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公开(公告)号：US20220351371A1
公开(公告)日：2022-11-03
申请号：US17620498
申请日：2020-06-26
Applicant: MACQUARIE UNIVERSITY
Inventor： Dominic ROWE , Ewa GOLDYS , Martin GOSNELL , Ayad ANWER
Abstract: Disclosed is a method for diagnosing a neurodegenerative disease in a subject. The method comprises obtaining from the subject a sample comprising at least one live blood cell, and optionally isolating at least one live blood cell from the sample. The method further comprises generating one or more multispectral or hyperspectral images of the at least one cell, and analysing spectral characteristics of autofluorescence from the at least one cell. Also disclosed is a system configured to aid in the detection or diagnosis of a neurodegenerative disease. Also disclosed is a method for selecting a subject for treatment for a neurodegenerative disease. Also disclosed is a method for monitoring the response of a subject to a therapeutic treatment for a neurodegenerative disease. Also disclosed is a protocol for monitoring the efficacy of a therapeutic treatment for a neurodegenerative disease.
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公开(公告)号：US20220038034A1
公开(公告)日：2022-02-03
申请号：US16944775
申请日：2020-07-31
Applicant: SAUDI ARABIAN OIL COMPANY , Macquarie University
Inventor： Chinthaka Pasan Gooneratne , Subhas Mukhopadhyay , Bodong Li , Guodong Zhan , Arturo Magana-Mora , Timothy Eric Moellendick
Abstract: An apparatus includes an outer structure body having an inner surface defining a cavity and an inner structure body rotatably supported within the cavity. The inner structure body has an outer surface in opposing relation to the inner surface and a central bore. Movable elements are positioned along the inner surface and movably coupled to the outer structure body. Ball elements are positioned along the outer surface and coupled to the inner structure body for movement with the inner structure body. The ball elements releasably contact the movable elements and impart motion to the movable elements in response to relative motion between the inner structure body and the outer structure body. Energy harvesters are positioned to generate electrical charges based on piezoelectric effect or magnetostrictive effect when motion is imparted to the movable elements by the ball elements.
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公开(公告)号：US20220038031A1
公开(公告)日：2022-02-03
申请号：US16944745
申请日：2020-07-31
Applicant: SAUDI ARABIAN OIL COMPANY , Macquarie University
Inventor： Chinthaka Pasan Gooneratne , Subhas Mukhopadhyay , Bodong Li , Guodong Zhan , Arturo Magana-Mora , Timothy Eric Moellendick
Abstract: An apparatus includes an outer structure body having a cavity and an inner structure body rotatably supported within the cavity. The inner structure body has a central bore. Movable elements are positioned along the inner surface and movably coupled to the outer structure body. Ball elements are positioned along the outer surface and coupled to the inner structure body for movement with the inner structure body. The ball elements are positioned to releasably contact and impart motion to the movable elements in response to relative motion between the inner structure body and the outer structure body. A plurality of triboelectric energy harvesters are positioned to generate electrical charges when motion is imparted to the movable elements by the ball elements.
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公开(公告)号：US20220034198A1
公开(公告)日：2022-02-03
申请号：US16944796
申请日：2020-07-31
Applicant: SAUDI ARABIAN OIL COMPANY , Macquarie University
Inventor： Chinthaka Pasan Gooneratne , Subhas Mukhopadhyay , Bodong Li , Guodong Zhan , Arturo Magana-Mora , Timothy Eric Moellendick
Abstract: A system includes sensing modules positioned along a length of a drill string. Each sensing module includes a structure arrangement composed of an outer structure body having a cavity and an inner structure body rotatably supported within the cavity. The structure arrangement is coupled to the drill string such that rotation of the drill string produces a relative rotation between the structure bodies. Ball elements are disposed in a gap between the structure bodies and move along a predetermined path defined in the gap in response to relative rotation between the structure bodies. Movable elements are positioned to physically interact with the ball elements as the ball elements move along the predetermined path. Energy harvesters in the sensor modules generate electrical energy from the mechanical energy produced by physical interaction between the ball elements and movable elements. The sensing modules include sensors to measure parameters in the drill string environment.
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公开(公告)号：US20190388519A1
公开(公告)日：2019-12-26
申请号：US16081384
申请日：2017-03-01
Applicant: MACQUARIE UNIVERSITY
Inventor： Lars Matthias ITTNER , Arne Anselm ITTNER
Abstract: The present invention relates to a method of treating or preventing a neurological condition mediated by a tau-dependent signalling complex in neurons of a subject, comprising treating the subject to: (a) promote phosphorylation of one or more amino acids residues of tau, wherein the phosphorylation of the amino acid residues causes disruption of the tau-dependent signalling complex in neurons of the subject; or (b) introduce a variant of tau that causes disruption of the tau-dependent signalling complex in neurons of the subject. The invention also relates to vectors, compositions and kits for treating or preventing a neurological condition mediated by a tau-dependent signalling complex in neurons of a subject.
