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公开(公告)号:US08757342B2
公开(公告)日:2014-06-24
申请号:US13266196
申请日:2010-03-11
申请人: Tomoya Takata , Takayuki Sanga , Makoto Suda
发明人: Tomoya Takata , Takayuki Sanga , Makoto Suda
CPC分类号: F16D69/026 , F16D23/025 , F16D2065/024 , F16D2069/004
摘要: For reduction in size and weight, friction materials aiming at a high coefficient of kinetic friction have been developed. However, friction materials with a high coefficient of kinetic friction may cause sticking to a sliding partner material and deteriorated feeling in operation in particular in the initial running-in period during the initial stage of use. Therefore, the use of friction materials with a high coefficient of kinetic friction has been restricted. Since such sticking to the sliding partner material is less likely to occur after experiencing an initial running-in period, developed was a friction material in a form that is effective in prevention of sticking during the initial running-in period. Among sliding surfaces 5 between the friction material 3 and the sliding partner material 7, only the initial sliding surface 5′, or only the initial sliding surface 5′ and the vicinity thereof are in contact during the initial running-in period, and the area in contact with the sliding partner material gradually increases over time to full-area contact, that is, full contact of the whole sliding surfaces 5. The above constitution provides a sliding friction material having excellent sticking resistance with excellent friction performance and abrasion resistance.
摘要翻译: 为了减小尺寸和重量,已经开发了针对高摩擦系数的摩擦材料。 然而,具有高动摩擦系数的摩擦材料可能会在使用初始阶段,特别是在初始进入期间,可能导致滑动伴侣材料的粘附和操作的恶化。 因此,使用具有高动摩擦系数的摩擦材料受到限制。 由于在经历初始磨合期之后不易发生滑动配合材料的粘附,所以显影为在初始运行期间有效防止粘着的形式的摩擦材料。 在摩擦材料3和滑动伴侣材料7之间的滑动表面5中,初始滑动面5'或初始滑动面5'及其附近仅在初始运行期间接触, 与滑动伴侣材料接触随着时间逐渐增加到全面接触,即整个滑动面5的完全接触。上述结构提供了具有优异的耐粘附性和优异的摩擦性能和耐磨性的滑动摩擦材料。
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公开(公告)号:US07504415B2
公开(公告)日:2009-03-17
申请号:US10474194
申请日:2002-04-18
申请人: Takashi Nakagawa , Makoto Suda , Yoichi Yamauchi
发明人: Takashi Nakagawa , Makoto Suda , Yoichi Yamauchi
IPC分类号: A61K31/47
CPC分类号: C07D215/14 , A61K31/47
摘要: The present invention is directed to a preventive or therapeutic agent for a glomerular disease comprising as an active ingredient a compound represented by formula (1): or a salt thereof. The preventive or therapeutic agent for glomerular diseases is useful for preventing or treating a variety of glomerular diseases including chronic glomerular nephritis.
摘要翻译: 本发明涉及用于肾小球疾病的预防或治疗剂,其包含由式(1)表示的化合物或其盐作为活性成分。 肾小球疾病的预防或治疗剂可用于预防或治疗各种肾小球疾病,包括慢性肾小球性肾炎。
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公开(公告)号:US06828316B2
公开(公告)日:2004-12-07
申请号:US09978102
申请日:2001-10-17
申请人: Hiroyuki Ishiwata , Mototsugu Kabeya , Hiromichi Shigyo , Masami Shiratsuchi , Yukio Hattori , Hiroshi Nakao , Takao Nagoya , Seiichi Sato , Soichi Oda , Makoto Suda , Manabu Shibasaki
发明人: Hiroyuki Ishiwata , Mototsugu Kabeya , Hiromichi Shigyo , Masami Shiratsuchi , Yukio Hattori , Hiroshi Nakao , Takao Nagoya , Seiichi Sato , Soichi Oda , Makoto Suda , Manabu Shibasaki
IPC分类号: A61K3155
CPC分类号: C07D213/69 , C07D213/56 , C07D213/70 , C07D213/82 , C07D215/12 , C07D231/12 , C07D233/56 , C07D241/04 , C07D241/42 , C07D243/08 , C07D249/08 , C07D295/185 , C07D471/04 , C07D487/04
摘要: The present invention relates to diamide derivatives represented by the following general formula (1): wherein A is a phenyl group or the like, which may be substituted, B is —CH═CH—, —C≡C—, —(CH═CH)2—, —C≡C—CH═CH—, —CH═CH—C≡C—, phenylene or the like, and W is and medicines comprising such a compound. These compounds have an excellent inhibitory effect on the production of an IgE antibody and are hence useful as antiallergic agents and the like.
