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公开(公告)号：USD610628S1
公开(公告)日：2010-02-23
申请号：US29341496
申请日：2009-08-06
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公开(公告)号：US20070030764A1
公开(公告)日：2007-02-08
申请号：US11544525
申请日：2006-10-05
申请人： Ole Skyggebjerg , Lars Christensen , Rasmus Panduro , Nina Bjorlig , Steffen Lav , Barry Weben , Manuel Alvarez-Icaza , Steven Syme
发明人： Ole Skyggebjerg , Lars Christensen , Rasmus Panduro , Nina Bjorlig , Steffen Lav , Barry Weben , Manuel Alvarez-Icaza , Steven Syme
IPC分类号： G04F10/00
CPC分类号： A61M5/20 , A61J7/0436 , A61M5/178 , A61M5/28 , A61M5/3129 , A61M2005/3125 , A61M2205/50 , A61M2205/581 , G04B25/06 , G04F1/005
摘要： The invention relates to a timer device capable of performing one or more control actions in response to the time lapsed since a user initiated action took place. The timer device comprises contact means operatable between two conditions, timer means, and means for storing first and second time stamps. The device further comprises control means for setting a first time stamp in response to the contact means being operated between first and second conditions, setting a second time stamp in response to the contact means being operated between the second and first conditions, calculating the time elapsed between the two time stamps, comparing the elapsed time with a preset time value, and performing a control action if the elapsed time is greater than the preset time value.
摘要翻译： 本发明涉及一种定时器装置，其能够响应于由于用户发起动作而发生的时间而执行一个或多个控制动作。 定时器装置包括可在两个状态之间操作的接触装置，定时器装置和用于存储第一和第二时间戳的装置。 该装置还包括控制装置，用于响应于在第一和第二条件之间操作的接触装置来设置第一时间戳，响应于在第二和第一条件之间操作的接触装置设置第二时间戳，计算经过的时间 在两个时间戳之间，将经过的时间与预设时间值进行比较，以及如果经过时间大于预设时间值，则执行控制动作。
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3.发明授权Process for producing an iron-dextran compound, iron-dextran compound produced according to said process, pharmaceutical composition for prophylaxis or treatment of iron-deficiency and use of said compound for the preparation of parenterally administrable pharmaceutical composition 失效用于制备铁 - 葡聚糖化合物的方法，根据所述方法制备的铁 - 葡聚糖化合物，用于预防或治疗缺铁的药物组合物和所述化合物用于制备肠胃外给药的药物组合物公开(公告)号：US06977249B1
公开(公告)日：2005-12-20
申请号：US09509681
申请日：1999-07-29
IPC分类号： A61K9/14 , A61K9/08 , A61K31/295 , A61K31/715 , A61K31/721 , A61K47/12 , A61K47/48 , A61P3/02 , A61P7/06 , C08B37/00 , C08B37/02 , A61K31/70
CPC分类号： C08B37/0021 , A61K31/721 , A61K47/61
摘要： In a process for producing an iron-dextran compound for use in parenteral treatment of iron-deficiency in humans or animals a stable compound of desired relatively low molecular weight is obtained by using first hydrogenation and then oxidation to convert reducing terminal groups on the dextran molecules before reaction with the iron. By varying the ratio of hydrogenated groups to oxygenated groups the average molecular weight of the resulting iron-dextran compound can be varied.
