公开(公告)号：US20100100175A1

公开(公告)日：2010-04-22

申请号：US12642525

申请日：2009-12-18

申请人： David Reuter ,  Mark Mathis ,  Greg Nieminen ,  Cruz Beeson

发明人： David Reuter ,  Mark Mathis ,  Greg Nieminen ,  Cruz Beeson

IPC分类号： A61F2/24

CPC分类号： A61F2/2451 ,  A61M25/1006

摘要： A tissue shaping device adapted to reshape target tissue adjacent to a lumen. In some embodiments, the device includes an expandable and contractable anchor, with the anchor having an adjustable height anchoring portion adapted to engage a wall of the lumen in at least first and second anchor heights, the anchoring portion being further adapted to be changed from the first anchor height to the second anchor height by a substantially proximally or a substantially distally directed actuation force. The invention is also a tissue shaping system including a tissue shaping device and a tool for adjusting the height of an anchor of the device. The invention also includes methods of using such tissue shaping devices and systems.

摘要翻译： 一种组织成形装置，适于重新形成邻近内腔的靶组织。 在一些实施例中，该装置包括可膨胀和可收缩的锚固件，锚具具有适于在至少第一和第二锚定高度处接合内腔壁的可调节高度锚固部分，锚定部分还适于从 第一锚定高度通过基本上向近端或基本上远端定向的致动力到第二锚定高度。 本发明还是一种组织成形系统，其包括组织成形装置和用于调节装置的锚的高度的工具。 本发明还包括使用这种组织整形装置和系统的方法。

公开(公告)号：US07670282B2

公开(公告)日：2010-03-02

申请号：US11153296

申请日：2005-06-14

申请人： Mark Mathis

发明人： Mark Mathis

IPC分类号： A61B1/00

CPC分类号： A61B1/0014 ,  A61B1/018 ,  A61B1/2676 ,  A61B17/3403 ,  A61B2010/045

摘要： This invention relates generally to lung access devices and methods of using the devices to gain access to the interior of a lung or to the mediastinal space around the lung. In particular, the invention relates to auxiliary access devices and tools for use with conventional bronchoscopes or other endoscopes to enable the delivery of more and larger devices to a target site than is currently possible through a typical endoscope or bronchoscope.

摘要翻译： 本发明一般涉及肺进入装置和使用这些装置以进入肺内部或肺周围的纵隔空间的方法。 特别地，本发明涉及用于与常规支气管镜或其它内窥镜一起使用的辅助进入装置和工具，以使得能够通过典型的内窥镜或支气管镜将目前可能的装置递送到目标部位。

公开(公告)号：US20080109059A1

公开(公告)日：2008-05-08

申请号：US11971174

申请日：2008-01-08

申请人： Lucas Gordon ,  Mark Mathis ,  Greg Nieminen

发明人： Lucas Gordon ,  Mark Mathis ,  Greg Nieminen

IPC分类号： A61F2/84

CPC分类号： A61F2/95 ,  A61B17/3468 ,  A61B2017/1205 ,  A61F2002/9511

摘要： A system for selectively deploying a medical device includes a cartridge that is engageable with a proximal end of a delivery catheter that is routed to a desired location in a patient's body. An advancement mechanism is provided for advancing the medical device out of the cartridge and into the delivery catheter for deploying the medical device at the desired location in the patient's body.

摘要翻译： 用于选择性地部署医疗装置的系统包括可与输送导管的近端接合的药筒，所述输送导管被路由到患者体内的期望位置。 提供了一种推进机构，用于将医疗装置推出药筒并进入输送导管，以将医疗装置展开在病人身体的所需位置。

公开(公告)号：US20070239270A1

公开(公告)日：2007-10-11

申请号：US11279352

申请日：2006-04-11

申请人： Mark Mathis ,  Gregory Nieminen ,  Nathan Aronson ,  Garrett Beget

发明人： Mark Mathis ,  Gregory Nieminen ,  Nathan Aronson ,  Garrett Beget

IPC分类号： A61F2/24

CPC分类号： A61F2/2451

摘要： The present invention relates to a medical device and uses thereof that supports or changes the shape of tissue near a vessel in which the device is placed. The present invention is particularly useful in reducing mitral valve regurgitation by changing the shape of or supporting a mitral valve annulus. The device includes a support structure, a proximal anchor adapted to be positioned in a superior vena cava, and a distal anchor adapted to be positioned in a coronary sinus. The support structure engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed.

