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公开(公告)号：US08224584B2
公开(公告)日：2012-07-17
申请号：US12913591
申请日：2010-10-27
IPC分类号： G01N33/48
CPC分类号： G06F19/24 , C12Q1/6851 , C12Q2537/165 , C12Q2545/101
摘要： System for quantifying analyte polynucleotides employs computer-implemented analysis of real-time amplification data using a calibration curve defined by parametric equations.
摘要翻译： 用于定量分析物多核苷酸的系统使用由参数方程定义的校准曲线的计算机实时分析实时放大数据。
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公开(公告)号：US20110076727A1
公开(公告)日：2011-03-31
申请号：US12959016
申请日：2010-12-02
CPC分类号： B01L3/565 , B01L3/50825 , B01L2200/026 , B01L2300/044 , B01L2300/047 , B01L2300/0681 , B01L2300/069 , B01L2300/0887 , B65D41/0414 , B65D51/002 , B65D51/1616 , B65G2203/044 , H01L21/67784
摘要： A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.
摘要翻译： 具有芯体结构的帽，其尺寸适于接收通过其的移液管。 盖子包括两个轴向对齐的易碎密封件，其以间隔的关系固定到芯部结构。 脆弱的密封件被构造成使得当移液管尖端穿透易碎密封件时，易碎密封件和移液管尖端之间形成空气通道。 盖可选地包括插入在第一和第二易碎密封件之间的过滤器。
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公开(公告)号：US20110040490A1
公开(公告)日：2011-02-17
申请号：US12913591
申请日：2010-10-27
IPC分类号： G06F19/00
CPC分类号： G06F19/24 , C12Q1/6851 , C12Q2537/165 , C12Q2545/101
摘要： System for quantifying analyte polynucleotides employs computer-implemented analysis of real-time amplification data using a calibration curve defined by parametric equations.
摘要翻译： 用于定量分析物多核苷酸的系统使用由参数方程定义的校准曲线的计算机实时分析实时放大数据。
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公开(公告)号：US20100277725A1
公开(公告)日：2010-11-04
申请号：US12838804
申请日：2010-07-19
申请人： Oleg Zimenkov , Xavier Amouretti , Robert M. Gifford , Mark R. Kennedy , Michael Kontorovich , Ben Norris , Richard N. Sears , Dan Venditti , Christopher Many
发明人： Oleg Zimenkov , Xavier Amouretti , Robert M. Gifford , Mark R. Kennedy , Michael Kontorovich , Ben Norris , Richard N. Sears , Dan Venditti , Christopher Many
IPC分类号： G01J3/42
CPC分类号： G01J3/42 , G01J3/0224 , G01J3/0294 , G01J3/10 , G01J3/4406 , G01J3/443 , G01N21/6452 , G01N21/76 , G01N2021/6463
摘要： An apparatus and a method for optically analyzing a sample are provided. The apparatus includes a first optical device that transmits a narrow waveband of light and has a first filter and a first monochromator that provide different paths for the narrow waveband of the light. The apparatus may also include a light source that generates the light as broadband excitation light, in which case the first optical device transmits a narrow waveband of the broadband excitation light through the first filter or the first monochromator. Further, the apparatus may include a second optical device that directs the narrow waveband of the broadband excitation light onto the sample and receives emission light from the sample, a third optical device that transmits a narrow waveband of the emission light, and a detector that converts the narrow waveband of the emission light into an electrical signal.
摘要翻译： 提供了用于光学分析样品的装置和方法。 该装置包括发射窄波段光的第一光学装置，并具有为光的窄波段提供不同路径的第一滤光器和第一单色仪。 该装置还可以包括产生作为宽带激发光的光的光源，在这种情况下，第一光学装置通过第一滤光器或第一单色器传输宽带激发光的窄波段。 此外，该装置可以包括第二光学装置，其将宽带激发光的窄波段引导到样本上并接收来自样品的发射光，透射发射光的窄波段的第三光学装置，以及转换 将发射光的窄波段变成电信号。
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公开(公告)号：US07691332B2
公开(公告)日：2010-04-06
申请号：US11869233
申请日：2007-10-09
CPC分类号： B01L3/565 , B01L3/50825 , B01L2200/026 , B01L2300/044 , B01L2300/047 , B01L2300/0681 , B01L2300/069 , B01L2300/0887 , B65D41/0414 , B65D51/002 , B65D51/1616 , B65G2203/044 , H01L21/67784
摘要： A cap which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis. To minimize potentially contaminating contact between a fluid sample present in the vessel and humans or the environment, the present invention features a cap having a frangible seal which is penetrable by a plastic pipette tip or other fluid transfer device. The cap further includes a filter for limiting dissemination of an aerosol or bubbles once the frangible seal has been pierced. The filter is positioned between the frangible seal and a retaining structure. The retaining structure is positioned on the cap above the filter and may be used to contain the filter within the cap. The material of the retaining structure may be penetrable by a fluid transfer device.
