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公开(公告)号：US08541174B2
公开(公告)日：2013-09-24
申请号：US11300808
申请日：2005-12-14
Applicant: Jacob N. Wohlstadter , James L. Wilbur , George B. Sigal , Mark T. Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau
Inventor： Jacob N. Wohlstadter , James L. Wilbur , George B. Sigal , Mark T. Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau
IPC: G01N33/53
CPC classification number: G01N21/66 , B82Y15/00 , B82Y30/00 , G01N21/76 , G01N33/54313 , G01N33/5438 , G01N33/582 , G01N33/585 , Y10S435/808 , Y10S435/81 , Y10S435/968 , Y10S435/975 , Y10S436/805
Abstract: Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.
Abstract translation: 提供材料和方法用于生产用于诊断的图案化多阵列多特异性表面。 本发明提供了用于检测或测量感兴趣分析物的电化学发光方法。 它还提供用于ECL测定的新型电极。 提供材料和方法用于化学和/或物理控制导电域和试剂沉积，以便使用多重特定的测试程序。
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公开(公告)号：US20120034645A1
公开(公告)日：2012-02-09
申请号：US13275398
申请日：2011-10-18
Applicant: Mark A. Billadeau , Jeff D. Debad , Eli N. Glezer , Jonathan K. Leland , Charles A. Wijayawardhana
Inventor： Mark A. Billadeau , Jeff D. Debad , Eli N. Glezer , Jonathan K. Leland , Charles A. Wijayawardhana
IPC: C12Q1/02
CPC classification number: G01N33/543 , G01N33/523 , G01N33/54366 , Y10T436/106664 , Y10T436/117497 , Y10T436/25125 , Y10T436/25375
Abstract: Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration of an analyte of interest in blood plasma from a whole blood sample without blood separation and hematocrit correction.
Abstract translation: 公开了用于进行可能含有细胞或其它颗粒物质的样品例如全血的测定的方法。 还公开了用于这些方法的系统，装置，设备，试剂盒和试剂。 某些公开的方法和系统的一个优点是能够在没有血液分离和血细胞比容校正的情况下从全血样品中快速测量血浆中目标分析物的浓度。
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公开(公告)号：US20100267063A1
公开(公告)日：2010-10-21
申请号：US12831139
申请日：2010-07-06
Applicant: Mark A. Billadeau , Jeff D. Debad , Eli N. Glezer , Jonathan K. Leland , Charles A. Wijayawardhana
Inventor： Mark A. Billadeau , Jeff D. Debad , Eli N. Glezer , Jonathan K. Leland , Charles A. Wijayawardhana
IPC: G01N33/53
CPC classification number: G01N33/543 , G01N33/523 , G01N33/54366 , Y10T436/106664 , Y10T436/117497 , Y10T436/25125 , Y10T436/25375
Abstract: Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration of an analyte of interest in blood plasma from a whole blood sample without blood separation and hematocrit correction.
Abstract translation: 公开了用于进行可能含有细胞或其它颗粒物质的样品例如全血的测定方法。 还公开了用于这些方法的系统，装置，设备，试剂盒和试剂。 某些公开的方法和系统的一个优点是能够在没有血液分离和血细胞比容校正的情况下从全血样品中快速测量血浆中目标分析物的浓度。
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公开(公告)号：US06207369B1
公开(公告)日：2001-03-27
申请号：US08715163
申请日：1996-09-17
Applicant: Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau
Inventor： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau
IPC: G01N33543
CPC classification number: G01N21/66 , B82Y15/00 , B82Y30/00 , G01N21/76 , G01N33/54313 , G01N33/5438 , G01N33/582 , G01N33/585 , Y10S435/808 , Y10S435/81 , Y10S435/968 , Y10S435/975 , Y10S436/805
Abstract: Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.
Abstract translation: 提供材料和方法用于生产用于诊断的图案化多阵列多特异性表面。 本发明提供了用于检测或测量感兴趣分析物的电化学发光方法。 它还提供用于ECL测定的新型电极。 提供材料和方法用于化学和/或物理控制导电域和试剂沉积，以便使用多重特定的测试程序。
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公开(公告)号：US08852922B2
公开(公告)日：2014-10-07
申请号：US13221427
申请日：2011-08-30
Applicant: Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
Inventor： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
CPC classification number: G01N21/76 , B01J19/0046 , B01J2219/00653 , B01J2219/00725 , B01J2219/0074 , B01L3/5027 , B01L3/502715 , B01L3/5029 , B01L9/527 , B01L2200/0684 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/049 , B01L2400/0688 , B33Y80/00 , C12Q1/001 , C40B40/10 , G01N27/30 , G01N33/5438 , G01N2458/30 , Y10T436/25 , Y10T436/25375 , Y10T436/255
Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
Abstract translation: 测定模块，优选测定盒，被描述为可用于控制模块操作的方面的读取器设备。 模块优选地包括具有集成电极的检测室，其可用于执行电极诱导的发光测量。 描述了以这种控制方式将测定试剂固定在这些电极和其它表面上的方法。 还描述了具有检测室，优选地具有集成电极的测定模块和盒，以及可以包括样品室，废物室，导管，通风口，气泡阱，试剂室，干试剂丸区等的其它流体组分。 在某些优选实施例中，这些模块适于接收和分析在施用器棒上收集的样品。
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Patent Agency Ranking
6.发明授权Assay buffer, compositions containing the same, and methods of using the same 有权测定缓冲液，含有该组合物的组合物及其使用方法公开(公告)号：US08785201B2
公开(公告)日：2014-07-22
申请号：US12368742
申请日：2009-02-10
Applicant: Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
Inventor： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
CPC classification number: G01N33/573 , C12Q1/485 , G01N21/76 , G01N33/5306 , G01N33/54386 , G01N33/58 , G01N33/582 , G01N2333/91205 , G01N2458/30 , G01N2458/40 , Y10S435/967 , Y10S435/968 , Y10T436/10 , Y10T436/108331
Abstract: The invention relates to improved electrochemiluminescence assay methods for phosphorylated peptides or proteins employing phospho-specific antibodies and buffer compositions that are substantially free of inorganic phosphate.