摘要翻译： 本发明涉及一种医疗装置及其用途，其用于支撑或改变其中放置该装置的血管附近的组织的形状。 本发明特别可用于通过改变二尖瓣环的形状或支撑二尖瓣环来减少二尖瓣反流。 该装置包括支撑结构，适于定位在上腔静脉中的近端锚，以及适于定位在冠状窦中的远侧锚。 支撑结构接合血管壁以改变邻近其中放置血管内支持物的血管的组织的形状。

公开(公告)号：US20070135912A1

公开(公告)日：2007-06-14

申请号：US11655710

申请日：2007-01-18

申请人： Mark Mathis

发明人： Mark Mathis

IPC分类号： A61F2/24

CPC分类号： A61F2/2451 ,  A61F2210/0023

摘要： A mitral valve annulus reshaping device includes at least a portion that is formed of a biocompatible shape memory alloy SMA having a characteristic temperature, Af, that is preferably below body temperature. The device is constrained in an unstable martensite (UM) state while being introduced through a catheter that passes through the venous system and into the coronary sinus of the heart. The reshaping device is deployed adjacent to the mitral valve annulus of the heart as it is forced from the catheter. When released from the constraint of the catheter, the SMA of the device at least partially converts from the UM state to an austenitic state and attempts to change to a programmed shape that exerts a force on the adjacent tissue and modifies the shape of the annulus. The strain of the SMA can be varied when the device is within the coronary sinus.

摘要翻译： 二尖瓣环整形装置包括至少一部分，该部分由具有特征温度优选低于体温的生物相容性形状记忆合金SMA形成。 该装置被限制在不稳定的马氏体（UM）状态，同时通过导管穿过静脉系统并进入心脏的冠状窦。 当从导管被迫时，整形装置邻近心脏的二尖瓣环部署。 当从导管的约束释放时，该装置的SMA至少部分地从UM状态转变为奥氏体状态，并尝试改变为在相邻组织上施加力并且修改环形的形状的编程形状。 当器件在冠状窦内时，SMA的应变可以变化。

公开(公告)号：US20050288549A1

公开(公告)日：2005-12-29

申请号：US11153295

申请日：2005-06-14

申请人： Mark Mathis

发明人： Mark Mathis

IPC分类号： A61B1/00 ,  A61B1/018 ,  A61B1/06 ,  A61B1/267 ,  A61B10/04 ,  A61B17/34

CPC分类号： A61B1/0014 ,  A61B1/018 ,  A61B1/2676 ,  A61B17/3403 ,  A61B2010/045

摘要： This invention relates generally to lung access devices and methods of using the devices to gain access to the interior of a lung or to the mediastinal space around the lung. In particular, the invention relates to auxiliary access devices and tools for use with conventional bronchoscopes or other endoscopes to enable the delivery of more and larger devices to a target site than is currently possible through a typical endoscope or bronchoscope.

摘要翻译： 本发明一般涉及肺进入装置和使用这些装置以进入肺内部或肺周围的纵隔空间的方法。 特别地，本发明涉及用于与常规支气管镜或其它内窥镜一起使用的辅助进入装置和工具，以使得能够通过典型的内窥镜或支气管镜将目前可能的装置递送到目标部位。

公开(公告)号：US20050149182A1

公开(公告)日：2005-07-07

申请号：US11069847

申请日：2005-02-28

申请人： Clifton Alferness ,  John Adams ,  Mark Mathis ,  David Reuter

发明人： Clifton Alferness ,  John Adams ,  Mark Mathis ,  David Reuter

IPC分类号： A61F2/24

CPC分类号： A61F2/2451 ,  A61F2/2466

摘要： A device, system and method affects mitral valve annulus geometry of a heart. The device includes a first anchor configured to be positioned within and fixed to the coronary sinus of the heart adjacent the mitral valve annulus within the heart. A cable is fixed to the first anchor and extends proximately therefrom and slidingly through a second anchor which is positioned and fixed in the heart proximal to the first anchor. A lock locks the cable to the second anchor when tension is applied to the cable for affecting the mitral valve annulus geometry.