摘要翻译： 可以与能够接收和保持流体样本或其他材料进行分析的开放式容器形成基本上防漏密封的盖。 为了最小化容器中存在的流体样品与人类或环境之间的潜在的污染接触，本发明的特征在于具有可由塑料吸头或其他流体传送装置穿透的易碎密封件的盖。 一旦破裂密封件被刺穿，盖子还包括用于限制气溶胶或气泡的传播的过滤器。 过滤器位于易碎密封件和保持结构之间。 保持结构定位在过滤器上方的帽上，并且可以用于将过滤器容纳在盖内。 保持结构的材料可以被流体转移装置穿透。
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公开(公告)号：US07294308B2
公开(公告)日：2007-11-13
申请号：US10954578
申请日：2004-09-29
CPC分类号： B01L3/565 , B01L3/50825 , B01L2200/026 , B01L2300/044 , B01L2300/047 , B01L2300/0681 , B01L2300/069 , B01L2300/0887 , B65D41/0414 , B65D51/002 , B65D51/1616 , B65G2203/044 , H01L21/67784
摘要： A cap which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis. To minimize potentially contaminating contact between a fluid sample present in the vessel and humans or the environment, the cap has a frangible seal which is penetrable by a plastic pipette tip or other fluid transfer device. The cap further includes a filter for limiting dissemination of an aerosol or bubbles once the frangible seal has been pierced. The filter is positioned between the frangible seal and a retainer. The retainer is positioned on the cap above the filter and may be used to contain the filter within the cap. The material of the retainer may be penetrable by a fluid transfer device.
摘要翻译： 可以与能够接收和保持流体样本或其他材料进行分析的开放式容器形成基本上防漏密封的盖。 为了最小化存在于容器中的流体样品与人体或环境之间的潜在的污染接触，盖具有可被塑料移液管尖端或其它流体传送装置穿透的易碎密封。 一旦破裂密封件被刺穿，盖子还包括用于限制气溶胶或气泡的传播的过滤器。 过滤器位于易碎密封件和保持器之间。 保持器定位在过滤器上方的帽上，并且可以用于将过滤器容纳在盖内。 保持器的材料可以被流体输送装置穿透。
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公开(公告)号：US07782454B2
公开(公告)日：2010-08-24
申请号：US11802831
申请日：2007-05-25
申请人： Oleg Zimenkov , Xavier Amouretti , Robert M. Gifford , Mark R. Kennedy , Michael Kontorovich , Ben Norris , Richard N. Sears , Dan Venditti , Christopher Many
发明人： Oleg Zimenkov , Xavier Amouretti , Robert M. Gifford , Mark R. Kennedy , Michael Kontorovich , Ben Norris , Richard N. Sears , Dan Venditti , Christopher Many
IPC分类号： G01J3/44
CPC分类号： G01J3/42 , G01J3/0224 , G01J3/0294 , G01J3/10 , G01J3/4406 , G01J3/443 , G01N21/6452 , G01N21/76 , G01N2021/6463
摘要： An apparatus and a method for optically analyzing a sample are provided. The apparatus includes a first optical device that transmits a narrow waveband of light and has a first filter and a first monochromator that provide different paths for the narrow waveband of the light. The apparatus may also include a light source that generates the light as broadband excitation light, in which case the first optical device transmits a narrow waveband of the broadband excitation light through the first filter or the first monochromator. Further, the apparatus may include a second optical device that directs the narrow waveband of the broadband excitation light onto the sample and receives emission light from the sample, a third optical device that transmits a narrow waveband of the emission light, and a detector that converts the narrow waveband of the emission light into an electrical signal.
