公开(公告)号：US4946782A

公开(公告)日：1990-08-07

申请号：US228512

申请日：1988-08-05

Applicant: Mohamad I. Farbood ,  James A. Morris ,  Mark A. Sprecker ,  Lynda J. Bienkowski ,  Kevin P. Miller ,  Manfred H. Vock ,  Myrna L. Hagedorn

Inventor： Mohamad I. Farbood ,  James A. Morris ,  Mark A. Sprecker ,  Lynda J. Bienkowski ,  Kevin P. Miller ,  Manfred H. Vock ,  Myrna L. Hagedorn

IPC: A24B15/40 ,  C11B9/00 ,  C12P7/40 ,  C12P7/42 ,  C12P17/02

CPC classification number: C12P17/02 ,  A24B15/403 ,  C11B9/0073 ,  C12P7/40 ,  C12P7/42

Abstract: Described is a process for the preparation of compositions of matter containing unsaturated lactones defined according to the generic structure: ##STR1## wherein R represents C.sub.6 alkyl or alkenyl; and X represents C.sub.2, C.sub.4 or C.sub.6 alkylene or alkenylene; with the provisos that R is C.sub.6 alkyl when X is alkenylene and R is C.sub.6 alkenyl when X is alkylene by means of the sequential steps of (i) fermentation of castor oil or ricinoleic acid using a microorganism selected from the group consisting of:Candida petrophilum, ATCC 20226;Candida oleophila, ATCC 20177;Candida sp., ATCC 20504; andCandida sake, ATCC 28137whereby gamma hydroxydecanoic acid and a mixture of other acids defined according to the generic structure: ##STR2## is formed wherein Y represents an oxo-saturated, oxo-unsaturated or di-unsaturated C.sub.9, C.sub.11 or C.sub.13 moiety according to the reaction: ##STR3## (ii) lactonization of the resulting gamma hydroxydecanoic acid by means of simultaneous acidification and heating according to the reaction: ##STR4## and (iii) lactonization (via distillation) of one or more of the resulting acids defined according to the structure: ##STR5## to form one or more lactones defined according to the generic structure: ##STR6## according to the reaction: ##STR7## wherein the sum of the number of carbon atoms in the X moiety and in the R moiety is equal to the number of carbon atoms in the Y moiety minus 1.Also described are the products produced according to such process as well as their organoleptic utilities for augmenting or enhancing the aroma or taste of consumable materials selected from the group consisting of perfume compositions, colognes, perfumed articles, foodstuffs, chewing gums, medicinal products, toothpastes, chewing tobaccos and smoking tobaccos.

Abstract translation: 描述了根据通用结构定义的含有不饱和内酯的物质组合物的方法：其中R表示C6烷基或烯基; X表示C2，C4或C6亚烷基或亚烯基; 条件是当X是亚烯基时R是C6烷基，当X是亚烷基时，R是C6链烯基，通过以下顺序的步骤：（i）使用选自以下的微生物来蓖麻油或蓖麻油酸发酵：念珠菌 ，ATCC 20226; 嗜油假丝酵母，ATCC 20177; 念珠菌属，ATCC 20504; 和念珠菌，ATCC 28137，由此形成根据通用结构定义的γ-羟基癸酸和其它酸的混合物：其中Y表示氧代饱和的，不饱和的或不饱和的C 9，C 11或C 13部分，根据 （ii）通过根据以下反应的同时酸化和加热来对所得的γ-羟基癸酸进行内酯化：（ⅲ）内酯化（经蒸馏） 根据以下结构定义的一种或多种所得酸：以形成根据通用结构定义的一种或多种内酯：根据该反应：其中，碳原子数 X部分和R部分等于Y部分中的碳原子数减1。还描述了根据这种方法产生的产物以及它们的感官效用，用于增强或增强co的香气或味道 选自香水组合物，古龙水，香料制品，食品，口香糖，药用产品，牙膏，咀嚼烟草和吸烟烟草的可选材料。

公开(公告)号：US4739105A

公开(公告)日：1988-04-19

申请号：US894834

申请日：1986-10-17

Applicant: Thomas F. Courtney, Jr. ,  Alan O. Pittet ,  Ranya Muralidhara ,  Manfred H. Vock ,  Charles Wiener

Inventor： Thomas F. Courtney, Jr. ,  Alan O. Pittet ,  Ranya Muralidhara ,  Manfred H. Vock ,  Charles Wiener

IPC: A23L27/20 ,  C07C149/20

CPC classification number: C07C323/00 ,  A23L27/2022

Abstract: Described are the esters of alkylthioalkanoic acids defined according to the structure: ##STR1## wherein R.sub.1 represents C.sub.3 -C.sub.6 alkenyl or C.sub.1 -C.sub.4 alkyl; R.sub.2 represents C.sub.3 alkyl; C.sub.3 hydroxyalkyl or C.sub.3 alkenyl; N represents 0, 1 or 2 amd M represents 0 or 1 and uses thereof in augmenting or enhancing the aroma or taste of foodstuffs.