Abstract translation: 本发明涉及使用磷酸化特异性抗体和基本上不含无机磷酸盐的缓冲组合物的磷酸化肽或蛋白质的改进的电化学发光测定方法。
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公开(公告)号：US20090066339A1
公开(公告)日：2009-03-12
申请号：US12244133
申请日：2008-10-02
Applicant: Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
Inventor： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
CPC classification number: G01N21/76 , B01J19/0046 , B01J2219/00653 , B01J2219/00725 , B01J2219/0074 , B01L3/5027 , B01L3/502715 , B01L3/5029 , B01L9/527 , B01L2200/0684 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/049 , B01L2400/0688 , B33Y80/00 , C12Q1/001 , C40B40/10 , G01N27/30 , G01N33/5438 , G01N2458/30 , Y10T436/25 , Y10T436/25375 , Y10T436/255
Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
Abstract translation: 测定模块，优选测定盒，被描述为可用于控制模块操作的方面的读取器设备。 模块优选地包括具有集成电极的检测室，其可用于执行电极诱导的发光测量。 描述了以这种控制方式将测定试剂固定在这些电极和其它表面上的方法。 还描述了具有检测室，优选地具有集成电极的测定模块和盒，以及可以包括样品室，废物室，导管，通风口，气泡阱，试剂室，干试剂丸区等的其它流体组分。 在某些优选实施例中，这些模块适于接收和分析在施用器棒上收集的样品。
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公开(公告)号：US08641986B2
公开(公告)日：2014-02-04
申请号：US12244119
申请日：2008-10-02
Applicant: Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
Inventor： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
CPC classification number: G01N21/76 , B01J19/0046 , B01J2219/00653 , B01J2219/00725 , B01J2219/0074 , B01L3/5027 , B01L3/502715 , B01L3/5029 , B01L9/527 , B01L2200/0684 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/049 , B01L2400/0688 , B33Y80/00 , C12Q1/001 , C40B40/10 , G01N27/30 , G01N33/5438 , G01N2458/30 , Y10T436/25 , Y10T436/25375 , Y10T436/255
Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
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公开(公告)号：US08273566B2
公开(公告)日：2012-09-25
申请号：US12831139
申请日：2010-07-06
Applicant: Mark A. Billadeau , Jeff D. Debad , Eli N. Glezer , Jonathan K. Leland , Charles A. Wijayawardhana
Inventor： Mark A. Billadeau , Jeff D. Debad , Eli N. Glezer , Jonathan K. Leland , Charles A. Wijayawardhana
CPC classification number: G01N33/543 , G01N33/523 , G01N33/54366 , Y10T436/106664 , Y10T436/117497 , Y10T436/25125 , Y10T436/25375
Abstract: Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration of an analyte of interest in blood plasma from a whole blood sample without blood separation and hematocrit correction.
Abstract translation: 公开了用于进行可能含有细胞或其它颗粒物质的样品例如全血的测定的方法。 还公开了用于这些方法的系统，装置，设备，试剂盒和试剂。 某些公开的方法和系统的一个优点是能够在没有血液分离和血细胞比容校正的情况下从全血样品中快速测量血浆中目标分析物的浓度。
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公开(公告)号：US20120055809A1
公开(公告)日：2012-03-08
申请号：US13221427
申请日：2011-08-30
Applicant: Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
Inventor： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
IPC: G01N27/416
CPC classification number: G01N21/76 , B01J19/0046 , B01J2219/00653 , B01J2219/00725 , B01J2219/0074 , B01L3/5027 , B01L3/502715 , B01L3/5029 , B01L9/527 , B01L2200/0684 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/049 , B01L2400/0688 , B33Y80/00 , C12Q1/001 , C40B40/10 , G01N27/30 , G01N33/5438 , G01N2458/30 , Y10T436/25 , Y10T436/25375 , Y10T436/255
Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
Abstract translation: 测定模块，优选测定盒，被描述为可用于控制模块操作的方面的读取器设备。 模块优选地包括具有集成电极的检测室，其可用于执行电极诱导的发光测量。 描述了以这种控制方式将测定试剂固定在这些电极和其它表面上的方法。 还描述了具有检测室，优选地具有集成电极的测定模块和盒，以及可以包括样品室，废物室，导管，通风口，气泡阱，试剂室，干试剂丸区等的其它流体组分。 在某些优选实施例中，这些模块适于接收和分析在施用器棒上收集的样品。
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