摘要翻译： 在制备用于人或动物缺铁处理的铁葡聚糖化合物的方法中，通过使用第一氢化然后氧化以转化葡聚糖分子上的还原性末端基团，获得所需相对低分子量的稳定化合物 在与铁反应之前。 通过改变氢化基团与氧化基团的比例，可以改变所得铁 - 葡聚糖化合物的平均分子量。
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公开(公告)号：USD600291S1
公开(公告)日：2009-09-15
申请号：US29327191
申请日：2008-10-31
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公开(公告)号：US20090170747A1
公开(公告)日：2009-07-02
申请号：US12394202
申请日：2009-02-27
申请人： Kim Vilbour Andersen , Martin Schulein , Torben Henriksen , Lars Christensen , Bo Damgaard , Claus Von der Osten
发明人： Kim Vilbour Andersen , Martin Schulein , Torben Henriksen , Lars Christensen , Bo Damgaard , Claus Von der Osten
CPC分类号： C11D3/38645 , C12N9/2437 , C12Y302/01004
摘要： The present invention relates to a method for improving the properties of a cellulolytic enzyme by amino acid substitution, deletion or insertion, the method comprising the steps of:a. constructing a multiple alignment of at least two amino acid sequences known to have three-dimensional structures similar to endoglucanase V (EGV) from Humicola insolens known from Protein Data Bank entry 4ENG; b. constructing a homology-built three-dimensional structure of the cellulolytic enzyme based on the structure of the EGV; c. identifying amino acid residue positions present in a distance from the substrate binding cleft of not more than 5 Å; d. identifying surface-exposed amino acid residues of the enzyme; e. identifying all charged or potentially charged amino acid residue positions of the enzyme; f. choosing one or more positions wherein the amino acid residue is to be substituted, deleted or where an insertion is to be provided; and g. carrying out the substitution, deletion or insertion by using conventional protein engineering techniques. Also described are cellulase variants obtained by this method.
摘要翻译： 本发明涉及通过氨基酸取代，缺失或插入改进纤维素分解酶的性质的方法，该方法包括以下步骤：a。 构建已知具有类似于蛋白质数据库条目4ENG中已知的Humicola insolens的内切葡聚糖酶V（EGV）的三维结构的至少两个氨基酸序列的多重比对; b。 基于EGV的结构构建纤维素分解酶的同源构建的三维结构; C。 鉴定存在于与所述基质结合裂缝一定距离的氨基酸残基位置不大于5埃; d。 鉴定酶的表面暴露的氨基酸残基; e。 鉴定酶的所有带电荷或潜在带电的氨基酸残基位置; F。 选择其中氨基酸残基被取代，缺失或提供插入的一个或多个位置; 和g。 通过使用常规蛋白质工程技术进行取代，缺失或插入。 还描述了通过该方法获得的纤维素酶变体。
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6.发明申请Use of glycosides of mono- and diacylglycerol as anti-inflammatory agents 审中-公开使用单酰基甘油和二酰基甘油的糖苷作为抗炎剂公开(公告)号：US20050049205A1
公开(公告)日：2005-03-03
申请号：US10962664
申请日：2004-10-13
IPC分类号： C07H15/10 , A61K31/00 , A61K31/70 , A61K31/7012 , A61K31/7024 , A61K31/7032 , A61K45/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P9/10 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/06 , A61P37/08 , A61P39/06 , C07H15/04 , C07H15/06
CPC分类号： A61K31/366 , A61K9/48
摘要： Glycosides of diacylglycerol, e.g. 3-β-D-galactopyranosyloxy-2-(octadeca-9Z,12Z,15Z-trienoyloxy)propanyl octadeca-9Z,12Z,15Z-trienoate (GOPO), which was isolated from extracts of rose-hips by activity guided fractionation, can be used as an oral anti-inflammatory agent for the treatment of inflammatory diseases such as arthritis and osteoarthrosis.