Abstract translation: 描述了根据以下结构定义的烷基硫代链烷酸的酯：其中R 1表示C 3 -C 6烯基或C 1 -C 4烷基; R2代表C3烷基; C3羟烷基或C3链烯基; N表示0,1或2 am，M表示0或1，并且其用于增强或增强食品的香气或味道。

公开(公告)号：US4631194A

公开(公告)日：1986-12-23

申请号：US789162

申请日：1985-12-06

Applicant: Thomas F. Courtney, Jr. ,  Alan O. Pittet ,  Ranya Muralidhara ,  Manfred H. Vock ,  Charles Wiener

Inventor： Thomas F. Courtney, Jr. ,  Alan O. Pittet ,  Ranya Muralidhara ,  Manfred H. Vock ,  Charles Wiener

IPC: A23L27/20 ,  A23L27/26 ,  A23L27/29 ,  A23L1/226 ,  A23L1/231 ,  A23L1/235

CPC classification number: C07C323/00 ,  A23L27/2022

Abstract: Described are the esters of alkylthioalkanoic acids defined according to the structure: ##STR1## wherein R.sub.1 represents C.sub.3 -C.sub.6 alkenyl or C.sub.1 -C.sub.4 alkyl; R.sub.2 represents C.sub.3 alkyl; C.sub.3 hydroxyalkyl or C.sub.3 alkenyl; N represents 0, 1 or 2 and M represents 0 or 1 and uses thereof in augmenting or enhancing the aroma or taste of foodstuffs.

Abstract translation: 描述了根据以下结构定义的烷基硫代链烷酸的酯：其中R 1表示C 3 -C 6烯基或C 1 -C 4烷基; R2代表C3烷基; C3羟烷基或C3链烯基; N表示0,1或2，M表示0或1，并且其用于增强或增强食品的香气或味道。

公开(公告)号：US4629586A

公开(公告)日：1986-12-16

申请号：US742301

申请日：1985-06-07

Applicant: Richard A. Wilson ,  Braja D. Mookherjee ,  Michael J. Zampino ,  Manfred H. Vock ,  Kevin P. Miller

Inventor： Richard A. Wilson ,  Braja D. Mookherjee ,  Michael J. Zampino ,  Manfred H. Vock ,  Kevin P. Miller

IPC: A23L27/20 ,  A61K7/46 ,  C11B9/00

CPC classification number: C07C69/24 ,  A23L27/202

Abstract: Described are the hexynyl alkanoates defined according to the generic structure: ##STR1## wherein R represents hydrogen or ethyl and organoleptic uses thereof in augmenting or enhancing the aroma or taste of consumable materials which are perfume compositions, colognes perfumed articles, foodstuffs, chewing gums, toothpastes and chewing tobaccos.

Abstract translation: 描述了根据通用结构定义的己炔基链烷酸酯：其中R表示氢或乙基，并且其感官用途是增强或增强作为香料组合物的消耗材料的香气或味道，香水加香制品，食品，口香糖， 牙膏和咀嚼烟草。

公开(公告)号：US4620945A

公开(公告)日：1986-11-04

申请号：US644053

申请日：1984-08-24

Applicant: Braja D. Mookherjee ,  Bernard J. Chant ,  William J. Evers ,  Richard A. Wilson ,  Michael J. Zampino ,  Manfred H. Vock

Inventor： Braja D. Mookherjee ,  Bernard J. Chant ,  William J. Evers ,  Richard A. Wilson ,  Michael J. Zampino ,  Manfred H. Vock

IPC: C07D331/02 ,  C11B9/00 ,  A61K7/46

CPC classification number: C07D331/02 ,  C11B9/0034

Abstract: Described are organoleptic utilities of mixtures of t-mercapto terpene isomers defined according to the generic structure: ##STR1## wherein one of the dashed lines is a carbon-carbon double bond and the other of the dashed lines is a carbon-carbon single bond taken further together with .alpha.-terpineol having the structure: ##STR2## .beta.-phenylethyl alcohol having the structure: ##STR3## 3-methyl-1-phenyl-pentanol-5 having the structure: ##STR4## and/or butanoyl cyclohexane derivatives defined according to the generic structure: ##STR5## wherein one of the dashed lines is a carbon-carbon double bond or two of the dashed lines represent carbon-carbon double bonds but that when two of the dashed lines represent carbon-carbon double bonds, the carbon-carbon double bonds are conjugated.