摘要翻译: 本发明涉及由以下通式(1)表示的二酰胺衍生物:其中A是可被取代的苯基等,B是-CH = CH-,-C = C-, - (CH = CH)2 - , - C = C-CH = CH - , - CH = CH-C = C-,亚苯基等,W为包含这种化合物的药物。 这些化合物对IgE抗体的产生具有优异的抑制作用,因此可用作抗变应性剂等。
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公开(公告)号:US06340682B1
公开(公告)日:2002-01-22
申请号:US09147711
申请日:1999-02-23
申请人: Hiroyuki Ishiwata , Mototsugu Kabeya , Hiromichi Shigyo , Masami Shiratsuchi , Yukio Hattori , Hiroshi Nakao , Takao Nagoya , Seiichi Sato , Soichi Oda , Makoto Suda , Manabu Shibasaki
发明人: Hiroyuki Ishiwata , Mototsugu Kabeya , Hiromichi Shigyo , Masami Shiratsuchi , Yukio Hattori , Hiroshi Nakao , Takao Nagoya , Seiichi Sato , Soichi Oda , Makoto Suda , Manabu Shibasaki
IPC分类号: A61K31495
CPC分类号: C07D213/69 , C07D213/56 , C07D213/70 , C07D213/82 , C07D215/12 , C07D231/12 , C07D233/56 , C07D241/04 , C07D241/42 , C07D243/08 , C07D249/08 , C07D295/185 , C07D471/04 , C07D487/04
摘要: The present invention provides diamide derivatives represented by the following general formula (1): wherein A is a phenyl group or the like, which may be substituted, B is —CH═CH—, —C═C—, —(CH═CH)2—, —C≡C—CH═CH—, —CH═CH—C≡C—, phenylene or the like, and W is or and medicines comprising such a compound. These compounds have an excellent inhibitory effect on the production of an IgE antibody and are hence useful as antiallergic agents and the like.
摘要翻译: 本发明提供由以下通式(1)表示的二酰胺衍生物:其中A是可以被取代的苯基等,B是-CH = CH-,-C = C-, - (CH = CH )2-,-C = C-CH = CH-,-CH = CH-C = C-,亚苯基等,以及含有这种化合物的W异构体药物。 这些化合物对IgE抗体的产生具有优异的抑制作用,因此可用作抗变应性剂等。
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公开(公告)号:US06297283B1
公开(公告)日:2001-10-02
申请号:US09269764
申请日:1999-04-09
申请人: Hiroyuki Ishiwata , Mototsugu Kabeya , Masami Shiratsuchi , Yukio Hattori , Hiroshi Nakao , Takao Nagoya , Seiichi Sato , Soichi Oda , Makoto Suda , Manabu Shibasaki
发明人: Hiroyuki Ishiwata , Mototsugu Kabeya , Masami Shiratsuchi , Yukio Hattori , Hiroshi Nakao , Takao Nagoya , Seiichi Sato , Soichi Oda , Makoto Suda , Manabu Shibasaki
IPC分类号: A61K31165
CPC分类号: C07D213/40 , C07C235/34 , C07C235/36 , C07C235/38 , C07C235/44 , C07C235/56 , C07C237/34 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D207/09 , C07D207/14 , C07D213/75 , C07D213/82
摘要: The present invention relates to compounds represented by the following general formula (1): wherein A is a phenyl, naphthyl, dihydronaphthyl, indenyl, pyridyl, indolyl, isoindolyl, quinolyl or isoquinolyl group which may be substituted; X is a lower alkylene group which may be substituted, or the like; Y is a single bond or an alkylene group; Z is a group of —CH═CH—, —C≡C—, —(CH═CH)2—, —C≡C—CH═CH— or —CH═CH—C≡C—, or the like; and R is a hydrogen atom, a lower alkyl group or the like, and medicines comprising such a compound. These compounds have an excellent inhibitory effect on the production of an IgE antibody and are hence useful as antiallergic agents and the like.
