Wei

IPC分类号： C07D487/04 ,  C07D498/04 ,  A61K31/519 ,  A61K31/404 ,  A61K31/4162 ,  A61K31/4188 ,  A61K31/424 ,  A61K31/4985 ,  A61P29/00 ,  A61P37/00 ,  A61P9/00 ,  A61P3/10 ,  C07D335/02

CPC分类号： C07D487/04 ,  C07D335/02 ,  C07D498/04 ,  C07B2200/07

摘要： The present invention is directed to novel substituted aminotetrahydrothiopyrans and derivatives thereof of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

摘要翻译： 本发明涉及作为二肽基肽酶-IV酶的抑制剂的结构式（I）的新型取代的氨基四氢硫代吡喃及其衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病， 如糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

公开(公告)号：US08193735B2

公开(公告)日：2012-06-05

申请号：US12527021

申请日：2008-02-15

申请人： Lan Wei ,  Junxiang Han ,  Guochun Liao

发明人： Lan Wei ,  Junxiang Han ,  Guochun Liao

IPC分类号： G05F1/00 ,  H05B37/02 ,  H05B39/04 ,  H05B41/36

CPC分类号： H05B33/0857 ,  F21K9/00 ,  F21Y2115/10 ,  H05B33/0809 ,  Y02B20/341

摘要： A LED lamp and a manufacturing method thereof are disclosed. At least one blue LED chip can be used as an excitation light source. A number of red LED chips are arranged around the blue LED chip. The blue LED chip and red chips are covered with a packaging material with phosphor. The intensity of red light can be adjusted by a control circuit. Thus, the white LED lamps with high efficacy and high color rendering at different color temperatures can be achieved.

摘要翻译： 公开了一种LED灯及其制造方法。 至少可以使用一个蓝色LED芯片作为激发光源。 蓝色LED芯片周围布置了许多红色LED芯片。 蓝色LED芯片和红色芯片用包含磷光体的材料覆盖。 红光的强度可以通过控制电路来调节。 因此，可以实现在不同色温下具有高效率和高显色性的白色LED灯。

公开(公告)号：US07687492B2

公开(公告)日：2010-03-30

申请号：US11587605

申请日：2005-04-29

申请人： Jinyou Xu ,  Lan Wei ,  Anthony Mastracchio ,  Scott D. Edmondson

发明人： Jinyou Xu ,  Lan Wei ,  Anthony Mastracchio ,  Scott D. Edmondson

IPC分类号： A61K31/4245 ,  A61K31/397 ,  A61K31/4525 ,  A61K31/454 ,  A61P3/10 ,  C07D271/07 ,  C07D413/08

CPC分类号： C07D271/06 ,  C07D413/06 ,  C07D417/06

摘要： The present invention is directed to novel 1,2,4-oxadiazole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的新的1,2,4-恶二唑衍生物，其可用于治疗或预防其中二肽基肽酶 - 涉及IV酶，如糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

公开(公告)号：US20130123237A1

公开(公告)日：2013-05-16

申请号：US13812536

申请日：2012-02-23

申请人： Rajan Anand ,  James M. Apgar ,  Tesfaye Biftu ,  Ping Chen ,  Lin Chu ,  Vincent J. Colandrea ,  Guizhen Dong ,  James F. Dropinski ,  Danqing Feng ,  Jacqueline D. Hicks ,  Jinlong Jiang ,  Alexander J. Kim ,  Kenneth J. Leavitt ,  Bing Li ,  Xiaoxia Qian ,  Iyassu Sebhat ,  Lan Wei ,  Robert R. Wilkening ,  Zhicai Wu

发明人： Rajan Anand ,  James M. Apgar ,  Tesfaye Biftu ,  Ping Chen ,  Lin Chu ,  Vincent J. Colandrea ,  Guizhen Dong ,  James F. Dropinski ,  Danqing Feng ,  Jacqueline D. Hicks ,  Jinlong Jiang ,  Alexander J. Kim ,  Kenneth J. Leavitt ,  Bing Li ,  Xiaoxia Qian ,  Iyassu Sebhat ,  Lan Wei ,  Robert R. Wilkening ,  Zhicai Wu

IPC分类号： A61K31/5377 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/351 ,  A61K31/397 ,  A61K31/4412 ,  C07D471/04 ,  A61K31/496

CPC分类号： A61K31/5377 ,  A61K31/351 ,  A61K31/366 ,  A61K31/397 ,  A61K31/437 ,  A61K31/4412 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/519 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00 ,  A61K2300/00

摘要： Novel compounds of structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.

