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19 条记录 (耗时 0.017 秒)

    Calcilytic compounds
    5.
    发明授权
    Calcilytic compounds 失效
    钙化合物

    公开(公告)号：US06291459B1

    公开(公告)日：2001-09-18

    申请号：US09762413

    申请日：2001-04-09

    申请人： Pradip Bhatnagar ,  Maria Amparo Lago

    发明人： Pradip Bhatnagar ,  Maria Amparo Lago

    IPC分类号： A61K315375

    CPC分类号： C07D265/30

    摘要： A compound selected from Formula (I) hereinbelow: or a pharmaceutically acceptable salt thereof, wherein m is an integer from 0 to 2; n is an integer from 1 to 3; X is selected from the group consisting of CN, NO2, Cl, F, and H; Y is selected from the group consisting of Cl, F, Br, I and H; and Q and Z are, independently, selected from the group consisting of H, R1, SO2R1′, R1C(O)OR1″, SO2NR1′R1″, C(O)NR1′R1″, NR1′SO2R″1, wherein R1, R1′ and R1″ are independently selected from the group consisting of hydrogen, C1-4 alkyl, C3-6 cycloalkyl, C2-5 alkenyl, C2-5 alkynyl, heterocycloalkyl, aryl and aryl C1-4 alkyl; or R1′ and R1″ together form a 3 to 7 membered optionally substituted heterocyclic ring; wherein any substituents are selected from the group consisting of CN, aryl, CO2R, CO2NHR, OH, OR, NH2, halo, CF3, OCF3 and NO2; wherein R represents H, C1-4 alkyl, and C3-6 cycloalkyl; and A is phenyl or naphthyl, unsubstituted or substituted with any substituents being selected from the group consisting of OH, halo, CO2R1, C1-4 alkyl, C1-4 alkoxy, C3-6 cycloalkyl, OSO2R1, CN, NO2, OCF3, CF3, and CH2CF3, (CH2)nCO2H, (CH2)nCO2R1, and O—(CH2)n CO2R1, wherein n is an integer from 0 to 3 0-3 and R1 represents C1-4 alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl, heteroaryl or fused heteroaryl (wherein the hetero-ring can contain N, O or S and can be aromatic, dihydro or tetrahydro) unsubstituted or substituted with any substituents being selected from the group consisting of OH, OCH3, CH(CH3)2, halo, CO2R1, C1-4 alkyl, C1-4 alkoxy, C3-6cycloalkyl, CN, NO2, OCF3, CF3, CH2CF3, (CH2)n CO2R1, and O—(CH2)nCO2R1 is provided.

    摘要翻译： 选自下式（I）的化合物或其药学上可接受的盐，其中m为0至2的整数; n为1-3的整数; X选自CN，NO2，Cl，F和H; Y选自Cl，F，Br，I和H; 并且Q和Z独立地选自H，R 1，SO 2 R 1'，R 1 C（O）OR 1“，SO 2 N R 1'R 1'，C（O）NR 1'R 1'，NR 1'SO 2 R” 其中R1，R1'和R1“独立地选自氢，C1-4烷基，C3-6环烷基，C2-5烯基，C2-5炔基，杂环烷基，芳基和芳基C1-4烷基; 或R 1'和R 1“一起形成3至7元任选取代的杂环; 其中任何取代基选自CN，芳基，CO 2 R，CO 2 NHR，OH，OR，NH 2，卤素，CF 3，OCF 3和NO 2; 其中R表示H，C 1-4烷基和C 3-6环烷基; 并且A是未被取代或被任选取代基取代的苯基或萘基，所述取代基选自OH，卤素，CO 2 R 1，C 1-4烷基，C 1-4烷氧基，C 3-6环烷基，OSO 2 R 1，CN，NO 2，OCF 3，CF 3 ，和CH 2 CF 3，（CH 2）n CO 2 H，（CH 2）n CO 2 R 1和O-（CH 2）n CO 2 R 1，其中n是0-3 0-3的整数，R 1表示C 1-4烷基，C 3-6环烷基， 6个环烷基，杂芳基或稠合杂芳基（其中杂环可以含有N，O或S并且可以是芳香族，二氢或四氢），未被取代或被任何取代基取代，所述取代基选自OH，OCH 3，CH（CH 3） 2