摘要翻译： 提供了用于光学分析样品的装置和方法。 该装置包括发射窄波段光的第一光学装置，并具有为光的窄波段提供不同路径的第一滤光器和第一单色仪。 该装置还可以包括产生作为宽带激发光的光的光源，在这种情况下，第一光学装置通过第一滤光器或第一单色器传输宽带激发光的窄波段。 此外，该装置可以包括第二光学装置，其将宽带激发光的窄波段引导到样本上并接收来自样品的发射光，透射发射光的窄波段的第三光学装置，以及转换 将发射光的窄波段变成电信号。
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公开(公告)号：US20090036327A1
公开(公告)日：2009-02-05
申请号：US12221129
申请日：2008-07-30
申请人： John Lawrence Ervin , Hus Tigli , Mark R. Kennedy
发明人： John Lawrence Ervin , Hus Tigli , Mark R. Kennedy
IPC分类号： C40B50/18
CPC分类号： G01N33/54353
摘要： A method which renders the 3D surface of the insides of the pores of porous silicon biochip appropriate for conducting studies on biomolecule interactions without labels.
摘要翻译： 使得多孔硅生物芯片的孔内部的3D表面适合于进行生物分子相互作用的标记的方法。
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公开(公告)号：US20140053662A9
公开(公告)日：2014-02-27
申请号：US13297136
申请日：2011-11-15
IPC分类号： B01L3/00
CPC分类号： B01L3/565 , B01L3/50825 , B01L2200/026 , B01L2300/044 , B01L2300/047 , B01L2300/0681 , B01L2300/069 , B01L2300/0887 , B65D41/0414 , B65D51/002 , B65D51/1616 , B65G2203/044 , H01L21/67784
摘要： A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals include a foil layer and are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.
摘要翻译： 具有芯体结构的帽，其尺寸适于接收通过其的移液管。 盖子包括两个轴向对齐的易碎密封件，其以间隔的关系固定到芯部结构。 易碎密封件包括箔层，并且构造成使得当移液管尖端穿透易碎密封件时，易碎密封件与移液管尖端之间形成空气通道。 盖可选地包括插入在第一和第二易碎密封件之间的过滤器。
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公开(公告)号：US08218141B2
公开(公告)日：2012-07-10
申请号：US12838804
申请日：2010-07-19
申请人： Oleg Zimenkov , Xavier Amouretti , Robert M. Gifford , Mark R. Kennedy , Michael Kontorovich , Ben Norris , Richard N. Sears , Dan Venditti , Christopher Many
发明人： Oleg Zimenkov , Xavier Amouretti , Robert M. Gifford , Mark R. Kennedy , Michael Kontorovich , Ben Norris , Richard N. Sears , Dan Venditti , Christopher Many
CPC分类号： G01J3/42 , G01J3/0224 , G01J3/0294 , G01J3/10 , G01J3/4406 , G01J3/443 , G01N21/6452 , G01N21/76 , G01N2021/6463
摘要： An apparatus and a method for optically analyzing a sample are provided. The apparatus includes a first optical device that transmits a narrow waveband of light and has a first filter and a first monochromator that provide different paths for the narrow waveband of the light. The apparatus may also include a light source that generates the light as broadband excitation light, in which case the first optical device transmits a narrow waveband of the broadband excitation light through the first filter or the first monochromator. Further, the apparatus may include a second optical device that directs the narrow waveband of the broadband excitation light onto the sample and receives emission light from the sample, a third optical device that transmits a narrow waveband of the emission light, and a detector that converts the narrow waveband of the emission light into an electrical signal.
摘要翻译： 提供了用于光学分析样品的装置和方法。 该装置包括发射窄波段光的第一光学装置，并具有为光的窄波段提供不同路径的第一滤光器和第一单色仪。 该装置还可以包括产生作为宽带激发光的光的光源，在这种情况下，第一光学装置通过第一滤光器或第一单色器传输宽带激发光的窄波段。 此外，该装置可以包括第二光学装置，其将宽带激发光的窄波段引导到样本上并接收来自样品的发射光，透射发射光的窄波段的第三光学装置，以及转换 将发射光的窄波段变成电信号。
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