Abstract translation: 描述了根据通用结构定义的t-巯基萜烯异构体混合物的感官效用：其中一条虚线是碳 - 碳双键，另一条虚线是碳 - 碳单键取代 进一步与具有以下结构的α-萜品醇结合：具有以下结构的具有以下结构的β-苯乙醇：具有以下结构的3-甲基-1-苯基 - 戊醇-5：具有以下结构的化合物：和/或丁酰基环己烷衍生物 涉及通用结构：其中虚线中的一条为碳 - 碳双键，或两条虚线表示碳 - 碳双键，但当虚线中的两条代表碳 - 碳双键时，碳 - 碳双键共轭。

公开(公告)号：US4613511A

公开(公告)日：1986-09-23

申请号：US800442

申请日：1985-11-21

Applicant: Alan O. Pittet ,  Ranya Muralidhara ,  Kevin P. Miller ,  Domenick Luccarelli, Jr. ,  Manfred H. Vock

Inventor： Alan O. Pittet ,  Ranya Muralidhara ,  Kevin P. Miller ,  Domenick Luccarelli, Jr. ,  Manfred H. Vock

IPC: A23G4/00 ,  A23G4/06 ,  A23L27/20 ,  A23L1/226 ,  A23L1/235

CPC classification number: A23G4/06 ,  A23L27/2022 ,  A23L27/203 ,  C07C321/00

Abstract: Described are dialkylthioalkenes, dialkylthioalkylcycloalkenes and monoalkylthioalkenylcycloalkenes defined according to the generic structure: ##STR1## as well as the genus defined according to the structure: ##STR2## wherein R represents C.sub.6 -C.sub.11 alkenyl or cycloalkenylalkyl; and wherein R.sub.2 represents C.sub.1 -C.sub.3 alkyl and R.sub.3 is C.sub.1 -C.sub.3 alkyl and organoleptic uses thereof in augmenting or enhancing the aroma or taste of foodstuffs, chewing gums, toothpastes or medicinal products.

Abstract translation: 根据通用结构定义的二烷基硫代链烯烃，二烷基硫代烷基环烯烃和单烷基硫代烯基环烯烃：以及根据以下结构定义的属：其中R表示C6-C11烯基或环烯基烷基; 并且其中R2表示C1-C3烷基，R3表示C1-C3烷基，并且其感官用途是增强或增强食品，口香糖，牙膏或药用产品的香味或味道。

公开(公告)号：US4599237A

公开(公告)日：1986-07-08

申请号：US768726

申请日：1985-08-23

Applicant: Alan O. Pittet ,  Ranya Muralidhara ,  Manfred H. Vock ,  Kevin P. Miller ,  Domenick Luccarelli, Jr.

Inventor： Alan O. Pittet ,  Ranya Muralidhara ,  Manfred H. Vock ,  Kevin P. Miller ,  Domenick Luccarelli, Jr.

IPC: A23L27/20 ,  A23L1/226 ,  A23L1/235

CPC classification number: A23L27/203

Abstract: Described are methylthioionene derivatives defined according to the structure: ##STR1## wherein n is 0 or 1; wherein the dashed lines each represent a carbon-carbon single bond or a carbon-carbon double bond with the proviso that when the dashed line at the 3'-4' position is a double bond, n represents 0 and uses thereof in augmenting or enhancing the aroma or taste of foodstuffs.

Abstract translation: 描述了根据以下结构定义的甲硫基衍生物衍生物：其中n为0或1; 其中虚线各自表示碳 - 碳单键或碳 - 碳双键，条件是当3'-4'位的虚线是双键时，n表示0，并且其用于增强或增强 食物的香气或味道。

公开(公告)号：US4568470A

公开(公告)日：1986-02-04

申请号：US691587

申请日：1985-01-15

Applicant: Augustinus G. Van Loveren ,  Marie R. Hanna ,  Domenick Luccarelli, Jr. ,  David R. Bowen ,  Manfred H. Vock ,  Wilhelmus J. Wiegers

Inventor： Augustinus G. Van Loveren ,  Marie R. Hanna ,  Domenick Luccarelli, Jr. ,  David R. Bowen ,  Manfred H. Vock ,  Wilhelmus J. Wiegers

IPC: C07D315/00 ,  C11B9/00 ,  C11D3/50 ,  C11D9/44

CPC classification number: C07D315/00 ,  C11B9/0073 ,  C11B9/0084

Abstract: Described for use in augmenting or enhancing the aroma or taste of consumable materials including perfume compositions, colognes and perfumed articles, foodstuffs, chewing gums, toothpastes and medicinal products are the cis and/or trans isomers of the macrocyclic lactone defined according to the structure: ##STR1## produced according to the process of first reacting the ester defined according to the structure: ##STR2## with the alkenol having the structure: ##STR3## in order to produce the di-unsaturated ester having the structure: ##STR4## and then causing the said diester to undergo an internal metathesis to form the compound having the structure: ##STR5##