摘要翻译： 结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制由AMPK激活的蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖症，高胆固醇血症和高血压。

公开(公告)号：US20120108595A1

公开(公告)日：2012-05-03

申请号：US13382469

申请日：2010-06-28

申请人： Anthony Ogawa ,  Feroze Ujjainwalla ,  Lin Chu ,  Bing Li ,  Lan Wei ,  Jinyou Xu ,  Hyun Ok ,  Aaron Lackner ,  Ihor Kopka

发明人： Anthony Ogawa ,  Feroze Ujjainwalla ,  Lin Chu ,  Bing Li ,  Lan Wei ,  Jinyou Xu ,  Hyun Ok ,  Aaron Lackner ,  Ihor Kopka

IPC分类号： A61K31/4196 ,  C07D471/04 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D487/04 ,  C07F5/04 ,  A61K31/4245 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/422 ,  A61K31/519 ,  A61K31/497 ,  A61P9/10 ,  A61P29/00 ,  A61P19/02 ,  A61P11/06 ,  A61P1/04 ,  A61P1/00 ,  A61P17/06 ,  C07D413/12

CPC分类号： G01C23/00 ,  G08G5/0056

摘要： Cyclohexyl sulfonamide compounds which are platelet-activating factor (PAF) receptor antagonists. Said compounds may be useful, for example, for the treatment of atherosclerosis or other PAF-mediated disorders, including inflammatory, cardiovascular, and immune disorders.

摘要翻译： 作为血小板活化因子（PAF）受体拮抗剂的环己基磺酰胺化合物。 所述化合物可用于例如治疗动脉粥样硬化或其它PAF介导的病症，包括炎性，心血管和免疫疾病。

公开(公告)号：US09029377B2

公开(公告)日：2015-05-12

申请号：US13382469

申请日：2010-06-28

申请人： Anthony Ogawa ,  Feroze Ujjainwalla ,  Lin Chu ,  Bing Li ,  Lan Wei ,  Jinyou Xu ,  Hyun Ok ,  Aaron Lackner ,  Ihor Kopka

发明人： Anthony Ogawa ,  Feroze Ujjainwalla ,  Lin Chu ,  Bing Li ,  Lan Wei ,  Jinyou Xu ,  Hyun Ok ,  Aaron Lackner ,  Ihor Kopka

IPC分类号： A61K31/50 ,  A61K31/4965 ,  A61K31/505 ,  A61K31/44 ,  A61K31/4245 ,  A61K31/4196 ,  A61K31/42 ,  C07D487/00 ,  C07D401/00 ,  C07D403/00 ,  C07D231/02 ,  C07D271/00 ,  C07D261/02 ,  C07D249/08 ,  G01C23/00 ,  G08G5/00

CPC分类号： G01C23/00 ,  G08G5/0056

摘要： Cyclohexyl sulfonamide compounds which are platelet-activating factor (PAF) receptor antagonists. Said compounds may be useful, for example, for the treatment of atherosclerosis or other PAF-mediated disorders, including inflammatory, cardiovascular, and immune disorders.

摘要翻译： 作为血小板活化因子（PAF）受体拮抗剂的环己基磺酰胺化合物。 所述化合物可用于例如治疗动脉粥样硬化或其它PAF介导的病症，包括炎性，心血管和免疫疾病。

公开(公告)号：US08796258B2

公开(公告)日：2014-08-05

申请号：US13812536

申请日：2012-02-23

申请人： Rajan Anand ,  James M. Apgar ,  Tesfaye Biftu ,  Ping Chen ,  Lin Chu ,  Vincent J. Colandrea ,  Guizhen Dong ,  James F. Dropinski ,  Danqing Feng ,  Jacqueline D. Hicks ,  Jinlong Jiang ,  Alexander J. Kim ,  Kenneth J. Leavitt ,  Bing Li ,  Xiaoxia Qian ,  Iyassu Sebhat ,  Lan Wei ,  Robert R. Wilkening ,  Zhicai Wu