摘要翻译： 二酰基甘油的糖苷，例如 可以通过活性引导分馏从玫瑰果提取物中分离出3-β-D-吡喃半乳糖氧基-2-（十八烷-9Z，12Z，15Z-三烯酰氧基）十八烷-9Z，12Z，15Z-三烯酸（GOPO） 用作治疗炎性疾病如关节炎和骨关节病的口服抗炎药。
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公开(公告)号：US07993898B2
公开(公告)日：2011-08-09
申请号：US12394202
申请日：2009-02-27
申请人： Kim Vilbour Andersen , Martin Schulein , Torben Henriksen, legal representative , Lars Christensen , Bo Damgaard , Claus Von der Osten
CPC分类号： C11D3/38645 , C12N9/2437 , C12Y302/01004
摘要： The present invention relates to a method for improving the properties of a cellulolytic enzyme by amino acid substitution, deletion or insertion, the method comprising the steps of: a. constructing a multiple alignment of at least two amino acid sequences known to have three-dimensional structures similar to endoglucanase V (EGV) from Humicola insolens known from Protein Data Bank entry 4ENG; b. constructing a homology-built three-dimensional structure of the cellulolytic enzyme based on the structure of the EGV; c. identifying amino acid residue positions present in a distance from the substrate binding cleft of not more than 5 Å; d. identifying surface-exposed amino acid residues of the enzyme; e. identifying all charged or potentially charged amino acid residue positions of the enzyme; f. choosing one or more positions wherein the amino acid residue is to be substituted, deleted or where an insertion is to be provided; and g. carrying out the substitution, deletion or insertion by using conventional protein engineering techniques. Also described are cellulase variants obtained by this method.
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公开(公告)号：US20070285652A1
公开(公告)日：2007-12-13
申请号：US11568552
申请日：2005-04-26
申请人： Jan Nielsen , Lars Christensen
发明人： Jan Nielsen , Lars Christensen
IPC分类号： G01N21/88
CPC分类号： H04N1/1013 , H04N1/128 , H04N2201/0456
摘要： Disclosed is an apparatus for scanning a surface with electromagnetic radiation. The apparatus comprises a base plate for supporting a medium said medium having a scanning surface to be scanned, an optical head unit adapted to scan the scanning surface with electromagnetic radiation propagating along an optical axis, a fluid film generation unit connected to the optical head unit and adapted to generate a fluid film between the scanning surface and a gliding surface of the fluid film generation unit for maintaining a predetermined distance between the gliding surface and the scanning surface during scanning operation of the optical head unit across the scanning surface, and control means for controlling the position of the fluid film relative to the optical axis.
摘要翻译： 公开了一种用电磁辐射扫描表面的装置。 该装置包括用于支撑介质的基板，所述介质具有要扫描的扫描表面;光头单元，适于沿着沿着光轴传播的电磁辐射扫描扫描表面;流体膜产生单元，连接到光学头单元 适于在所述扫描面与所述流体膜产生单元的滑动面之间产生流体膜，用于在所述光学头单元横扫所述扫描面的扫描动作期间，在所述滑行面与所述扫描面之间保持规定的距离， 用于控制流体膜相对于光轴的位置。
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公开(公告)号：US20070239133A1
公开(公告)日：2007-10-11
申请号：US11763024
申请日：2007-06-14
申请人： Lars Christensen , Jens Poulsen , Jan Simonsen
发明人： Lars Christensen , Jens Poulsen , Jan Simonsen
IPC分类号： A61M31/00
CPC分类号： A61B5/0404 , A61B5/14532
摘要： This invention relates to a doser comprising a syringe (2) with a needle (3) which extends beyond the doser (1), which comprises an engagement face (4) in the vicinity of the needle so that the engagement face rests against the surface of the tissue into which the needle is inserted. Detector means (5) are provided on said engagement face to sample signals on the skin of the patient. The invention further provides means (13) for receiving external information related to health monitoring of a patient. This provides a doser that may record heart rate, EKG, BGM and hypo-alarm administered medicine. The doser may further be arranged to calculate an appropriate dose of medication on the basis of a number of acquired inputs.
摘要翻译： 本发明涉及一种配料器，其包括具有延伸超过定料器（1）的针（3）的注射器（2），其包括在针附近的接合面（4），使得接合面靠在表面 的针被插入其中的组织。 检测器装置（5）设置在所述接合面上以对患者的皮肤采样信号。 本发明还提供了用于接收与患者的健康监测相关的外部信息的装置（13）。 这提供了可以记录心率，EKG，BGM和低报警药物的加药器。 可以进一步将加料器设置为基于所获取的输入的数量来计算适当剂量的药物。
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