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公开(公告)号:US20080076762A1
公开(公告)日:2008-03-27
申请号:US11720181
申请日:2005-11-21
申请人: Christoph Boss , Daniel Bur , Olivier Corminboeuf , Corinna Grisostomi , Lars Prade , Thomas Weller
发明人: Christoph Boss , Daniel Bur , Olivier Corminboeuf , Corinna Grisostomi , Lars Prade , Thomas Weller
IPC分类号: A61K31/541 , A61K31/4468 , A61K31/4523 , A61P33/06 , C07D241/04 , C07D295/00 , C07D221/00 , A61K31/496 , A61K31/5377
CPC分类号: C07D409/14 , C07D211/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14
摘要: Novel substituted 4-aminopiperidine derivatives of the formula I: wherein n, R1, Y, and are as defined in claim 1, and optically pure enantiomers, mixtures of enantiomers, racemates, diastereomers, mixtures of diastereomers, diastereomeric racemates, mixtures of diastereomeric racemates and meso-forms, as well as salts and solvent complexes of such compounds, and morphological forms, that exhibit useful parasite aspartic proteases inhibiting properties and can thus be used in the form of pharmaceutical compositions as antimalarial medicines.
摘要翻译: 式I的新型取代的4-氨基哌啶衍生物:其中n,R 1,Y和如权利要求1中所定义,和光学纯对映异构体,对映异构体的混合物,外消旋体,非对映异构体,非对映异构体的混合物 ,非对映异构体外消旋体,非对映体外消旋体和内消旋体的混合物,以及这些化合物的盐和溶剂配合物,以及形态形式,其表现出有用的寄生虫天冬氨酸蛋白酶抑制性质,因此可以以药物组合物的形式用作抗疟药物 。