发明人： Rajan Anand ,  James M. Apgar ,  Tesfaye Biftu ,  Ping Chen ,  Lin Chu ,  Vincent J. Colandrea ,  Guizhen Dong ,  James F. Dropinski ,  Danqing Feng ,  Jacqueline D. Hicks ,  Jinlong Jiang ,  Alexander J. Kim ,  Kenneth J. Leavitt ,  Bing Li ,  Xiaoxia Qian ,  Iyassu Sebhat ,  Lan Wei ,  Robert R. Wilkening ,  Zhicai Wu

IPC分类号： A61K31/00 ,  C07D513/02

CPC分类号： A61K31/5377 ,  A61K31/351 ,  A61K31/366 ,  A61K31/397 ,  A61K31/437 ,  A61K31/4412 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/519 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00 ,  A61K2300/00

摘要： Novel compounds of structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.

摘要翻译： 结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制由AMPK激活的蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖症，高胆固醇血症和高血压。

公开(公告)号：US20100072919A1

公开(公告)日：2010-03-25

申请号：US12527021

申请日：2008-02-15

申请人： Lan Wei ,  Junxiang Han ,  Guochun Liao

发明人： Lan Wei ,  Junxiang Han ,  Guochun Liao

IPC分类号： H05B37/02

CPC分类号： H05B33/0857 ,  F21K9/00 ,  F21Y2115/10 ,  H05B33/0809 ,  Y02B20/341

摘要： A LED lamp and a manufacturing method thereof are disclosed. At least one blue LED chip can be used as an excitation light source. A number of red LED chips are arranged around the blue LED chip. The blue LED chip and red chips are covered with a packaging material with phosphor. The intensity of red light can be adjusted by a control circuit. Thus, the white LED lamps with high efficacy and high color rendering at different color temperatures can be achieved.

摘要翻译： 公开了一种LED灯及其制造方法。 至少可以使用一个蓝色LED芯片作为激发光源。 蓝色LED芯片周围布置了许多红色LED芯片。 蓝色LED芯片和红色芯片用包含磷光体的材料覆盖。 红光的强度可以通过控制电路来调节。 因此，可以实现在不同色温下具有高效率和高显色性的白色LED灯。

公开(公告)号：US20240002359A1

公开(公告)日：2024-01-04

申请号：US18254190

申请日：2021-12-01

申请人： Stephane L. BOGEN ,  Ping CHEN ,  Dane James CLAUSSEN ,  Xianhai HUANG ,  Michael T. RUDD ,  Shawn P. WALSH ,  Lan WEI ,  Dexi YANG ,  Merck Sharp & Dohme LLC

发明人： Stephane L. Bogen ,  Ping Chen ,  Dane James Claussen ,  Xianhai Huang ,  Michael T. Rudd ,  Shawn P. Walsh ,  Lan Wei ,  Dexi Yang

IPC分类号： C07D401/04 ,  C07D417/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14

CPC分类号： C07D401/04 ,  C07D417/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14

摘要： The present invention is directed to 3-heteroaryl pyrrolidine and piperidine compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

公开(公告)号：US20230365533A1

公开(公告)日：2023-11-16

申请号：US18040896

申请日：2021-08-16

申请人： Stephane L. BOGEN ,  Dane James CLAUSEN ,  Deodial Guy GUIADEEN ,  Jinsong HAO ,  Shishi LIN ,  Michael T. RUDD ,  Lan WEI ,  Li XIAO ,  Dexi YANG ,  MERCK SHARP & DOHME CORP.

发明人： Stephane L. Bogen ,  Dane James Clausen ,  Deodial Guy Guiadeen ,  Jinsong Hao ,  Shishi Lin ,  Michael T. Rudd ,  Lan Wei ,  Li Xiao ,  Dexi Yang

IPC分类号： C07D403/12 ,  C07D403/14 ,  C07D417/12 ,  C07D491/048

CPC分类号： C07D403/12 ,  C07D403/14 ,  C07D417/12 ,  C07D491/048

摘要： The present invention is directed to bicyclo[4.1 0]heptane pyrrolidine compounds of formula (I) which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.




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