摘要翻译: 本发明涉及由以下通式(1)表示的化合物:其中A为可被取代的苯基,萘基,二氢萘基,茚基,吡啶基,吲哚基,异吲哚基,喹啉基或异喹啉基; X是可以被取代的低级亚烷基等; Y是单键或亚烷基; Z是-CH = CH-,-C = C - , - (CH = CH)2 - , - C = C-CH = CH-或-CH = CH-C = C - 等的基团; R为氢原子,低级烷基等,以及含有该化合物的药物。 这些化合物对IgE抗体的产生具有优异的抑制作用,因此可用作抗变应性剂等。
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公开(公告)号:US20050101634A1
公开(公告)日:2005-05-12
申请号:US10690671
申请日:2003-10-23
申请人: Hiroyuki Ishiwata , Seiichi Sato , Mototsugu Kabeya , Soichi Oda , Makoto Suda , Manabu Shibasaki
发明人: Hiroyuki Ishiwata , Seiichi Sato , Mototsugu Kabeya , Soichi Oda , Makoto Suda , Manabu Shibasaki
IPC分类号: A61P9/10 , A61P11/06 , A61P29/00 , A61P37/08 , A61P43/00 , C07D213/74 , C07D401/14 , C07D405/14 , C07D409/14 , C07D487/04 , A61K31/444
CPC分类号: C07D487/04 , C07D213/74 , C07D401/14 , C07D405/14 , C07D409/14
摘要: A bis(5-aryl-2-pyridyl) compound represented by formula (1) or a salt thereof: wherein A is a substituted or unsubstituted aromatic hydrocarbyl group or a substituted or unsubstituted aromatic heterocyclic group, and X is a group selected from the group consisting of moieties having formulas (2) to (5): wherein, in formula (2), m is an integer of 1 or 2; in formula (3), n is an integer of 1 to 6; and in formula (4), R is hydrogen or a lower alkyl group and p is an integer of 1 to 6.
摘要翻译: 由式(1)表示的双(5-芳基-2-吡啶基)化合物或其盐:其中A是取代或未取代的芳族烃基或取代或未取代的芳族杂环基,X是选自 由具有式(2)至(5)的部分组成的组:其中,在式(2)中,m为1或2的整数; 在式(3)中,n为1〜6的整数, 在式(4)中,R为氢或低级烷基,p为1〜6的整数。
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公开(公告)号:US06706703B2
公开(公告)日:2004-03-16
申请号:US09893698
申请日:2001-06-29
申请人: Hiroyuki Ishiwata , Seiichi Sato , Mototsugu Kabeya , Soichi Oda , Makoto Suda , Manabu Shibasaki
发明人: Hiroyuki Ishiwata , Seiichi Sato , Mototsugu Kabeya , Soichi Oda , Makoto Suda , Manabu Shibasaki
IPC分类号: C07D40104
CPC分类号: C07D487/04 , C07D213/74 , C07D401/14 , C07D405/14 , C07D409/14
摘要: A bis(5-aryl-2-pyridyl) compound represented by formula (1) or a salt thereof: wherein A is a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group, and X is a group selected from the group consisting of moieties having formulas (2) to (5): wherein, in formula (2), m is an integer of 1 or 2; in formula (3), n is an integer of 1 to 6; and in formula (4), R is hydrogen or a lower alkyl group and p is an integer of 1 to 6.
摘要翻译: 由式(1)表示的双(5-芳基-2-吡啶基)化合物或其盐:其中A是取代或未取代的芳族烃基或取代或未取代的芳族杂环基,X是选自 由具有式(2)至(5)的部分组成的组:其中,在式(2)中,m为1或2的整数; 在式(3)中,n为1〜6的整数, 在式(4)中,R为氢或低级烷基,p为1〜6的整数。
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公开(公告)号:US07196101B2
公开(公告)日:2007-03-27
申请号:US10690671
申请日:2003-10-23
申请人: Hiroyuki Ishiwata , Seiichi Sato , Mototsugu Kabeya , Soichi Oda , Makoto Suda , Manabu Shibasaki
发明人: Hiroyuki Ishiwata , Seiichi Sato , Mototsugu Kabeya , Soichi Oda , Makoto Suda , Manabu Shibasaki
IPC分类号: A61P37/08 , A61K31/44 , C07D213/00
CPC分类号: C07D487/04 , C07D213/74 , C07D401/14 , C07D405/14 , C07D409/14
摘要: A bis(5-aryl-2-pyridyl) compound represented by formula (1) or a salt thereof: wherein A is a substituted or unsubstituted aromatic hydrocarbyl group or a substituted or unsubstituted aromatic heterocyclic group, and X is a group selected from the group consisting of moieties having formulas (2) to (5): wherein, in formula (2), m is an integer of 1 or 2; in formula (3), n is an integer of 1 to 6; and in formula (4), R is hydrogen or a lower alkyl group and p is an integer of 1 to 6.