摘要翻译： 装置，系统和方法影响心脏的二尖瓣环形几何。 该装置包括构造成定位在心脏内邻近二尖瓣环的心脏的冠状窦内并固定到其的冠状窦的第一锚。 电缆固定到第一锚固件并且从其向近侧延伸并且滑动地穿过定位并固定在靠近第一锚固件的心脏中的第二锚固件。 当张力施加到电缆以影响二尖瓣环形几何时，锁将电缆锁定到第二锚定器。

公开(公告)号：US20050149179A1

公开(公告)日：2005-07-07

申请号：US10994168

申请日：2004-11-19

申请人： Mark Mathis ,  Leonard Kowalsky ,  David Reuter ,  Cruz Beeson

发明人： Mark Mathis ,  Leonard Kowalsky ,  David Reuter ,  Cruz Beeson

IPC分类号： A61F2/24

CPC分类号： A61F2/2451 ,  A61F2/2466 ,  A61F2002/91591 ,  A61F2210/0014 ,  A61F2220/0091 ,  A61F2230/0023 ,  A61F2250/0004 ,  A61F2250/0008 ,  A61F2250/0012 ,  A61F2250/0086 ,  A61F2310/00017 ,  A61F2310/00023

摘要： An anchor anchors a therapeutic device having an elongated body within a body lumen. The anchor includes a fixation member carried on the device which is adjustable from a first configuration that permits placement of the device in the body lumen to a second configuration that anchors the device within the body lumen. The anchor further includes a lock that locks the fixation member in the second configuration. The fixation member may be locked in any one of a plurality of intermediate points between the first configuration and a maximum second configuration.

摘要翻译： 锚定器将具有细长体的治疗装置锚定在体腔内。 所述锚固件包括承载在所述装置上的固定构件，所述固定构件可从第一构造调节，所述第一构型允许将所述装置放置在所述体腔内到达将所述装置固定在所述体腔内的第二构造。 锚固件还包括将固定构件锁定在第二构造中的锁。 固定构件可以锁定在第一构造和最大第二构造之间的多个中间点中的任何一个中。

公开(公告)号：US06602266B1

公开(公告)日：2003-08-05

申请号：US09492729

申请日：2000-01-27

申请人： Bryan Loomas ,  James Davenport ,  Mark Mathis

发明人： Bryan Loomas ,  James Davenport ,  Mark Mathis

IPC分类号： A61F900

CPC分类号： A61F2/147 ,  A61B2017/306 ,  A61B2017/320052 ,  A61F9/013

摘要： This invention is a surgical device for producing a generally circular, interlamellar pathway within the corneal stroma of the eye. The device is made up of three major components: a vacuum centering guide having an inner bore which fits at one end against the front of the eye, a barrel which fits within the inner bore of the centering guide and to which is attached the third major component, a generally circular dissecting ring. The dissecting ring is shaped in such way that when an eye surgeon twists the barrel to which the ring is attached, the ring moves through the interlamellar space in the stroma producing the desired channel or pathway. The centering guide may optionally include a ring having one or more pins which firmly engage the cornea's epiphilium. The constituent parts of the surgical device, particularly the dissecting ring, also form a part of this invention. A split ring, or intracorneal ring (“ICR”), is inserted into the intrastromal passageway produced by the inventive device. The ICR changes the shape of the cornea and, in doing so, provides a chosen measure of visual correction.

摘要翻译： 本发明是用于在眼睛的角膜基质内产生大致圆形的层间途径的手术装置。 该装置由三个主要部件组成：具有内孔的真空定心导向件，该内孔适合于一端靠近眼睛的前端，一个装在中心导向件内孔内的筒体， 组件，一般为环形解剖环。 解剖环的形状使得当眼外科医生扭转环所附着的圆筒时，环移动通过基质中的层间空间，产生所需的通道或通路。 定心引导件可以可选地包括具有一个或多个销的环，其牢固地接合角膜的骨架。 手术装置的组成部分，特别是解剖环，也构成本发明的一部分。 将裂口环或颈内环（“ICR”）插入由本发明装置产生的基质内通道。 ICR改变了角膜的形状，在这样做时，提供了一种选择的视力矫正措施。

公开(公告)号：US06562067B2

公开(公告)日：2003-05-13

申请号：US09877506

申请日：2001-06-08

申请人： Mark Mathis

发明人： Mark Mathis

IPC分类号： A61F206

CPC分类号： A61F2/915 ,  A61F2/91 ,  A61F2/958 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/91591 ,  A61F2230/0054

摘要： A stent comprises a lattice of interconnecting elements defining a substantially cylindrical configuration having a first open end and a second open end. The lattice has a locked configuration and an open configuration. The stent also comprises a plurality of bridges connecting the interconnecting elements wherein each bridge interlocks with an adjacent bridge in the locked configuration and each bridge separates from the adjacent bridge in the open configuration. A second embodiment for the stent also comprises a lattice of interconnecting elements including a plurality of struts wherein each strut interlocks with an adjacent strut in the locked configuration and each strut separates from the adjacent strut in the open configuration.