Abstract translation: 用于增强或增强消耗材料（包括香水组合物，古龙水和香料制品，食品，口香糖，牙膏和药用产品）的香味或味道是根据以下结构定义的大环内酯的顺式和/或反式异构体： 根据以下结构定义的酯首先反应制得的：为了制备具有以下结构的二不饱和酯：＆lt; IMAGE＆gt;然后 使所述二酯进行内部复分解以形成具有以下结构的化合物：

公开(公告)号：US4472446A

公开(公告)日：1984-09-18

申请号：US533777

申请日：1983-09-19

Applicant: Alan O. Pittet ,  Thomas F. Courtney, Jr. ,  Manfred H. Vock ,  David R. Bowen ,  Ranya Muralidhara

Inventor： Alan O. Pittet ,  Thomas F. Courtney, Jr. ,  Manfred H. Vock ,  David R. Bowen ,  Ranya Muralidhara

IPC: A23L27/20 ,  A23L27/26 ,  C07D339/06 ,  A23L1/226 ,  A23L1/231

CPC classification number: C07D339/06 ,  A23L27/2052 ,  A23L27/26

Abstract: Described is the genus of methyl(methylthioalkyl)-1,3-dithiolanes defined according to the structure: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each represents methyl or hydrogen with the proviso that at least one of R.sub.1 and R.sub.2 is methyl; and wherein m represents an integer of 1 or 2 and uses of such methyl(methylthioalkyl)-1,3-dithiolanes in augmenting or enhancing the aroma or taste of foodstuffs.

Abstract translation: 描述了根据以下结构定义的甲基（甲硫基烷基）-1,3-二硫戊环：其中R 1和R 2相同或不同，并且各自表示甲基或氢，条件是R 1和R 2中的至少一个 是甲基; 并且其中m表示1或2的整数，并且使用这种甲基（甲硫基烷基）-1,3-二硫戊环来增强或增强食品的香气或味道。

公开(公告)号：US4470963A

公开(公告)日：1984-09-11

申请号：US546383

申请日：1983-10-28

Applicant: Mark A. Sprecker ,  Marie R. Hanna ,  Richard J. Tokarzewski ,  Robert P. Belko ,  Hugh Watkins ,  Manfred H. Vock

Inventor： Mark A. Sprecker ,  Marie R. Hanna ,  Richard J. Tokarzewski ,  Robert P. Belko ,  Hugh Watkins ,  Manfred H. Vock

IPC: A24B15/34 ,  C07C47/347 ,  C07C47/445 ,  A23L1/226 ,  A23L1/235

CPC classification number: C07C47/347 ,  A24B15/345 ,  C07C47/445

Abstract: Described are mono-oxomethyl substituted polyhydrodimethanonaphthalene derivatives having the generic structure: ##STR1## wherein the dashed line represents a carbon-carbon single bond or a carbon-carbon double bond; wherein R.sub.1, R.sub.1 ', R.sub.1 ", R.sub.1 '", R.sub.1 "", R.sub.3, R.sub.5, R.sub.5 ', R.sub.5 ", R.sub.5 '", R.sub.5 "" and R.sub.6 represent hydrogen or methyl with the provisos:(i) at least four of R.sub.1, R.sub.1 ', R.sub.1 ", R.sub.1 '" and R.sub.1 "" are hydrogen; and (ii) at least four of R.sub.5, R.sub.5 ', R.sub.5 ", R.sub.5 '" and R.sub.5 "" represent hydrogen;and wherein Z represents one of the moieties:(i) carboxaldehyde having the structure: ##STR2## (ii) alkylene dioxy or dialkoxy methyl having the structure: ##STR3## (iii) hydroxy methyl having the structure: ##STR4## (iv) acetoxymethyl having the structure: ##STR5## and wherein R.sub.7 and R.sub.8 taken separately represent C.sub.1 -C.sub.4 lower alkyl or R.sub.7 and R.sub.8 taken together represent C.sub.2 -C.sub.4 alkylene; wherein the line represented by:[++++]is either (i) a carbon-carbon single bond when R.sub.7 and R.sub.8 taken together are C.sub.2 -C.sub.4 alkylene or (ii) no bond at all when R.sub.7 and R.sub.8 taken separately represent C.sub.1 -C.sub.4 lower alkyl. Also described are processes for preparing such mono-oxomethyl substituted polyhydrodimethanonaphthalene derivatives, and processes for using the above defined mono-oxomethyl substituted polyhydrodimethanonaphthalene derivatives for their organoleptic properties and compositions containing said mono-oxomethyl substituted polyhydrodimethanonaphthalene derivatives including perfumes, perfumed articles (such as solid or liquid anionic, cationic, nonionic or zwitterionic detergents, perfumed polymers, fabric softeners and cosmetic powders), foodstuffs, chewing gums, toothpastes, medicinal products, chewing tobaccos, smoking tobaccos and smoking tobacco articles.