摘要翻译: 由式(1)表示的双(5-芳基-2-吡啶基)化合物或其盐:
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公开(公告)号:US06890940B2
公开(公告)日:2005-05-10
申请号:US09893680
申请日:2001-06-29
申请人: Hiroyuki Ishiwata , Seiichi Sato , Mototsugu Kabeya , Soichi Oda , Makoto Suda , Manabu Shibasaki
发明人: Hiroyuki Ishiwata , Seiichi Sato , Mototsugu Kabeya , Soichi Oda , Makoto Suda , Manabu Shibasaki
IPC分类号: A61P37/00 , A61P37/08 , A61P43/00 , C07D213/74 , C07D401/14 , C07D405/14 , A61K31/44 , C07D213/00
CPC分类号: C07D213/74 , C07D401/14 , C07D405/14
摘要: A bis(2-aryl-5-pyridyl) compound having formula (1) or a salt thereof: wherein A is a substituted or unsubstituted aromatic hydrocarbon group, and X is a substituent having one of the following formulas (2) to (4): wherein, in formula (2), R1 is a hydrogen atom or a di(lower alkyl)amino(lower alkyl) group, and m is an integer of 1 or 2; in formula (3), Y1 and Y2 each is a nitrogen atom or a CH group, and n is 0 or an integer of 1 to 6; in formula (4), R2 and R3 each is a hydrogen atom or a lower alkyl group, Z represents a single bond, a substituted methylene group, a substituted imino group, an oxygen atom or a cycloalkylene group, and p and q each is 0 or an integer of 1 to 6.
摘要翻译: 具有式(1)的双(2-芳基-5-吡啶基)化合物或其盐:其中A是取代或未取代的芳族烃基,X是具有下式(2)至(4)中的一个的取代基 )其中,在式(2)中,R 1是氢原子或二(低级烷基)氨基(低级烷基)基团,m是1或2的整数; 在式(3)中,Y 1和Y 2各自为氮原子或CH基团,n为0或1至6的整数; 在式(4)中,R 2和R 3各自为氢原子或低级烷基,Z表示单键,取代亚甲基,取代亚氨基 基团,氧原子或亚环烷基,p和q各自为0或1〜6的整数。
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公开(公告)号:US06576642B2
公开(公告)日:2003-06-10
申请号:US09858592
申请日:2001-05-17
申请人: Hiroyuki Ishiwata , Mototsugu Kabeya , Masami Shiratsuchi , Yukio Hattori , Hiroshi Nakao , Takao Nagoya , Seiichi Sato , Soichi Oda , Makoto Suda , Manabu Shibasaki
发明人: Hiroyuki Ishiwata , Mototsugu Kabeya , Masami Shiratsuchi , Yukio Hattori , Hiroshi Nakao , Takao Nagoya , Seiichi Sato , Soichi Oda , Makoto Suda , Manabu Shibasaki
IPC分类号: A61K31165
CPC分类号: C07D213/40 , C07C235/34 , C07C235/36 , C07C235/38 , C07C235/44 , C07C235/56 , C07C237/34 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D207/09 , C07D207/14 , C07D213/75 , C07D213/82
摘要: Compounds having the formula (1): wherein A is a phenyl, naphthyl, dihydronaphthyindeny, pyridyl, indolyl,isoindolyl, quinolyl or isoquinolyl group which are optionally substituted; X is optionally substituted alicyclic, aromatic, imino or heterocyclic groups or —S— or —O—; Y is a single bond or an alkylene group; Z is an unsubstituted aliphatic group or divalent residue of benzene or pyridine, which is optionally substituted; anis hydrogen, lower alkyl, cycloalkyl, aryl or aralkyl; with certain provisos. These compounds exhibit an inhibitory effect on the production of IgE antibodies and are, hence, useful as antiallergic agents.
摘要翻译: 具有式(1)的化合物:其中A是任选取代的苯基,萘基,二氢萘并噻吩基,吡啶基,吲哚基,异吲哚基,喹啉基或异喹啉基; X是任选取代的脂环族,芳族,亚氨基或杂环基或-S-或-O-; Y是单键或亚烷基; Z是任选取代的未取代的脂族基团或苯或吡啶的二价残基; 芳烃氢,低级烷基,环烷基,芳基或芳烷基; 具有一定的条件。 这些化合物对IgE抗体的产生具有抑制作用,因此可用作抗过敏剂。
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