公开(公告)号：US20060193920A1

公开(公告)日：2006-08-31

申请号：US11275069

申请日：2005-12-07

Applicant: H. Bosch ,  Greta Cary ,  Douglas Hovey ,  Rajeev Jain ,  Laura Kline ,  Elaine Merisko-Liversidge ,  Kevin Ostrander

Inventor： H. Bosch ,  Greta Cary ,  Douglas Hovey ,  Rajeev Jain ,  Laura Kline ,  Elaine Merisko-Liversidge ,  Kevin Ostrander

IPC: A61K48/00 ,  A61K38/17 ,  A61K31/66 ,  A61K31/525 ,  A61K31/522 ,  A61K31/385 ,  A61K31/557 ,  A61K36/82 ,  A61K36/886 ,  A61K36/328

CPC classification number: A61K38/1709 ,  A61K9/0075 ,  A61K9/146 ,  A61K9/2022 ,  A61K31/385 ,  A61K31/522 ,  A61K31/525 ,  A61K31/557 ,  A61K31/66

Abstract: Nanoparticulate compositions comprising at least one poorly soluble MAP kinase inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions.

Abstract translation: 描述了包含至少一种难溶性MAP激酶抑制剂和至少一种表面稳定剂的纳米颗粒组合物。 纳米颗粒组合物具有小于约2000nm的平均粒度。 本发明还描述了制备和使用这些组合物的方法。

公开(公告)号：US07763278B2

公开(公告)日：2010-07-27

申请号：US10457811

申请日：2003-06-10

Applicant: Eugene R. Cooper ,  Laura Kline ,  Gary G. Liversidge ,  Niels P. Ryde

Inventor： Eugene R. Cooper ,  Laura Kline ,  Gary G. Liversidge ,  Niels P. Ryde

IPC: A61K9/00 ,  A61K9/10 ,  A61K9/12 ,  A61K9/14

CPC classification number: A61K45/06 ,  A23L33/10 ,  A23L33/105 ,  A61K9/145 ,  A61K31/045 ,  A61K31/56

Abstract: The present invention is directed to nanoparticulate compositions comprising one or more polycosanols. The polycosanol particles of the composition have an effective average particle size of less than about 2000 nm. In another aspect of this invention, novel combinations of polycosanols and other cholesterol lowering agents are described and methods of using same are taught.

Abstract translation: 本发明涉及包含一种或多种聚果糖的纳米颗粒组合物。 组合物的聚山糖醇颗粒具有小于约2000nm的有效平均粒度。 在本发明的另一方面，描述了聚山梨醇和其它降胆固醇剂的新型组合，并教导了其使用方法。

公开(公告)号：US20100143962A1

公开(公告)日：2010-06-10

申请号：US12704426

申请日：2010-02-11

Applicant: Eugene R. COOPER ,  Laura Kline ,  Gary G. Liversidge ,  Niels P. Ryde

Inventor： Eugene R. COOPER ,  Laura Kline ,  Gary G. Liversidge ,  Niels P. Ryde

IPC: C12N5/078 ,  C12M3/00 ,  C12M3/06 ,  C12Q1/02

CPC classification number: A61K45/06 ,  A23L33/10 ,  A23L33/105 ,  A61K9/145 ,  A61K31/045 ,  A61K31/56

Abstract: The invention provides a culture device comprising a plurality of culture units, wherein each unit comprises a culture chamber, an inlet port for liquid supply of the culture and an outlet port for discharging liquid from the unit, wherein the inlet port is in fluid communication with the culture chamber and the culture chamber is in fluid communication with the outlet port for allowing a liquid flow through the culture chamber. The culture device is particularly suitable for testing immune cells and immunofunction in vitro. Aspects of the invention include a culture device and associated methods for cultivating immune cells and an in vitro method of analysing the effect of a test compound on immune cells.

Abstract translation: 本发明提供了一种包括多个培养单元的培养装置，其中每个单元包括培养室，用于液体供应培养物的入口和用于从该单元排出液体的出口，其中入口端口与 培养室和培养室与出口流体连通，以允许液体流过培养室。 培养装置特别适用于体外检测免疫细胞和免疫功能。 本发明的方面包括培养装置和培养免疫细胞的相关方法以及分析试验化合物对免疫细胞的作用的体外方法。

公开(公告)号：US08512727B2

公开(公告)日：2013-08-20

申请号：US10784900

申请日：2004-02-24

Applicant: Eugene R. Cooper ,  Tuula Ryde ,  John Pruitt ,  Laura Kline

Inventor： Eugene R. Cooper ,  Tuula Ryde ,  John Pruitt ,  Laura Kline

IPC: A61F13/00 ,  A61K9/14

CPC classification number: A61K9/145 ,  A61K9/0019 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/146 ,  A61K9/2059 ,  Y10T428/2982 ,  Y10T428/2985 ,  Y10T428/2987

Abstract: The present invention is directed to nanoparticulate compositions comprising meloxicam. The meloxicam particles of the composition have an effective average particle size of less than about 2000 nm.

Abstract translation: 本发明涉及包含美洛昔康的纳米颗粒组合物。 组合物的美洛昔康颗粒具有小于约2000nm的有效平均粒度。

公开(公告)号：US20100297252A1

公开(公告)日：2010-11-25

申请号：US12788203

申请日：2010-05-26

Applicant: Eugene R. Cooper ,  Tuula Ryde ,  John Pruitt ,  Laura Kline

Inventor： Eugene R. Cooper ,  Tuula Ryde ,  John Pruitt ,  Laura Kline

IPC: A61K9/14 ,  A61K31/5415 ,  A61P29/00 ,  C07D417/12

CPC classification number: A61K31/5415 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/10 ,  A61K9/14 ,  A61K9/145 ,  A61K9/146 ,  A61K9/5123 ,  A61K9/5138 ,  A61K9/5169 ,  A61K9/5192

Abstract: The present invention is directed to nanoparticulate compositions comprising meloxicam particles having an effective average particle size of less than about 2000 nm.

Abstract translation: 本发明涉及包含有效平均粒径小于约2000nm的美洛昔康颗粒的纳米颗粒组合物。