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公开(公告)号：US20190229490A1
公开(公告)日：2019-07-25
申请号：US16308085
申请日：2017-06-08
Applicant: MACQUARIE UNIVERSITY , NEWSOUTH INNOVATIONS PTY LIMITED
Inventor： Alex Fuerbach , Christoph Wieschendorf , Francois Ladouceur , Leonardo Silvestri
IPC: H01S3/115 , C09K11/77 , H01S3/11 , H01S3/106 , G02F1/141 , H01S3/067 , H01S3/17 , H01S3/16 , H01S3/08 , H01S3/10 , H01S3/105
Abstract: A voltage-controllable output coupler for a laser, comprising: a liquid crystal cell that provides a change in birefringence in response to an applied voltage; and a polariser oriented with respect to the liquid crystal cell to collectively form a variable reflectance mirror for the laser; wherein output coupling of the laser is controllable by applying voltage to the liquid crystal cell for a switching interval to switch the variable reflectance mirror from high reflectance to low reflectance, and vice versa, thus actively Q-switching or cavity dumping the laser.
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公开(公告)号：US20190222309A1
公开(公告)日：2019-07-18
申请号：US16324511
申请日：2017-08-09
Applicant: MACQUARIE UNIVERSITY
Inventor： Simon GROSS , Michael WITHFORD
IPC: H04B10/07 , H04B10/073
CPC classification number: H04B10/0705 , G02B6/0288 , G02B6/125 , G02B6/14 , G02B6/2821 , G02B2006/1209 , G02B2006/12152 , G02B2006/12164 , H04B10/073 , H04B10/077 , H04B10/85
Abstract: A system for detecting the installation of an optical tap on an optical fiber link. The system comprises a spatial mode de-multiplexer optically coupled to the optical fiber link. The spatial mode de-multiplexer is configured to isolate an optical signal in a first spatial mode of the optical fiber link. The spatial mode de-multiplexer is configured to isolate light in a second spatial mode of the optical fiber link 14. The system comprises an optical sensor optically coupled to the spatial mode de-multiplexer for measuring the optical power of the light in the second spatial mode of the optical fiber link. Also disclosed herein are methods for detecting installation of an optical tap and methods for securing an optical signal in an optical fiber.
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公开(公告)号：US20190199440A1
公开(公告)日：2019-06-27
申请号：US16328702
申请日：2017-08-30
Applicant: Macquarie University
Inventor： Simon GROSS , Michael WITHFORD , Nicolas RIESEN
IPC: H04B10/2581 , H04J14/02 , H04J14/04
CPC classification number: H04B10/2581 , H04B10/2503 , H04J14/0202 , H04J14/04
Abstract: An optical signal transmission system comprising a multimode optical fiber link. The multimode optical fiber link is for transmission of a plurality of optical signals in a plurality of spatial modes supported by the multimode optical fiber link. The optical signal transmission system comprises a photonic device in the form of a spatial mode add drop multiplexer coupled to the multimode optical fiber link and configured for at least one of coupling into the multimode optical fiber link an optical signal of the plurality of optical signals into a spatial mode of the plurality of spatial modes and coupling out of the multimode optical fiber link and into an optical fiber the optical signal of the spatial mode.
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公开(公告)号：US09972966B2
公开(公告)日：2018-05-15
申请号：US15110212
申请日：2015-01-07
Applicant: Macquarie University
Inventor： Richard Paul Mildren , Aaron McKay
CPC classification number: H01S3/30 , G02F1/353 , G02F2001/3542 , H01S3/0804 , H01S3/08045 , H01S3/094038 , H01S3/094076 , H01S3/0941 , H01S3/1611 , H01S3/163 , H01S3/1673
Abstract: The disclosure herein generally relates to a system (10) for converting an input light (12) into an output light beam (14) that has a spatial beam quality that is greater than that of the input light (12). The system (10) comprises an optical resonator having disposed therein a Raman crystal (20). The Raman crystal (20) is for receiving the input light (12) and the optical resonator is configured to resonate a Stokes light beam (22) generated from the input light (12) by at least one nonlinear interaction within the Raman crystal (20). The at least one nonlinear interaction comprises at least one Raman interaction. The Stokes light beam (22) has a spatial beam quality that is greater than that of the input light (12). The system (10) comprises a light extractor (18) arranged to generate the output light beam (14) by extracting at least some of the Stokes light beam (22) from the optical resonator.
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公开(公告)号：US09658513B2
公开(公告)日：2017-05-23
申请号：US14395751
申请日：2013-04-19
Applicant: Macquarie University
Inventor： Richard Paul Mildren , Ondrej Kitzler
IPC: G02F1/35 , G02F1/355 , H01S3/30 , G02F1/365 , H01S3/00 , H01S3/081 , H01S3/083 , H01S3/094 , H01S3/109 , H01S3/042
CPC classification number: G02F1/353 , G02F1/3534 , G02F1/3551 , G02F1/365 , H01S3/0092 , H01S3/042 , H01S3/0816 , H01S3/083 , H01S3/094038 , H01S3/109 , H01S3/30
Abstract: Disclosed herein is a device (10) for converting a light (12) received thereby. The device (10) comprises a resonating structure (14) comprising a Raman medium. The resonating structure is arranged to resonate Raman light (18) generated by a Raman interaction between the Raman medium and the light (12) when so received.
