中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

16 records (took 0.015 seconds)

筛选除外

    Alkanolamine derivatives
    6.
    发明授权
    Alkanolamine derivatives 失效
    烷醇胺衍生物

    公开(公告)号：US4171374A

    公开(公告)日：1979-10-16

    申请号：US878446

    申请日：1978-02-16

    Applicant: Leslie H. Smith

    Inventor： Leslie H. Smith

    IPC: C07C233/00 ,  C07C271/20 ,  C07C275/14 ,  C07C275/28 ,  A61K31/17 ,  A61K31/215 ,  A61K31/275 ,  C07C127/19

    CPC classification number: C07C275/28 ,  C07C233/00 ,  C07C271/20 ,  C07C275/14

    Abstract: Novel 1-aryloxy-3-amidoalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity and some of them additionally possess cardiac stimulant activity. Representative of the compounds disclosed is 1-(2-fluorophenoxy)-3-.beta.-(3-benzylureido) ethylamino-2-propanol.

    Abstract translation: 新的1-芳氧基-3-酰氨基烷基氨基-2-丙醇衍生物，其制备方法，含有它们的药物组合物和使用它们在治疗心脏病中的方法。 该化合物具有β-肾上腺素能阻滞活性，其中一些另外具有心脏兴奋剂活性。 所公开的化合物的代表是1-（2-氟苯氧基）-3-β-（3-苄基脲基）乙基氨基-2-丙醇。

    Pharmaceutical compositions and uses of alkanolamine derivatives
    8.
    发明授权
    Pharmaceutical compositions and uses of alkanolamine derivatives 失效
    烷醇胺衍生物的药物组合物和用途

    公开(公告)号：US4131685A

    公开(公告)日：1978-12-26

    申请号：US880495

    申请日：1978-02-23

    Applicant: Leslie H. Smith

    Inventor： Leslie H. Smith

    IPC: C07C233/00 ,  C07C271/20 ,  C07C275/14 ,  C07C275/28 ,  A61K31/17 ,  A61K31/275

    CPC classification number: C07C275/28 ,  C07C233/00 ,  C07C271/20 ,  C07C275/14

    Abstract: 1-Aryloxy-3-amidoalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity and some of them additionally possess cardiac stimulant activity. Representative of the compounds disclosed is 1-phenoxy-3-.beta.-isobutyramidoethylamino-2-propanol.

    Abstract translation: 1-芳氧基-3-酰氨基烷基氨基-2-丙醇衍生物，其制备方法，含有它们的药物组合物和使用它们治疗心脏病的方法。 该化合物具有β-肾上腺素能阻滞活性，其中一些另外具有心脏兴奋剂活性。 所公开的化合物的代表是1-苯氧基-3β-异丁酰胺基乙基氨基-2-丙醇。

    Alkanolamine derivatives
    10.
    发明授权
    Alkanolamine derivatives 失效
    烷醇胺衍生物

    公开(公告)号：US4399138A

    公开(公告)日：1983-08-16

    申请号：US344969

    申请日：1982-02-02

    Applicant: Jeffrey J. Barlow ,  Leslie H. Smith

    Inventor： Jeffrey J. Barlow ,  Leslie H. Smith

    IPC: A61K31/495 ,  A61K31/535 ,  A61P7/10 ,  A61P25/02 ,  C07D241/26 ,  C07D241/28 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D241/16

    CPC classification number: C07D403/12 ,  C07D241/26 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

    Abstract: Novel alkanolamine derivatives of the formula: ##STR1## wherein Ar is phenyl or naphthyl which is unsubstituted or which bears one or two substituents selected from halogen, trifluoromethyl, hydroxy, amino, nitro, carbamoyl, carbamoylmethyl and cyano, and alkyl, alkenyl, alkoxy, alkenyloxy, alkylthio, alkanoyl and alkanoylamino each of up to 6 carbon atoms, or Ar is 4-indolyl, 4-benzo[b]thienyl, 5-benzo[1,4]dioxanyl, 4- or 5-indanyl, 5- or 6- 1,2,3,4-tetrahydronaphthyl), 2,3-dihydroxy-1,2,3,4-tetrahydronaphth-5-yl or 4- morpholino-1,2,5-thiadiazol-3-yl;wherein R is halogen;wherein A.sup.1 is alkylene of 2 to 6 carbon atoms; andwherein A.sup.2 is alkylene of 1 to 7 carbon atoms which in unsubstituted or bears a phenyl, hydroxy or carbamoyl substituent, or A.sup.2 is cycloalkylene of 3 to 6 carbon atoms;or acid-addition salts thereof.The compounds possess either .beta.-adrenergic blocking activity or diuretic activity or both such activities and may be used in the treatment of heart disease or hypertension. Also disclosed are processes for the manufacture of the compounds and pharmaceutical compositions containing them.

    Abstract translation: 其中Ar是未取代的苯基或萘基，或含有一个或两个选自卤素，三氟甲基，羟基，氨基，硝基，氨基甲酰基，氨基甲酰基甲基和氰基的取代基的新的链烷醇胺衍生物：ArOCH 2 CH 2 CH 2 NHA 1 NHCO + 和至多6个碳原子的烷基，烯基，烷氧基，烯氧基，烷硫基，烷酰基和烷酰基氨基，或Ar是4-吲哚基，4-苯并[b]噻吩基，5-苯并[1,4]二氧杂环己烷基， 或5-二氢化茚基，5-或6- 1,2,3,4-四氢萘基），2,3-二羟基-1,2,3,4-四氢萘-5-基或4-吗啉代-1,2,5 - 噻二唑-3-基; 其中R是卤素; 其中A1是2至6个碳原子的亚烷基; 并且其中A2是1至7个碳原子的亚烷基，其在未取代的或带有苯基，羟基或氨基甲酰基取代基中，或A2是3至6个碳原子的亚环烷基; 或其酸加成盐。 该化合物具有β-肾上腺素能阻断活性或利尿活性或这两种活性，可用于治疗心脏病或高血压。 还公开了制备含有它们的化合物和药物组合物的方法。

Patent Agency Ranking