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1.发明授权Method for treating muscular dystrophy using antagonist antibodies against GDF-8 有权使用针对GDF-8的拮抗剂抗体治疗肌营养不良的方法公开(公告)号：US08349327B2
公开(公告)日：2013-01-08
申请号：US13030978
申请日：2011-02-18
Applicant: Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley, legal representative , Xiang-Yang Tan , Seung Poon Kwak , Menelas N. Pangalos
Inventor： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , Xiang-Yang Tan , Seung Poon Kwak , Menelas N. Pangalos
IPC: A61K39/395
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
Abstract: The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
Abstract translation: 本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。 本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。 此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。
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公开(公告)号：US20120064600A1
公开(公告)日：2012-03-15
申请号：US13208162
申请日：2011-08-11
Applicant: Erwin R. BOGHAERT , Nitin K. Damle , Philip Ross Hamann , Kiran Khandke , Arthur Kunz , Kimberly A. Marquette , Lioudmila Tchistiakova , Davinder Gill , Kodangattil R. Sreekumar
Inventor： Erwin R. BOGHAERT , Nitin K. Damle , Philip Ross Hamann , Kiran Khandke , Arthur Kunz , Kimberly A. Marquette , Lioudmila Tchistiakova , Davinder Gill , Kodangattil R. Sreekumar
CPC classification number: C07K16/28 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K14/82 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/77 , C07K2317/92
Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.
Abstract translation: 抗5T4抗体，抗5T4抗体/药物偶联物，以及制备和使用该抗体的方法。
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公开(公告)号：US07501121B2
公开(公告)日：2009-03-10
申请号：US11155843
申请日：2005-06-17
Applicant: Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
Inventor： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
IPC: A61K39/395 , C07K16/24
CPC classification number: C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
Abstract: Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
Abstract translation: 公开了特异性结合IL13并调节IL-13与IL-13受体和信号传导介质相互作用的能力的试剂（例如抗体及其片段）。
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公开(公告)号：US06733755B2
公开(公告)日：2004-05-11
申请号：US09775743
申请日：2001-02-02
Applicant: Lioudmila Tchistiakova , Shengmin Li , Grzegorz Pietrzynski , Valery Alakhov
Inventor： Lioudmila Tchistiakova , Shengmin Li , Grzegorz Pietrzynski , Valery Alakhov
IPC: C01D132
Abstract: The present invention relates to compositions comprised of a peptide ligand or derivatives thereof that are capable of specific binding to the high affinity receptor-1 of vascular endothelial growth factor (VEGF) and structure similar receptors. The invention further provides a peptide ligand or derivatives thereof that are capable of inhibiting angiogenesis induced by VEGF. The present invention also provides a method for treatment or diagnosis of disease associated with angiogenesis in a patient in need of therapy comprising administering to the patient an effective amount of the pharmaceutical composition of the present invention and a pharmaceutical acceptable carrier.
Abstract translation: 本发明涉及能够与血管内皮生长因子（VEGF）和结构类似受体的高亲和力受体-1特异性结合的肽配体或其衍生物的组合物。 本发明还提供能够抑制由VEGF诱导的血管发生的肽配体或其衍生物。 本发明还提供了在需要治疗的患者中治疗或诊断与血管发生相关的疾病的方法，包括向患者施用有效量的本发明的药物组合物和药学上可接受的载体。
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公开(公告)号：US08372625B2
公开(公告)日：2013-02-12
申请号：US13038954
申请日：2011-03-02
Applicant: Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Lioudmila Tchistiakova , Riyez Karim , Xiang-Yang Tan , Seung Poon Kwak , Menelas N. Pangalos , William Kelley
Inventor： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , Xiang-Yang Tan , Seung Poon Kwak , Menelas N. Pangalos
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
Abstract: The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
Abstract translation: 本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。 本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。 此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。
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Patent Agency Ranking
6.发明申请ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES IN TREATMENT OF ALS AND OTHER GDF-8 ASSOCIATED DISORDERS 有权针对GDF-8的拮抗剂抗体和用于治疗ALS和其他GDF-8相关疾病的用途公开(公告)号：US20120016106A1
公开(公告)日：2012-01-19
申请号：US13038954
申请日：2011-03-02
Applicant: Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L.F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
Inventor： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L.F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
Abstract: The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
Abstract translation: 本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。 本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。 此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。
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公开(公告)号：US08044178B2
公开(公告)日：2011-10-25
申请号：US11684329
申请日：2007-03-09
Applicant: Erwin R. Boghaert , Nitin K. Damle , Philip Ross Hamann , Kiran Khandke , Arthur Kunz , Kimberly A. Marquette , Lioudmila Tchistiakova , Davinder Gill , Kodangattil Sreekumar
Inventor： Erwin R. Boghaert , Nitin K. Damle , Philip Ross Hamann , Kiran Khandke , Arthur Kunz , Kimberly A. Marquette , Lioudmila Tchistiakova , Davinder Gill , Kodangattil Sreekumar
CPC classification number: C07K16/28 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K14/82 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/77 , C07K2317/92
Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.
Abstract translation: 抗5T4抗体，抗5T4抗体/药物偶联物，以及制备和使用该抗体的方法。
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公开(公告)号：US07943342B2
公开(公告)日：2011-05-17
申请号：US12358111
申请日：2009-01-22
Applicant: Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
Inventor： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
CPC classification number: C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
Abstract: Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
Abstract translation: 公开了特异性结合IL13并调节IL-13与IL-13受体和信号传导介质相互作用的能力的试剂（例如抗体及其片段）。
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公开(公告)号：US20100330089A1
公开(公告)日：2010-12-30
申请号：US12664166
申请日：2008-06-12
Applicant: Nitin K. Damle , Lioudmila Tchistiakova , Kyriaki Dunussi-Joannopoulos , Sandy Alexander Simon , William Brady , Laura Sue Grosmaire , Jeffrey Alan Ledbetter
Inventor： Nitin K. Damle , Lioudmila Tchistiakova , Kyriaki Dunussi-Joannopoulos , Sandy Alexander Simon , William Brady , Laura Sue Grosmaire , Jeffrey Alan Ledbetter
IPC: A61K39/395 , C07K16/28 , C07H21/00 , C12N15/63 , C12N5/10 , C12P21/02 , G01N33/566 , A61P37/02 , A61P29/00 , A61P25/00 , A61P35/00
CPC classification number: C07K16/2887 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2319/00
Abstract: The present invention provides materials and methods for treatment of diseases involving aberrant B-cell activity, using a CD20-specific binding molecule, in particular, antibodies or antigen binding fragment thereof. The compositions disclosed herein is useful for the treatment and diagnosis of B-cell disorders, such as B-cell malignancies and autoimmune diseases.
Abstract translation: 本发明提供了使用CD20特异性结合分子，特别是抗体或其抗原结合片段治疗涉及异常B细胞活性的疾病的材料和方法。 本文公开的组合物可用于治疗和诊断B细胞病症，例如B细胞恶性肿瘤和自身免疫性疾病。
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10.发明申请ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES IN TREATMENT OF ALS AND OTHER GDF-8 ASSOCIATED DISORDERS 有权针对GDF-8的拮抗剂抗体和用于治疗ALS和其他GDF-8相关疾病的用途公开(公告)号：US20090285827A1
公开(公告)日：2009-11-19
申请号：US12508618
申请日：2009-07-24
Applicant: Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L. F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
Inventor： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L. F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
IPC: A61K39/395 , G01N33/53
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
Abstract: The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
Abstract translation: 本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。 本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。 此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。
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